Researchers have now used genetically engineered DNA binding proteins to target specific processes within a gene - located within a brain reward center in the mouse. By regulating the activity of this specific gene, the scientists found they were able to alter gene expression and behaviors related to addiction and stress. This technique may lead to new treatments for substance use and other mental health disorders.
This research was funded by NIDA and NIMH. For a copy of the article (published online October 27), go to: www.nature.com/neuro/journal/v17/n12/full/nn.3871.html#abstract. For a press release from the study’s authors, go to: http://icahn.mssm.edu/about-us/news-and-events/changes-in-a-single-genes-action-can-control-addiction-and-depression-related-behaviors.
For more information, contact the NIDA press office at media@nida.nih.gov or 301-443-6245.