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NIDA. (2014, July 30). Regular marijuana users may have impaired brain reward centers. Retrieved from

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Science Spotlight

July 30, 2014

New research shows that regular marijuana users show impairments in the brain’s ability to respond to dopamine – a brain chemical that is involved in reward, among other functions.

Although this research can’t determine if regular marijuana use causes deficits in brain reward centers – or if users take marijuana to compensate for less reactive dopamine systems – these results could help explain why regular marijuana users are more prone towards depression, anxiety, irritability, and increased sensitivity to stress.

The study, first-authored by NIDA Director Dr. Nora Volkow, was supported by the intramural research program of the National Institute on Alcohol Abuse and Alcoholism. For a copy of the study abstract (published online July 14), go to:

For more information, contact the NIDA press office at or 301-443-6245.

Brain dopamine pathways