March 2011
Affected proteins include enzymes that influence DNA repair, cell death, stress resistance, metabolism, and aging.

Describes research findings that show that chronic cocaine abuse may change the production of many proteins in the neurons of the brain’s reward system, aiding in our understanding how the drug causes addiction.

October 2010
Cellular studies of cocaine and methamphetamine offer clues to underlying mechanism.

Reports on two studies showing a high prevalence of HIV infection and more rapid progression to disability and death among drug abusers.

October 2010

Describes study findings revealing that cocaine abusers who maintain high levels of a certain receptor in their brain during early abstinence relapse sooner than abusers whose levels drop.

October 2010

Describes research results reporting that people who favor novelty have lower-than-average availability of a receptor that inhibits dopamine's release from neurons, which likely stimulates the activity of reward circuits.

October 2010
Dendritic spine proliferation seems to compensate for some impacts of cocaine use.

Reports evidence that a cocaine-induced change in the structure of brain cells represents an adaptive response that may limit the drug’s impact.

April 2010

Describes an animal study reporting that peer interaction enhances adolescent rats’ drug reward and discusses the impact of these findings to future research on drug reward in social context.

April 2010

Describes a literature analysis reporting on the prevalence of people with bipolar disorder who also have a substance use disorder and discusses the genetic link that may contribute to this comorbidity.

December 2009

Describes an animal study showing that rats raised in isolation may prove useful in future studies exploring the neurobiology that links impulsivity and vulnerability to addiction.

December 2009
Genes for protein constituents of nicotinic acetylcholine receptors influence early smoking responses and the likelihood of nicotine dependence.

Reports study results suggesting that genes for several acetylcholine receptor proteins influence early smoking responses and the likelihood of nicotine dependence.

December 2009
Molecular change in rat brains parallels increase in drug-seeking behavior.

Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

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