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Emerging Technologies and New Directions in Drug Abuse Research

NIDA Research Monograph, Number 112 [Printed in 1991]

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Table of Contents


Emerging Technologies and New Directions in Drug Abuse Research: An Overview-----1
Rao S. Rapaka, Alexandros Makriyannis, and Michael J. Kuhar

Voronoi Binding Site Models-----7
Gordon M. Crippen

A Mechanistic Basis for Design of Selective Agonists for 5-HT Receptors-----21
Roman Osman and Harel Weinstein

Computer-Aided Drug Design for the Benzodiazepine Receptor Site-----43
Gilda H. Loew, Hugo O. Villar, Waymond Jung, and M. Frances Davies

3D-Searching: An Overview of a New Technique for Computer-Assisted Molecular Design-----62
Robert S. Pearlman

Protein Structure Determination in Solution Using Nuclear Magnetic Resonance Spectroscopy-----76
Angela M. Gronenborn and G. Marius Clore

Combined Use of Solid-State Nuclear Magnetic Resonance Spectroscopy, Small-Angle X-Ray Diffraction, and Differential Scanning Calorimetry in Studies of Cannabinoid: Membrane Interactions-----106
Alexandros Makriyannis, De-Ping Yang, and Thomas Mavromoustakos

Characterization and Localization of Cannabinoid Receptors in Brain: An In Vitro Technique Using Slide-Mounted Tissue Sections-----129
Miles Herkenham

New Developments in Radiotracers for Positron Emission Tomography-----146
Joanna S. Fowler and Alfred P. Wolf

Use of Positron Emission Tomography To Study Cocaine in the Human Brain-----166
Nora D. Volkow, Joanna S. Fowler, and Alfred P. Wolf

Development of Opioid Peptide Analogs as Pharmacologic Tools and as Potential Drugs: Current Status and Future Directions-----180
Peter W. Schiller

Conformational Analysis of Opioid Receptor-Selective Peptides Using Nuclear Magnetic Resonance and Theoretical Calculations-----198
Victor J. Hruby, Om Prakash, Wieslaw Kazmierski, Catherine Gehrig, and Terry O. Matsunaga

Peptidomimetic Opioids-Synthesis, Spectroscopy, and Computer Simulations-----218
Murray Goodman, Odile E. Said-Nejad, Eduard Felder, Dale F. Mierke, Toshimasa Yamazaki, and Peter W. Schiller

Modified Solid-Phase Methods for the Rapid Synthesis of Opioid Peptides-----239
Richard A. Houghten, John M. Ostresh, and Suzanne M. Pratt

Irreversible Ligands as Probes for Drug Receptors-----256
Amy Hauck Newman

Important Compounds in the Cocaine Class: A Synthesis Overview-----284
F.I. Carroll and Anita H. Lewin

lmmunomodulatory Effects of Drugs of Abuse and the Importance of Structure-lmmunomodulatory Activity Studies-----300
Rao S. Rapaka and Charles P. Hoiberg

FDA Regulatory Requirements for Investigational New Drugs and New Drug Applications: An Update-----313
Charles P. Hoiberg and Rao S. Rapaka

List of NIDA Research Monographs-----326

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