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Report Calls for Sweeping Changes in Health Care for Mental and Substance Abuse Problems

Published February 2007

Reviews a report from the National Academy of Sciences’ Institute of Medicine that discusses ways to improve the quality of health care among people with mental health and substance abuse disorders.

Brain Changes Accompany Cocaine Withdrawal

Basic Science, Published February 2007

Summarizes an animal study of the neural changes in the amygdala portion of the brain that occur as a result of cocaine exposure followed by withdrawal of the drug.

Medical Care During Addiction Treatment Reduces Hospital Use

Published February 2007

Reports on an analysis comparing three types of addiction treatment programs: methadone maintenance programs, long-term residential programs, and nonmethadone programs.

Studies Focus on Acculturation and Hispanic Youth

Published February 2007

Summarizes a study that analyzes factors associated with the risk of drug addiction among 19- to 21-year-old Hispanic women born in the United States as compared with immigrants.

GHB Intoxication Reports Decline in California

Published February 2007

Highlights statistics on the number of reports of gamma-hydroxybutyrate (GHB) use intoxication in California from 1999 to 2003.

How Drug Abuse Affects the Brain and Alters Behavior Are Key Questions Driving Division's Work

NIDA @ Work, Published February 2007

Discusses the work of NIDA’s Division of Basic Neuroscience and Behavioral Research, the Institute’s locus for studies into the fundamental brain mechanisms underlying drug abuse and addiction.

Nicotine Alters the Developing Rat Brain

Basic Science, Published February 2007
Exposure to the drug during gestation or adolescence may cause lasting alterations in reward and motivation circuits.

Describes animal studies that suggested exposure to the drug during gestation or adolescence may cause lasting alterations in reward and motivation circuits.

Addiction and Co-Occurring Mental Disorders

Director's Perspective, Published February 2007

Presents an overview of the research underway to investigate medication and behavioral therapies for co-occurring disorders.

Cocaine Craving Activates Brain Reward Structures; Cocaine "High" Dampens Them

Basic Science, Published February 2007
A study documented changing emotional and neurobiological responses to cocaine with successive doses during a single session of drug taking.

Reports on a study that documenting changing emotional and neurobiological responses to cocaine with successive doses during a single session of drug taking.

Cocaine Abusers' Pretreatment Cue Responses Predict Recovery Success

Published February 2007
In the future, patients' brain scans may help clinicians tailor addiction treatment to improve therapeutic outcomes.

Reports on the work of researchers who used brain images to correlate cocaine-addicted patients' regional brain responses to drug cues with their outcomes in subsequent treatment.

Behavioral Response to Novelty Foreshadows Neurological Response to Cocaine

Published February 2007
Young rats' engagement with novel objects correlates with cocaine-induced dopamine release, shedding light on the mechanisms of drug abuse vulnerability.

Describes evidence supporting the view that developmental differences in brain systems that use the neurotransmitter dopamine underlie age differences in susceptibility to drug abuse.

Journal Highlights Opportunities in Hispanic Drug Abuse Research

Bulletin Board, Published February 2007

Reviews a journal supplement that compiles information on drug abuse research in the Hispanic population.

Videos Help Treat Deaf People

Bulletin Board, Published February 2007

Reviews a training DVD that presents dialectical behavior therapy skills being taught by deaf clinicians to deaf consumers as an approach to improve deaf people's access to behavioral health care.

Methylphenidate for Comorbid Cocaine Abuse, ADHD

Published October 2006

Describes an inpatient study investigating the effectiveness of sustained-release methylphenidate as a treatment for cocaine-addiction patients with ADHD.

Stress Response May Underlie African- Americans' Reduced Pain Tolerance

Basic Science, Published October 2006

Summarizes research suggesting a physiological difference as the explanation for African-Americans' reported low tolerance for pain.

Ethnicity Influences Early Smoking and Progression to Drug Abuse

Published October 2006

Summarizes findings from a 10-year study that monitored smoking and progress to other drugs among youth that found ethnicity to be an influential factor.

NIDA Launches Criminal Justice Publication in Chicago

Published October 2006

Highlights a publication that outlines 13 research-based principles of successful treatment of drug abusers in the criminal justice system.

Study Finds Withdrawal No Easier With Ultrarapid Opiate Detox

Published October 2006
Three serious adverse events among 35 ultrarapid procedures were all related to unreported preexisting medical conditions.

Presents findings from a clinical trial comparing ultrarapid, anesthesia-assisted detoxification with detoxification by traditional methods among patients addicted to heroin.

First-time Patients Opt for Office-Based Buprenorphine

Published October 2006

Presents highlights of a study suggesting that compared with methadone, office-based buprenorphine treatment attracts individuals who have less extensive addiction histories.

High School Seniors Steadily Increase Nonmedical Use of Sedatives Over 15 years

Basic Science, Published October 2006

Highlights data from an annual national survey of youth showing a pattern of rising nonmedical use of sedatives among high school seniors.

Marijuana Smoking Is Associated With a Spectrum of Respiratory Disorders

Published October 2006
Two NIDA-funded studies identify health risks that underscore the importance of curbing marijuana abuse.

Highlights two studies suggesting significant associations between marijuana smoking and respiratory disease.

Steroid Abuse Is a High-Risk Route to the Finish Line

Director's Perspective, Published October 2006

Highlights research on the effects of steroid use on the brain and the rest of the body, and stresses the need to educate young people about the serious health risks associated with its use.

Low-Cost Incentives Improve Outcomes in Stimulant Abuse Treatment

Published October 2006
In community-based treatment programs, the intervention added $2.42 per patient per day to counseling costs.

Reports on a study investigating the use of incentives in the form of prizes to motivate outpatients to stay in behavioral therapy and remain drug free.

Buprenorphine Plus Behavioral Therapy Is Effective For Adolescents With Opioid Addiction

Published October 2006
A new study looks at extending the role of buprenorphine for treatment of adolescents.

Reports on a study of adolescents addicted to opioids who responded better to buprenorphine than clonidine in a clinical trial in which all patients also received behavioral therapy.

Brain Mechanism Turns Off Cocaine-Related Memory in Rats

Published October 2006
An exploration of memory's molecular basis suggests potential novel therapeutic approaches to cue-induced craving.

Describes a series of experiments that have added to evidence that a brain enzyme controls key memory processes that link drug experiences, the surroundings in which they take place, and the urge to repeat them.

Walk the Line Is Among 10th Annual PRISM Awardees

Bulletin Board, Published October 2006

Announces the winners of the 10th Annual PRISM Awards, including Walk the Line, a film portraying the life of singer Johnny Cash and his battle with drug addiction.

NIDA's National Advisory Council Welcomes New Members

Bulletin Board, Published October 2006

Introduces four new members to NIDA’s National Advisory Council on Drug Abuse, including Drs. Warren K. Bickel, Ellie E. Schoenbaum, and Marina E. Wolf, and Ms. Janet Wood.

Methamphetamine Increases, and HIV Decreases, Brain Volumes

Basic Science, Published July 2006
HIV infection and methamphetamine addiction produce distinct, partly overlapping effects on brain structures.

HIV infection and methamphetamine addiction produce distinct, partly overlapping effects on brain structures.

Sensory Aspects May Drive Addiction in Obese Smokers

Basic Science, Published July 2006
Obesity appears to reduce nicotine's rewarding effect in mice and humans.

Obesity appears to reduce nicotine's rewarding effect in mice and humans.

Bulletin Board

Bulletin Board, Published July 2006

NIDA Honors Dr. William L. Dewey, HHS and NIH Recognize NIDA Staff, ATLAS and ATHENA Prevention Programs Receive First Sports Illustrated Champion Award

Methamphetamine Evokes and Subverts Brain Protective Responses

Published July 2006
Two new studies appear to highlight the role of glial cells—the nervous system's equivalents to the body's immune cells—in methamphetamine abuse.

Two new studies appear to highlight the role of glial cells—the nervous system's equivalents to the body's immune cells—in methamphetamine abuse.

Research in Brief: Highlights of Recently Published NIDA-Supported Studies

Research in Brief, Published July 2006

"Light" Cigarettes Deliver Heavy Carcinogen Load; African-Americans Metabolize Nicotine Slowly; The Brain in Pain; Parents' Actions, More Than Their Words, Influence Kids' Smoking

Drugs Affect Men's and Women's Brains Differently

Published July 2006
Gender appears to influence biological responses to nicotine, cocaine, and alcohol.

Gender appears to influence biological responses to nicotine, cocaine, and alcohol.

Court-Mandated Treatment Works as Well as Voluntary

Published July 2006
Regardless of their impetus for participating in drug treatment—internal drive or external pressure—men had similar outcomes in the long term.

Regardless of their impetus for participating in drug treatment—internal drive or external pressure—men had similar outcomes in the long term.

Checkup System Catches Relapse Early and Facilitates Return to Treatment

Published July 2006
Researchers in Chicago apply an old medical maxim: "Chronic diseases require chronic cures."

Researchers in Chicago apply an old medical maxim: "Chronic diseases require chronic cures."

Animal Research Shows GHB Acts on GABA Receptors

Published April 2006
Baboon studies may help researchers learn how the club drug gamma-hydroxybutyrate exerts such a powerful grip when abusers try to quit.

Baboon studies may help researchers learn how the club drug gamma-hydroxybutyrate exerts such a powerful grip when abusers try to quit.

Cocaine Abuse and HIV Are Linked With Coronary Calcification

Published April 2006
Cardiovascular changes that are potential risk factors for serious heart disease are detected in relatively young people with HIV infection or a history of cocaine abuse.

Cardiovascular changes that are potential risk factors for serious heart disease are detected in relatively young people with HIV infection or a history of cocaine abuse.

Treatment During Work Release Fosters Offenders' Successful Community Reentry

Published April 2006
Long-term studies are helping to determine the most effective drug treatment protocols for prisoners in transition.

Long-term studies are helping to determine the most effective drug treatment protocols for prisoners in transition.

Brain Activity Patterns Signal Risk of Relapse to Methamphetamine

Published April 2006
Methamphetamine abusers who relapse after treatment appear to make decisions using different brain regions than do those who remain abstinent

Methamphetamine abusers who relapse after treatment appear to make decisions using different brain regions than do those who remain abstinent

Animal Experiments in Addiction Science

Published April 2006
To learn how drugs promote abuse and produce addiction, researchers focus on animal behaviors that parallel human drug-related behaviors.

To learn how drugs promote abuse and produce addiction, researchers focus on animal behaviors that parallel human drug-related behaviors.

Highlights of Recently Published NIDA-Supported Studies

Research in Brief, Published April 2006

Nicotine and Cocaine Vaccines Move Forward; No-Smoking Policy Did Not Deter Enrollment In Addiction Programs; GVG Shows Promise In Early Human Trials; Methamphetamine Disrupts Focus

Bulletin Board

Bulletin Board, Published April 2006

Clinical Trials Network Adds Texas and Appalachia Sites; NIDA Launches HIV/AIDS Public Awareness Campaign

Bupropion Helps People With Schizophrenia Quit Smoking

Published April 2006
Data address physicians' concerns about prescribing the medication for smokers with schizophrenia.

Data address physicians' concerns about prescribing the medication for smokers with schizophrenia.

Community-Based Treatment Benefits Methamphetamine Abusers

Published April 2006
A large California study finds favorable effects for inpatients and outpatients; women's gains are larger.

A large California study finds favorable effects for inpatients and outpatients; women's gains are larger.

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