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Combined Treatments Improve Dual Abstinence

Treatment, Published October 2009

Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.

Conferees Discuss Ways to Eliminate Disparities in Care

Bulletin Board, Published October 2009

Presents highlights of a meeting summit to discuss ways to eliminate disparities in care, particularly as they relate to drug abuse and HIV.

Three Scientists Receive Grants for Innovative AIDS Research

Bulletin Board, Published October 2009

Announces the recipients of the inaugural Avant-Garde Award for research to prevent and treat HIV/AIDS in drug abusers, Drs. Julio Montaner, Ileana Cristea, and Jerome Groopman.

NIDA Reprises Online Chat Day

Bulletin Board, Published October 2009

Highlights NIDA’s second annual Chat Day where NIDA scientists and staff responded to drug abuse and addiction questions from teachers and students.

Receptor Complexes Link Dopamine to Long-Term Neuronal Effects

Basic Science, Published October 2009
Discovery may open a new window on substance abuse and potential therapies.

Reports on a discovery of previously unrecognized dopamine receptors in the brain that when triggered by drug abuse lead to potentially long-term neuronal effects.

Program Reduces Girls' Delinquent Behavior

Prevention, Published October 2009
The power of the family and a focus on homework were keys to success.

Reports on a study involving adolescent girls who were treated for delinquent behaviors in a well-supervised family setting, referred to as Multidimensional Treatment Foster Care.

Manic Mice Show Heightened Sensitivity to Rewards

Basic Science, Published October 2009
Manipulation of a gene produces mice with behaviors characteristic of bipolar disorder and signs of drug abuse vulnerability.

Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.

Intervention for Disruptive Children Shows Long-Term Benefits

Prevention, Published October 2009
Teaching aggressive youngsters social coping skills reduces their chances of becoming substance abusers.

Reports on research providing evidence that teaching aggressive youngsters social coping skills reduces their chances of becoming substance abusers.

Ethnic Groups Have Contrasting Genetic Risks for Nicotine Addiction

Basic Science, Published October 2009
Differences and similarities show up in genetic profiles of African-Americans and European-Americans who are heavy smokers.

Describes research exploring differences and similarities in the genetic profiles of African-Americans and European-Americans who are heavy smokers.

Suiting Treatment to the Nature of the Disease

Director's Perspective, Published October 2009

Highlights NIDA-sponsored research underway to understand and respond to substance abusers’ needs at all points of care, from the initial presentation for treatment through recovery.

Abstinent Smokers' Nicotinic Receptors Take More Than a Month to Normalize

Treatment, Published October 2009
Prolonged increase in brain receptors after smokers quit may explain the struggle to kick cigarettes and high risk for relapse during early abstinence.

Describes research revealing that for up to 6 weeks after smokers quit, their brain cells have more nicotine-binding receptors than nonsmokers, which may explain the struggle to quit.

High School Seniors Report Alcohol- or Drug-Impaired Driving Experiences

Public Health, Published April 2009

Examines the incidence of high school seniors’ alcohol- or drug-related driving experiences based on 2001 through 2006 data.

Adolescent Rats Self-Administer More Nicotine Than Adults

Basic Science, Published April 2009

Highlights an animal study involving the self-administration of nicotine among adolescent and adult rats to gain understanding of their potential vulnerability to the substance.

New Tracer for Nicotinic Receptors Promises Improved Specificity

Basic Science, Published April 2009

Reports on NIDA researchers who developed a new tracer compound that binds readily to nicotine receptors and enhances positron emission tomography images.

Court Mandates Help Men With Antisocial Personality Disorders Stay in Treatment

Treatment, Published April 2009

Reports on a study of men with co-occurring substance abuse and antisocial personality disorders and the potential benefit of judicially mandated addiction treatment.

Prenatal Nicotine Exposure May Damage Receptors That Influence Auditory Processing

Basic Science, Published April 2009
Tests correlate biochemical abnormality with deficits in rats' responses to sounds.

Reports on a series of animal experiments indicating that nicotine exposure during prenatal fetal development damages a set of receptors in the brain's auditory processing center.

Legal Pressure Increases Treatment Retention

Treatment, Published April 2009

Presents data on the length of stay in substance abuse treatment among people who were in treatment as a result of legal pressure as compared with those in treatment voluntarily.

Research Addresses Needs of Criminal Justice Staff and Offenders

NIDA @ Work, Published April 2009

Highlights a project in which nine research centers collaborate with criminal justice partners to test science-based tools for integrating drug abuse treatment in prisons and probation and parole programs.

Methamphetamine Abusers Show Increased Distractibility

Basic Science, Published April 2009
Reduced ability to choose between conflicting stimuli corresponds to neural damage.

Highlights findings from a study of former methamphetamine abusers showing evidence of impairment in areas of the brain known to influence cognition, emotion, and decision making.

Low Dopamine Receptor Availability May Promote Cocaine Addiction

Basic Science, Published April 2009
Reduced availability heightens reinforcing effects of cocaine in monkeys, and the drug drives this measure even lower.

Describes findings from an animal study showing that cocaine lowers availability of dopamine receptors in the basal ganglia, an area of the brain that includes portions of the reward system.

Stimulus Money Will Fund a Surge in Knowledge

Director's Perspective, Published April 2009

Describes NIDA’s drug abuse and addiction research priorities for the use of the American Recovery and Reinvestment Act of 2009 funds.

Damage to Brain Area May Immediately Halt Cigarette Addiction

Basic Science, Published April 2009
Patients with injury to the insula lost the urge to smoke.

Describes a study among people who had sustained brain injuries to investigate whether certain damaged areas of the brain are associated with the ability to quit smoking.

Cocaine Locks Rats Into Unrewarding Behaviors

Basic Science, Published April 2009
Brain circuits that guide behavior by registering consequences become less flexible after drug exposure.

Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.

NIDA Initiates Pediatrics Symposium on Adolescent Health

Bulletin Board, Published April 2009

Presents highlights of a symposium sponsored by NIDA in October 2008 to discuss adolescent brain and cognitive development and consider the impact of drug abuse on young people.

Universities Offer Online Master's Program in Addiction Studies

Bulletin Board, Published April 2009

Describes a consortium of three universities that launched a 12-month intensive online program last August that leads to a master's degree in addiction studies.

NIDA's National Advisory Council Welcomes New Members

Bulletin Board, Published April 2009

Introduces five new members to the NIDA National Advisory Council meeting, including Drs. Xavier Castellanos, Steven Childers, Thomas Crowley, Anita Everett, and Hazel Szeto.

Henry Yamamura Obituary

Bulletin Board, Published December 2008

Remembers Henry I. "Hank" Yamamura, an eminent neuropharmacologist who pioneered radioligand binding assays, contributing valuable knowledge about neurotransmitter transporters and receptors.

Fewer Young Adults Abuse Cocaine and Methamphetamine, National Survey Finds

Public Health, Published December 2008

Reports prevalence rates of illicit drug abuse among youths and young adults based on 2007 data from a national survey of drug use and health.

Lofexidine May Enhance Naltrexone Efficacy

Treatment, Published December 2008

Highlights results from a pilot study suggesting that lofexidine, an anti-hypertensive medication, can enhance success rates among patients taking maintenance naltrexone to avoid opioid relapse.

Reducing Postpartum Drug Use

Prevention, Published December 2008

Highlights a computerized intervention that reduced new mothers' drug abuse in the first 4 months postpartum as reported in a clinical trial of 107 women who abused drugs.

Brain Proteins Differ in Cocaine-Overdose Victims

Basic Science, Published December 2008

Describes research findings showing differences in protein concentrations in the brain pleasure centers of people who died from cocaine overdose as compared with those who did not abuse the drug.

Selenium Shows Promise as an Adjunct Therapy for HIV

Treatment, Published December 2008

Reports on a randomized controlled trial of HIV-infected men and women who, as a result of receiving selenium supplements, experienced lower HIV viral load and greater CD4 cell count.

Nicotine Dependence is Linked With Mental Disorders in Pregnant Women

Treatment, Published December 2008

Reports on a link between mental disorders, including mood, anxiety, or personality disorder and nicotine dependence in pregnancy women.

Methadone Reduces Rats' Cocaine Seeking

Treatment, Published December 2008
High-dose methadone undermines animals' motivation to acquire cocaine.

Reports on an animal study showing that methadone, normally used as a therapy for opioid abuse, may prove to be an effective treatment for cocaine abuse.

Long-Term Cocaine Self-Administration Depresses Brain Activity

Basic Science, Published December 2008
Neural activity of monkeys diminishes in regions linked with cognition and emotion.

Discusses research exploring how widespread the reduction of neural activity is in the brain with chronic exposure to cocaine.

Imaging Studies Elucidate Neurobiology of Cigarette Craving

Basic Science, Published December 2008
Researchers observe brain circuit activation, rapid receptor occupation.

Reports on three separate imaging studies illuminating the neurobiology of cigarette craving.

High-Risk Drug Offenders Do Better With Close Judicial Supervision

Prevention, Published December 2008
Low-risk offenders do equally well with and without regularly scheduled court appearances.

Reports on research showing that increasing the mandatory drug court monitoring sessions for high-risk drug offenders can enhance program success rates.

New Vaccines Are Being Developed Against Addiction and Relapse

Director's Perspective, Published December 2008

Highlights NIDA-funded research to develop vaccines against addiction to drugs such as cocaine, nicotine, phencyclidine (PCP), and methamphetamine.

NIDA Centers Raise Physicians' Awareness of Drug Abuse Issues

Bulletin Board, Published December 2008

Highlights four Centers of Excellence for Physician Information designed to increase physicians' awareness of research on the medical consequences of drug abuse and addiction and incorporate research findings into clinical practice.

Aripiprazole Prevents Rats From Resuming Cocaine Seeking

Treatment, Published December 2008
A medication prescribed for schizophrenia and manic phases of bipolar disorder shows promise as a cocaine addiction treatment.

Reports on study results indicating a medication prescribed for schizophrenia and manic phases of bipolar disorder shows promise as a cocaine addiction treatment.

New Technique Links 89 Genes to Drug Dependence

Basic Science, Published September 2008
Results point to importance of memory in addiction.

Presents research findings linking 89 genes to drug abuse and dependence, found using genome-wide association studies, a new technique for identifying genes.

Optical Technologies Expand Vistas Into the Brain

Basic Science, Published September 2008
Researchers in optics, genetics, and bioengineering have developed a powerful tool for visualizing cells deep in the brain and a remote control for activating brain cells.

Describes new tools under development, including one to visualize cells deep in the brain and another one that remotely activates brain cells.

Immune System Plays Unexpected Role in Brain Development

Basic Science, Published September 2008
In adulthood, however, the immune complement cascade may contribute to neurodegenerative disease.

Describes research findings demonstrating that the immune system participates in the shaping of brain circuits during a child's development, a finding that may shed light on the origins of neurodegenerative diseases.

Research Breakthroughs in Drug Abuse Have Wide Applications in Other Fields

Director's Perspective, Published September 2008

Offers an overview of some of the NIDA-supported innovative research achievements to reduce the health and social effects of drug abuse and addiction.

NIDA Bestows Prizes at International Science Fair

Bulletin Board, Published September 2008

Announces the three winners of the NIDA and Scholastic Corporation 2008 Addiction Science Awards honoring high school students’ award-winning addiction-related projects.

Basic Science Discoveries Yield Novel Approaches to Analgesia

Treatment, Published September 2008
Research on glial cells and receptors leads to compounds that outperform morphine in preclinical trials.

Describes research to develop new compounds that match or exceed the pain relief provided by opioids while avoiding their shortcomings.

Booklet Explains the Science of Addiction

Bulletin Board, Published June 2008

Describes a booklet that explains what scientists know about how drug addiction changes the brain and affects behavior and clears up misconceptions about drug addiction.

Methamphetamine Restricts Fetal Growth, Increases Lethargy in Newborns

Basic Science, Published June 2008

Reports on research showing that newborns whose mothers abused methamphetamine during pregnancy showed lower rates of fetal growth as compared with unexposed newborns.

Morphine Speeds AIDS Onset in Monkeys

Treatment, Published June 2008

Highlights the work of investigators who discovered key ways in which morphine may accelerate the progression of AIDS in animal studies.

Intervention Improves Employment Outlook For Methadone Patients

Treatment, Published June 2008

Describes a study of unemployed methadone patients and the use of assertive outreach and motivational techniques to improve the patients’ employment outlook.