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Mice With Genetic Alteration Eschew Cocaine

Basic Science, Published June 2008
A South American caterpillar inspired a successful 10-year quest to desensitize the dopamine transporter to the drug.

Reports on a study involving researchers who successfully desensitized mice to cocaine by genetically altering their dopamine transporters.

Linking NIDA to Researchers on a Global Scale

NIDA @ Work, Published June 2008

Highlights the NIDA International Program which works to strengthen international research networks, creating opportunities for global research collaboration, training, and scientific exchange.

Neuroscience Blueprint Promotes Efficiency, Synergy

Director's Perspective, Published June 2008

Describes a knowledge- and resource-sharing system for NIH-funded neuroscientists to access to data, advanced research tools, and technical assistance.

Behavioral Problems Related to Maternal Smoking During Pregnancy Manifest Early in Childhood

Prevention, Published June 2008
Researchers find probable precursors of adolescent conduct disorders in the behavior of toddlers and schoolchildren.

Describes research providing evidence that maternal smoking during pregnancy contributes to behavioral conduct disorders among toddlers, school-age children, and teens.

NIDA Renames Addiction Journal

Bulletin Board, Published June 2008

Alerts readers to the new renamed journal, Addiction Science and Clinical Practice, formerly titled Science and Practice Perspectives.

Social Neuroscience Meeting Aims To Improve Prevention, Treatment

Bulletin Board, Published June 2008

Presents highlights of a meeting of scientists and clinicians to review research results from the field of social neuroscience, the study of how neurobiology and the social environment interact.

Animal Studies Elaborate Toluene's Effects

Basic Science, Published June 2008
Toluene abuse can harm the nervous system and body, yet scientists know relatively little about its specific actions.

Reports on evidence that toluene abuse can harm the nervous system and body, although scientists know relatively little about its specific actions.

Teen Substance Abuse Continues to Decline

Public Health, Published March 2008

Reports on the prevalence of substance abuse among youth based on 2007 data from a national survey of behaviors, attitudes, and values.

Sertraline Does Not Help Methamphetamine Abusers Quit

Treatment, Published March 2008
Selective serotonin reuptake inhibitors do not relieve the depressive symptoms of methamphetamine withdrawal and may produce unpleasant side effects.

Describes a new research finding indicating that the antidepressant sertraline (Zoloft), prescribed to relieve depression during the methamphetamine withdrawal process, may make quitting harder.

Researchers Develop a New Tracer for Cannabinoid Receptor

Basic Science, Published March 2008

Describes a new chemical tracer that binds specifically to cannabinoid receptors making it potentially useful in future research to clarify the relationship between the receptors and drug abuse.

Cocaine Can Mobilize Stored Dopamine

Basic Science, Published March 2008

Describes a study showing that cocaine, which increases dopamine levels, also can tap into an intracellular dopamine reserve pool.

Bupropion Reduces Meth's Subjective Effects and Cue-Induced Craving

Treatment, Published March 2008

Describes a study investigating the use of the antidepressant bupropion as a potential therapy for methamphetamine addiction.

Long-Term Cocaine Abuse Linked With Impaired Heart Function

Basic Science, Published March 2008

Summarizes research on the effects of long-term regular cocaine abuse on the cardiovascular system in African Americans.

HIV Patients Show Better Immune Recovery With Early Initiation of HAART

Published March 2008

Presents evidence that among men and women with HIV, those who received early initiation of HAART therapy, those with higher CD4+ levels, achieved better immune recovery.

Not All Mesolimbic Dopamine Neurons Are Alike

Basic Science, Published March 2008
Understanding the receptor composition of circuits governing pleasure and motivation could help fine-tune drug treatment.

Reports on research showing that the neurons that deliver dopamine to two regions of the brain's mesolimbic reward system respond differently to opioids, an important finding for drug treatment research.

Epigenetics: The Promise of a New Science

Director's Perspective, Published March 2008

Discusses the role of epigenetics, the study of cellular mechanisms that control gene expression and its impacts on health and behavior, in addiction research.

Combination Treatment Extends Marijuana Abstinence

Published March 2008
Vouchers provide a strong incentive for abstinence during treatment, and cognitive-behavioral therapy helps patients maintain abstinence after treatment ends.

Describes research investigating the use of a treatment that combines vouchers and cognitive behavioral therapy as compared with the use of either treatment alone for marijuana abuse.

Chronic Cocaine Abusers Have Occult Insomnia in Early Abstinence

Published March 2008
Patients in early treatment may not recognize their own sleep impairment or its impact on their performance.

Reports on research of chronic cocaine abusers who may feel they are sleeping better during early abstinence revealed that the opposite may be true.

Chromosome 17 Harbors Opioid Dependence Genes

Basic Science, Published March 2008
A comparison of genetic markers of opioid abusers and their relatives brings scientists closer to identifying those that contribute to abuse and dependence.

Describes the work of researchers who have found a statistical link between one region on chromosome 17 and an increased risk of opioid dependence.

Scientific Society Honors Dr. Kenner Rice's Research

Bulletin Board, Published March 2008

Announces the 2007 Smissman Award from the American Chemical Society to Dr. Kenner Rice, NIDA, for significant contributions to fundamental knowledge in medicinal chemistry.

Researchers Report on Progress of NIDA's Southern Africa Initiative

Bulletin Board, Published March 2008

Presents an update on NIDA’s Southern African Initiative, a program that aims to build research capacity and infrastructure in the area of addiction, particularly drug-related HIV transmission.

Alcohol Abuse Makes Prescription Drug Abuse More Likely

Public Health, Published March 2008
Those under age 25 are particularly vulnerable to dual abuse.

Reports on results from a study showing that men and women with alcohol use disorders are more likely to report nonmedical use of prescription drugs than people who don't drink at all.

Journal Highlights Global Nexus of Drug Abuse and HIV/AIDS

Published October 2007

Reviews a journal supplement that compiles studies on drug-related HIV transmission, with a focus on injection drug use, in 16 different localities across the globe.

Study Links Anabolic Steroids to Brain Changes in Adolescent Female Mice

Published October 2007
Exposure may promote aggression in girls.

Reports on an animal study finding that links anabolic steroids to brain changes in adolescent female mice, changes that can potentially lead to steroid abuse.

Exposure to Morphine During Early Adolescence Sensitizes Rats as Adults

Basic Science, Published October 2007

Presents highlights of a study indicating that exposure to morphine during adolescence may increase sensitivity to the drug during adulthood.

Controlling College Students' ADHD Symptoms May Protect Them Against Substance Abuse

Prevention, Published October 2007

Reports data on the prevalence of substance use among college students with ADHD, comparing those who received ADHD treatment with those who did not.

Tracing NET

Basic Science, Published October 2007

Describes research that has led to the development of a new tool, a new radiotracer, for studying the neurobiology of depression, attention deficit hyperactivity disorder, and stimulant abuse.

Among Young Attendees at STD Clinics, Substance Abusers Report More Risky Sexual Behavior

Public Health, Published October 2007

Highlights data on the risky sexual behaviors of patients at a sexually transmitted disease clinic who had a substance abuse disorder as compared to those without a substance abuse disorder.

NIDA's Newest Division Mines Clinical Applications From Basic Research

NIDA @ Work, Published October 2007
NIDA's Division of Clinical Neuroscience and Behavioral Research

Describes the role of the Division of Clinical Neuroscience and Behavioral Research in NIDA’s drug abuse and addiction research plan.

Neuropeptide Promotes Drug-Seeking and Craving in Rats

Basic Science, Published October 2007
Orexin emerges as a link in the chain of brain mechanisms regulating appetite for rewards.

Reports on two studies indicating that orexin, a neuropeptide that stimulates eating and regulates wakefulness, also fosters animals' drug seeking and craving responses to drugs.

Gene Experiment Confirms a Suspected Cocaine Action

Basic Science, Published October 2007
Building on knowledge from developmental and cancer biology, addiction researchers are learning how acute and chronic cocaine exposure regulates certain genes.

Reports on the work of addiction researchers who are learning how acute and chronic cocaine exposure regulates certain genes, based on knowledge from developmental and cancer biology.

Endorphin Derivative Inhibits Reward From Morphine and Nicotine in Rats

Treatment, Published October 2007
Recent studies suggest therapeutic potential for glycyl-glutamine in opiate and nicotine addiction.

Describes research investigating a naturally occurring brain chemical that shows early promise as a treatment for addiction in animal studies.

NIDA Will Contribute to Obesity Research

Director's Perspective, Published October 2007

Describes an NIH-wide obesity task force and research plan and explores some of the links between addiction and compulsive eating.

Adolescent Inhalant Use Is Stable Overall, but Rising Among Girls

Public Health, Published October 2007

Reports patterns and trends in inhalant use among adolescents based on an analysis of data from a 2002-2005 national survey on drug use and health.

Vaccine May Reduce Fetal Exposure to Nicotine

Published April 2007
Antibodies that block nicotine's path across the blood brain barrier may also inhibit placental absorption.

Describes research on a vaccine developed to facilitate smoking cessation by blocking nicotine penetration into the brain.

Uneven Regional Brain Development Contributes to Adolescent Risk-Taking

Published April 2007
Along with immature impulse regulation, heightened motivational drive appears to predispose adolescents to risky behavior.

Reports on the work of scientists who have linked impulsiveness and risk-taking among adolescents to immaturity of the brain region called the orbitofrontal cortex.

Latest Information on MDMA/Ecstasy, Steroids, and HIV/AIDS Is Available on NIDA's Web Site

Published April 2007

Announces updates to research reports on MDMA/ecstasy and steroids and a new report on HIV/AIDS that provide the latest available information on drugs and drug-related topics.

Standard Treatments Help Depressed Smokers Quit

Published April 2007
As smoking rates fall in the United States, mentally ill individuals comprise a larger percentage of people who continue to light up.

Describes a study comparing Staged Care Intervention, a combination treatment for smoking cessation, among smokers in outpatient treatment for depression and a control group.

Serotonin System May Have Potential as a Target for Cocaine Medications

Published April 2007
By targeting specific receptors of the neurochemical serotonin, investigators hope to advance the development of potential relapse prevention agents.

Describes investigations to advance the development of potential drug abuse relapse prevention agents by targeting specific receptors of the neurochemical serotonin.

Antipsychotic Drug Prevents Morphine Tolerance in Mice

Published April 2007

Summarizes animal studies indicating that an antipsychotic drug, trifluoperazine, prevents morphine tolerance in mice.

Scientists Pinpoint Brain's Sweet Tooth

Basic Science, Published April 2007

Reports on research that successfully traced rats’ liking for sweets to a 1-cubic millimeter site in the medial shell of the nucleus accumbens in the brain.

Naltrexone-Nicotine Patch Combination Shows Promise

Published April 2007

Reports findings from a clinical trial investigating the effectiveness of naltrexone as a supplement to nicotine replacement therapy for smoking cessation.

Incentives Reduce Stimulant Abuse During Methadone Maintenance

Published April 2007

Summarizes a study on the use of incentives to encourage abstinence among methadone maintenance patients in outpatient programs.

Abstinent Patients Continue to Show Benefits of Treatment

Published April 2007

Reports on data that reviewing the benefits of addiction treatment among abstinent men as compared with those who continued to abuse cocaine.

Interim Methadone Raises Odds of Enrolling in Comprehensive Treatment

Published April 2007
Patients reduced heroin abuse and criminal activity while awaiting admission to a treatment program.

Reports on a study to investigate the use of methadone maintenance for heroin addicts wait-listed for a treatment program to encourage their likelihood to enroll in the program.

Genes and Smoking

Director's Perspective, Published April 2007

Reports on the research underway to identify gene variations associated with nicotine addiction and the interaction of genetic makeup, experiences, and surroundings to addiction.

Depot Naltrexone Appears Safe and Effective for Heroin Addiction

Published April 2007
A long-lasting, injectable formula of naltrexone performed well in a pilot clinical trial.

Presents results of a pilot study to investigate the safety and efficacy of a new long-lasting injectable formulation of naltrexone to treat of heroin addiction in an outpatient setting.

NIDA Investigator Receives 2006 Waletzky Memorial Award

Bulletin Board, Published April 2007

Announces the recipient of a 2006 award for innovation in research on drug addiction and alcoholism, Dr. Yavin Shaham, and describes his research which focused on the stress-induced drug use relapse.

Meeting Reviews Progress On Prescription Opioid Misuse

Bulletin Board, Published April 2007

Describes a meeting of researchers and clinicians who gathered to discuss the challenges in balancing appropriate pain treatment with efforts to minimize prescription opioid misuse.

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