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NIDA. (2013, March 14). Prior marijuana use could increase addictive power of nicotine . Retrieved from

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Science Spotlight

March 14, 2013

Rats previously exposed to tetrahydrocannabinol (THC), the main active ingredient in marijuana, found nicotine more rewarding than rats not exposed to THC, according to NIDA research published in Neuropsychopharmacology. Although the doses of THC used in this study were high, this research suggests that marijuana use may increase the risk for nicotine dependence, which – through the use of tobacco – is the leading cause of preventable death in the United States.

For a copy of the study abstract, go to For related research being conducted at NIDA’s Intramural Research Program, go to

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