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Etiology of Cardiovascular Complications in HIV Infection
Endothelial Dysfunction in HIV Infection
Cardiovascular Complications from Cocaine Abuse in HIV Infection
Genesis of Cardiomyopathy with HIV Infection and Alcohol Abuse

May 2-3, 2002

[Meeting Summary], [Agenda], [Roster]

Recommendations for Future Research:

  • The role of covariates in HIV-related cardiovascular complications.

    • Role of other pathogens in HIV-related cardiovascular complications.

    • Autoimmune mechanisms in HIV-related cardiac conditions, particularly in combination with other pathogens.

    • Genetic predisposition for transition to dilated cardiomyopathy.

    • Incidence, prevalence, and pathophysiology of HIV-related cardiovascular disease in other vulnerable populations such as women, infants, and older individuals exposed to HIV and substance abuse.

    • Influence of other conditions such as diabetes, atherosclerosis, as well as lifestyle and behavior choices such as smoking and recreational drug abuse on HIV-related cardiovascular complications.

  • Mechanisms of cellular injury in HIV-related cardiovascular complications.

    • Interactions of viral replication, immune system activation, inflammatory pathways, and reactive oxygen species in HIV-related cardiovascular complications.

    • Metabolic/energetic mechanisms such as the role of mitochondrial ATP production, cardiac myocyte energetics, increased reactive oxygen species, altered oxygen utilization, and changes in gene expression in HIV-related cardiovascular complications.

    • Role of highly active antiretroviral therapies (HAART) in HIV-related cardiovascular complications.

    • Pharmacokinetic drug interactions between HAART and pharmaceuticals use in the treatment of cardiac disease.

    • Interactions between immune cell (infected and/or uninfected) and cardiac myocytes and their effects on recruitment mechanisms, gene expression alterations, and cell-cell signaling events.

    • Role of hypothalamic-pituitary-adrenal axis in HIV progression and HIV-related cardiovascular complications.

  • Pre-clinical investigations for therapies for HIV/AIDS-related cardiovascular complications.

    • Animal models for studying the effects of antiretroviral and immunorestorative therapies on HIV-related cardiovascular complications.

    • Animal models for testing optimal therapies for the treatment of HIV-related cardiovascular complications.

  • Therapeutics and prevention trials for HIV/AIDS-related cardiovascular complications.

    • Optimal therapies for treating HIV-related cardiomyopathy considering whether these therapies should be different from other forms of cardiomyopathy.

    • Possibility and advantage of early intervention for HIV-related cardiovascular complications.

    • Alternative therapies (e.g., anti-oxidants, immunomodulators, nutritional therapies) for HIV-related cardiovascular complications.

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