Skip Navigation

Link to  the National Institutes of Health  
The Science of Drug Abuse and Addiction from the National Institute on Drug Abuse Archives of the National Institute on Drug Abuse web site
Go to the Home page

Cocaine and the Changing Brain

CART: A Novel Addiction Peptide

Michael J. Kuhar, Ph.D.
Emory University
Atlanta, GA

CART (cocaine- and amphetamine-regulated transcription factors) peptides are novel putative neurotransmitters/cotransmitters. They have psychostimulant-like effects in that they alter locomotor activity and feeding behaviors. CART peptides are localized to regions in the brain that are associated with these behaviors, as well as other regions suggesting involvement in a variety of physiologic functions.


This research was supported by National Institute on Drug Abuse Grant No. DA-10732.

Selected References

Couceyro, P.R.; Koylu, E.O.; and Kuhar, M.J. Further studies on the anatomical distribution of CART by in situ hybridization. J Chem Neuroanat 12:229-241, 1997.

Douglass, J.; McKinzie, A.A.; and Couceyro, P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J Neurosci 15:2471-2481, 1995.

Koylu, E.O.; Couceyro, P.R.; Lambert, P.D.; Ling, N.C.; DeSouza, E.B.; and Kuhar, M.J. Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland. J Neuroendocrinol 9:823- 833, 1997.

Lambert, P.D.; Couceyro, P.R.; Koylu, E.O.; Ling, N.C.; DeSouza, E.B.; and Kuhar, M.J. CART peptides have a physiological role in the central control of food intake (Abstract). Abstracts of the 27th Annual Meeting of the Society for Neuroscience, New Orleans, LA, Oct 25-30, 1997. p. 966.

Smith, Y.; Koylu, E.O.; Couceyro, P.; and Kuhar, M.J. Ultrastructural localization of CART (cocaine- and amphetamine-regulated transcript) peptides in the nucleus accumbens of monkeys. Synapse 27:90-94, 1997.

[Home] [Contents] [Previous Section]

Archive Home | Accessibility | Privacy | FOIA (NIH) | Current NIDA Home Page
National Institutes of Health logo_Department of Health and Human Services Logo The National Institute on Drug Abuse (NIDA) is part of the National Institutes of Health (NIH) , a component of the U.S. Department of Health and Human Services. Questions? See our Contact Information. . The U.S. government's official web portal