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Exposure to Morphine During Early Adolescence Sensitizes Rats as Adults

Basic Science, Published October 2007

Presents highlights of a study indicating that exposure to morphine during adolescence may increase sensitivity to the drug during adulthood.

Controlling College Students' ADHD Symptoms May Protect Them Against Substance Abuse

Prevention, Published October 2007

Reports data on the prevalence of substance use among college students with ADHD, comparing those who received ADHD treatment with those who did not.

Tracing NET

Basic Science, Published October 2007

Describes research that has led to the development of a new tool, a new radiotracer, for studying the neurobiology of depression, attention deficit hyperactivity disorder, and stimulant abuse.

Among Young Attendees at STD Clinics, Substance Abusers Report More Risky Sexual Behavior

Public Health, Published October 2007

Highlights data on the risky sexual behaviors of patients at a sexually transmitted disease clinic who had a substance abuse disorder as compared to those without a substance abuse disorder.

NIDA's Newest Division Mines Clinical Applications From Basic Research

NIDA @ Work, Published October 2007
NIDA's Division of Clinical Neuroscience and Behavioral Research

Describes the role of the Division of Clinical Neuroscience and Behavioral Research in NIDA’s drug abuse and addiction research plan.

Neuropeptide Promotes Drug-Seeking and Craving in Rats

Basic Science, Published October 2007
Orexin emerges as a link in the chain of brain mechanisms regulating appetite for rewards.

Reports on two studies indicating that orexin, a neuropeptide that stimulates eating and regulates wakefulness, also fosters animals' drug seeking and craving responses to drugs.

Gene Experiment Confirms a Suspected Cocaine Action

Basic Science, Published October 2007
Building on knowledge from developmental and cancer biology, addiction researchers are learning how acute and chronic cocaine exposure regulates certain genes.

Reports on the work of addiction researchers who are learning how acute and chronic cocaine exposure regulates certain genes, based on knowledge from developmental and cancer biology.

Endorphin Derivative Inhibits Reward From Morphine and Nicotine in Rats

Treatment, Published October 2007
Recent studies suggest therapeutic potential for glycyl-glutamine in opiate and nicotine addiction.

Describes research investigating a naturally occurring brain chemical that shows early promise as a treatment for addiction in animal studies.

NIDA Will Contribute to Obesity Research

Director's Perspective, Published October 2007

Describes an NIH-wide obesity task force and research plan and explores some of the links between addiction and compulsive eating.

Adolescent Inhalant Use Is Stable Overall, but Rising Among Girls

Public Health, Published October 2007

Reports patterns and trends in inhalant use among adolescents based on an analysis of data from a 2002-2005 national survey on drug use and health.

Scientists Pinpoint Brain's Sweet Tooth

Basic Science, Published April 2007

Reports on research that successfully traced rats’ liking for sweets to a 1-cubic millimeter site in the medial shell of the nucleus accumbens in the brain.

Interim Methadone Raises Odds of Enrolling in Comprehensive Treatment

Published April 2007
Patients reduced heroin abuse and criminal activity while awaiting admission to a treatment program.

Reports on a study to investigate the use of methadone maintenance for heroin addicts wait-listed for a treatment program to encourage their likelihood to enroll in the program.

Genes and Smoking

Director's Perspective, Published April 2007

Reports on the research underway to identify gene variations associated with nicotine addiction and the interaction of genetic makeup, experiences, and surroundings to addiction.

NIDA Investigator Receives 2006 Waletzky Memorial Award

Bulletin Board, Published April 2007

Announces the recipient of a 2006 award for innovation in research on drug addiction and alcoholism, Dr. Yavin Shaham, and describes his research which focused on the stress-induced drug use relapse.

Meeting Reviews Progress On Prescription Opioid Misuse

Bulletin Board, Published April 2007

Describes a meeting of researchers and clinicians who gathered to discuss the challenges in balancing appropriate pain treatment with efforts to minimize prescription opioid misuse.

Brain Changes Accompany Cocaine Withdrawal

Basic Science, Published February 2007

Summarizes an animal study of the neural changes in the amygdala portion of the brain that occur as a result of cocaine exposure followed by withdrawal of the drug.

How Drug Abuse Affects the Brain and Alters Behavior Are Key Questions Driving Division's Work

NIDA @ Work, Published February 2007

Discusses the work of NIDA’s Division of Basic Neuroscience and Behavioral Research, the Institute’s locus for studies into the fundamental brain mechanisms underlying drug abuse and addiction.

Nicotine Alters the Developing Rat Brain

Basic Science, Published February 2007
Exposure to the drug during gestation or adolescence may cause lasting alterations in reward and motivation circuits.

Describes animal studies that suggested exposure to the drug during gestation or adolescence may cause lasting alterations in reward and motivation circuits.

Addiction and Co-Occurring Mental Disorders

Director's Perspective, Published February 2007

Presents an overview of the research underway to investigate medication and behavioral therapies for co-occurring disorders.

Cocaine Craving Activates Brain Reward Structures; Cocaine "High" Dampens Them

Basic Science, Published February 2007
A study documented changing emotional and neurobiological responses to cocaine with successive doses during a single session of drug taking.

Reports on a study that documenting changing emotional and neurobiological responses to cocaine with successive doses during a single session of drug taking.

Journal Highlights Opportunities in Hispanic Drug Abuse Research

Bulletin Board, Published February 2007

Reviews a journal supplement that compiles information on drug abuse research in the Hispanic population.

Videos Help Treat Deaf People

Bulletin Board, Published February 2007

Reviews a training DVD that presents dialectical behavior therapy skills being taught by deaf clinicians to deaf consumers as an approach to improve deaf people's access to behavioral health care.

Stress Response May Underlie African- Americans' Reduced Pain Tolerance

Basic Science, Published October 2006

Summarizes research suggesting a physiological difference as the explanation for African-Americans' reported low tolerance for pain.

High School Seniors Steadily Increase Nonmedical Use of Sedatives Over 15 years

Basic Science, Published October 2006

Highlights data from an annual national survey of youth showing a pattern of rising nonmedical use of sedatives among high school seniors.

Steroid Abuse Is a High-Risk Route to the Finish Line

Director's Perspective, Published October 2006

Highlights research on the effects of steroid use on the brain and the rest of the body, and stresses the need to educate young people about the serious health risks associated with its use.

Buprenorphine Plus Behavioral Therapy Is Effective For Adolescents With Opioid Addiction

Published October 2006
A new study looks at extending the role of buprenorphine for treatment of adolescents.

Reports on a study of adolescents addicted to opioids who responded better to buprenorphine than clonidine in a clinical trial in which all patients also received behavioral therapy.

Walk the Line Is Among 10th Annual PRISM Awardees

Bulletin Board, Published October 2006

Announces the winners of the 10th Annual PRISM Awards, including Walk the Line, a film portraying the life of singer Johnny Cash and his battle with drug addiction.

NIDA's National Advisory Council Welcomes New Members

Bulletin Board, Published October 2006

Introduces four new members to NIDA’s National Advisory Council on Drug Abuse, including Drs. Warren K. Bickel, Ellie E. Schoenbaum, and Marina E. Wolf, and Ms. Janet Wood.

Methamphetamine Increases, and HIV Decreases, Brain Volumes

Basic Science, Published July 2006
HIV infection and methamphetamine addiction produce distinct, partly overlapping effects on brain structures.

HIV infection and methamphetamine addiction produce distinct, partly overlapping effects on brain structures.

Sensory Aspects May Drive Addiction in Obese Smokers

Basic Science, Published July 2006
Obesity appears to reduce nicotine's rewarding effect in mice and humans.

Obesity appears to reduce nicotine's rewarding effect in mice and humans.

Bulletin Board

Bulletin Board, Published July 2006

NIDA Honors Dr. William L. Dewey, HHS and NIH Recognize NIDA Staff, ATLAS and ATHENA Prevention Programs Receive First Sports Illustrated Champion Award

Methamphetamine Evokes and Subverts Brain Protective Responses

Published July 2006
Two new studies appear to highlight the role of glial cells—the nervous system's equivalents to the body's immune cells—in methamphetamine abuse.

Two new studies appear to highlight the role of glial cells—the nervous system's equivalents to the body's immune cells—in methamphetamine abuse.

Research in Brief: Highlights of Recently Published NIDA-Supported Studies

Research in Brief, Published July 2006

"Light" Cigarettes Deliver Heavy Carcinogen Load; African-Americans Metabolize Nicotine Slowly; The Brain in Pain; Parents' Actions, More Than Their Words, Influence Kids' Smoking

Drugs Affect Men's and Women's Brains Differently

Published July 2006
Gender appears to influence biological responses to nicotine, cocaine, and alcohol.

Gender appears to influence biological responses to nicotine, cocaine, and alcohol.

Court-Mandated Treatment Works as Well as Voluntary

Published July 2006
Regardless of their impetus for participating in drug treatment—internal drive or external pressure—men had similar outcomes in the long term.

Regardless of their impetus for participating in drug treatment—internal drive or external pressure—men had similar outcomes in the long term.

Checkup System Catches Relapse Early and Facilitates Return to Treatment

Published July 2006
Researchers in Chicago apply an old medical maxim: "Chronic diseases require chronic cures."

Researchers in Chicago apply an old medical maxim: "Chronic diseases require chronic cures."

Animal Research Shows GHB Acts on GABA Receptors

Published April 2006
Baboon studies may help researchers learn how the club drug gamma-hydroxybutyrate exerts such a powerful grip when abusers try to quit.

Baboon studies may help researchers learn how the club drug gamma-hydroxybutyrate exerts such a powerful grip when abusers try to quit.

Cocaine Abuse and HIV Are Linked With Coronary Calcification

Published April 2006
Cardiovascular changes that are potential risk factors for serious heart disease are detected in relatively young people with HIV infection or a history of cocaine abuse.

Cardiovascular changes that are potential risk factors for serious heart disease are detected in relatively young people with HIV infection or a history of cocaine abuse.

Treatment During Work Release Fosters Offenders' Successful Community Reentry

Published April 2006
Long-term studies are helping to determine the most effective drug treatment protocols for prisoners in transition.

Long-term studies are helping to determine the most effective drug treatment protocols for prisoners in transition.

Brain Activity Patterns Signal Risk of Relapse to Methamphetamine

Published April 2006
Methamphetamine abusers who relapse after treatment appear to make decisions using different brain regions than do those who remain abstinent

Methamphetamine abusers who relapse after treatment appear to make decisions using different brain regions than do those who remain abstinent

Animal Experiments in Addiction Science

Published April 2006
To learn how drugs promote abuse and produce addiction, researchers focus on animal behaviors that parallel human drug-related behaviors.

To learn how drugs promote abuse and produce addiction, researchers focus on animal behaviors that parallel human drug-related behaviors.

Highlights of Recently Published NIDA-Supported Studies

Research in Brief, Published April 2006

Nicotine and Cocaine Vaccines Move Forward; No-Smoking Policy Did Not Deter Enrollment In Addiction Programs; GVG Shows Promise In Early Human Trials; Methamphetamine Disrupts Focus

Bulletin Board

Bulletin Board, Published April 2006

Clinical Trials Network Adds Texas and Appalachia Sites; NIDA Launches HIV/AIDS Public Awareness Campaign

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