April 2009

Reports on NIDA researchers who developed a new tracer compound that binds readily to nicotine receptors and enhances positron emission tomography images.

April 2009
Reduced availability heightens reinforcing effects of cocaine in monkeys, and the drug drives this measure even lower.

Describes findings from an animal study showing that cocaine lowers availability of dopamine receptors in the basal ganglia, an area of the brain that includes portions of the reward system.

April 2009

Highlights an animal study involving the self-administration of nicotine among adolescent and adult rats to gain understanding of their potential vulnerability to the substance.

April 2009
Reduced ability to choose between conflicting stimuli corresponds to neural damage.

Highlights findings from a study of former methamphetamine abusers showing evidence of impairment in areas of the brain known to influence cognition, emotion, and decision making.

April 2009
Brain circuits that guide behavior by registering consequences become less flexible after drug exposure.

Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.

April 2009
Tests correlate biochemical abnormality with deficits in rats' responses to sounds.

Reports on a series of animal experiments indicating that nicotine exposure during prenatal fetal development damages a set of receptors in the brain's auditory processing center.

December 2008
Neural activity of monkeys diminishes in regions linked with cognition and emotion.

Discusses research exploring how widespread the reduction of neural activity is in the brain with chronic exposure to cocaine.

December 2008

Describes research findings showing differences in protein concentrations in the brain pleasure centers of people who died from cocaine overdose as compared with those who did not abuse the drug.

December 2008
Researchers observe brain circuit activation, rapid receptor occupation.

Reports on three separate imaging studies illuminating the neurobiology of cigarette craving.

September 2008
Results point to importance of memory in addiction.

Presents research findings linking 89 genes to drug abuse and dependence, found using genome-wide association studies, a new technique for identifying genes.

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