September 2017

Electroencephalography (EEG) may provide an objective measure of cocaine-addicted participants’ vulnerability to cue-induced relapse. The assessment of cue-induced responsiveness may be useful in the clinical setting for assessing relapse risk and tailoring interventions to maintain abstinence among cocaine-addicted adults. 

August 2017

A single nucleotide polymorphism in the messenger RNA of the µ-opioid receptor gene was associated with patients’ responses to methadone treatment for opioid dependence.

August 2017

New research demonstrates that the hormone estradiol is responsible for females’ increased sensitivity to stimulant drugs.

March 2017

Investigators have shown that 2-AG, an endocannabinoid (i.e., a cannabinoid manufactured within the body, as opposed to plant-derived), augments the cocaine-induced dopamine surge in the brain’s reward system. The discovery adds to evidence that inhibiting activity in the endocannabinoid system might reduce cocaine’s rewarding and addictive effects.

March 2017
The defining features of drug intoxication and addiction can be traced to disruptions in neuron-to neuron signaling.

Drugs can alter the way people think, feel, and behave by disrupting neurotransmission, the process of communication between brain cells. This article discusses the central importance of studying drugs’ effects on neurotransmission and describes some of the most common experimental methods used in this research. 

March 2017

Research suggests that unique patterns of gene regulation have contributed to the differences in brain size and capacity that distinguish humans from other animals.

February 2017

New studies show that two novel compounds powerfully suppressed animals’ pain responses, while producing little or none of the respiratory depression and liability for misuse and abuse associated with morphine and other typical opioids.

September 2016

Researchers monitored the activity of two types of neurons in mice: “urge” neurons, which promote feelings of reward and repeating behaviors that have produced rewards, and “control” neurons, which dampen those feelings and inhibit behavior.

September 2016

A new study proposes that research into the discrete roles played by the brain’s two hemispheres could yield important and actionable insights into drug use and addiction. Evidence indicates that two risk factors for substance use, impulsivity and craving, primarily reflect activity in the right and left hemispheres, respectively.

September 2016

A brain imaging study strongly suggests that regular users of marijuana have smaller orbitofrontal cortex (OFC) volumes. Such a deficit could make it more difficult to change counterproductive behaviors, including drug use.

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