Methamphetamine

Nerve-Cell Growth During Abstinence From Methamphetamine May Promote Reinstatement of Drug Use in Rats

Neurogenesis that occurs during abstinence from methamphetamine in a brain region related to memory and learning may promote relapse-like behavior.

Narrative of Discovery: The Quest for a Medication To Treat Methamphetamine Addiction, Part 4

In 2017, Dr. Linda Dwoskin applied to NIDA's Grand Opportunity for Medications Development program for support to continue her quest to develop the first-ever medication to reduce craving and relapse in methamphetamine use disorder. The goal of her project aligned perfectly with the program's objective "to fund medication studies that will have a high impact and quickly yield the necessary results to advance medication closer to FDA approval." Success would fill an enormous need, affecting nearly 700,000 Americans with problematic use of the stimulant. Moreover, Dr. Dwoskin and her team at the

Study shows impact of social interactions on addictive behavior

A new study published in Nature Neuroscience finds that social interactions can have a profound effect on behaviors related to addiction, and on the brain’s response to drug-associated cues.

A look at drug craving

Studies using animal models of addiction have shown that drug seeking progressively increases after drug self-administration stops, which is a phenomenon called incubation of drug craving.

Narrative of Discovery: The Quest for a Medication To Treat Methamphetamine Addiction, Part 3

Dr. Linda Dwoskin feels just one small step away from success in her effort to develop the first-ever medication to treat methamphetamine addiction. She and colleagues at the Universities of Kentucky and Arkansas have created a molecule that blocks methamphetamine’s addictive effects and completed preclinical testing without raising any red flags for undesirable side effects.

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