The primary objective of this study is to replicate the finding that performance on the Stroop color-word interference task is predictive of treatment completion in participants with cocaine use disorders and to extend this finding to participants with METH use disorders.  Secondary objectives include evaluating whether: 1.) performance on various neurocognitive tests, including the Stroop, Rey Auditory-Verbal Learning Test (RAVLT), Iowa Gambling Task (GT), Wisconsin Card Sorting Task (WCST), and the Barratt Impulsiveness Scale version -11 (BIS-11) is predictive of treatment attrition and stimulant use outcomes in METH/cocaine abusers; 2.) neurocognitive test performance is associated with oxidative damage, a severe consequence of oxidative stress, in METH/cocaine abusers; 3.)  oxidative damage, as assessed by two plasma measures, is predictive of treatment attrition and substance use outcomes in METH/cocaine abusers, and 4.)  oxidative damage in METH/cocaine abusers is significantly greater than that of a normal comparison group.

CTN Protocol ID: 
CTN-0031-A-1
DSMB ID: 
DSMB-0031
Enrollment Status: 
Completed
ClinicalTrials.gov ID: 
Primary Outcomes Article: 

Winhusen, et al. (2013).  Impulsivity is associated with treatment non-completion in cocaine- and methamphetamine-dependent patients but differs in nature as a function of stimulant-dependence diagnosis.  Journal of Substance Abuse Treatment. 44(5):541-547.  http://www.ncbi.nlm.nih.gov/pubmed/23305820

Principal Investigator(s): 

Theresa Winhusen, Ph.D.
Professor of Psychiatry and Behavioral Neuroscience, Director of Addiction Sciences Division 
University of Cincinnati
Addiction Sciences Division
3131 Harvey Avenue, Suite 104
Cincinnati, OH 45229-3006
winhust@ucmail.uc.edu

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