Epidemiologic Trends in Drug Abuse - Community Epidemiology Work Group -
Volume I: Executive Summary - January 2009 (Publication Date: August 2009)
NIH Pub. No.: 09-7420
This report provides descriptive information on the most recent significant trend, emerging problems and populations at risk within and across areas participating in the Community Epidemiology Work Group. This report provides program administrators and officials with specific indicator data in tabular and graphic format, and ethnographic information on current patterns and trends as well as emerging problems.
Heads Up: Real News about Drugs and Your Body—Year 7 Compilation for Teachers
HURN09-07TC (Publication Date: September 2009)
This booklet provides skill-building extension activities and further resources to those included for students in Publication # HURN09-07SC. The topics covered in this compilation of teacher editions published in Scholastic magazines during the 2008-2009 school year include: the risk factors for addiction, the heath consequences of drug abuse, and the treatment of addiction and its relationship to other mental health disorders—as well as profiles of student researchers and their addiction science projects.
Heads Up: Real News about Drugs and Your Body—Year 7 Compilation for Students
HURN09-07SC (Publication Date: September 2009)
This booklet is a collection of articles that were originally published in Scholastic magazines as well as supplemental articles published on Scholastic's website for the 2008-2009 school year. Together these articles teach students about the full spectrum of drug abuse and addiction including the risk factors for addiction (Genetics and Addiction & Do You Know Your Risk for Addiction), the health consequences of drug abuse (Stimulant Addiction & Health Effects of Stimulants), and the treatment of drug addiction and its relationship to other mental health disorders (The Truth About "Rehab" and Drug Addiction & Overlapping Illnesses). Also included are articles highlighting the addiction research of remarkable teens (Teen Science Investigators & In Their Own Words: Teen-Science Investigators).
Mind Over Matter: The Brain's Response to Cocaine (Rev.)
(Publication Date: September 2009) NIH Pub. No.: 09-3857
Explains how cocaine changes the way nerve cells communicate and affect neurotransmission.
Mind Over Matter: The Brain's Response to Opiates (Rev.)
(Publication Date: September 2009) NIH Pub. No.: 0909-3856
Explains how opiates affect the brain stem, the spinal cord, and the limbic system. Discusses dependency and the results of long-term exposure to opiates.
Mind Over Matter: The Brain's Response to Hallucinogens (Rev.)
(Publication Date: September 2009) NIH Pub. No.: 09-3858
Explains how hallucinogens affect the brain's communication centers as well as its ability to control sleep and emotions.
Mind Over Matter: The Brain's Response to Steroids (Rev.)
(Publication Date: September 2009) NIH Pub. No.: 09-3860
Shows how anabolic steroids can cause liver damage, cancer and weaken the immune system.
Mind Over Matter: The Brain's Response to Prescription Drugs
(Publication Date: September 2009) NIH Pub. No.: 09-7423
This brochure contains scientific information on how various prescription drugs act in the body and brain to elicit their effects. It provides this information in a format that uses drug information to teach science and engender student interest in science, while also providing messages of the harmful effects associated with the abuse of prescription drugs.
Principles of Drug Abuse Treatment for Criminal Justice Populations: A Research-Based Guide (Rev.) (Publication Date: September 2009) NIH Pub. No.: 09-5316
This booklet provides treatment principles and research findings that are of particular relevance to the criminal justice community and to treatment professionals working with drug-abusing offenders.
Mentoring: A Guide for Drug Abuse Researchers - Tips for Mentors and Mentees
(Publication Date: September 2009) NIH Pub. No.: 09-5770
This publication will describe "best practices" for recruiting, training, mentoring, and advancing the careers of highly talented scientists focused upon drug abuse epidemiological, services, and prevention research.
The Brain: Understanding Neurobiology Through the Study of Addiction (Rev.)
(Publication Date: September 2009)
This educational supplement was developed for high school teachers to use when teaching neurobiology to high school students. It uses drug abuse and addiction to teach neurobiology topics such as neurotransmission, brain chemistry, etc. Included are 5 lessons, correlations with the National Science Education Standards and a website.
Brain Power! K-1 (Rev.) (Publication Date: September 2009)
This educational supplement provides teachers with 5 days of lessons and activities that can be incorporated into the kindergarten-first grade classroom. The lessons cover what it means to be a scientist, the amazing brain, and how to keep your brain healthy.
In June 2009, the Special Populations Office published NIDA-Supported Research on Drug Abuse and Addiction in Racial/Ethnic Minority Populations; A Resource Guide, designed to share information on the progress that NIDA has made in developing and supporting drug abuse research and resources related to racial/ethnic minority populations.
NIDA NOTES, Vol. 22, No. 5
The lead story describes how computer-based interventions can promote drug abstinence by reinforcing and expanding the well-established benefits of therapy delivered by a counselor. The story presents three groundbreaking examples of interactive multimedia therapies that may reduce costs and extend access to treatment. Also included in the issue are features reporting an immunotherapy that shows promise as a treatment for methamphetamine overdose; evidence that a person's genetic makeup influences success in quitting smoking and also which smoking cessation technique works best; and a new technique that uses dime-size arrays of tiny needles to painlessly deliver naltrexone and other medications. Another feature explores how extended cocaine exposure impairs attention in rats. In the Director's Perspective, Dr. Nora Volkow describes NIDA coalition with other federal agencies to assess and find solutions to the problems of substance abuse among service men and women, veterans, and members of military families.
NIDA NOTES, Vol. 22, No. 6
This issue begins with a description of research from several laboratories that links contrasting smoking patterns with variations in half a dozen genes that dictate the structure of the brain receptor to which nicotine binds. The results suggest that genes for several receptor subunits drive different aspects of the multi-step process of nicotine addiction. Also included in the issue is a feature reporting that a checkup system provided after treatment for substance abuse may be especially beneficial for clients with co-occurring mental disorders. Another feature presents evidence that highly active antiretroviral therapy (HAART) is as useful in combating HIV in people who use illicit injection drugs as in other people infected with the virus. The issue also includes a report that proliferation of a rare receptor may underlie the intensification of craving that cocaine abusers experience during their first weeks of abstinence. In the Director's Perspective, Dr. Nora Volkow notes NIDA's 35th Anniversary, listing the Institute's major accomplishments and describing current challenges.
Eight editions of the CTN Bulletin Board were distributed. The Bulletin Board is an electronic report on the progress of the protocols, committees, and node activity in the CTN. The Bulletin has wide readership within and outside the CTN and NIDA.
Data from 19 CTN trials are now available on the CTN Data Sharing Web Site. Over 300 research scientists have downloaded one or more data sets. These data sets are in compliance with HIPAA and CDISC (Clinical Data Interchange Standards Consortium) standards in support of the interoperability required by the NIH Roadmap.
International Program-Related Publications
NIDA International Program Issues 2008 Annual Report
The 2008 Annual Report demonstrates how the NIDA International Program links the Institute to research organizations and scientists throughout the world, providing the opportunity for collaborators develop knowledge jointly that neither partner could have developed independently. The report is available on the IP Website, http://www.international.drugabuse.gov/.
Glantz MD, Anthony JC, Berglund PA, Degenhardt L, Dierker L, Kalaydjian A, Merikangas KR, Ruscio AM, Swendsen J, Kessler RC. Mental disorders as risk factors for later substance dependence: estimates of optimal prevention and treatment benefits. Psych Med. 2009;39(8): 1365-1377.
Swendsen J, Conway KP, Degenhardt L, Dierker L, Glantz M, Jin R, Merikangas KR, Sampson N, Kessler RC. Sociodemographic risk factors for alcohol and drug dependence: The 10-year follow-up of the National Comorbidity Survey. Addiction. 2009 June 22. [published online ahead of print June 22, 2009].
Price LN, Maholmes V. Understanding the nature and consequences of children's exposure to violence: Research perspectives. Clinical Child and Family Psych Rev. 2009;12(2): 65-70.
Booth B, Shields J, Chandler R. Recent achievements in alcohol and drug abuse health services research. Journal of Behavioral Health Service and Research. 2008;36(1):5-10.
Rothenberg R, Jenkins R, Lambert E. Special issue on the sexual acquisition and transmission of HIV Cooperative Agreement Program (SATHCAP): Commentary. J Urb Health July 86: [Epub ahead of print].
Mejia R, Jenkins RA, Carey JW, Amaro H, Morrill AC, Krech L, Logan JA, Cranston K. Longitudinal observation of an HIV Prevention Community Planning Group (CPG). Health Promotion Practice. 2009;10:136-143.
Jennings JM, Ellen JM, Deeds BG, Harris R, Muenz LR, Barnes W, Lee SS, Auerswald CL, and the Adolescent Trials Network for HIV/AIDS Interventions. Youth living with HIV and partner-specific risk for the secondary transmission of HIV. Sexually Transmitted Diseases. 2009;36(7): 439-444.
Hitsman B, Moss TG, Montoya ID, George TP. Treatment of tobacco dependence in mental health and addictive disorders. Can J Psychiatry. 2009 Jun;54(6):368-378.
Kahn R, Biswas K, Childress AR, Shoptaw S, Fudala PJ, Gorgon L, Montoya I, Collins J, McSherry F, Li SH, Chiang N, Alathari H, Watson D, Liberto J, Beresford T, Stock C, Wallace C, Gruber V, Elkashef A. Multi-center trial of baclofen for abstinence initiation in severe cocaine-dependent individuals. Drug Alc Dep. 2009 Jul 1;103(1-2):59-64. E-pub 2009 May 2.
Saccone SF, Bierut LB, Chesler, EJ, Kalivas PW, Lerman C, Saccone NL, et al., Supplementing high-density SNP microarrays for additional coverage of disease-related genes: Addiction as a paradigm. PLoS ONE. 2009;4: e5225; p1-6.
Wu DY, Pollock JD, Shurtleff D. Seminars in Cell & Developmental Biology. The molecular and cellular mechanisms in the development of addiction. Editorial. Semin Cell Dev Biol. 2009 Jun;20(4):377. Epub 2009 Mar 13.
Pollock JD, Koustova E, Hoffman A, Shurtleff D, Volkow ND. Treatments for nicotine addiction should be a top priority. The Lancet. April 27, 2009.
Francesconi W, Berton F, Repunte-Canonigo V, Hagihara K, Thurbon D, Lekic D, et al., Protracted withdrawal from alcohol and other drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis. J Neurosci. 2009 Apr 29; 29(17):5389-5401.
Tanda G, Newman A, Ebbs AL, Tronci V, Green J, Tallarida RJ, Katz JL. Combinations of cocaine with other dopamine uptake inhibitors: Assessment of additivity. J Pharm Exp Ther. 2009 May 29. [Epub ahead of print]
Hiranita T, Soto PL, Newman AH, Katz JL. Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors. J Pharmacol Exp Ther. 2009 May;329(2):677-686.
Collins GT, Truccone A, Haji-Abdi F, Newman AH, Grundt P, Rice KC, Husbands
SM, Greedy BM, Enguehard-Gueiffier C, Gueiffier A, Chen J, Wang S, Katz JL, Grandy DK, Sunahara RK, Woods JH. Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. J Pharm Exp Ther. 2009 Apr;329(1): 210-217.
Soto PL, Katz JL. Fluoxetine does not alter the ability of dopamine D(1)- and D(2)-like agonists to substitute for cocaine in squirrel monkeys. Pharm Biochem Behav. 2009 Apr;92(2):219-223.
Newman, AH, Katz JL. The benztropines: atypical dopamine uptake inhibitors that provide clues about cocaine's mechanism at the dopamine transporter. In: Transporters as Targets for Drugs (S. Napier and M. Bingham, eds.) Topics in Medicinal Chemistry, 4: 95–129, 2009.
Newman AH, Grundt P, Cyriac GC, Deschamps JR, Taylor M, Kumar R, Ho D, Luedtke RR. N-(4-(4-(2,3-Dichloro- or 2-methoxyphenyl)piperazin-1-yl)-butyl)-heterobiarylcarboxamides with Functionalized Linking Chains as High Affinity and Enantioselective D3 Receptor Antagonists. J Med Chem. 2009; 52:2559-2570.
Eriksen J, Rasmussen SGF, Vaegter CB, Cha JH, Zou M-F, Newman AH, Gether U. Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogues. J Neurosci. 2009; 29(21):6794-6808.
Kulkarni SS, Zou M-F, Cao J, Deschamps JR, Rodriguez A, Conn PJ, Newman AH. Structure Activity Relationships Comparing N-(6-methylpyridin-yl)-substituted Aryl Amides to 2-Methyl-6-(substituted-arylethynyl) pyridines or 2-Methyl-4-(substituted-aryl ethynyl)thiazoles as Novel mGluR5 antagonists. J Med Chem. 2009;52:3563-3575.
Achat-Mendes C, Platt DM, Newman AH, Spealman RD, Modulation of behavioral effects of cocaine by the dopamine D3 receptor partial agonist CJB 090 [N-(4-(4-(2,3-dichlorophenyl) piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide] in squirrel monkeys. Psychopharmacology 2009, e-pub June 10.