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NIDA Home > Publications > Director's Reports > September, 2008 Index    

Director's Report to the National Advisory Council on Drug Abuse - September, 2008


NIDA Publications

Drugs, Brain and Behavior - The Science of Addiction (Spanish)
NIH Pub. No.: 08-5605S
This is the Spanish translation of "The Science of Addiction," NIDA's 30-page, full-color booklet that explains in layman's terms how science has revolutionized our understanding of drug addiction as a brain disease that affects behavior. It uses simple language, diagrams, and graphics to help people understand how drugs change the brain in structure and in function. The booklet explores some of the reasons that people take drugs, helps explain why some people become addicted while others do not, and demonstrates how addiction, like other chronic diseases, may be prevented and treated.

College on Problems of Drug Dependence
NIH Pub. No.: 08-6408
This publication is more than just a "proceedings" from a meeting--it is valued as one of the only research tools and references for scientists and other professionals in the drug abuse field. It is the most comprehensive gathering of scientific information on all aspects of substance abuse and is invaluable to researchers and other scientists.

Heads Up: Real News About Drugs and Your Body: Student Compilation
This booklet is a collection of articles designed to teach youth in grades 6-12 about how drugs of abuse affect the brain and body. Topics covered are The Science of Addiction, Tobacco Addiction and Secondhand Smoke, Stress and Drug Abuse, and Health Literacy and Drug Abuse. These articles were distributed in Scholastic magazines nationwide during the 2007/2008 school year.

Heads Up: Real News About Drugs and Your Body: Teacher Compilation
This booklet provides skill-building extension activities and further resources for teachers. Topics covered are The Science of Addiction, Tobacco Addiction and Secondhand Smoke, Stress and Drug Abuse, and Health Literacy and Drug Abuse. These "teacher editions" were distributed nationwide during the 2007/2008 school year with Scholastic student magazines containing Heads Up articles.

Monitoring the Future National Results on Adolescent Drug Use - Overview of Key Findings: 2007
NIH Pub. No.: 08-6418
Provides a summary of drug use trends from a survey of 8th, 10th, and 12thgrade students nationwide. Also includes perceived risk, personal disapproval, and perceived availability of each drug by this group.

National Survey Results from the Monitoring the Future 2007, Volume I: Secondary Students
NIH Pub. No.: 08-6418A
Reports on the prevalence of drug use among students in 8th, 10th, and 12th grades. Trends are analyzed to understand the changing drug abuse problem and to formulate appropriate prevention and treatment polices.

National Survey Results from the Monitoring the Future 2007, Volume II: College Students and Adults Ages 19-40
NIH Pub. No.: 08-6418B
Reviews trends in drug use by populations based on gender, college plans, regions of the country, population density, race/ethnicity, and parents' education. Trends are analyzed to understand the changing drug abuse problem and to formulate appropriate prevention and treatment polices.

Brain Power! NIDA Junior Scientists
NIDA has reprinted its award winning curricula, "Brain Power! NIDA Junior Scientists" for grades 2-3 and 4-5. These curricula, developed for teachers, span 5 class periods each and cover a variety of neuroscience/drug abuse topics relevant to the particular age. For example, the curriculum for grades 2-3 covers scientific inquiry, basic brain biology, neurotransmission, medicines and drugs, and the science related to smoking. All topics are covered in an age appropriate manner and each session includes activities for both the classroom and home. Each topic also includes a parent newsletter and trading cards for the kids. The materials are available for free from NIDA's Research Dissemination Center.


NIDA NOTES, Vol. 22, No. 1 Innovations Special Issue
NIH Pub. No. 08-6455, August 2008

This special issue features recent groundbreaking discoveries in drug abuse research that connect to the work of scientists across many disciplines. The lead story describes findings about receptors on neurons and glial cells that offer promise for pain relief without the negative side effects of currently used opioids. The Director's Perspective looks at how NIDA fosters interdisciplinary, breakthrough work; it describes two innovative NIDA programs: Cutting-Edge Basic Research Awards (CEBRA) and the Translationally Oriented Approaches, Devices and Strategies (TOADS) Workgroup. Other research reports discuss optical technologies that expand research and therapeutic possibilities by revealing neural circuits in living animals; discoveries of an unexpected role for the immune system in eliminating extra synapses during brain development; and work in genetics that identifies dozens of genes that influence vulnerability to drug dependence and indicates parts of the brain beyond the dopamine reward system that may contribute to addiction risk. The issue also announces the winners of the first Addiction Science Award for high school student at the Intel International Science and Engineering Fair.

NIDA Journal of Addiction Science and Clinical Practice

Addiction Science and Clinical Practice Volume 4, Number 2
NIH Pub. No.: 08-6452, June, 2008
The issue's feature article is a comprehensive discussion by Dr. Seddon R. Savage and colleagues on the challenges of using opioids to treat pain in patients with substance use disorders. Addressing an audience of addiction specialists, the authors describe the nature and physiological basis of pain, explore its interrelationships with substance use, present methodical approaches to the evaluation and treatment of pain and co-occurring substance use disorder, and discuss the clinical and ethical challenges that both pain management specialists and addiction professionals face when treating this population. Drs. Linda A. Dimeff and Marsha M. Linehan describe Dialectical Behavior Therapy (DBT), a treatment originally developed for suicidal patients with severe psychosocial disorders. The authors discuss their modification of DBT for treating substance abusers, DBT's strategies for promoting abstinence and preventing relapse, and the clinical trials that demonstrate the therapy's efficacy. Finally, Dr. Kyle Kampman discusses current research efforts toward developing effective medications for stimulant dependence.

CTN-Related Publications

Six editions of the CTN Bulletin Board were distributed. The Bulletin Board is an electronic report on the progress of the protocols, committees, and node activity in the CTN. The Bulletin has wide readership within and outside the CTN and NIDA.

Data from fourteen CTN trials are now available on the CTN Data Sharing Web Site. Another three data sets will be available by the end of December 2008. Currently more than 120 research scientists have downloaded one or more data sets. These data sets are in compliance with HIPAA and CDISC (Clinical Data Interchange Standards Consortium) standards in support of the interoperability required by the NIH Roadmap. Starting next year, flat file postings of the current data sets will also be available on the CTN Data Sharing website.

International Publications

NIDA International Program 2007 Annual Report
The 2007 Annual Report demonstrates how each NIDA International Program activity independently addresses one aspect of addiction's impact on public health and simultaneously supports the wider network of NIDA's international activities and partners.

NIDA International Program E-News Letter
August 2008 - This issue reported on the NIDA International Forum, the NIDA International Program Awards of Excellence, the Institute's international research interests and opportunities, and the IP 2007 Annual Report. The issue also announced the Mentor International Prevention Awards and provided links to the newly published UNAIDS 2008 Report on the Global AIDS Epidemic and the United Nations Office on Drugs and Crime World Drug Report 2008.

June 2008 - This issue reported on the International Poster Session at the Society for Prevention Research meeting and the inauguration of the International Programme in Addiction Studies, an online, 12-month master's degree program offered jointly by the University of Adelaide, King's College London, and Virginia Commonwealth University. The issue also announced the second round of NIDA/CICAD Research Awards for pre- or postdoctoral students from Latin America who are conducting research in any area of the drug use field.

Other Publications

A research monograph entitled "Drug Addiction - From Basic Research to Therapies" edited by Drs. Rao S. Rapaka and Wolfgang Sadee was recently published. This resulted from a NIDA-AAPS symposium. Springer-Verlag, 2008.

Bjork, J.M., Momenan, R., Smith, A.R., and Hommer, D.W. Substance-Dependent Patients Show Blunted Recruitment of Posterior Mesofrontal Cortex Recruitment by Risky Rewards Drug and Alcohol Dependence, 95(1-2), pp. 115-128, 2008.

Rapaka, R., Schnur, P. and Shurtleff, D. Obesity and Addiction: Common Neurological Mechanisms and Drug Development. Physiology & Behavior, online May 2008.

Schnur, P. and Shurtleff, D. Social Neuroscience: Applications to Addiction. Drug &Alcohol Dependence, 94, pp. 285-290, 2008.

Ananyeva, N.M., Makogonenko, Y.M., Kouiavskaia, D.V., Ruiz, J., Limburg, V., Meijer, A.B., Khrenov, A.V., Shima, M., Strickland, D.K., and Saenko, E.L. The Binding Sites for the Very Low Density Lipoprotein Receptor and Low-density Lipoprotein Receptor-related Protein are Shared within Coagulation Factor VIII. Blood Coag. Fibrinolysis 19, pp. 166-177, 2008.

Denisco R.A. and Compton, W.M. Prescription Drug Abuse, published in M. Galanter and H. Kleber (Eds.). Textbook of Substance Abuse Treatment, 4th Edition. Washington, D.C.; American Psychiatric Publishing, Inc., 2008.

Sacks, S., Chandler, R., and Gonzales, J. Responding to the Challenge of Co-occurring Disorders: Suggestions for Future Research. J. Subst. Abuse Treat., 34(1), pp., 139-146, 2008.

Reider, E.E., and Sims, B.E. Is Early Prevention Intervention Later AIDS Prevention? Society for Child and Family Policy and Practice Advocate (newsletter), Division 37 of the American Psychological Association, 30(3), pp. 7-9, 2008.

Jutkiewicz, E. M., Baladi, M.G., Folk, J.E., Rice, K.C. and Woods, J.H. The Delta-Opioid Receptor Agonist SNC80 [(+)-4-[alpha(R)-alpha-[(2S,5R)4-allyl-2,5-dimethyl-1-piperazinyl]-(3-methoxybenzyl)-N, N-diethylbenzamide] Synergistically Enhances the Locomotor-activating Effects of Some Psychomotor Stimulants, but not Direct Dopamine Agonists, in Rats J. Pharmacol. Exp. Ther., 324, pp. 714-724, 2008.

Li, J.X., Rice, K.C., France, C.P. Discriminative Stimulus Effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) in Rhesus. J. Pharm. Exp. Ther., 324, pp. 827-833, 2008.

Hsin, L.-W., Chang, L.-T., Rothman, R.B., Dersch, C.M., Jacobson, A.E. and Rice, K.C. Design and Synthesis of 2- and 3-Substituted-3-phenylpropyl Analogs of 1-[2-[Bis(4-fluorophenyl) methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-propyl)piperazine: Role of Amino, Fluoro, Hydroxyl, Methoxyl, Methyl, Methylene, and Oxo Substituents on Affinity for the Dopamine and Serotonin Transporters. J. Med. Chem., 51, pp. 2795-2806, 2008.

Yang, X., Wang, S., Rice, K.C., Munro, C.A. and Wand, G.S. Restraint Stress and Ethanol Consumption in Two Mouse Strains, Alcoholism-Clinical and Experimental Research, 32, pp. 840-852, 2008.

Hutchinson, M.R., Zhang, Y., Brown, K., Coats, B.D., Shridhar, M., Sholar, P.W., Patel, S.J., Crysdale, N.Y., Maier, S.F., Rice, K.C., and Watkins, L.R. Non-Stereoselective Reversal of Neuropathic Pain by Naloxone and Naltrexone: Involvement of Toll-Like Receptor 4 (TLR4). Eur. J. Neurosci., 28, pp. 20-29 2008.

Reissig, C.J., Eckler, J.R., Rabin, R.A. and Winter, J.C. The Stimulus Effect of 8-OH-DPAT: Evidence for a 5-HT(2A) Receptor - mediated Component. Pharmacol., Biochem. Behav., 88, pp. 312-317, 2008.

Fantegrossi, W.E., Reissig, C.J., Katz, E.B., Yarosh, H.L., Rice, K.C. and Winter, J.C. Hallucinogen-like Effects of N,N-dipropyltryptamine (DPT): Possible Mediation by Serotonin 5-HT1A and 5-HT2A Receptors in Rodents. Pharmacol. Biochem. Behav., 88, pp. 358-365, 2008.

Pascoe, J.E., Williams, K.L., Mukhopadhyay, P., Rice, K.C., Woods, J.H. and Ko, M.C. Effects of Mu, Kappa, and Delta Opioid Receptor Agonists on the Function of Hypothalamic-Pituitary-Adrenal Axis in Monkeys. Psychoneuroendocrinol., 33, pp. 478-486, 2008.

Rutherford, J.M., Wang, J., Xu, H., Dersch, C.M., Partilla, J.S., Rice K.C. and Rothman, R.B. Evidence for a Mu-Delta Opioid Receptor Complex in CHO Cells Co-expressing Mu and Delta Opioid Peptide Receptors. Peptides, 29, pp. 1424-1431, 2008.

Yang, X., Wang, S., Rice, K.C., Munro, C.A. and Wand, G.S. Restraint Stress and Ethanol Consumption in Two Mouse Strains. Alc. Clin. Exp. Res. 32, pp. 840-852, 2008.

Zezula, J., Singer, L., Przyby, A.K., Hashimoto, A., Dersch, C.M., Rothman, R.B., Deschamps, J., Lee, Y.S., Jacobson, A.E. and Rice, K.C. Synthesis and Pharmacological Effects of the Enantiomers of The N-Phenethyl Analogues of the Ortho and Para E- and F-Oxide-bridged Phenylmorphans. Org. & Biomolec. Chem. 6, pp. 2868-2883, 2008.

Roma, P.G., Rinker, J.A., Serafine, K.M., Chen, S.A., Barr, C.S., Cheng, K. et al. The Kappa Opioid System Mediates Gene-Environment Interaction Effects on Voluntary Alcohol Consumption in Female Rats. Pharm. Biochem. Behav., E-pub June 29, 2008.

Davis, C., Stevenson, G., Canadas, F., Ullrich T., Rice, KC. and Riley A.L. Discriminative Stimulus Properties of Naloxone in Long-Evans Rats: Assessment with the Conditioned Taste Aversion Baseline of Drug Discrimination Learning. Psychopharm. (Berl)., Epub July 2, 2008.

Pereira Do Carmo, G., Polt, R., Bilsky, E.J., Rice, K.C. and Negus, S.S. Behavioral Pharmacology of the Mu/Delta Opioid Glycopeptide MMP2200 in Rhesus Monkeys, J. Pharmacol. Exp., Ther. E-pub May 29, 2008.

Parnas, M.L., Gaffaney, J.D.. Zou, M.-F., Lever, J.R., Newman A.H., Vaughan, R.A. Photoaffinity Labeling of Dopamine Transporter Transmembrane Domain 1 with the Tropane Ligand [125I]MFZ 2-24 Implicates Proximity of Cocaine and Substrate Active Sites. Mol. Pharmacol. 73(4), pp. 11141-1150, 2008.

Thanos, P.K., Michaelides, M., Ho, C.W., Wang, G.J., Newman, A.H., Heidbreder, C.A., Ashby, C.R., Gardner, E.L., and Volkow, N.D. The Effects of Two Highly Selective D3 Receptor Antagonists (SB 277011A and NGB 2904) on Food Self-Administration in a Rodent Model of Obesity. Pharmacol. Biochem. Behav. 89(4), pp. 499-507, 2008.

Collins, G.T., Calinski, D.M.,Newman, A.H., Grundt, P., and Woods, J.H. Food Restriction Alters Pramipexole-induced Yawning, Hypothermia, and Locomotor Activity in Rats: Evidence for Sensitization of Dopamine D2 Receptor-mediated Effects J. Pharmacol. Exp. Ther. 325(2), pp. 691-697, 2008.

Syed, S.A., Newman, A.H., and Eddington, N.D. Population Pharmacokinetics, Brain Distribution and Pharmacodynamics of 2nd Generation Dopamine Transporter Selective Benztropine Analogs Developed as Potential Substitute Therapeutics for Treatment of Cocaine Abuse. J. Pharm. Sci., 97(5), pp. 1993-2007, 2008.

Othman, A.A., Newman, A.H., and Eddington, N.D. The Novel N-substituted Benztropine Analog GA2-50 Possesses Pharmacokinetic and Pharmacodynamic Profiles Favorable for a Candidate Substitute Medication for Cocaine Abuse. J. Pharm. Sci. E-pub April 18, 2008.

Tobin, S., Newman, A.H., Quinn, T., and Shalev, U. A Role for Dopamine D1-like Receptors in Acute Food Deprivation-induced Reinstatement of Heroin Seeking in Rats. Int. J. Neuropsychopharmacology, E-pub April 14, 2008.

Beuming, T., Bergmann, M.L., Shi, L., Gracia, L., Raniszewska, K., Newman, A.H., Javitch, J. A., Weinstein, H., Gether, U., and Loland, C.J. Mapping of the Binding Sites for Cocaine and Dopamine in the Dopamine Transporter. Nat. Neurosci., 11(7), pp. 780-789, 2008.


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