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NIDA Home > Publications > Director's Reports > September, 2006 Index    

Director's Report to the National Advisory Council on Drug Abuse - September, 2006


NIDA Publications


Principles of Drug Abuse Treatment for Criminal Justice Populations: A Research-Based Guide
NIH Pub. No. 06-5316

A new NIDA publication, Principles of Drug Abuse Treatment for Criminal Justice Populations, drafted by Bennett Fletcher, Ph.D., and Redonna Chander, Ph.D., was introduced at the American Parole and Probation Association meeting in Chicago on July 24. The guidelines are intended to help criminal justice professionals - judges, correctional officers, parole/probation officers, and others in criminal justice who work with substance-abusing offenders - to understand more about abuse and addiction and how to treat it. The guidelines are also intended for treatment providers who work with patients who are involved with the criminal justice system. NIDA Director Dr. Nora Volkow and Deputy Director Dr. Timothy Condon held a press conference to announce the release, and strong media interest was generated through Reuters and AP stories and satellite news broadcasts. As of early August, approximately 3,000 copies of the publication had been distributed and an additional 20,000 requests for copies were on pre-publication order.

Research Report Series: Tobacco Addiction (Rev.)
NIH Pub. No.

This research report describes what tobacco is, presents current epidemiological research data regarding its use, and reports on the medical consequences of tobacco use. The report emphasizes the effects on the brain as well as current research findings about use during pregnancy. Includes treatment approaches.

Serie de Reportes: De Investigación El VIH/SIDA
(Research Report series: HIV/AIDS)
NIH Pub. No.

This research report was designed to highlight the latest NIDA-supported research into the multiple ways in which drugs of abuse contribute to the spread of HIV. It was released to coincide with the launch of NIDA's new public awareness campaign. "Drug Abuse and HIV: Learn the Link." The campaign was created specifically to raise awareness among teens and young adults about the links between drug abuse and HIV, and features nationally televised public service announcements and NIDA's new web site,

National Survey Results from the Monitoring the Future 2005, Volume I: Secondary Students
NIH Pub. No. 06-5883

Reports on the prevalence of drug use among students in 8th, 10th-, and 12th grades. Trends are analyzed to understand the changing drug abuse problem and to formulate appropriate prevention and treatment policies.

National Survey Results from the Monitoring the Future 2005, Volume II: College Students and Adults Ages 19-40
NIH Pub. No. 06-5884

Reviews trends in drug use by populations based on gender, college plans, regions of the country, population density, race/ethnicity, and parents' education. Trends are analyzed to understand the changing drug abuse problem and to formulate appropriate prevention and treatment policies.

Assessing Drug Abuse Within and Across Communities - Rev. 2006
NIH Pub. No. 06-3614

This publication helps communities understand their local drug abuse problems and develop drug abuse epidemiologic surveillance systems to assess local drug patterns and trends.

NIDA Notes

NIDA Notes Volume 20 Issue No. 6
NIH Pub. No. 06-3478

The lead story discusses the effectiveness of legally mandated treatment for drug and alcohol problems. The Director's Perspective looks at the continuing challenges presented by HIV/AIDS, and discusses some factors that contribute to the disproportionate disease burden carried by the African-American community. Other research reports discuss the Recovery Management Checkup system, designed to help patients who are experiencing relapse; the potential role of glial cells in the brain's protective response to methamphetamine; the effects of obesity on nicotine reward; and gender influences on biological response to nicotine, cocaine, and alcohol. Issue 20-6 also features a "NIDA at Work" article, an in-depth look at the Division of Pharmacotherapies and Medical Consequences of Drug Abuse. The Tearoff feature discusses data from the 2004 National Survey on Drug Use and Health. "Research in Brief" highlights recently published, NIDA-funded studies, "What the Numbers Say" provides a data snapshot of the benefits of on-site psychiatric treatment among teens with co-occurring disorders. The issue also carries the full index to NIDA Notes Volume 20.

CTN-Related Publications

Seven editions of the CTN Bulletin Board were distributed. The Bulletin Board is an electronic report on the progress of the protocols, committees, and node activity in the CTN.

A patient recruitment brochure was printed and distributed for Protocol CTN 0027, Starting Treatment with Agonist Replacement Therapies (START).

A patient recruitment brochure was printed and distributed for Protocol CTN 0030, Prescription Opioid Addiction Treatment Study (POATS).

CCTN developed a data sharing web site for the public use of CTN clinical data. To support the NIH Roadmap and data sharing policy, CCTN adopted the Clinical Data Interchange Standards Consortium (CDISC) data standards for interoperability and ensured that data met HIPAA's security and privacy requirements.

NIDA International Program

The NIDA International Program issues an E-News Letter every other month to inform the international drug abuse research community about recent events, funding opportunities, NIDA's the research training and exchange programs for international scientists, and forthcoming meetings.

June 2006 - This issue reported on the NIDA International Forum, the Institute's international research priorities, the NIDA International Program Awards of Excellence, the NIH transition to electronic submission of grant applications, and several new funding opportunities for international researchers.

Other Publications

Compton, W.M., and Volkow, N.D. Drug Alcohol Depend. 83 Suppl 1:S4-7, June 2006. Abuse of Prescription Drugs and the Risk of Addiction. Abuse of several categories of prescription drugs has increased markedly in the United States in the past decade and is now at alarming levels for certain agents, especially opioid analgesics and stimulants. Prescription drugs of abuse fit into the same pharmacological classes as their non-prescription counterparts. Thus, the potential factors associated with abuse or addiction versus safe therapeutic use of these agents relates to the expected variables: dose, route of administration, co-administration with other drugs, context of use, and expectations. Future scientific work on prescription drug abuse will include identification of clinical practices that minimize the risks of addiction, the development of guidelines for early detection and management of addiction, and the development of clinically effective agents that minimize the risks for abuse. With the high rates of prescription drug abuse among teenagers in the United States, a particularly urgent priority is the investigation of best practices for effective prevention and treatment for adolescents, as well as the development of strategies to reduce diversion and abuse of medications intended for medical use.

Dr. Kevin Conway, DCNBR, co-edited a special issue on Novel Approaches to Phenotyping Drug Abuse, which was published as the June 2006 issue of Addictive Behaviors. The papers appearing in this special issue emphasize innovative research that better describes, discriminates, and predicts the complex nature and course of drug abuse so as to offer more precise phenotypic indicators for testing the hypothesized underlying genetic and environmental risks for drug abuse. Conway, K.P., Compton, W.M., and Miller, P.M. Novel Approaches to Phenotyping Drug Abuse. Addictive Behaviors, 31, pp. 923-928, 2006.

Khalsa, J.H., Vocci, Frank, and Dobs, A. Hormonal and Metabolic Disorders of Human Immunodeficiency Virus Infection and Substance Abuse, Am J. Infect. Dis. 2(3), pp. 125-129, 2006.

Montoya, I.D., and Vocci, F. Suggestions for Future Research. In: Medications Treatments for Nicotine Dependence. George, T. Ed. Taylor & Francis Group. Boca Raton, FL. pp. 293-299, 2006.

Israelsson, C., Lewen, A., Kylberg, A., Usoskin, D., Althini, S., Lindeberg, J., Deng, C.X., Fukuda, T., Wang, Y., Kaartinen, V., Mishina, Y., Hillered, L., and Ebendal, T. Genetically Modified Bone Morphogenetic Protein Signalling Alters Traumatic Brain Injury-induced Gene Expression Responses in the Adult Mouse. J Neurosci Res. 84, pp. 47-57, 2006.

Wang, Y., Alexander, O.B., Woodward-Pu, Y-M., Stahl, C.E., and Borlongan, C.V. Viral Vector Strategy for Glial Cell Line-derived Neurotrophic Factor Therapy for Stroke. Front Biosci. 11, pp. 1101-1107, 2006.

Woods, A.S., Kaminski, R., Morat, O., Wang, Y., Hauser, K., Goody, R., Wang, H-YJ., Jackson, S.N., Zeitz, P., Zeitz, K.P., Zolkowska, D., Schepers, R., Nold, M., Danielson, J., Graslund, A., Vukojevic, V., Bakalkin, G., Basbaum, A., and Shippenberg, T. Decoy Peptides that Bind Dynorphin Noncovalently Prevent NMDA Receptor-Mediated Neurotoxicity. J Proteome Res. 5, pp. 1017-1023, 2006.

Borlongan, C.V., Yu, G., Matsukawa, N., Xu, L., Hess, D.C., Sanberg, P.R., and Wang, Y. Acute Functional Effects of Cyclosporine-A and Methylprednisolone Treatment in Adult Rats Exposed to Transient Ischemic Stroke. Life Sci. 76, pp. 1503-1512, 2005.

Chiang, Y.H., Borlongan, C.V., Zhou, F.C., Hoffer, B.J., and Wang, Y. Transplantation of Fetal Kidney Cells: Neuroprotection and Neuroregeneration. Cell Transplantation. 14, pp. 1-9, 2005.

Chou, J., Harvey, B.K., Chang, C.F., Shen, H., Morales, M., and Wang, Y. Neuroregenerative Effects of BMP7 After Stroke in Rats. J Neurol Sci. 240, pp. 21-29, 2005.

Gong, J.P., Liu, Q.R., Zhang, P.W., Wang, Y., and Uhl, G.R. Mouse Brain Localization of the Protein Kinase C Enhanced Phosphatase 1 Inhibitor: KEPI. Neuroscience. 132, pp. 713-727, 2005.

Harvey, B.K., Hoffer, B.J., Wang, Y. Stroke and TGF-b Proteins: Glial Cell Line Derived Neurotrophic Factor and Bone Morphogenetic Protein. Pharmacol Ther. 105, pp. 113-125, 2005.

Shen, H., Chen, G.J., Harvey, B.K., and Wang, Y. Response: Inosine, Calcium Channels, and Neuroprotection Against Ischemic Brain Injury -Letters to the Editor. Stroke. 36, p. 1823, 2005.

Shen, H., Chen, G.J., Harvey, B.K., Bickford, P.L., and Wang, Y. Inosine Reduces Ischemic Brain Injury in Rats. Stroke. 36, pp. 654-659, 2005.

Wang, Y., Chang, C.F., Chou, J., Chen, H.L., Deng, X., Harvey, B.K., Cadet, J.L., and Bickford, PL. Dietary Supplementation with Blueberries, Spinach, or Spirulina Reduces I Schemic Brain Damage. Exp Neurol. 193, pp. 75-84, 2005.

Raje, S., Cornish, J., Newman, A.H., Cao, J., Katz, J.L., and Eddington, N.D. Investigation of the Potential Pharmacokinetic and Pharmacodynamic Drug Interaction Between AHN 1-055, A Potent Benztropine Analog Used for Cocaine Abuse, and Cocaine after Dosing in Rats Using Intracerebral Microdialysis. Biopharm Drug Dispos. 27, pp. 229-240, 2006.

Kulkarni, S.S., Kopajtic, T.A., Katz, J.L., and Newman, A.H. Comparative Structure-Activity Relationships of Benztropine Analogues at the Dopamine Transporter and Histamine H1 Receptors. Bioorganic & Medicinal Chemistry. 14, pp. 3625-3634, 2006.

Li, S.M., Campbell, B.L. and Katz, J.L. Interactions of Cocaine with Dopamine Uptake Inhibitors or Dopamine Releasers in Rats Discriminating Cocaine. Journal of Pharmacology and Experimental Therapeutics, 317, pp. 1088-1096, 2006.

Cha, J.H., Zou, M.F., Adkins, E.M., Rasmussen, S.G.F., Loland, C.J., Schoenenberger, B., Gether, U., and Newman, A.H. Rhodamine-Labeled-2b-Carbomethoxy-3b-(3,4-dichlorophenyl)-tropane Analogues as High Affinity Fluorescent Probes for the Dopamine Transporter. J. Med. Chem. 48, pp. 7513-7516, 2005.

Henry, L.K., Field, J.R., Adkins, E.M., Parnas, M.L., Vaughan, R.A., Zou, M-F., Newman, A.H., and Blakely, R.D. TYR95 and ILE172 in Transmembrane Segments I and III of Human Serotonin Transporters Interact to Establish High-Affinity Recognition of Antidepressants. J. Biol. Chem. 281, pp. 2012-2023, 2006.

Martinat, C., Bacci, J-J., Leete, T., Kim, J., Vanti, W., Newman, A.H., Cha, J.H., Gether, U., Wang, H., and Abeliovich, A. Cooperative Transcription Activation by Nurr1 and Pitx3 Induces Embryonic Stem Cell Maturation to the Midbrain Dopamine Neuron Phenotype. Proc. Natl. Acad. Sci. 103, pp. 2874-2879, 2006.

Kulkarni, S.S., Kopajtic, T., Katz, J.L., and Newman, A.H. Comparative Structure-Activity Relationships of Benztropine Analogues at the Dopamine Transporter and Histamine H1 Receptors. Bioorg. Med. Chem. 14, pp. 3625-3634, 2006.

Kulkarni, S.S., Nightingale, B., Dersch, C.M., Rothman, R.B., and Newman, A.H. Design and Synthesis of Noncompetitive Metabotropic Glutamate Receptor Subtype 5 Antagonists. Bioorg. Med. Chem Lett. 16, pp. 3371-3375, 2006.

Raje, S., Cornish, J., Newman, A.H., Cao, J., Katz, J.L., and Eddington, N.D. Investigation of the Potential Pharmacokinetic and Pharmacodynamic Drug Interaction Between the Benztropine Analogue AHN 1-055, a Potent Benztropine Analog Used for Cocaine Abuse, and Cocaine After Dosing in Rats Using Intracerebral Microdialysis. Biopharmaceutics and Drug Disposition, 27, pp. 229-240, 2006.


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