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National Institute on Drug Abuse

Director's Report to the National Advisory Council on Drug Abuse

May, 2000


Research Report Series: Anabolic Steroids Abuse (Revision)
NIH Pub. No. 00-3721

The Research Report Series provides an authoritative and unbiased overview of particular topics and brings together the more recent and pertinent scientific information in an individual issue, along with a reference list. The revisions to this publication reflect the most recent findings from research on anabolic steroid use and surveys on youth drug use.

Community Drug Alert Bulletin-Anabolic Steroid Abuse
NIH Pub. No. 00-4771

This publication alerts communities that steroid abuse is a growing problem among adolescents and elaborates on the dangers of steroid abuse. There is increasing concern about the use of steroids, and NIDA is in a prime position to provide research-based information. NIDA wishes to inform the public about attempts being made to control steroid abuse and to make the public aware that the Institute is a resource for information about the problem.

Community Drug Alert Bulletin-Hepatitis C
NIH Pub. No. 00-4663

There currently exists a substantial need to alert health care workers, the prevention community, and the general public about the health risks posed by hepatitis C infection and its association with injection drug use. The purpose of this Bulletin is to provide information about the link between injection drug use and hepatitis C infection. The Bulletin contains information as follows: scientific information on hepatitis C infection and disease; the effects of hepatitis C virus infection on the body; the adverse consequences on the disease process of ongoing substance abuse; current treatment options; the risk for infection posed by injection drug use; screening recommendations for testing for the virus; and prevention efforts. In addition, the Bulletin lists other information sources.

Epidemiologic Trends in Drug Abuse: Community Epidemiology Work Group
Volume I, December 1999
NIH Pub. No. 00-4739

This publication provides more detailed descriptions than the Advanced Report of drug abuse patterns, trends, and consequences. The report provides an ongoing assessment of the epidemiology of drug abuse in major metropolitan areas of the United States with the purpose of keeping both public and private sector policy makers and researchers informed with current and accurate data.

Epidemiologic Trends in Drug Abuse: Community Epidemiology Work Group
Volume II, December 1999
NIH Pub. No. 00-4740

The International Epidemiology Work Group (IEWG) is a network of drug abuse researchers from various countries, regions, and international organizations. The IEWG is an outgrowth of efforts to establish a global drug abuse surveillance network. The IEWG is based on recognition of the essential need to coordinate and share the most timely and accurate information about the changing dynamics of drug abuse worldwide.

National Survey Results on Drug Use from the Monitoring the Future Study,
1975-1999, Overview of Key Findings
NIH Pub. No. 00-4690

The Monitoring the Future Study is a large-scale epidemiological survey of drug use attitudes and behavior among the nation's youth. The survey is based on a national probability sample of approximately 16,000 public and private high school seniors in the contiguous United States. The Advance Report provides systematically recurring annual estimates of drug use among students. The trends are useful for understanding the changing drug abuse problems and for formulating the appropriate interventions (both prevention and treatment) and policies.

The Problems of Drug Dependence, 1999: Proceedings of the 61st Annual Scientific Meeting of the College on Problems of Drug Dependence
NIH Pub. No. 00-4737

This publication is more than just a "proceedings" from a meeting-it is valued as one of the only research tools and references for scientists and other professionals in the drug abuse field. The publication is the most comprehensive gathering of scientific information on all aspects of substance abuse and is invaluable to researchers and other scientists.


NIDA NOTES Vol. 14, Issue 5
NIH Pub. No. 00-3478

Drug addiction treatment research is highlighted in this issue beginning with the lead story, which announces NIDA's new Principles of Drug Addiction Treatment guide, and continuing in the Director's Column, which links Principles to the Institute's 25 years of treatment research. This issue's Tearoff sums up the 13 principles of effective drug addiction treatment from the guide. Other treatment articles discuss methadone dosage, the additive effects of additional counseling and 12-step programs in treatment, and the benefits of combining drug-counseling methods to treat cocaine addiction. Research on the use of peers to provide drug abusers with AIDS prevention information is featured, and an article on NIDA's science education program highlights efforts to introduce young women in rural Appalachia to hands-on science.

NIDA NOTES Vol. 14, Issue 6
NIH Pub. No. 00-3478

NIDA's broad-based initiative to combat an alarming rise in the use of club drugs is highlighted in the lead article. An accompanying list describes common club drugs, how they are used, and the consequences of their use. The Director's Column warns of the dangers of this trend, especially for youngsters who may be uninformed or misinformed about the hazards of club drug use. The first six sites for NIDA's landmark Clinical Trials Network are announced in this issue, and highlights of a symposium celebrating NIDA's 25th anniversary are covered as well. Another article looks at how research is translated into practice as programs developed by NIDA-funded prevention research are instituted in communities.

NIDA NOTES Vol. 15, Issue 1
NIH Pub. No. 00-3478

The lead story announces NIDA's partnership with the National Cancer Institute and the Robert Wood Johnson Foundation in launching seven tobacco research centers across the nation. In the Director's Column, Dr. Leshner describes how research seeks ways to address the medical consequences of drug abuse. The Tearoff presents facts about drug abuse and hepatitis C. Other articles examine promising findings for cocaine abuse treatment and report new information on marijuana and its abuse. In addition, results of the annual Monitoring the Future study on teen drug use are announced.

Other Publications

Goodman C.B., Heyliger S., Emilien B., Partilla J.S., Yang H.Y., Lee C.H., Cadet J.L. and Rothman R.B. Chronic Exposure to Antibodies Directed against Anti-opiate Peptides Alters Delta-opioid Receptor Levels. Peptides, 20(12), pp. 1419-24, 1999.

Jones, H.E., Herning, R.I., Cadet, J.L., and Griffiths, R.R. Caffeine Withdrawal Increases Cerebral Blood Flow Velocity and Alters Quantitative Electroencephalography (EEG). Psychopharmacology, (Berl)147(4), pp. 371-377, 2000.

Herning, R.I., Better, W., Nelson, R., Gorelick, D. and Cadet, J.L. The Regulation of Cerebral Blood Flow during Intravenous Cocaine Administration in Cocaine Abusers. Ann. N Y Acad. Sci. 890, pp. 489-94, 1999.

Deng, X. and Cadet, J.L. Methamphetamine Administration Causes Overexpression of nNOS in the Mouse Striatum. Brain Res. 851(1-2), pp. 254-257, 1999.

Deng, X., Ladenheim, B., Tsao, L. and Cadet, J.L. Null Mutation of c-fos Causes Exacerbation of Methamphetamine-induced Neurotoxicity. J Neurosci. 19(22), pp. 10107-10115, 1999.

Woolverton, W.L., Rowlett, J.K.,Wilcox, K.M., Paul, I.A., Kline, R.H., Newman, A.H., and Katz, J.L. 3'- and 4'-Chloro-substituted Analogs of Benztropine: Intravenous Self-Administration and In Vitro Radioligand Binding Studies in Rhesus Monkeys. Psychopharmacology, 147, pp. 426-435, 2000.

Robarge, M.J., Agoston, G.E., Izenwasser, S., Kopajtic, T., George, C., and Newman, A.H. Highly Selective Chiral N-Substituted 3_-[bis(4'-fluorophenyl)methoxy]tropane Analogues for the Dopamine Transporter: Synthesis and Comparative Molecular Field Analysis. J. Med. Chem., 43, pp. 1085-1093, 2000.

Heishman, S.J. Behavioral and Cognitive Effects of Smoking: Relationship to Nicotine Addiction. Nicotine and Tobacco Research, 1 (Suppl. 2), pp. 141-145, 1999.

Taylor, R.C., Harris, N.A., Singleton, E.G., Moolchan, E.T., and Heishman, S.J. Tobacco Craving: Intensity-related Effects of Imagery Scripts in Drug Abusers. Experimental and Clinical Psychopharmacology, 8, pp. 75-87, 2000.

Haverkos, H.W., Rohrer, M.S. and Pickworth, W.B. The Cause of Cervical Cancer Could be Multifactorial. Biomedicine Pharmacotherapy, 54, pp. 54-59, 2000.

Fant, R.V., Henningfield, J.E., Nelson, R.A. and Pickworth, W.B. Pharmacokinetics and Pharmacodynamics of Moist Snuff in Humans. Tobacco Control, 8, pp. 387-392, 1999.

Pickworth, W.B., Fant, R.V., Nelson, R.A., Rohrer, M.S. and Henningfield, J.E. Pharmacodynamic Effects of New De-nicotinized Cigarettes. Nicotine and Tobacco Research 1, pp. 357-364, 1999.

Hogan, D., Etz, K., and Tudge, J. Reconsidering The Role of Children in Family Research: Conceptual and Methodological Issues. In F Berardo and C. Shehan Contemporary Perspectives on Family Research. (Vol. 1) Through the Eyes of the Child: Revisioning Children as Active Agents of Family Life, pp. 93-108, 1999.

Tudge, J., Hogan, D., and Etz, K. Using Naturalistic Observations as a Window Into Children's Everyday Lives: An Ecological Approach. In F. Berardo and C. Shehan Contemporary Perspectives On Family Research. (Vol. 1) Through The Eyes Of The Child: Revisioning Children as Active Agents Of Family Life, pp. 109-132, 1999.

Futris, T.G., Hicks, S., Hal, A.H., Etz, K., Doucet, F. and Lange, G. Preparing Graduate Students For A Diverse Job Market: A Comparison Of Human Development And Family Science Programs. Family Science Review, 1999.

Kozel, N.J., and Agar, M.H. (Guest Editors) Special Issue of Substance Use and Misuse on Ethnography and Substance Abuse: Talking Numbers, Volume 34, Number 14, 1999.

Kiesewetter, D.O., Sassaman, M.B., Robbins, J., Jagoda, E.M., Carson, R.E., Appel, N.M., Sutkowski, E., Herscovitch, P., Braun, A. and Eckelman, W.C. Synthesis and Evaluation of an F-18 Analog of Forskolin for Imaging Adenylyl Cyclase. J. Fluorine Chem. 101, pp. 297-304, 2000.

Levin, F.R., Evans, S.M., and Kleber, H.D. Practical Guidelines for the Treatment of Substance Abusers with Adult Attention-Deficit Hyperactivity Disorder. Columbia University, New , NY. Psychiatr. Serv., 50(8), pp. 1001-1003, August 1999.

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