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NIDA Home > Publications > Director's Reports > February, 2007 Index    

Director's Report to the National Advisory Council on Drug Abuse - February, 2007


NIDA Publications

Epidemiologic Trends in Drug Abuse - Community Epidemiology Work Group
Advance Report - June 2006 - NIH Pub. No. 06-5880A

This report provides descriptive information on the most recent significant trends, emerging problems and populations at risk.

Epidemiologic Trends in Drug Abuse - Community Epidemiology Work Group
Volume I - June 2006 - NIH Pub. No. 06-5881A

This report provides an ongoing assessment of drug abuse in major metropolitan areas of the United States with the purpose of keeping both public and private sector policymakers and researchers informed with current and accurate data.

Epidemiologic Trends in Drug Abuse - Community Epidemiology Work Group - Volume II - June 2006 - NIH Pub. No. 06-5882A
This report provides an in-depth analysis of the epidemiologic trends and special reports for a limited audience made up primarily of drug abuse researchers who utilize this volume to identify potential areas for further research.

Mind Over Matter (8 Booklets - Spanish)
NIH Pub. Nos.: 06-3858; 06-4038; 06-3859; 06-4394; 06-4248; 06-3856; 06-3860; 06-3857

This series encourages young teens to reject drug use by helping them understand the effects of drugs on the brain. In each booklet, Sara Bellum--a budding science student--takes students on a scientific journey to learn about the brain's complex responses to specific drugs, including hallucinogens, inhalants, marijuana, methamphetamine, nicotine, opiates, steroids, and stimulants. This is the first time the series is available in the Spanish language.


Science of Addiction
NIH Pub. No. 07-5605

New advances in science demonstrate that addiction is a brain disease--a disease that is accompanied by disruption of the mechanisms responsible for generating, modulating and controlling an individual's cognitive, emotional, and social behavior.

NIDA Notes

NIDA Notes Volume 21 Issue No. 1
NIH Pub. No. 06-3478

The lead story looks at the effectiveness of low-cost incentives in a stimulant abuse treatment program. The Director's Perspective reports on the ongoing problem of steroid abuse and the many risks associated with steroids. Other research looked at ultra rapid detoxification programs; buprenorphine in adolescent opiate addiction; the brain mechanisms of memory in rats; and the potential respiratory consequences of marijuana abuse. This issue also reports on NIDA's July launch of the new criminal justice document in Chicago.

NIDA Notes Volume 21 Issue No. 2
NIH Pub. No. 06-3478

The Director's Perspective addresses addiction and co-occurring mental disorders. The NIDA at Work feature looks at NIDA's Division of Basic Neuroscience and Behavioral Research. Research findings review how combination treatment of vouchers and cognitive-behavioral therapy extended marijuana abstinence; a study linking treatment outcome and brain response to cocaine cues; nicotine's effects on the development of rat brains, cocaine craving and high effects on brain activation patterns. The Bulletin Board reports on the use of Dialectical Behavior Therapy in deaf populations, and summarizes the recent NIDA-funded supplemental issue of Alcohol and Drug Dependence.

NIDA Notes Volume 21 Issue No. 3
NIH Pub. No. 06-3478

The Director's Perspective examines genes and smoking, and NIDA's work with Perlegen Sciences. Research findings include how regional brain development contributes to adolescent risk-taking; animal studies looking at the serotonin system as a potential target for cocaine medications; endorphin derivative inhibiting reward from morphine and nicotine in rats; depot naltrexone's safety and efficacy for heroin addiction; and the use of standard treatments to help depressed smokers quit. The Bulletin Board discusses the NIDA International Program-sponsored special supplement to Drug and Alcohol Dependence, and What the Numbers Say looks at cocaine abstinence rates.

Science and Practice Perspectives

Science and Practice Perspectives Volume 3, Issue No. 2
Research Review articles include "Assessing Organizational Functioning as a Step Toward Innovation," by Drs. Dwayne D. Simpson and Donald F. Dansereau; "Imaging the Addicted Human Brain," by Dr. Joanna Fowler and NIDA Director Dr. Nora Volkow; Clinical Perspectives: One Program's Experience Incorporating Research-Based Strategies into Methamphetamine Treatment, by Jay Hansen; Quality and Performance Improvement: What's a Program To Do? by Dr. Frank McCorry. The Science and Practice in Action feature is "Attending to Emotional Cues for Drug Abuse: Bridging the Gap Between Clinic and Home Behaviors" by Drs. Michael Otto, Conall O'Cleirigh, and Mark Pollack.

International Program E-News Letter

The NIDA International Program issues an E-News Letter every other month to inform the international drug abuse research community about recent events, funding opportunities, NIDA's research training and exchange programs for international scientists, and forthcoming meetings.

  • October 2006 - This issue announced the dates and deadlines for the 2007 NIDA International Forum, discussed new budget rules for grant applications from non-U.S. institutions, and reported on research conducted by DISCA scientists.
  • December 2006 - The issue discussed research results from a NIDA-supported binational research team in Tanzania, reported that NIH support had been awarded to a former NIDA INVEST and DISCA scientist, and announced new Administrative Supplements for binational research co-funded by NIDA and the Dutch Addiction Program.

CTN-Related Publications

Seven editions of the CTN Bulletin Board were distributed. The Bulletin Board is an electronic report on the progress of the protocols, committees, and node activity in the CTN.

The CTN Data Sharing Web Site was established to support the NIH data sharing policy. The data sets of four protocols are available for public use; another four data sets will be available before the end of April 2007. These data sets are in compliance with HIPAA and CDISC (Clinical Data Interchange Standards Consortium) standards in support of the interoperability required by the NIH Roadmap.

Other Publications

Compton W.C., Conway K.P., Stinson F.S., and Grant B.F. Changes in the Prevalence of Major Depression and Comorbid Substance Use Disorders in the United States between 1991-1992 and 2001-2002. American Journal of Psychiatry 163: 2141-2147, 2006.

Dr. Rao Rapaka, DBNBR, guest edited a special themed issue of the AAPS (American Association of the Pharmaceutical Scientists) Journal entitled "Themed Issue: 2005 AAPS National Biotechnology Conference Symposium on Lipidomics."

Drs. Rao Rapaka, DBNBR, and Jagitsing Khalsa, guest edited a special themed issue of the AAPS (American Association of the Pharmaceutical Scientists) Journal entitled "Themed Issue: NIDA/AAPS Symposium on Drugs of Abuse: Mechanisms of Toxicity, Toxicokinetics and Medical Consequences, November 4-5, 2005."

Drs. Rao Rapaka, DBNBR, and Wolfgang Sadee, Ohio State University, guest edited a special themed issue of the AAPS (American Association of the Pharmaceutical Scientists) Journal entitled "Themed Issue: Drug Addiction - From Basic Research to Therapies."

Rutter, J.L. Symbiotic Relationship of Pharmacogenetics and Drugs of Abuse. AAPS Journal, 8(1) pp. E174-E184, 2006.

Rutter, J.L. Topiramate Pharmacogenetics: Towards Understanding and Personalizing Addiction Therapies. TOP Stories, 1, pp. 3, 2006.

Price, L.N., Reider, E.E., and Robertson, E.B. Health-Risking Social Behaviors: Moving Forward. Journal of Abnormal Child Psychology, 34(4), pp. 489-494, 2006.

Ginexi, E.M. and Hilton, T.F. What's Next for Translation Research? Evaluation and the Health Professions, 29(3), pp. 334-347, 2006. Bierut, L.J., Madden, P.A.F., Breslau, N., Johnson, E.O., Hatsukami, D., Pomerleau, O.F., Swan, G.E., Rutter, J., Bertelsen, S., Fox, L., Fugman, D., Goate, A.M., Hinrichs, A.L., Konvicka, K., Martin, N.G., Montgomery, G.W., Saccone, N.L., Saccone, S.F., Wang, J.C., Chase, G.A., Rice, J.P., Ballinger, D.G. Novel Genes Identified in a High Density Genome Wide Association Study for Nicotine Dependence. Human Molecular Genetics (epub ahead of publication), 2006.

Saccone, S.F., Hinrichs, A.L., Saccone, N.L., Chase, G.A., Konvicka, K., Madden, P.A.F., Breslau, B., Johnson, E.O., Hatsukami, D., Pomerlau, O. Swan, G.E., Goate, A.M., Rutter, J., Bertelsen, Sa., Fox, L., Fugman, D., Martin, N.G., Montgomery, G.W., Wang, J.C., Ballinger, D.G., Rice, J.P., Bierut, L.J. Cholinergic Nicotinic Receptor Genes Implicated in a Nicotine Dependence Association Study Targeting 348 Candidate Genes with 3,713 SNPs. Human Molecular Genetics (epub ahead of publication), 2006.

Haigney, M.C., Alam S., Tebo, S., Marhefka, G., Elkashef, A., Kahn, R., Chiang, C.N., Vocci, F., and Cantilena, L. Intravenous Cocaine and QT Variability. J Cardiovasc Electrophysiol 17(6), pp. 610-161, 2006.

Khalsa, J.H., Vocci, F.J., and Dobs, A. Hormonal and Metabolic Disorders of Human Immunodeficiency Virus Infection and Substance Abuse. Am J Infectious Dis 2(3), pp. 125-129, 2006.

Khalsa, J., Vocci, F., Altice, F., Fiellin, D., and Miller, V. Buprenorphine and HIV Primary Care: New Opportunities for Integrated Treatment. Clin Infect, Dis. 15:Suppl 4:S169-172, 2006.

Onaivi, E.S., Ishiguro, H., Gong, J.P., Patel, S., Perchuk, A., Meozzi, P.A., Myers, L., Mora, Z., Tagliaferro, P., Gardner, E., Brusco, A., Akinshola, B.E., Liu, Q.R., Hope, B., Iwasaki, S., Arinami, T., Teasenfitz, L., and Uhl, G.R. Discovery of the Presence and Functional Expression of Cannabinoid CB2 Receptors in Brain. Ann N Y Acad Sci. 1074, pp. 514-536, August 2006.

Liu, Q.R., Drgon, T., Johnson, C., Walther, D., Hess, J., and Uhl, G.R. Addiction Molecular Genetics: 639,401 SNP Whole Genome Association Identifies Many "Cell Adhesion" Genes. Am J Med Genet B Neuropsychiatr Genet. November 10, 2006.

Harburg, G.C., Hall, F.S., Harrist, A.V., Sora, I., Uhl, G.R., and Eisch, A.J. Knockout of the mu Opioid Receptor Enhances the Survival of Adult-generated Hippocampal Granule Cell Neurons. Neuroscience. October 19, 2006.

Johnson, C., Drgon, T., Liu, Q.R., Walther, D., Edenberg, H., Rice, J., Foroud, T., and Uhl, G.R. Pooled Association Genome Scanning for Alcohol Dependence Using 104,268 SNPs: Validation and Use to Identify Alcoholism Vulnerability Loci in Unrelated Individuals from the Collaborative Study on the Genetics of Alcoholism. Am J Med Genet B Neuropsychiatr Genet. 2006.

Drgon, T., D'Addario, C., and Uhl, G.R. Linkage Disequilibrium, Haplotype and Association Studies of a Chromosome 4 GABA Receptor Gene Cluster: Candidate Gene Variants for Addictions. Am J Med Genet B Neuropsychiatr Genet. 2006.

Katz, J.L., Kopajtic, T.A. and Terry, P. The Effects of Dopamine D1-like Receptor Agonists on Food-maintained Operant Behavior in Rats. Behavioural Pharmacology, 17, pp. 303-309, 2006.

Zou, M.-F., Cao, J., Kopajtic, T., Desai, R.I., Katz, J.L., and Newman, A.H. Structure-Activity Relationship Studies on a Novel Series of (S)-2_-Substituted 3_-[Bis(4-fluoro- or 4-chloro-phenyl)methoxy]tropane Analogs for In Vivo Investigation. J. Med. Chem., 49, pp. 6391-6399, 2006.

Newman, A.H., Cha, J.H., Cao, J., Kopajtic, T., Katz, J.L., Parnas, M.L., Vaughan, R., and Lever, J.R. Design and Synthesis of a Novel Photoaffinity Ligand for the Dopamine and Serotonin Transporters Based on 2_-carbomethoxy-3 _ -biphenyltropane. J Med Chem., 49, pp. 6621-6625, 2006.

Othman, A. A., Syed, S. A., Newman, A.H., and Eddington, N.D. In vitro Transport, Human and Rat CYP Phenotyping and in vivo Population Pharmacokinetics and Brain Distribution of the Chloro benztropine (BZT) Analogs; A Class of Compounds Extensively Evaluated in Animal Models of Drug Abuse. J. Pharmacol. Exp. Ther. 2006, manuscript published online September 25, 2006.

Grundt, P., Husbands, S.L.J., Luedtke, R.R., Taylor, M., and Newman, A.H. Analogues of the Dopamine D2 Receptor Antagonist L741,626: Binding, Function and SAR. Bioorg. Med. Chem. Lett. 2006, manuscript published online October 29, 2006.


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