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National Institute on Drug Abuse

Director's Report to the National Advisory Council on Drug Abuse

February, 2000


National Survey Results on Drug Use from the Monitoring the Future Study, 1975-1998.
Volume I: Secondary School Students (NIH Pub. No 99-4660)
Volume II: College Students and Young Adults (NIH Pub. No 99-4661)

These two publications (both printed in September 1999) report the cumulative findings of the NIDA-supported Monitoring the Future study which examines the prevalence of drug use among American secondary students (i.e. 8th, 10th, and 12th grades), college students, and young adults.

Epidemiologic Trends in Drug Abuse: Community Epidemiology Work Group,
Vol. I, June 1999
NIH Pub. No. 00-4529

This publication provides more detailed descriptions of drug abuse patterns, trends, and consequences reported in the Advanced Report. The report provides an ongoing assessment of epidemiology of drug abuse in major metropolitan areas of the United States with the purpose of keeping both public and private sector policy makers and researchers informed with current and accurate data.

Epidemiologic Trends in Drug Abuse: Community Epidemiology Work Group,
Volume II: International Epidemiology Work Group on Drug Abuse, June 1999
NIH Pub. No. 00-4530

This publication includes papers from the International Epidemiology Work Group (IEWG) that is a network of drug abuse researchers from various countries, regions, and international organizations. It includes efforts to establish a global drug abuse surveillance network.

NIDA Community Drug Alert Bulletin-Club Drugs
NIH Pub. No. 00-4723

The Community Drug Alert Bulletin on Club Drugs provides a synopsis of NIDA's research knowledge on club drugs and refers individuals to additional reliable sources of information.


NIDA NOTES Vol. 4, Issue 3
NCADI - NN0038

This issue's lead article and Director's Column deal with the subtle but significant effects of prenatal cocaine exposure. The Atlanta Town Meeting, NIDA's biggest so far, is covered. Another article looks at how a NIDA-supported science education project in a California high school is sparking student interest in science in general and drug abuse research. The Tearoff offers information in brief on cocaine abuse and treatment.

NIDA NOTES, Vol. 4, Issue 4
NCADI - NN0039

The lead story in this issue describes how twin studies provide valuable information on the interrelationship between genetic and environmental risk factors for drug abuse. The Director's Column examines how comorbid mental health problems complicate drug abuse treatment. A related article looks at the relationships between attention-deficit/hyperactivity disorder and drug abuse. The effects of "ecstasy" on the brain and memory are reviewed and the Tearoff provides a primer on the drug. NIDA's new Teen Tobacco Addiction Treatment Research Clinic is highlighted in this issue as well.

Drug Abuse: Origins and Interventions. Meyer Glantz and Christine Hartel (Eds.). Washington, D.C., American Psychological Association Press, 1999. Based on a NIDA-APA sponsored conference, this book includes 14 chapters by leading drug abuse researchers on new findings in a range of different drug abuse fields and their implications and three chapters reviewing and synthesizing the research on the origins, prevention, and treatment of drug abuse.

Resilience and Development: Positive Life Adaptations. Meyer Glantz and Jeannette Johnson (Eds.). New York: Kluwer Academic/Plenum Press, 1999. Based on a multi-institute sponsored conference, this book presents the latest findings, concepts and applications of research on resilience through chapters written by the leading experts in the field. The book is the 3rd volume in the Interdisciplinary Series entitled: Longitudinal Research in the Social and Behavioral Sciences.

The Origins of Drug Abuse: Mapping the Paths. M. Glantz, N. Weinberg, L. Miner and J. Colliver. In M. Glantz and C. Hartel (Eds.). Drug Abuse: Origins and Interventions. Washington, D.C., American Psychological Association Press, 1999. This chapter reviews the research literature on the origins and development of drug abuse.

The Treatment of Drug Abuse: Changing the Paths. C. Hartel and M. Glantz. In M. Glantz and C. Hartel (Eds.). Drug Abuse: Origins and Interventions. Washington, D.C., American Psychological Association Press, 1999. This chapter reviews the research literature on the treatment of drug abuse.

Analysis and Reconceptualization of Resilience. M. Glantz and Z. Sloboda. In M. Glantz & J. Johnson (Eds.), Resilience and Development: Positive Life Adaptations. New York: Plenum Press 1999. This chapter analyses the concept of resilience and proposes an alternative approach to the use of the concept.

Frontline Surveillance: the Community Epidemiology Work Group on Drug Abuse. Zili Sloboda and Nicholas Kozel. In M. Glantz and C. Hartel (Eds.). Drug Abuse: Origins and Interventions. Washington, D.C., American Psychological Association Press, 1999. This chapter discusses the history and function of the CEWG with a discussion of the unique characteristics that make its work important.

Stone, A.A., Turkkan, J.S., Bachrach, C.A. (et al.) Eds. The Science of Self-Report: Implications for Research and Practice. Mahwah NJ, Lawrence Erlbaum, 380 pages, 2000.

Turkkan, J.S. and Shurtleff, D.S. Cognitive Sciences Research : More than Thinking About Drug Abuse. Psychological Science 10: pp.179-181, 1999.

McCann, D.J., Mello, N.K., Negus, S.S., Bergman, J., Forster, M. and Schenk, S.: Selegiline as a Potential Cocaine Treatment Medication: Behavioral Evaluations in Rhesus Monkeys and Comparisons with Other MAO Inhibitors in Rodents. Behav. Pharmacol. 10: S59-S60, 1999.

Lavori, P.W., Bloch, D.A., Bridge, T.P., Leiderman, D.B., LoCastro, J.S., and Somoza, E. Plans, Designs and Analyses for Clinical Trials of Anti-Cocaine Medications: Where We Are Today. J Clinical Psychopharmacology, 19(3), pp. 246-256, 1999.

Deng, X., Ladenheim, B., Tsao, LI., and Cadet, J.L. Null Mutation of c-fos Causes Exacerbation of Methamphetamine-induced Neurotoxicity. J Neurosci, 19(22), pp. 10107-10115, 1999.

Jayanthi, S., Ordonez, S., McCoy, M.T., and Cadet, J.L. Dual Mechanism of fas-induced Cell Death in Neuroglioma Cells: A Role for Reactive Oxygen Species. Mol Brain Res, 72(2), pp. 158-65, 1999.

Yeh, S.Y., Dersch, C., Rothman, R., and Cadet, J.L. Effects of Antihistamines on 3,4-Methylenedioxymethamphetamine-induced Depletion of Serotonin in Rats. Synapse, 33(3), pp. 207-217, 1999.

Heishman, S.J., Weingartner, H.J., and Henningfield, J.E. Selective Deficits in Reflective Cognition of Polydrug Abusers: Preliminary Findings. Psychology of Addictive Behaviors, 13, pp. 227-231, 1999.

Heishman, S.J. Nicotine: Pharmacology and Addiction. Therapeutic Drug Monitoring and Toxicology, 20, pp. 227-238, 1999.

Katz, J.K., Izenwasser, S., Kline, R.H., Allen, A.C.; and Newman, A.H. Novel 3_-Diphenylmethoxytropane Analogs: Selective Dopamine Uptake Inhibitors with Behavioral Effects Distinct from those of Cocaine. J. Pharmacol. Exp. Ther., 288, pp. 302-315, 1999.

Vaughan, R.A., Agoston, G.E., Lever, J.R, and Newman, A.H. Differential Binding Sites of Tropane-Based Photoaffinity Ligands on the Dopamine Transporter. J. Neurosci., 19, pp. 630-636, 1999.

Tolliver, B.K., Ho, L.B., Newman, A.H., Fox, L.M., Katz, J.L., and Berger, S.P. Behavioral and Neurochemical Effects of Dopamine Transporter Ligands Alone and in Combination with Cocaine: Characterization of 4-Chlorobenztropine in vivo. J. Pharmacol. Exp. Ther., 103, pp. 110-122, 1999.

Newman, A.H., Robarge, M., Izenwasser, S., and Kline, R.H. A Comparative Molecular Field Analysis (CoMFA) Study of Novel Ring-Substituted 3_-(Diphenylmethoxy)tropane Analogs at the Dopamine Transporter. J. Med. Chem., 42, pp. 3502-3509, 1999.

Tortella, F.C., Britton, P., Williams, A., Chung, X., Lu, M., and Newman, A.H. Neuroprotection (Focal Ischemia) and Neurotoxicity (Electroencephalographic) Studies in Rats with AHN649, a 3-Amino Analog of Dextromethorphan and Low Affinity NMDA Antagonist. J. Pharmacol. Exp. Ther., 291, pp. 399-408, 1999.

Husbands, S.H., Kopajtic, T., Izenwasser, S., Bowen, W.D., Vilner, B.J., Katz, J.L. and Newman, A.H. Structure-Activity Relationships at the Monoamine Transporters and _ Receptors for a Novel Series of 9-[3-cis-3,5-Dimethyl-1-piperazinyl)propyl] carbazole (Rimcazole) Analogs. J. Med. Chem., 42, pp. 4446-4455, 1999.

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