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Cannabinoid Assays in Humans



NIDA Research Monograph, Number 7 [Printed in 1976]

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FOREWORD

PREFACE

QUANTITATION OF CANNABINOIDS IN BIOLOGICAL FLUIDS BY RADIOIMMUNOASSAY-----1
Arleen R. Chase, Paul R. Kelley, Alison Taunton-Rigby, Reese T. Jones, Theresa Harwood

SEPARATE RADIOIMMUNE MEASUREMENTS OF BODY FLUID D9-THC AND 11-NOR-9-CARBOXY-D 9-THC-----10
Stanley J. Gross, M.D. and James R. Soares, Ph.D.

RADIOIMMUNOASSAY OF D 9-TETRAHYDROCANNABINOL-----15
Clarence E. Cook, Ph.D., Mary L. Hawes, B.A., Ellen W. Amerson, B.A., Colin G. Pitt, Ph.D., and David Williams, B.A.

DETERMINATION OF THC AND ITS METABOLITES BY EMITĘ HOMOGENEOUS ENZYME IOIMMUNOASSAY: A SUMMARY REPORT-----28
G.L. Rowley, Ph.D., T.A. Armstrong, C.P. CrowL, W.M. Eimstad, W.M. Hu, Ph.D., J.K. Kam, R. Rodgers, Ph.D., R.C. Ronald, Ph.D., K.E. Rubenstein, Ph.D., B.G. SkeLdon, and E.F. Ullman, Ph.D.

SEPARATION AND SENSITIVE ANALYSIS OF TETRAHYDROCANNABINOL IN BIOLOGICAL FLUIDS BY HPLC AND GLC------33
Edward R. Garrett and C. Anthony Hurt

DETERMINATION OF D9-TETRAHYDROCANNABINOL IN HUMAN BLOOD SERUM BY ELECTRON CAPTURE GAS CHROMATOGRAP'HY-----42
David C. Fenimore, Ph.D., Chester M. Davis, Ph.D., and Alec H. Horn

DETECTION AND QUANTIFICATION OF TETRAHYDROCANNABINOL IN IN BLOOD PLASMA-----48
Agneta Ohlsson, Jan-Erik Lindgren, Kurt Leander, Stig Agurell

A METHOD FOR THE IDENTIFICATION OF ACID METABOLITES OF TETRAHYDROCANNABINOL (THC) BY MASS FRAGMENTOGRAPHY-----64
Marianne Nordqvist, Jan-Erik Lindgren, Stig Agurell

QUANTITATION OF CANNABINOIDS IN BIOLOGICAL SPECIMENS USING PROBABILITY BASED MATCHING GAS CHROMATOGRAP'HY/MASS SPECTROMlETRY-----70
Donald E. Green, Ph.D.

QUANTITATION OF D9-TETRAHYDROCANNABINOL IN BODY FLUIDS BY GAS CHROMATOGRAPHY/ CHEMICAL IONIZATION-MASS SPECTROMETRY-----88
Ruthanne Detrick and Rodger L. FoItz

HPLC-MS DETERMINATION OF D 9-TETROHYDROCANNABINOL IN HUMAN BODY SAMPLES-----96
Jimmie L. Valentine, Ph.D., Paul J. Bryant, Ph.D., Paul L. Gutshall, M.S., Owen H.M. Gan, B.S., Everett D. Thompson, B.S., Hsien Chi Niu, Ph.D.

ANALYTICAL METHODS FOR THE DETERMINATION OF CANNABINOIDS IN BIOLOGICAL MATERIALS-----107
M.E. Wall, Ph.D., T.M. Harvey, Ph.D., J.T. Bursey, Ph.D., D.R. Brine, B.S., and D. Rosenthal, Ph.D.

LIST OF CONTRIBUTORS-----118

LIST OF MONOGRAPHS-----120




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