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Mechanisms of Tolerance and Dependence



NIDA Research Monograph, Number 54 [Printed in 1984]

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Table of Contents

Preface-----ix

In Memoriam: H. 0. J. Collier-----1
Sydney Archer

Mechanisms of Tolerance and Dependence: An Overview-----4
Leo G. Abood

Phenomenology and Theoretical Basis of Tolerance and Dependence-----12
William R. Martin

Contributions of Neuropharmacology to Understanding Mechanisms of Tolerance and Dependence-----27
Martin W. Adler and Ellen B. Geller

Various Factors Which Affect the Rate of Development of Tolerance and Physical Dependence to Abused Drugs-----39
William L. Dewey

Genetic Determinants of Responses to Drugs of Abuse: An Evaluation of Research Strategies-----50
Louis Shuster

Opioid Tolerance and Dependence in Light of the Multiplicity of Opioid Receptors-----70
Rudiger Schulz and Albert Herz

Sites and Mechanisms of Dependence in the Myenteric Plexus of Guinea Pig Ileum-----81
H. 0. J. Collier and J. F. Tucker

Biochemical Reactions Between Opiate Receptor Binding and Inhibition of Neurotransmission-----95
Doris H. Clouet and Norifumi Yonehara

The Role of Adenyl Cyclase in Opiate Tolerance and Dependence-----109
Werner A. Klee, Graeme Milligan, William S. Simonds, and Bruno Tocque

Mechanisms of Multiple Cellular Adaptation Processes in Clonal Cell Lines During Chronic Opiate Treatment-----119
Ping-Yee Law, Michael T. Griffin, and Horace H. Loh

The Opioid-Induced Desensitization (Tolerance) in Neuroblastoma X Glioma NG 108-15 Hybrid Cells: Results from Receptor Uncoupling-----136
Michael Wuster and Tomnaso Costa

Opiate Receptor Upregulation and Functional Supersensitivity-----146
R. Suzanne Zukin, Ann Tempel, and Eliot L. Gardner

The Role of Dynorphin in Narcotic Tolerance Mechanisms-----162
Nancy M. Lee

Post-Translational Processing of Neuropeptide Precursors-----168
Richard E. Mains and Betty A. Eipper

Opiate-Mediated Control of Luteinizing Hormone in the Male; Role in the Development of Narcotic Tolerance and Physical Dependence-----184
Theodore J. Cicero

Modulation of Opioid Physical Dependence During the Hibernation Cycle-----209
Alexander L. Beckman, Carmen Llados-Eckman, Steven K. Salzman, and Toni L. Stanton

Neurophysiological Investigations of Opiate Tolerance and Dependence in the Central Nervous System-----239
Steven Jon Henriksen

Spinal Cord Tissue Culture Models for Analyses of Opioid Analgesia, Tolerance and Plasticity-----260
Stanley M. Crain

Experimental Approaches Toward Determining the Neuronal Circuits Most Affected by Chronic Opiate Administration-----293
Robert Elde

Effects of Opiates and Neuropeptides on Immune Functions-----300
Robert E. Faith, N. P. Plotnikoff, and A. J. Murgo

Changes in CNS Sensitivity to Cannabinoids with Repeated Treatment: Tolerance and Auxoesthesia-----312
R. Karler, L. D. Calder, and S. A. Turkanis

Catecholamine-Independent Behavioral and Neurochemical Effects of Cocaine in Rats-----323
Karen Gale

Barbiturate Tolerance and Physical Dependence: Contribution of Pharmacological Factors-----333
Michiko Okamoto

Behavioral and Biochemical Studies in Rats After Chronic Exposure to Nicotine-----348
Leo G. Abood, Susan Grassi, Maria Costanzo, and Jeffrey Junig

Psychobiological Foundations of Behaviors Induced by Amphetamines-----356
Philip M. Groves and David S. Segal

Index-----367

List of NIDA Research Monographs-----371




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