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Membranes and Barriers: Targeted Drug Delivery



NIDA Research Monograph, Number 154 [Printed in 1995]

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Table of Contents

Retrometabolic Approaches to Drug Targeting-----1
Nicholas Bodor

Vector-Mediated Delivery of Opioid Peptides to the Brain-----28
Ulrich Bickel and William M. Pardridge

Conformationally Constrained Peptide Drugs Targeted at the Blood-Brain Barrier-----47
Thomas P. Davis, Thomas J. Abbruscato, Elizabeth Brownson,and Victor J. Hruby

Passive and Facilitative Transport of Nucleobases, Nucleosides, and OligonucleotidesóApplication to Antiviral and Other Therapies-----61
Marcus E. Brewster and Nicholas Bodor

Oral Peptide Delivery: Improving the Systemic Availability of Small Peptides and Enkephalin Analogs-----86
Hye J. Lee and Gordon L. Amidon

The Use of Polymers in the Construction of Controlled-Release Devices-----107
Jorge Heller

Pharmacokinetics and Pharmacodynamics of Maternal-Fetal Transport of Drugs of Abuse: A Critical Review-----132
Srikumaran Melethil

Placental Permeability for Drugs of Abuse and Their Metabolites-----152
George D. Olsen

Pharmacodynamics in the Maternal-Fetal-Placental Unit-----163
Abraham M. Rudolph

New Approaches for Drug and Kinetic Analysis in the Maternal-Fetal Unit-----175
George R. Tonn, Ahmad Doroudian, John G. Gordon,Dan W. Rurak, K. Wayne Riggs, Frank S. Abbott, and James E. Axelson

Maternal-Fetal Pharmacokinetics: Summary and Future Directions-----203
Hazel H. Szeto

Technical Issues Concerning Hair Analysis for Drugs of Abuse-----218
Martha R. Harkey

Models for Studying the Cellular Processes and Barriers to the Incorporation of Drugs Into Hair-----235
Douglas E. Rollins, Diana G. Wilkins, and Gerald Krueger




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