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Neurobiological Models for Evaluating Mechanisms Underlying Cocaine Addiction

NIDA Research Monograph, Number 145 [Printed in 1994]

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Table of Contents

Role for the Mesocortical Dopamine System in the Motivating Effects of Cocaine-----1
George F. Koob, Barak Caine, Athina Markou, Luigi Pulvirenti, and Freidbert Weiss

Dopamine, a Common Substrate for the Rewarding Effects of Brain Stimulation Reward, Cocaine, and Morphine-----19
Conan Kornetsky and Christine Duvauchelle

Neurobehavioral Pharmacology of Cocaine: Role for Serotonin in Its Locomotor and Discriminative Stimulus Effects-----40
Kathryn A. Cunningham and Patrick M. Callahan

A Review of the Effects of Dopaminergic Agents in Humans: Implications for Medication Development-----67
Richard B. Rothman

Use of Rodent Self-Administration Models to Develop Pharmacotherapies for Cocaine Abuse-----88
Steven I. Dworkin and Raymond C. Pitts

Pharmacological and Behavioral Treatment of Cocaine Addiction: Animal Models-----113
Marilyn E. Carroll

Preclinical Assessment of Cocaine Antagonist Drugs in Squirrel Monkeys-----131
Jack Bergman

Cocaine Self-Administration Research: Treatment Implications-----139
Richard W. Foltin and Marian W. Fischman

Neurobiological Mechanisms Underlying the Acquisition and Expression of Incentive Motivation by Cocaine-Associated Stimuli: Relationship to Craving-----163
Agu Pert

Cocaine Reward and Cocaine Craving: The Role of Dopamine in Perspective-----191
Roy A. Wise

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