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Imaging Techniques in Medications Development: Preclinical and Clinical Aspects

NIDA Research Monograph, Number 138 [Printed in 1994]

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Table of Contents

PET, SPECT, and Probes in Drug Design and Development-----1
Henry N. Wagner, Jr.

Positron Emission Tomography in Studies of Drug Abuse-----15
Edythe D. London

Imaging Brain Function in Animals To Understand Drugs of Abuse and Potential Pharmacotherapies-----25
M.F. Piercey

Brain-Imaging Studies of the Combined Use of Cocaine and Alcohol and of the Pharmacokinetics of Cocaethylene-----41
Nora D. Volkow and Joanna S. Fowler

Positron Emission Tomography of Cocaine Binding Sites on the Dopamine Transporter-----57
Bertha K. Madras, David R. Elmaleh, Peter C. Meltzer, Anna Y. Liang, Gordon L. Brownell, and Anna-Liisa Brownell

Metabolic Mapping Methods for the Identification of the Neural Substrates of the Effects of Novel Tropane Analogs-----71
Linda J. Porrinno, Lisa Williams-Hemby, and Huw M.L. Davies

Noninvasive Evaluation of the Sympathetic Nervous System of the Heart by Nuclear Imaging Procedures-----85
Markus Schwaiger, James C. Sisson, and Donald Wieland

Development of PET/SPECT Ligands for the Serotonin Transporter-----111
Ursula Scheffel, Robert F. Dannals, Makiko Suehiro, George A. Ricaurte, F. Ivy Carroll, Michael J. Kuhar, and Henry N. Wagner, Jr.

SPECT Imaging of Dopamine and Serotonin Transporters in Nonhuman Primate Brain-----131
Marc Laruelle, Ronald M. Baldwin, and Robert B. Innis

Cerebra Blood Flow Changes With Acute Cocaine Intoxication: Clinical Correlations With SPECT, CT, and MRI-----161
I. Mena, R.J. Giornbetti, B.L. Miller, K. Garrett, J. Villanueva-Meyer, C. Mody, and M.A. Goldberg

An Introduction to Magnetic Resonance Methods for Clinical Research-----175
Gerald G. Blackwell

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