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Molecular Approaches to Drug Abuse Research Volume I: Receptor Cloning, Neurotransmitter Expression, and Molecular Genetics



NIDA Research Monograph, Number 111 [Printed in 1991]

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Table of Contents

Introduction-----1
Theresa N.H. Lee

Brain Nicotinic Receptor Genes-----3
Stephen F. Heinemann, Jim Boulter, John Connolly, Evan Deneris, Robert Duvoisin, Melissa Hartley, Irm Hermans-Borgmeyer, Michael Hollmann, Anne O'Shea-Greenfield, Roger Papke, Scott Rogers, and Jim Patrick

Regulation of Acetylcholine Receptor Gene Expression-----24
Alex M. Simon, Emma K. Dutton, and Steven J. Burden

Mutations Affecting Local Anesthetic Block of the Nicotinic Acetylcholine Receptor Ion Channel-----28
Reid J. Leonard, Pierre Charnet, Cesar Labarca, Nancy J. Vogelaar, Linda Czyzyk, Annie Gouin, Norman Davidson, and Henry A. Lester

Molecular Biology of the Dopamine D2 Receptor-----45
Olivier Civelli, James Bunzow, Paul Albert, Hubert Van Tol, and David Grandy

Characterization of Mammalian Potassium Channel Genes-----54
James O. Douglass, Macdonald Christie, John P. Adelman, and R. Alan North

Problems and Approaches in Studylng Membrane Opioid Receptors-----69
Andrew P. Smith and Horace H. Loh

An Approach to the Molecular Biology of Opiate Tolerance: Identification of Opiate-Regulated Transcripts-----85
Mark vonZastrow, Jack D. Barchas, and James H. Eberwine

Prenatal Expression of Pro-Opiomelanocortin mRNA, POW-Derived Peptides, and -Opiate Receptors in the Mouse Embryo-----96
Y. Peng Loh, R. Adrian Rius, Stela Elkabes, Wojciech Bern, and Carmine J. Coscia

Regulation of Endorphin Biosynthesis in the Brain: Different Effects of Morphine Pelleting and Repeated Stress-----113
David M. Bronstein, Jeffrey E. Kelsey, and Huda Akil

Transcriptional Regulation of the Rat Prodynorphin Gene-----133
James O. Douglass, Michael J. ladarola, Jau-Shyong Hong, James E. Garrett, and Cynthia T. McMurray

Mechanisms Underlying Synaptic Regulation of Proenkephalin Transcription-----149
Michael Comb, Steven E. Hyman, Linda Kobierski, Hung Ming Chu, and Tuong Van Nguyen

Regulation of Carboxypeptidase E (Enkephalin Convertase)-----171
Lloyd D. Fricker, Banasree Das, Robyn S. Klein, David Greene, and Yong-Keun Jung

Use of Site-Directed Mutagenesis To Elucidate the Active Site of Neutral Endopeptidase 24.11 (Enkephalinase)-----188
Louis B. Hersh

Human Cytochrome P450: Possible Roles of Drug-Metabolizing Enzymes and Polymorphic Drug Oxidation in Addiction-----202
Frank J. Gonzalez

List of NIDA Research Monographs-----214




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