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Etiology of Cardiovascular Complications in HIV Infection
Endothelial Dysfunction in HIV Infection
Cardiovascular Complications from Cocaine Abuse in HIV Infection
Genesis of Cardiomyopathy with HIV Infection and Alcohol Abuse

May 2-3, 2002


[Meeting Summary], [Recommendations], [Roster]

Agenda

Thursday, May 2, 2002

8:00 a.m. Registration and Poster Setup
8:30 a.m. Welcome and Introduction
Lan-Hsiang Wang, NHLBI
Jag Khalsa, NIDA
Sandra Colombini Hatch, NHLBI
8:40 a.m. Lance Terada (1)
University of Texas Southwestern
Effect of HIV Tat on Endothelial Cell Function
9:00 a.m. Mitchell Finkel (16)
West Virginia University
P38 MAP Kinase Regulates Negative Inotropic Effect of HIV gp120 on Cardiac Myocytes through Troponin I Phosphorylation
9:20 a.m. Jian-Feng Wang (3)
Beth Israel Deaconess Medical Center
Functional Studies of HIV-Tat Effects on Endothelium
9:40 a.m. Winnie Henderson (4)
Oregon Health Sciences University
HIV-1 vpu and tat Modulate Endothelial Cell-B Lymphoma Cell Interactions:
Implications for AIDS-Associated Non-Hodgkin's Lymphoma
10:00 a.m. Break
10:20 a.m. John Ho (5)
Cornell University
HIV-1 Activates Innate Immune Cells via Toll-Like Receptor 2
10:40 a.m. Emily D. Overholser (6)
Johns Hopkins University
Mechanisms of Endothelial Cell Dysfunction in SIV Infection
11:00 a.m. Lingjun Zhao (7)
Saint Louis University Medical Center
Regulation of Myosin Light Chain Phosphorylation by HIV-1 Vpr
11:20 a.m. Changyi Chen (8)
Baylor College of Medicine
HIV-1 gp120 Down-Regulates Endothelial Nitric Oxide Synthase (eNOS) Expression in Human Endothelial Cells
11:40 a.m. Kwang Sik Kim (9)
Johns Hopkins University
Gp120 Induces Cytotoxicity of Human Brain Microvascular Endothelial Cells
12:00 p.m. Lunch
1:00 p.m. Poster Session (Atrium)
Posters will be displayed from 8:30 a.m. until 5 p.m.
Poster presenters with odd numbers will be present from 1 p.m. to 1:50 p.m.
Poster presenters with even numbers will be present from 1:50 p.m. to 2:40 p.m.

Harris McFerrin (2)--poster presentation only
Tulane University
Molecular Mechanism of Tat-Induced Angiogenesis
2:40 p.m. Break
3:00 p.m. Douglas Larson (10)
University of Arizona
Dilated Cardiomyopathy in Murine Acquired Immunodeficiency Syndrome (MAIDS)
3:20 p.m. Ronald Watson (11)
University of Arizona
Selenium Supplementation Decreases Coxsackievirus Heart Disease During Murine AIDS
3:40 p.m. J. Bruce Sundstrom (12)
Emory University
An in vitro Model for Investigating the Role of Mast Cells in Mechanisms of Increased Fibrosis Associated with AIDS-Related Cardiomyopathies
4:00 p.m. Debasis Mondal (13)
Tulane University
Synergistic Effects of Cocaine and the Inflammatory Cytokines in Modulating Vascular Endothelial Cell Function
4:20 p.m. Guha Krishnaswamy (14)
East Tennessee State University
Role of the Inflammatory Network in Cocaine and HIV-Mediated Atherogenesis
4:40 p.m. Shenghan Lai (17)
Johns Hopkins University
Association of Cocaine Use With Coronary Calcification in Injecting Drug Users in Baltimore
5:00 p.m. Recommendations for Future Directions Ronald Watson
5:20 p.m. Conclusion of Today's Program
5:20 - 5:40 p.m. Remove posters from poster boards

Friday, May 3, 2002

8:30 a.m. Milan Fiala (15)
University of California Los Angeles
(A) Human Immunodeficiency Virus Type 1 Enters Brain and Coronary Endothelia by Macropinocytosis Dependent upon Lipid Rafts.
(B) Cocaine Binds to a G-Protein Coupled Receptor, Signals and Restructures Coronary Artery Endothelial Cells.
8:50 a.m. John Bauer (18)
Ohio State University
Cocaine Induced Cardiotoxicity in Mice
9:10 a.m. Roy Sutliff (19)
Emory University
Cocaine Administration Increases LV Mass in HIV-1 Transgenic Mice
9:30 a.m. Sonia Flores (20)
University of Colorado
Evidence of Inflammation in Tat-Transgenic Mice
9:50 a.m. John Bauer (21)
Ohio State University
Mechanistic Studies of Retrovirus Related Cardiac Dysfunction: the Murine AIDS Model and Human HIV Infection
10:10 a.m. Douglas Wallace (22)
Emory University
Ethanol and AIDS Cardiomyopathy: A Mitochondrial Connection?
10:30 a.m. Break
10:50 a.m. Paul Jolicoeur (23)
Clinical Research Institute of Montreal
Studies of Cardiac Disease in HIV-1 Transgenic Mice
11:10 a.m. William Lewis (24)
Emory University
Combined Antiretroviral Therapy Causes Cardiomyopathy and Elevates Plasma Lactate in Transgenic AIDS Mice
11:30 a.m. Richard Shannon (25)
New England Regional Primate Research Center
Cellular Pathways Involved in Myocardial Injury in Simian AIDS: Role of Cytokines, Inducible Nitric Oxide, and CD95
11:50 a.m. Milan Fiala (26)
University of California Los Angeles
HIV-1 Envelope Protein gp120 Induces Cardiomyocyte Apoptosis and Is Associated with HIV-1 Cardiomyopathy
12:10 a.m. Neil Bowles (27)
Baylor College of Medicine
The Pathogenesis of Heart Disease in HIV-Infected Children
12:30 p.m. Closing Remarks
12:40 p.m. Adjournment Of Meeting



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