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Signal Integration in the Brain

Paul Greengard, Ph.D.

Signal Integration in the Brain SUMMARY: Dr. Paul Greengard stated that a major step forward in his teamís attempts to discern how dopamine achieves its affects was the discovery of the molecule dopamine and cAMP-regulated phospho-protein, MW=32kDa (DARPP-32). The researchers discovered that DARPP-32 is involved in mediating the actions of virtually all neurotransmitters in all parts of the brain. According to Dr. Greengard, virtually every known drug of abuse works through DARPP-32. Greengard offered as evidence that fact that, in his teamís research, mice from which the researchers removed DARPP-32 no longer responded to drugs of abuse. Substances they studied included opiates, cocaine, and amphetamines. The same response was observed when antipsychotic medications were tested.





Integrating the Science of Addiction Into Psychiatric Practice



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