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Glutamate Cascade Research

The Glutamate Cascade: Common Pathways of Central Nervous System Disease States

Program List


Click on title to go to corresponding abstract.


Sunday, May 3, 1998 - Arrival of Participants
5:00 p.m. - 7:00 p.m.Reception and Posters
Visitors Center Level and Nobel Laureate Level
Building 10
Monday, May 4, 1998
8:00 a.m. - 9:00 a.m.Registration
9:00 a.m. - 9:25 a.m.Introduction for NINDSAudrey Penn, M.D.
Acting Director, NINDS, NIH
Introduction for NIAAAEnoch Gordis, M.D.
Director, NIAAA, NIH
9:25 a.m. - 9:35 a.m."Pooling Medications Development Initiatives on Glutamate and CNS Disorders Across Intramural and Extramural NIH Worlds"Barbara H. Herman, Ph.D.
Chair, Glutamate Cascade Meeting
NIDA, NIH
May 4th Morning Session Presentations
Receptors/Stroke/Epilepsy

Philip H. Sheridan, M.D., Chair
NINDS, NIH
9:35 a.m. - 10:15 a.m.Glutamate Receptors
"Overview of Glutamate Receptors" and "Kainate Receptor Deficient Mice"
Stephen F. Heinemann, Ph.D.
The Salk Institute
10:15 a.m. - 10:55 a.m."Manipulating Glutamatergic Neurotransmission as a Strategy for Drug Development" and "Glutamate and the Ischemic Brain"Dennis W. Choi, M.D., Ph.D.
Washington University
School of Medicine
10:55 a.m. - 11:15 a.m.Break
11:15 a.m. - 11:45 a.m."Glutamate Neurotransmission in Epilepsy: New Treatment Strategies"Michael A. Rogawski, M.D., Ph.D.
NINDS, NIH
11:45 a.m. - 11:55 a.m.Questions and Answers for Morning PresentationSpeaker Panel
11:55 a.m. - 12:00 p.m.Medications Summary from the MorningPhilip H. Sheridan, M.D.
Chair
12:00 p.m. - 1:30 p.m.Lunch
12:00 p.m. - 1:30 p.m.Author-Attended Poster Presentations (GI-A and GI-B)
May 4th Afternoon Session Presentations
Opiate/Cocaine/Amphetamine/Alcohol

Barbara H. Herman, Ph.D., Chair
NIDA, NIH
1:30 p.m. - 2:00 p.m."NMDA Receptors/Nitric Oxide Synthase Cascade in Pain and Opiate Tolerance"Gavril Pasternak, M.D., Ph.D.
Memorial Sloan-Kettering Cancer Center
2:00 p.m. - 2:30 p.m."NMDA Antagonists Modify Opiate Drug-Seeking: Preclinical and Preliminary Clinical Findings"Piotr Popik, M.D., Ph.D.
Polish Academy of Sciences
2:30 p.m. - 3:00 p.m."Glutamate During the Natural History of Psychostimulant Dependence: Synaptic Plasticity and Medications Development"Luigi Pulvirenti, M.D.
University of Rome - Tor Vergata
3:00 p.m. - 3:30 p.m.Break
3:30 p.m. - 4:00 p.m."Glutamate-Mediated Neuroplasticity: Role in Amphetamine Addiction"Marina E. Wolf, Ph.D.
The Chicago Medical School
4:00 p.m. - 4:30 p.m."Alcohol and NMDA Receptor Function"Paula L. Hoffman, Ph.D.
University of Colorado
Health Sciences Center
4:30 p.m. - 5:00 p.m."Acamprosate, A Novel Anti-Craving Compound Acts via Glutamatergic Pathways"Walter Zieglgänsberger, M.D., Ph.D.
Max Planck - Institute of Psychiatry
5:00 p.m. - 5:10 p.m.Questions and Answers for Afternoon PresentationSpeaker Panel
5:10 p.m. - 5:15 p.m.Medications Summary from the AfternoonBarbara H. Herman, Ph.D.
Chair
Tuesday, May 5, 1998
May 5th Morning Session Presentations
Neurodegenerative Disorders and Brain Injury

Bradley Wise, Ph.D., Chair
NIA, NIH
9:00 a.m. - 9:30 a.m."Glutamate Receptor Plasticity in the Hippocampus: Implications for Aging"John H. Morrison, Ph.D.
Mount Sinai School of Medicine
9:30 a.m. - 10:00 a.m."Excitotoxic Apoptoses and Necrosis in AIDS Dementia and Stroke: Potential Treatment with NMDA Open-Channel Blockers and Nitric Oxide-Related Species"Stuart A. Lipton, M.D., Ph.D.
Brigham and Women's Hospital
Harvard Medical School
10:00 a.m. - 10:30 a.m."Glutamatergic Mechanisms in the Cause and Treatment of Parkinson's Disease"J. Timothy Greenamyre, M.D., Ph.D.
Emory University
10:30 a.m. - 11:00 a.m.Break
11:00 a.m. - 11:30 a.m."Glutamatergic Mechanisms in the Pathophysiology and Treatment of Traumatic Brain Injury"Tracy K. McIntosh, Ph.D.
University of Pennsylvania
11:30 a.m. - 12:00 p.m."Role of Glutamate Receptor Maturation in Perinatal Brain Injury"Frances E. Jensen, M.D.
Children's Hospital (Boston)
and Harvard Medical School
12:00 p.m. - 12:10 p.m.Questions and Answers for Morning PresentationSpeaker Panel
12:10 p.m. - 12:15 p.m.Medications Summary from the MorningBradley Wise, Ph.D.
Chair
12:15 p.m. - 1:45 p.m.Lunch
12:15 p.m. - 1:45 p.m.Author-Attended Poster Presentations (GII-A and GII-B)
May 5th Afternoon Session Presentations
Psychiatric Disorders/Affective States/Pain

Linda Brady, Ph.D., Chair
NIMH, NIH
1:45 p.m. - 2:15 p.m."Schizophrenia: A Glutamatergic Perspective"Stephen R. Zukin, M.D.
NIDA, NIH
2:15 p.m. - 2:45 p.m."Development of Novel Anxiolytics and Antidepressants via Modulation of Glutamatergic Pathways"Phil Skolnick, Ph.D.
Lilly Research Laboratories
2:45 p.m. - 3:15 p.m.Break
3:15 p.m. - 3:45 p.m."The Role of Glutamate in Chronic Inflammatory Pain and Painful Peripheral Neuropathies"Gary J. Bennett, Ph.D.
Allegheny University of the Health Sciences
3:45 p.m. - 4:15 p.m."Clinical Studies of NMDA and AMPA/Kainate Receptor Blockers in Acute and Chronic Pain"Mitchell B. Max, M.D.
NIDR, NIH
4:15 p.m. - 4:25 p.m.Questions and Answers for Afternoon PresentationSpeaker Panel
4:25 p.m. - 4:30 p.m.Medications Summary from the AfternoonLinda Brady, Ph.D.
Chair
4:30 p.m. - 4:45 p.m.Conclusions and New DirectionsBarry J. Hoffer, M.D., Ph.D.
NIDA, NIH
4:45 p.m.Adjournment

[Index][List of Speakers][List of Abstracts][List of Posters]

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