To explore the evidence that the "glutamate cascade" appears to be associated with several seemingly diverse disease processes of the CNS. The related excitotoxic cascade has been demonstrated in some of these processes. The hope is to stimulate a cross-fertilization of ideas in basic brain mechanisms and preclinical and clinical medications development of direct or indirect glutamatergic antagonists in diverse medical disciplines which focus on these disorders.
Disorders in which a role for glutamate have been demonstrated include: addiction (tolerance, sensitization, dependence, and/or neurotoxicity that is associated with drugs of abuse including opiates, cocaine, amphetamine, alcohol); stroke; epilepsy; brain trauma; certain types of neuropathic pain; AIDS dementia; schizophrenia; depression; anxiety; and aging/Alzheimer's. A role of NMDA receptor complex and NO has also been implicated in LTP and in other models for learning and memory.
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