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The 2000 Grantees Meeting For the HIV RFA Programs on

Etiology of Cardiovascular Complications of HIV Infection
Endothelial Dysfunction in HIV Infection
Cardiovascular Complications from Cocaine Abuse in HIV Infection
Genesis of Cardiomyopathy with HIV Infection and Alcohol Abuse

September 18-19, 2000
Holiday Inn Bethesda
8120 Wisconsin Avenue
Bethesda, MD

Sponsored by
National Heart, Lung, and Blood Institute
National Institute on Drug Abuse
National Institutes of Health


Agenda

Monday, September 18, 2000

8:00 a.m. - 8:30 a.m. Registration
8:30 a.m. - 8:45 a.m. Welcome and Introduction
Lan-Hsiang Wang, NHLBI
Jag H. Khalsa, NIDA
Hannah H. Peavy, NHLBI
Sandra Colombini Hatch, NHLBI

I. Etiology of Cardiovascular Complications in HIV Infection/Genesis of Cardiomyopathy With HIV Infection and Alcohol Abuse-Section A
Moderator: Paul Jolicoeur, Clinical Research Institute of Montreal

8:45 a.m. - 9:10 a.m. Cardiac Disease in Transgenic Mice Expressing Only HIV-1 Nef
Paul Jolicoeur, Clinical Research Institute of Montreal Monday, September 18, 2000 - continued
9:10 a.m. - 9:35 a.m. Localization of SIV and Mechanisms of Cellular Injury in the Myocardium of Nonhuman Primates With Simian AIDS
Richard P. Shannon, New England Regional Primate Research Center, Harvard Medical School
9:35 a.m. - 10:00 a.m. Cause of Cardiovascular Complications in HIV Infection
Neil E. Bowles (Jeffrey A. Towbin), Section of Cardiology, Department of Pediatrics, Baylor College of Medicine
10:00 a.m. - 10:20 a.m. Break
10:20 a.m. - 10:45 a.m. LPS Immunostimulation Enhances Retrovirus-Related Cardiac Dysfunction During Murine AIDS
John A. Bauer, Division of Pharmacology, College of Pharmacy, and OSU Heart and Lung Research Institute, Ohio State University
10:45 a.m. - 11:10 a.m. Mechanisms of HIV-1 Tat-Mediated Myocarditis
Adela Cota-Gomez (Sonia C. Flores), Webb-Waring Institute for Cancer, Aging, and Antioxidant Research, University of Colorado Health Sciences Center

I. Etiology of Cardiovascular Complications in HIV Infection: Genesis of Cardiomyopathy With HIV Infection and Alcohol Abuse - Section B
Moderator: William Lewis, Department of Pathology, Emory University School of Medicine

11:10 a.m. - 11:35 a.m. HIV-1 Tat Transgenically Targeted to Ventricular Cardiac Myocytes Alters Mitochondrial Structure
William Lewis, Department of Pathology, Emory University School of Medicine
11:35 a.m. - 12:00 noon Cardiac Dysfunction in Murine Acquired Immunodeficiency Syndrome
Douglas F. Larson (Ronald R. Watson), Sarver Heart Center, University of Arizona Health Sciences Center
12:00 noon - 1:00 p.m. Lunch
1:00 p.m. - 1:25 p.m. During Murine AIDS, Ethanol Consumption Accentuates Heart Pathology due to Coxsackievirus
Ronald R. Watson, College of Public Health, University of Arizona School of Medicine
1:25 p.m. - 1:50 p.m. Ethanol and AIDS Cardiomyopathy-A Mitochondrial Connection?
Douglas C. Wallace, Center for Molecular Medicine, Emory University School of Medicine
1:50 p.m. - 2:05 p.m. Open Discussion

II. Cardiovascular Complications From Cocaine Abuse in HIV Infection - Section A
Moderator: Aftab A. Ansari, Departments of Pathology and Laboratory Medicine, Emory University School of Medicine

2:05 p.m. - 2:30 p.m. The Effects of Cocaine, Catecholamines, and HIV Infection on Leukocyte-Endothelial Cell Interactions and Cardiovascular Disease
Aftab A. Ansari, Departments of Pathology and Laboratory Medicine, Emory University School of Medicine
2:30 p.m. - 2:55 p.m. Induction of Atherogenesis by Cocaine and HIV Infection
Guha Krishnaswamy, Department of Internal Medicine, East Tennessee State University, and James H. Quillen Veterans Affairs Medical Center
2:55 p.m. - 3:15 p.m. Break
3:15 p.m. - 3:40 p.m. Cocaine-Induced Cardiac and Vascular Toxicity: Involvement of Oxidative Stress
John A. Bauer, College of Pharmacy and OSU Heart and Lung Research Institute, Ohio State University
3:40 p.m. - 4:05 p.m. Cocaine Treatment in AIDS Transgenic Mice Increases the Risk of Sudden Death and Is Associated With Histochemical Evidence of Cardiac Remodeling
William Lewis, Department of Pathology, Emory University School of Medicine
4:05 p.m. - 4:30 p.m. In Vitro Studies of the Effects of Cocaine on HERG-Encoded K Channel in HEK293 Cells and on Molecular Parameters Affecting Growth, Migration, and Adhesive Properties of Vascular Endothelial Cells and Vascular Smooth Muscle Cells
Krishna C. Agrawal, Department of Pharmacology, Tulane University School of Medicine
4:30 p.m. - 4:45 p.m. Open Discussion
4:45 p.m. Conclusion of Today's Program

Tuesday, September 19, 2000

8:00 a.m. - 8:30 a.m. Registration
II. Cardiovascular Complications From Cocaine Abuse in HIV Infection - Section B
Moderator: James P. Morgan, Harvard Medical School and Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center
8:30 a.m. - 8:55 a.m. Cocaine Enhances the Susceptibility of Mice to Viral Myocarditis
James P. Morgan, Harvard Medical School and Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center
8:55 a.m. - 9:20 a.m. Subclinical Atherosclerosis in HIV-Positive Black Cocaine Users
Joao Lima (Shenghan Lai), Cardiology Division, Department of Medicine, Johns Hopkins University School of Medicine
9:20 a.m. - 9:45 a.m. HIV and Cocaine Use: Cardiovascular Effects and Therapy
Henry M. Rinder (Arthur Margolin), Department of Laboratory Medicine, Yale University School of Medicine
9:45 a.m. - 10:10 a.m. Cocaine's Effects on Coronary Artery Endothelial Permeability and HIV-1 Invasion
Milan Fiala, Reed Neurology Research Center, University of California Los Angeles School of Medicine
10:10 a.m. - 10:25 a.m. Open Discussion
10:25 a.m. - 10:45 a.m. Break

III. Endothelial Dysfunction in HIV Infection - Section A
Moderator: Janice E. Clements, Division of Comparative Medicine, Johns Hopkins University

10:45 a.m. - 11:10 a.m. Mechanisms of Endothelial Dysfunction in SIV Infection
Janice E. Clements, Division of Comparative Medicine, Johns Hopkins University
11:10 a.m. - 11:35 a.m. The Effect of HIV-1 Gene Expression on Endothelial Cell-B Lymphoma Cell Interactions: Implications for AIDS-Related Non-Hodgkin's Lymphoma
Winnie W. Henderson (Ashlee Moses), Department of Molecular Microbiology and Immunology, Oregon Health Sciences University
11:35 a.m. - 12:00 noon Biochemical Characterization of the Vpr-Interacting Kinase
Ling-Jun Zhao, Institute for Molecular Virology, Saint Louis University Medical Center
12:00 noon - 1:00 p.m. Lunch
1:00 p.m. - 1:25 p.m. Molecular Mechanism of Tat-Induced Angiogenesis
Cindy A. Morris, Department of Clinical Laboratory Sciences, Health Sciences Center, Louisiana State University Medical Center
1:25 p.m. - 1:50 p.m. Effect of HIV Tat on Endothelial Cell Function
Lance S. Terada, University of Texas Southwestern and Dallas Veterans Affairs Medical Center

III. Endothelial Dysfunction in HIV Infection - Section B
Moderator: Jerome E. Groopman, Harvard Medical School and Division of Experimental Medicine, Beth Israel Deaconess Medical Center

1:50 p.m. - 2:15 p.m. Functional Studies of HIV-Tat Effects on Endothelium
Jerome E. Groopman, Harvard Medical School and Division of Experimental Medicine, Beth Israel Deaconess Medical Center
2:15 p.m. - 2:40 p.m. Effects of HIV/SIV Envelope Glycoproteins on Endothelial Cell Functions
Changyi J. Chen, Department of Surgery, Emory University School of Medicine
2:40 p.m. - 3:00 p.m. Break
3:00 p.m. - 3:25 p.m. Molecular Mechanisms of Endothelial Dysfunction
John L. Ho, Weill Medical College, Cornell University, and Aaron Diamond AIDS Research Center
3:25 p.m. - 3:50 p.m. Open Discussion
3:50 p.m. - 5:00 p.m. Recommendations for Future Research
Lan-Hsiang Wang, NHLBI
Jag H. Khalsa, NIDA
Hannah H. Peavy, NHLBI
Sandra Colombini Hatch, NHLBI
John A. Bauer, Ohio State University
5:00 p.m. Conclusion

 

Meeting Summary

Roster



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