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Cocaine and the Changing Brain

CART: A Novel Addiction Peptide


Michael J. Kuhar, Ph.D.
Emory University
Atlanta, GA

CART (cocaine- and amphetamine-regulated transcription factors) peptides are novel putative neurotransmitters/cotransmitters. They have psychostimulant-like effects in that they alter locomotor activity and feeding behaviors. CART peptides are localized to regions in the brain that are associated with these behaviors, as well as other regions suggesting involvement in a variety of physiologic functions.


Acknowledgment

This research was supported by National Institute on Drug Abuse Grant No. DA-10732.


Selected References

Couceyro, P.R.; Koylu, E.O.; and Kuhar, M.J. Further studies on the anatomical distribution of CART by in situ hybridization. J Chem Neuroanat 12:229-241, 1997.

Douglass, J.; McKinzie, A.A.; and Couceyro, P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J Neurosci 15:2471-2481, 1995.

Koylu, E.O.; Couceyro, P.R.; Lambert, P.D.; Ling, N.C.; DeSouza, E.B.; and Kuhar, M.J. Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland. J Neuroendocrinol 9:823- 833, 1997.

Lambert, P.D.; Couceyro, P.R.; Koylu, E.O.; Ling, N.C.; DeSouza, E.B.; and Kuhar, M.J. CART peptides have a physiological role in the central control of food intake (Abstract). Abstracts of the 27th Annual Meeting of the Society for Neuroscience, New Orleans, LA, Oct 25-30, 1997. p. 966.

Smith, Y.; Koylu, E.O.; Couceyro, P.; and Kuhar, M.J. Ultrastructural localization of CART (cocaine- and amphetamine-regulated transcript) peptides in the nucleus accumbens of monkeys. Synapse 27:90-94, 1997.


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