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Proceedings of a Mini-Symposium:
Substance Abuse and Neuropsychiatric Disorders at The International Workshop on Brain Banking



[Introduction] [Agenda] [Abstracts] [Recommendations] [Roster]

Agenda

Monday, March 11, 2002

7:30 - 8:30 a.m. Registration and Continental Breakfast
8:30 - 9:00 a.m. Welcome and Opening Remarks

Audrey Penn, M.D.
Acting Director
National Institute of Neurological Disorders and Stroke

Glen Hanson, D.D.S., Ph.D.
Acting Director
National Institute on Drug Abuse
9:00 - 10:15 a.m. Plenary Session: Brain Banking in the United States

Session Chair:

Piotr B. Kozlowski, M.D., Ph.D.
New York State Institute for Basic Research in Developmental Disabilities

Speakers:

Piotr B. Kozlowski, M.D., Ph.D.
New York State Institute for Basic Research in Developmental Disabilities
Brain Banking in the United States

Edward G. Stopa, M.D.
Brown University
Control Brain Specimens: A Complex Dilemma

Jeffrey Jentzen, M.D.
Milwaukee County Medical Examiners Office
A Medical Examiner's Perspectives on Retaining Tissues and Organs
10:15 - 10:30 a.m. BREAK
10:30 - 12 noon Plenary Session: Models of Brain Banking

Session Chairs:

A.P. Kerza-Kwiatecki, Ph.D.
National Institute of Neurological Disorders and Stroke

Carol Petito, M.D.
University of Miami School of Medicine

Speakers:

Carol Petito, M.D.
University of Miami School of Medicine
Tissue Collection for Multiple Users

Christine Hulette, M.D.
Duke University Medical Center
Rapid Brain Autopsy: Fifteen Years Later

Kevin Ryder, Ph.D.
National Disease Research Interchange
An Investigator-Oriented System for Tissue Retrieval and Preservation

Stephen L. Vincent, Ph.D.
Ardais Corporation
Model for a MultiMedical Institution Tissue Banking Network

Francine M. Benes, M.D., Ph.D.
McLean Hospital/Harvard Medical School
Ethical Issues in Brain Banking
12 noon - 1:00 p.m. LUNCH
1:00 - 4:30 p.m. BREAKOUT SESSIONS (Concurrent)

Breakout Session: Central Nervous System Injury and Repair

Stem Cells

Session Chairs:

Arlene Chiu, Ph.D.
National Institute of Neurological Disorders and Stroke

Mahendra Rao, M.D., Ph.D.
National Institute on Aging

Speakers:

Dennis A. Steindler, Ph.D.
McKnight Brain Institute, University of Florida
Harvesting Neural Stem/Progenitor Cells From Human Biopsy and Cadaver Specimens

Steven A. Goldman, M.D., Ph.D.
Cornell University Medical College
Stem Cells From Tissue Obtained From Patients With Epilepsy or Other Disorders

Panel Discussion:

Speakers:

Mahendra Rao, M.D., Ph.D.
National Institute on Aging
Sources of Cells for Research and Therapy

Philip H. Schwartz, Ph.D.
Children's Hospital of Orange County
Postnatal Postmortem Neural Stem Cell Banking

Eugene O. Major, Ph.D.
National Institute of Neurological Disorders and Stroke
Caveats on Disease Transmission

Neuropathology Studies

Session Chairs:

Naomi Kleitman, Ph.D.
National Institute of Neurological Disorders and Stroke

Thomas Gennarelli, M.D.
Medical College of Wisconsin

Speakers:

J. Clay Goodman, M.D.
Baylor College of Medicine
Brain Banking in Human TBI: Unique Problems and Opportunities Compared to Brain Banking for Other Neurological Disorders

Jean R. Wrathall, Ph.D.
Georgetown University Medical Center
Animal Models of Traumatic Spinal Cord Injury

Blair Calancie, Ph.D.
State University of New York
Human SCI: Linking Functional Questions to Pathology

David Hovda, Ph.D.
University of California at Los Angeles

Panel Discussion:

Thomas A. Gennarelli, M.D.
Medical College of Wisconsin

Speakers:

Thomas A. Gennarelli, M.D.
Medical College of Wisconsin
CNS Injury and Repair Breakout: Neuropathology Studies

Jeffrey S. Augenstein, M.D., Ph.D., F.A.C.S.
University of Miami School of Medicine
CIREN Traffic Accident Database: Working With Trauma Units and Medical Examiners

Renee L. Johnson, R.P.T., M.S.P.H.
Centers for Disease Control and Prevention
State TBI and SCI Surveillance Systems and Registry
National Center for Injury Prevention and Control


Kathryn E. Saatman, Ph.D.
University of Pennsylvania
Promoting Neuropathology Collaborations in TBI Research Through Brain Banking

Elling E. Eidbo, M.B.A.
Large Scale Biology Corporation
Understanding Organ Procurement Organizations

Jeffrey Jentzen, M.D.
Milwaukee County Medical Examiner
Regulations Relating to Release of Postmortem Samples


Breakout Session: Neurodevelopmental Brain Banking

Session Chairs:

H. Ronald Zielke, Ph.D.
Brain and Tissue Bank for Developmental Disorders

Giovanna Spinella, M.D.
National Institute of Neurological Disorders and Stroke

Speakers:

Jane Pickett, Ph.D.
Autism Tissue Program
Autism Tissue Program: An Example of an Adjunct Advocacy-Based Brain Acquisition Program Providing Outreach and Research Information With NIH Bank

Ronald Zielke, Ph.D.
Brain and Tissue Bank for Developmental Disorders
Brain and Tissue Banks for Developmental Disorders

Vicky Holets-Whittemore, Ph.D.
Center Without Walls, Tuberous Sclerosis Alliance
Cooperation With Private Foundations

Stewart Stein, M.D.
Eastern Maine Medical Center

Stephen Nelson, M.A., M.D.
Florida Department of Law Enforcement


Breakout Session: Substance Abuse and Neuropsychiatric Disorders

Drug Abuse

Session Chairs:

Jonathan Pollock, Ph.D.
National Institute on Drug Abuse

Joseph Frascella, Ph.D.
National Institute on Drug Abuse

Jagjitsing H. Khalsa, Ph.D.
National Institute on Drug Abuse

Speakers:

Michael J. Bannon, Ph.D.
Wayne State University School of Medicine
Determining the Molecular Consequences of Cocaine Abuse

Walter Royal III, M.D.
Morehouse School of Medicine
The Role of Butyrylcholinesterase in the Pathogenesis of HIV-1 Dementia

Thea Kalebic, M.D., Ph.D.
Cancer Biomarkers Research Group
NCI Tissue Resources and New Challenges

Ian Paul Everall, M.D., Ph.D.
UCLA Neuro-Oncology Program
Neuronal Loss in Intravenous Drug Users

Jeanne E. Bell, M.D.
Western General Hospital
NIH International Workshop on Brain Banking: Challenges and Research Outcomes in Brain Banking at the Drug Abuse/HIV Interface

Deborah C. Mash, Ph.D.
University of Miami School of Medicine
Banking on Brains for Cocaine Abusers

Avindra Nath, M.D.
University of Kentucky Medical Center
Combined Effects of Drug Abuse and HIV Infection on the Brain: Correlation's Between Experimental, Clinical, and Pathological Studies

Linda Chang, M.D.
Brookhaven National Laboratory
Neuroimaging Studies in HIV and Drug Abuse

Donald Kuhn, M.D.
Wayne State University School of Medicine

Karoly Mirnics, M.D.
University of Pittsburgh School of Medicine
Uncovering Transcriptome Differences With DNA Microarrays in Postmortem Tissue: Technical Considerations

Richard Woychik, Ph.D.
Lynx Therapeutics, Inc.
A New Technology for Indepth Gene Expression Profiling

Neuropsychiatric Disorders

Session Chairs:

Jagjitsing H. Khalsa, Ph.D.
National Institute on Drug Abuse

Joel Kleinman
National Institute of Mental Health

Speakers:

Joel Kleinman
National Institute of Mental Health
Molecular Aspects of Schizophrenia

Aleksej Duma, M.D., Ph.D.
Institute for Forensic Medicine
Brain Collection in the Republic of Macedonia

Therese Garrick, R.N.
University of Sydney
Diagnosis and Clinical Assessment Protocols for Brain Banks
4:30 - 5:00 p.m. REPORTS FROM BREAKOUT SESSIONS
5:00 p.m. ADJOURNMENT

 

Tuesday, March 12, 2002

7:30 - 8:30 a.m. Registration and Continental Breakfast
8:30 - 10:15 a.m. Plenary Session: International Collaboration, Networking, and Specimen and Data Exchange

Session Chairs:

Rivka Ravid, Ph.D.
The Netherlands Brain Bank

Andrew J. Dwork, M.D.
New York State Psychiatric Institute

Speakers:

Clive Harper, M.D.
University of Sydney
Brain Banking in Australia and the Pacific Basin

Rivka Ravid, Ph.D.
The Netherlands Brain Bank
Methodological, Ethical, and Legal Issues in European Brain Banking

Andrew Dwork, M.D.
New York State Psychiatric Institute
Archival and Overseas Brain Collection for Psychiatric Research

10:15 - 10:30 a.m. BREAK
10:30 a.m. - 12:30 p.m. Plenary Session: New Developments and Challenges

Session Chairs:

Katrina Gwinn-Hardy, M.D.
National Institute of Neurological Disorders and Stroke

Mark Cookson, M.D.
National Institute on Aging

Speakers:

Ronnie Horner, Ph.D.
National Institute of Neurological Disorders and Stroke Underrepresentation of Minorities in Repositories and Registries

Elling E. Eidbo, M.B.A.
Large Scale Biology Corporation
Understanding Organ Procurement Organizations

Daniel P. Perl, M.D.
Mount Sinai School of Medicine
The Stereologically Friendly Brain Bank and Practical Approaches to Morphometric Studies in the Setting of a Human Brain Bank Repository

Jerzy Wegiel, V.M.D., Ph.D.
New York State Institute for Basic Research in Developmental Disabilities
The New Face of Morphometric Studies

Mark Cookson, Ph.D.
National Institute on Aging
Human Brain Samples as Critical Resources for Genomic and Proteomic Studies

Stephen J. Nelson, M.D.
Florida Department of Law Enforcement
Legal Aspects of Tissue Procurement From Medical-Legal Autopsies: A Developing Worldwide Trend

12:30 - 1:30 p.m. LUNCH (On your own)
1:30 - 4:30 p.m. BREAKOUT SESSIONS (Concurrent)

Breakout Session: Neurodegenerative Disorders, Alzheimer's Disease, Parkinson's Disease, and Other Dementias

Session Chairs:

Diana Murphy, Ph.D.
National Institute of Neurological Disorders and Stroke

Dennis Dickson, M.D.
Mayo Clinic Jacksonville

Speakers:

Dennis W. Dickson, M.D.
Mayo Clinic Jacksonville
Society for Progressive Supranuclear Palsy Brain Bank

Christine Hulette, M.D.
Duke University Medical Center
Rapid Brain Autopsy: Fifteen Years Later

Harry V. Vinters, M.D.
University of California at Los Angeles
Vascular Dementia

Tamas Revesz, M.D.
Institute of Neurology
Brain Banking at the Institute of Neurology, University College London

Andrew Lees, M.D.
Reta Lila Weston Institute of Neurological Studies

Mark Forman, M.D., Ph.D.
University of Pennsylvania

Bradley F. Boeve, M.D.
Mayo Clinic
The Critical Need for Clinicopathologic Analyses in Neurodegenerative Disease


Breakout Session: Neuroinfectious Disorders

Neuro-AIDS and Prion Diseases

Session Chairs:

Benjamin Gelman, M.D.
University of Texas Medical Branch

David Eckstein, Ph.D.
National Institute of Neurological Disorders and Stroke

Speakers:

Benjamin B. Gelman, M.D., Ph.D.
University of Texas Medical Branch
Microscopic Diagnosis of HIV-Related Lesions and the Need for Diagnostic Consensus

Susan Morgello, M.D.
Mount Sinai Medical Center
The National Neuro-AIDS Tissue Consortium as a Model of Brain Banking

Elyse Singer, M.D.
UCLA School of Medicine
Banking of AIDS/HIV Specimens: Working With Minority Communities

Mahendra Kumar, Ph.D.
University of Miami School of Medicine
Neuro-AIDS and Its Progression in India: A Model for an International CNS Tissue Consortium?

Tom Abbott
Saf-T-Pak, Inc.
Shipping of Biohazard Specimens in an Age of Bioterrorism

Pierluigi Gambetti, M.D.
Case Western Reserve University
The National Prion Pathology Surveillance Center and Prion Brain Banking

Pedro Piccardo, M.D.
Indiana University School of Medicine
Prion Diseases and the Organization of a Brain Bank


Breakout Session: Central Nervous System Tumors, Stroke, and Epilepsy

Session Chairs:

Mary Ellen Michel, Ph.D.
National Institute of Neurological Disorders and Stroke

Jean Paul Vonsatel, M.D.
The Taub Institute-Columbia University

Speakers:

Gregory N. Fuller, M.D., Ph.D.
Anderson Medical Center
The "Tissue Expansion" Role of Tissue Microarray Technology in Brain Banking and the Concept of Array Tissue Banking

Jaclyn A. Biegel, Ph.D.
The Children's Hospital of Philadelphia
Brain Tumor Banking - Strategies, Challenges, and Applications

Timothy F. Cloughesy, M.D.
University of California at Los Angeles School of Medicine
Collaborative Web-Based Glioma Informatics

Joseph Broderick, M.D.
University of Cincinnati

Brain Banking for Stroke: Don't Forget the Blood Vessels

Speakers:

Edward Neuwelt, M.D.
Oregon Health Sciences University

Steven M. Greenberg, M.D., Ph.D.
Massachusetts General Hospital
Maximizing the Benefits of a Stroke Bank: The Importance of Clinical and Imaging Data

Jean-Paul Vonsattel, M.D.
The Taub Institute-Columbia University

Epilepsy

Session Chair:

Margaret Jacobs
National Institute of Neurological Disorders and Stroke

Speakers:

Peter B. Crino, M.D., Ph.D.
University of Pennsylvania Medical Center
Molecular Strategies To Study the Pathogenesis of Human Epilepsy

Nihal C. de Lanerolle, D.Phil., D.Sc.
Yale University School of Medicine
Strategies for Neuropathological Studies of Epilepsy on Postmortem Brains
4:30 - 5:00 p.m. Closing Session Session Chair:

Piotr B. Kozlowski, M.D., Ph.D.
New York State Institute for Basic Research in Developmental Disabilities
5:00 p.m. Wrap-Up and Adjournment

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