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Director's Report to the National Advisory Council on Drug Abuse - September, 2009



Program Activities

New NIDA PAs and RFAs

On June 25, 2009, NIDA issued a Program Announcement (PA) entitled Cutting-Edge Basic Research Awards (CEBRA) (R21) (PAR-09-222). The CEBRA is designed to foster highly innovative or conceptually creative research related to drug abuse and addiction and how to prevent and treat them. It supports research that is high-risk and potentially high-impact that is underrepresented or not included in NIDA's current portfolio. The proposed research should: (1) test a highly novel and significant hypothesis for which there is scant precedent or preliminary data and which, if confirmed, would have a substantial impact on current thinking; and/or (2) develop or adapt innovative techniques or methods for addiction research, or that have promising applicability to drug abuse research. This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism with modifications.

On July 22, 2009, NIDA issued a PA entitled HIV/AIDS, Drug Use, and Vulnerable Populations in the US (R21) (PA-09-237). This Funding Opportunity Announcement (FOA) encourages Research Project Grant (R01) applications to identify the role(s) that drug abuse plays in fueling the HIV/AIDS epidemic in vulnerable groups (racial/ethnic minorities, men who have sex with men, youth) in the United States and to develop effective interventions to prevent new infections and to improve the health and well-being of those living with HIV/AIDS. It is essential to understand the factors (biological, behavioral, psychosocial, environmental, institutional, etc.) responsible for the profoundly disproportionate burden of HIV/AIDS among vulnerable groups. This FOA will support studies to: 1) understand the contribution of drug abuse (both injection and non-injection) to the acquisition and/or transmission of HIV; 2) study disease progression and disease outcomes; 3) develop and/or improve prevention and treatment interventions; 4) address organizational, structural, and/or community level factors including social, drug-using, and sexual networks.

On July 23, 2009, NIDA issued a PA entitled Behavioral Science Track Award for Rapid Transition (B/START) (R03) (PAR-09-239). This FOA will use the NIH Small Research Grant (R03) award mechanism and seeks to facilitate the entry of beginning investigators into the field of behavioral science research related to drug abuse. To be appropriate for a B/START award, research must be primarily focused on behavioral processes and research questions. The R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. The R03 is intended to support small research projects that can be carried out in a short period of time with limited resources.

On May 28, 2009, NIDA issued an RFA entitled Integrating Translational Neuroscience and Adolescent Drug Abuse Treatment (R21) (RFA-DA-10-003). The goal of this FOA is to discover innovative approaches to drug abuse treatment for adolescents integrating innovations in neuroscience. This FOA encourages exploratory/developmental grant applications to develop collaborations integrating developmental neuroscience and adolescent drug abuse treatment. The primary goal of this announcement is to facilitate translational research that ultimately integrates findings from research on brain development, cognition and neuroscience into the development of innovative and effective, developmentally sensitive drug abuse treatments for adolescents. The grants awarded under this program will allow investigative teams exploratory and planning resources to develop translational research proposals for subsequent R01 grant application. This may include preliminary studies, scientific workshops, specialized training in research methodologies and other collaborative activities to foster multidisciplinary and/or multi-site translational research approaches to adolescent drug abuse treatment. Opening Date for this RFA: August 1, 2009; Letters of Intent Receipt Date: August 1, 2009; Application Due Date: September 1, 2009.

On May 29, 2009, NIDA issued an RFA entitled International Research Collaborations on HIV/AIDS and Drug Use (R01) (RFA-DA-10-008). This FOA solicits RO1 grant applications from applicant organizations that propose to conduct collaborative regionally focused international research on drug use and HIV/AIDS. This program fosters research related to biomedical and clinical science, epidemiology, prevention, and treatment of HIV/AIDS associated with drug use. The FOA seeks to foster international research collaborations with a regional geographic focus that take advantage of populations, resources, talent, or environmental/contextual conditions outside the U.S. that offer special opportunities to advance scientific knowledge. Opening Date for this RFA: October 18, 2009; Letters of Intent Receipt Date: October 18, 2009; Application Due Date: November 18, 2009.

On June 1, 2009, NIDA issued an RFA entitled The National Drug Abuse Treatment Clinical Trials Network (U10) (RFA-DA-10-009). This FOA announces a competition for new cooperative agreement applications and cooperative agreement renewal applications from established clinical investigators to participate in the National Drug Abuse Treatment Clinical Trials Network (CTN). As a nation-wide partnership for translational research among addiction treatment providers, researchers, and NIDA staff, the CTN's mission is to test and validate effective and efficient treatments that can be adopted by addiction treatment providers through-out the Nation, using science as the vehicle. The CTN provides an enterprise in which community-based addiction service providers, other health practitioners working with patients that have addiction problems, addiction treatment researchers, and NIDA cooperatively develop, validate, refine, and deliver new treatment options for patients in community-level clinical practice. Letters of Intent Receipt Date: October 2, 2009;Application Receipt Date: November 2, 2009.

PAs/RFAs Issued with Other NIH Components/Agencies

On May 15, 2009, NIDA, in collaboration with a number of other NIH components issued a PA entitled NIH Clinical Trial Planning Grant Program (R34) (PA-09-186). This FOA invites applications under the NIH Clinical Trial Planning Grant Program, the purpose of which is to provide support for the development of a Phase III clinical trial. This includes the establishment of the research team, the development of tools for data management and oversight of the research, the definition of recruitment strategies, and the finalization of the protocol and other essential elements of the study included in a manual of operations/procedures. The Clinical Trial Planning Grant is not designed for the collection of preliminary data or the conduct of pilot studies to support the rationale for a clinical trial.

On June 12, 2009, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral MD/PhD and Other Dual Doctoral Degree Fellows (F30) (PA-09-207). The purpose of the Ruth L. Kirschstein National Research Service Awards (Kirschstein-NRSA) is to provide support to individuals for combined MD/PhD and other dual doctoral degree training (e.g. DO/PhD, DDS/PhD, AuD/PhD). The participating Institutes award this Kirschstein-NRSA individual fellowship (F30) to qualified applicants with the potential to become productive, independent, highly trained physician-scientists and other clinician-scientists, including patient-oriented researchers in their scientific mission areas. This funding opportunity supports individual predoctoral F30 fellowships with the expectation that these training opportunities will increase the number of future investigators with both clinical knowledge and skills in basic, translational or clinical research.

On June 12, 2009, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (F31) (PA-09-208). The purpose of this individual predoctoral research training fellowship is to provide support for promising doctoral candidates who will be performing dissertation research and training in scientific health-related fields relevant to the missions of the participating NIH Institutes and Centers (ICs) during the tenure of the award.

On June 11, 2009, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships (F31) to Promote Diversity in Health-Related Research (PA-09-209). The purpose of this individual predoctoral research training fellowship is to improve the diversity of the health-related research workforce by supporting the training of predoctoral students from groups that have been shown to be underrepresented. Such candidates include individuals from underrepresented racial and ethnic groups, individuals with disabilities, and individuals from disadvantaged backgrounds. Detailed eligibility criteria are described in the full announcement.

On June 12, 2009, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (F32) (PA-09-210). The purpose of this individual postdoctoral research training fellowship is to provide support to promising Fellowship Applicants with the potential to become productive, independent investigators in scientific health-related research fields relevant to the missions of participating NIH Institutes and Centers.

On June 12, 2009, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (F33) (PA-09-211). The National Institutes of Health (NIH) awards individual senior level research training fellowships to experienced scientists who wish to make major changes in the direction of their research careers or who wish to broaden their scientific background by acquiring new research capabilities as independent investigators in research fields relevant to the missions of participating NIH Institutes and Centers.

On July 22, 2009 NIDA, in collaboration with the National Institute of Nursing Research (NINR), issued a PA entitled HIV/AIDS, Drug Use, and Vulnerable Populations in the US (R01) (PA-09-236). This FOA encourages Research Project Grant (R01) applications to identify the role(s) that drug abuse plays in fueling the HIV/AIDS epidemic in vulnerable groups (racial/ethnic minorities, men who have sex with men, youth) in the United States and to develop effective interventions to prevent new infections and to improve the health and well-being of those living with HIV/AIDS. It is essential to understand the factors (biological, behavioral, psychosocial, environmental, institutional, etc.) responsible for the profoundly disproportionate burden of HIV/AIDS among vulnerable groups. This FOA will support studies to: 1) understand the contribution of drug abuse (both injection and non-injection) to the acquisition and/or transmission of HIV; 2) study disease progression and disease outcomes; 3) develop and/or improve prevention and treatment interventions; 4) address organizational, structural, and/or community level factors including social, drug-using, and sexual networks.

On August 5, 2009, NIDA, in collaboration with numerous other NIH Institutes, issued a PA entitled Innovations in Biomedical Computational Science and Technology (R01) (PAR-09-218). The NIH is interested in promoting research and developments in biomedical informatics and computational biology that will support rapid progress in areas of scientific opportunity in biomedical research. As defined here, biomedical informatics and computational biology includes database design, graphical interfaces, querying approaches, data retrieval, data visualization and manipulation, data integration through the development of integrated analytical tools, and tools for electronic collaboration, as well as computational and mathematical research including the development of structural, functional, integrative, and analytical computational models and simulations.

On August 5, 2009, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Innovations in Biomedical Computational Science and Technology Initiative (SBIR [R43/R44]) (PAR-09-220). This FOA solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose innovative research in biomedical informatics and computational biology to promote the progress of biomedical research. There exists an expanding need to speed the progress of biomedical research through the power of computing to manage and analyze data and to model biological processes. The NIH is interested in promoting research and developments in biomedical computational science and technology that will support rapid progress in areas of scientific opportunity in biomedical research. As defined here biomedical computing or biomedical information science and technology includes database design, graphical interfaces, querying approaches, data retrieval, data visualization and manipulation, data integration through the development of integrated analytical tools, and tools for electronic collaboration, as well as computational research including the development of structural, functional, integrative, and analytical computational models and simulations.

On August 5, 2009, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Innovations in Biomedical Computational Science and Technology Initiative (STTR [R41/R42]) (PAR-09-221). This FOA solicits Small Business Technology Transfer (STTR) grant applications from small business concerns (SBCs) that propose innovative research in biomedical informatics and computational biology to promote the progress of biomedical research. There exists an expanding need to speed the progress of biomedical research through the power of computing to manage and analyze data and to model biological processes. The NIH is interested in promoting research and developments in biomedical computational science and technology that will support rapid progress in areas of scientific opportunity in biomedical research. As defined here biomedical computing or biomedical information science and technology includes database design, graphical interfaces, querying approaches, data retrieval, data visualization and manipulation, data integration through the development of integrated analytical tools, and tools for electronic collaboration, as well as computational research including the development of structural, functional, integrative, and analytical computational models and simulations.

On August 13, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Optimization of Small Molecule Probes for the Nervous System (R21) (PAR-09-251). This FOA encourages research grant applications from institutions/organizations that propose to develop new small molecule probes for investigating biological function in the nervous system via the application of advanced medicinal chemistry and the biological testing of compounds. Eligible investigators will have identified probe candidates via screening of small molecule collections, using in vitro assays of biological activity developed to interrogate these collections, and be able to show that the structural features of these small molecules are related to their biological activity. Proposals should nominate small molecule probe candidates from distinct structural series for the further, iterative design and testing of analogues in structure-activity relationship studies, using in vitro assays of biological function adapted to the medium throughput screening requirements of this work. These studies should have the goal of developing a small molecule probe possessing the attributes (eg: affinity, selectivity, activity) required for its use in future pharmacological studies proposed by the investigator.

On August 17, 2009, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Exploratory Innovations in Biomedical Computational Science and Technology (R21) (PAR-09-219). The NIH is interested in promoting research and developments in biomedical informatics and computational biology that will support rapid progress in areas of scientific opportunity in biomedical research. As defined here, biomedical informatics and computational biology includes database design, graphical interfaces, querying approaches, data retrieval, data visualization and manipulation, data integration through the development of integrated analytical tools, and tools for electronic collaboration, as well as computational and mathematical research including the development of structural, functional, integrative, and analytical computational models and simulations. This FOA will utilize the R21 grant mechanism. This FOA is intended to support exploratory biomedical informatics and computational biology research—applications should be innovative, with high risk/high impact in new areas that are lacking preliminary data or development.

On June 2, 2009, NIDA, in collaboration with numerous other NIH components, issued an RFA entitled Recovery Act Limited Competition: Biomedical Research, Development, and Growth to Spur the Acceleration of New Technologies (BRDG-SPAN) Pilot Program (RC3) (RFA-OD-09-008). This FOA, supported by funds provided to the NIH under the American Recovery & Reinvestment Act of 2009, Public Law 111-5, solicits grant applications for a new initiative called Biomedical Research, Development, and Growth to Spur the Acceleration of New Technologies (BRDG-SPAN) Pilot Program (RC3). The purpose of this pilot program is to address the funding gap between promising research and development (R&D) and transitioning to the market by contributing to the critical funding needed by applicants to pursue the next appropriate milestone(s) toward ultimate commercial-ization; i.e., to carry out later stage research activities necessary to that end. This program aims to accelerate the transition of research innovations and technologies toward the development of products or services that will improve human health, help advance the mission of NIH and its Institutes and Centers (ICs), and create significant value and economic stimulus. Opening Date: August 1, 2009; Letters of Intent Due Date: August 3, 2009; Application Due Date: September 1, 2009.

On June 2, 2009, NIDA, in collaboration with numerous other NIH components, issued an RFA entitled Recovery Act Limited Competition: Small Business Catalyst Awards for Accelerating Innovative Research (R43) (RFA-OD-09-009). This NIH FOA, supported by funds provided to the NIH under the American Recovery & Reinvestment Act of 2009 ("Recovery Act" or "ARRA"), Public Law 111-5, invites grant applications from small business concerns that propose to accelerate innovation through high risk, high reward research and development (R&D) that has commercial potential and is relevant to the mission of the NIH. The Small Business Catalyst Award is further expected to support entrepreneurs of exceptional creativity, drawn from scientific and technological environments beyond NIH, who propose pioneering and possibly transformative approaches to addressing major biomedical or behavioral challenges with the potential for downstream commercial development. Opening Date: August 1, 2009; Letters of Intent Due Date: August 3, 2009; Application Due Date: September 1, 2009.

On July 15, NIDA, in collaboration with numerous other NIH components, issued an RFA entitled The Human Connectome Project (U54) (RFA-MH-10-020). This FOA is issued as an initiative of the NIH Blueprint for Neuroscience Research. The Neuroscience Blueprint is a collaborative framework through which 16 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders. The overall purpose of this five year Human Connectome Project (HCP) is to develop and share knowledge about the structural and functional connectivity of the human brain. This purpose will be pursued through the following specific efforts: Existing, but cutting-edge, non-invasive imaging technologies will be optimized and combined to acquire structural and functional in vivo data about axonal projections and neural connections from brains of hundreds of healthy adults. Demographic data and data regarding sensory, motor, cognitive, emotional, and social function will also be collected for each subject, as will DNA samples and blood (to establish cell lines). Models to better understand and use these data will be developed. Connectivity patterns will be linked to existing architectonic data. Data and models will be made available to the research community immediately via a user-friendly system to include tools to query, organize, visualize and analyze data. Outreach activities will be conducted to engage and educate the research community about the imaging tools, data, models, and informatics tools. Letters of Intent Receipt Date: October 24, 2009; Application Receipt Date: November 24, 2009.

On July 17, 2009, NIDA, in collaboration with a number of other NIH components, issued an RFA entitled Building Interdisciplinary Research Careers in Women's Health (K12) (RFA-OD-09-006). The NIH Office of Research on Women's Health (ORWH) and its cosponsors invite institutional career development award applications for Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Career Development Programs, hereafter termed "Programs." Programs will support mentored research career development of junior faculty members, known as BIRCWH Scholars, who have recently completed clinical training or postdoctoral fellowships, and who will be engaged in interdisciplinary basic, translational, behavioral, clinical, and/or health services research relevant to women's health or sex/gender factors. Letters of Intent Receipt Date: September 23, 2009; Application Receipt Date: October 22, 2009.

On July 29, 2009, NIDA, in collaboration with NIAAA, NCI, and the Department of Veterans Affairs, issued an RFA entitled Substance Use and Abuse among U.S. Military Personnel, Veterans and their Families (R01) (RFA-DA-10-001). This FOA is issued to enhance and accelerate research on the epidemiology/ etiology, identification, and prevention and treatment of alcohol, tobacco, and other drug use and abuse (including illicit and prescription drugs) and associated mental health problems among active-duty or recently separated (e.g., Iraq and Afghanistan) military troops and their families. VA has specific interest in supporting research directed towards advancing prevention and treatment of mental health and comorbid substance use/abuse problems in veterans of Iraq and Afghanistan deployments (including National Guard and Reservists) and their families. Opening Date: November 22, 2009; Application Due Date: December 22, 2009.

On July 29, 2009, NIDA, in collaboration with NIAAA, and NCI, issued an RFA entitled Substance Use and Abuse among U.S. Military Personnel, Veterans and their Families (R21) (RFA-DA-10-002). This FOA is issued for exploratory and pilot feasibility studies designed to enhance and accelerate research on the epidemiology/ etiology, identification, and prevention and treatment of alcohol, tobacco, and other drug use and abuse (including illicit and prescription drugs) and associated mental health problems among active-duty or recently separated (e.g., Iraq and Afghanistan) military troops and their families. This FOA will utilize the R21 grant mechanism and runs in parallel with a FOA of identical scientific scope, DA-10-001 that solicits applications under the R01 mechanism. Opening Date: November 22, 2009; Letters of Intent Receipt Date: November 23, 2009; Application Due Date: December 22, 2009.

Other Program Activities

Clinical Trials Network (CTN) Update

RFP: Proposals in response to the RFP N01DA-9-2217, Data and Statistics Center for the NIDA Clinical Trials Network, were reviewed in May, 2009, with an award planned around mid-September.

Protocols: A total of 43 protocols have been initiated since 2001, including multi-site clinical trials (29), multi-site surveys (3), studies in special populations (5), and secondary analyses of data across various trials (6). Twenty-three trials have completed data lock; one is in the follow-up, data-lock phase; three are currently enrolling and five are in development. In addition, 18 ancillary studies have been supported by CTN and non-CTN funds. Seven protocols are in the development phase. Over 11,000 participants have enrolled in studies.

Primary outcome papers are published and dissemination materials have been developed with CSAT's ATTC on the following:

  • Protocol CTN 0001, Buprenorphine/Naloxone versus Clonidine for Inpatient Opiate Detoxification
  • Protocol CTN 0002, Buprenorphine/Naloxone versus Clonidine for Outpatient Opiate Detoxification
  • Protocol CTN 0005, MI (Motivational Interviewing) To Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse
  • Protocol CTN 0006, Motivational Incentives for Enhanced Drug Abuse Recovery: Drug Free Clinics
  • Protocol CTN 0007, Motivational Incentives for Enhanced Drug Abuse Recovery: Methadone Clinics

Primary outcome papers are published or in press for:

  • Protocol CTN 0003, Bup/Nx: Comparison of Two Taper Schedules
  • Protocol CTN 0004, MET (Motivational Enhancement Treatment) To Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse
  • Protocol CTN 0008, A Baseline for Investigating Diffusion of Innovation
  • Protocol CTN 0009, Smoking Cessation Treatment with Transdermal Nicotine Replacement Therapy in Substance Abuse Rehabilitation Programs
  • Protocol CTN 0010, Buprenorphine/Naloxone-Facilitated Rehabilitation for Heroin Addicted Adolescents/Young Adults
  • Protocol CTN 0011, A Feasibility Study of a Telephone Enhancement Procedure (TELE) to Improve Participation in Continuing Care Activities
  • Protocol CTN 0012, Characteristics of Screening, Evaluation, and Treatment of HIV/AIDS, Hepatitis C Viral Infection, and Sexually Transmitted Infections in Substance Abuse Treatment Programs
  • Protocol CTN 0013, Motivational Enhancement Therapy to Improve Treatment Utilization and Outcome In Pregnant Substance Abusers
  • Protocol CTN 0015, Women's Treatment for Trauma and Substance Use Disorder: A Randomized Clinical Trial
  • Protocol CTN 0016, Patient Feedback: A Performance Improvement Study in Outpatient Addiction Treatment
  • Protocol CTN 0018, Reducing HIV/STD Risk Behaviors: A Research Study for Men in Drug Abuse Treatment
  • Protocol CTN 0019, Reducing HIV/STD Risk Behaviors: A Research Study for Women in Drug Abuse Treatment
  • Protocol CTN 0021, Motivational Enhancement Treatment to Improve Treatment Engagement and Outcome for Spanish-Speaking Individuals Seeking Treatment for Substance Abuse. This is the first Spanish-only protocol in the CTN.
  • Protocol CTN 0029, A Pilot Study of Osmotic-Release Methylphenidate (OROS MPH) in Initiating and Maintaining Abstinence in Smokers with ADHD.

In addition, the following protocols have submitted primary paper:

  • Protocol CTN 0017, HIV and HCV Intervention in Drug Treatment Settings

The following protocols have locked the data:

  • Protocol CTN 0014, Brief Strategic Family Therapy for Adolescent Drug Abusers (BSFT)
  • Protocol CTN 0028, Randomized Controlled Trial of Osmotic-Release Methylphenidate (OROS MPH) for Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents with Substance Use Disorders (SUD).

The following protocols has ended new enrollment, and are in the follow-up or data-lock phase:

  • Protocol CTN 0030, Prescription Opioid Addiction Treatment Study (POATS) is a randomized 2-phase, open-label, multi-center study in outpatient treatment settings. Pre-screening began in May 2006. The study is being carried out in 9 sites, and has randomized 653 participants into phase 1 and 360 participants into phase 2.
  • CTN 0030A1, Collection of Economic Data for the Prescription Opioid Addiction Treatment Study. This ancillary study was conducted in collaboration with NIDA DESPR and it is in the data analysis phase.
  • CTN 0030A2, Effects of Chronic Opioids is conducted in collaboration with NIDA DCNBR to obtain anatomical MR scans in subjects with a history of opioid use to evaluate neural changes that may occur with such use and compare with age/gender healthy controls. This study is in the data analysis phase.
  • CTN 0030A3, POATS Long-Term Follow Up Study (LTFU) is being implemented at all POATS sites to examine long-term outcomes for individuals who participated in CTN-0030 with opioid analgesic (OA) dependence.
  • Protocol CTN 0032, HIV Rapid Testing and Counseling in Drug Abuse Treatment Programs in the U.S. This study seeks to evaluate the most effective strategy to ensure that persons in drug treatment programs are tested for HIV and receive their HIV test results. The protocol has completed the enrollment phase and the one-month follow-up for the primary goal. Twelve hundred and eighty one patients in 12 CTN drug abuse community centers were enrolled in 5 months with a 97.5% retention rate at one-month follow-up.
  • CTN 0032A1, Economic Analysis of HIV Rapid Testing in Drug Abuse Treatment Programs. This is an ancillary study is an assessment of the cost-effectiveness of on-site HIV testing in drug abuse treatment settings vs. referral for off-site testing. The PI is Dr. Bruce Schackman. The project is conducted in collaboration with NIDA's DESPR.

The following protocols are currently enrolling:

  • Protocol CTN 0027, Starting Treatment with Agonist Replacement Therapies (START) is a randomized, open-label, multi-center study that was developed in collaboration with the Division of Pharmacotherapies & Medical Consequences of Drug Abuse (DPMCDA). Enrollment began in April 2006. As of February 28, 2009, 1,040 participants had been randomized.

  • CTN 0027A1, START Pharmacogenetics: Exploratory Genetic Studies In Starting Treatment With Agonist Replacement Therapies.
  • CTN-0027A2, Retention of Suboxone Patients in START: Perspectives of Providers and Patients. The overall purposes of the supplemental study are to identify and assess barriers for retaining Suboxone patients. This ancillary study is in the development phase.
  • Protocol CTN 0031, Stimulant Abuser Groups to Engage in 12-Step (STAGE-12): Evaluation of a Combined Individual-Group Intervention to Reduce Stimulant and Other Drug Use by Increasing 12-Step Involvement. As of August 3, 2009, two of the three Wave 1 sites have completed recruitment and the third Wave 1 site is approaching its final recruitment target. The seven Wave 2 sites continue to actively recruit.
  • CTN 0031A1, An Evaluation of Neurocognitive Function, Oxidative Damage, and Their Association with Treatment Outcomes in Methamphetamine and Cocaine Abusers. Potential participants are being recruited at six sites.

  • CTN 0031A2, The Role of Alcohol Consumption in Classifications of Alcohol Use Disorders: A Clinical Study. It investigates the utility of adding a frequency measure of alcohol consumption (i.e., the first three items of the Alcohol Use Disorders Identification Test [AUDIT-C]), to the DSM-IV diagnostic criteria for alcohol use disorders. This study is funded by an MOU between NIDA and NIAAA. Data will be collected for this study throughout the life of the main STAGE-12 study.
  • Protocol CTN 0033-Ot, Methamphetamine Use among American Indians. The first area of research emphasis in the National Institute on Drug Abuse's Strategic Plan on Reducing Health Disparities (2004 Revision) is the epidemiology of drug abuse, health consequences and infectious diseases among minority populations. The study is a collaboration among four Nodes: Pacific NW, Southwest, Oregon/Hawaii, and Ohio Valley.
  • Protocol CTN 0035-Ot, Access to HIV and Hepatitis Screening and Care among Ethnic Minority Drug Users In and Out of Drug Treatment. This study is in collaboration with the NIH National Center for Minority Health and Health Disparities and is being conducted in the California/Arizona Node.
  • Protocol CTN 0036-Ot, Epidemiology and Ethnographic Survey of "Cheese" Heroin Use among Hispanics in Dallas County. This study is in collaboration with the NIH National Center for Minority Health and Health Disparities and is being conducted in the Texas Node.

The following protocols are in the development phase:

  • Protocol CTN 0034-Ot, Developing Research Capacity and Culturally Appropriate Research Methods: Community-based Participatory Research Manual for Collaborative Research in Drug Abuse for American Indians and Alaska Natives. This study is in collaboration with the NIH National Center for Minority Health and Health Disparities and will be conducted in the Pacific Northwest Node.
  • Protocol CTN 0037, Exercise as a Treatment for Substance Use Disorders. This clinical trial will test the effectiveness of the addition of exercise in improving drug abuse treatment outcomes.
  • Protocol CTN-0038-Ot, Barriers to Substance Abuse Treatment among Asian Americans and Pacific Islanders. The objective of this study is to gain a better understanding of the factors that may influence the under-utilization of substance abuse treatment services by Asian Americans and Pacific Islanders (AAPIs) and the readiness of substance abuse treatment programs serving AAPIs to participate in clinical trials and adopt evidence based practices. This study is a collaboration with NIH NCMHD.
  • Protocol CTN 0044, Web-delivery of Evidence-Based, Psychosocial Treatment for Substance Use Disorders. The purpose of this study is to evaluate the effectiveness of adding an interactive, web-based version of the Community Reinforcement Approach (CRA) intervention plus abstinence incentives as an adjunct to community-based, outpatient substance abuse treatment.
  • Protocol CTN 0045-Ot,Rates of HIV Testing and Barriers to Testing in African Americans Receiving Substance Abuse Treatment. This is an observational study seeking to: (1) Compare the proportion of African American and non-African Americans receiving treatment at substance abuse treatment clinics that have been tested for HIV within the past 12 months; (2) Observe relationships between rates of African Americans who have not been tested and a) the types of testing offered at substance abuse treatment clinics and b) the types of outreach strategies used to engage persons in HIV testing; and (3) assess African American clients' self-reported barriers to accessing HIV testing, in relation to other ethnicities.
  • Protocol CTN-0046, Smoking-Cessation and Stimulant Treatment (S-CAST): Evaluation of the Impact of Concurrent Outpatient Smoking-Cessation and Stimulant Treatment on Stimulant-Dependence Outcomes. The primary objective of this study is to evaluate the impact of substance abuse treatment as usual plus smoking cessation treatment (TAU+SCT), relative to substance abuse treatment as usual (TAU), on drug abuse outcomes.
  • Protocol CTN-0047, Screening, Motivational Assessment, Referral and Treatment in Emergency Departments (SMART-ED). The study objective is to evaluate the implementation of and outcomes associated with a screening and brief intervention (SBI) process to identify individuals with substance use, abuse, or dependence seen in emergency departments (EDs) and to provide interventions and/or referral to treatment consistent with the severity of their substance use disorder.
  • Protocol CTN-0048, Screening, Motivational Assessment, Referral and Treatment in Dental Clinics. This concept is currently being developed into a protocol, in collaboration with the NIDCR and their clinical networks.

In addition to the primary CTN trials, there are currently five secondary analyses using data across several of the completed trials:

  1. Gender Differences in the Prevalence and Predictors of HIV Risk Behaviors, PI: Audrey Brooks (CA/AZ Node);
  2. Pattern of alcohol use and alcohol-related diagnoses among drug abusing/dependent participants, PIs: Dennis Donovan and Bryan Hartzler (Pacific Northwest Node);
  3. The relationships between demographic characteristics of patients and therapists, measures of therapeutic process and therapeutic alliance, and outcomes, PIs: Alyssa Forcehimes (Southwest Node) and Kathleen Burlew (Ohio Valley Node);
  4. The Efficacy of Motivational Enhancement Therapy for African Americans, PI: Kathleen Burlew (Ohio Valley Node);
  5. Substance Abuse Treatment Outcomes in Racial/Ethnic Minority Populations, PI: Carmen Masson (California-Arizona Node).

There are also about 40 funded studies supported by independent grants that use CTN studies as a platform.

Summer Research with NIDA

The Special Populations Office coordinated the 13th annual Summer Research with NIDA program. Sixty-eight high school and college students engaged in drug abuse research with various NIDA grantees for 8-10 weeks over the summer. Participants received certificates of completion and were invited to submit their photo and brief statements about their research experience to the NIDA Notes editor for inclusion in an upcoming issue.




NIDA's New and Competing Continuation Grants Awarded Since May 2009

Agrawal, Arpana -- Washington University
Characterizing the 3-Year Course of Cannabis Involvement in NESARC

Ahijevych, Karen L. -- Ohio State University
Bitter Taste Phenotype as a Risk Factor of Oral Nicotine Replacement Non-adherence

Akbarali, Hamid I. -- Virginia Commonwealth University
Morphine-Induced Tolerance in the Ileum and Colon

Al'absi, Mustafa N. -- University of Minnesota (Duluth)
Khat Research Program: Neurobehavioral Impact of Long-Term Use

Aldrich, Jane V. -- University of Kansas (Lawrence)
Affinity Labels for Opioid Receptors

Amara, Susan G. -- University of Pittsburgh at Pittsburgh
Molecular Studies of Catecholamine Transporters

Ambrose, Bridget Kathleen -- Johns Hopkins University
Tobacco Smoking and Cessation Seeking Behavior in the ALIVE Study

Ames, Susan L. -- Claremont Graduate University
Functional Imaging of Implicit Marijuana Associations during IAT Performance

Andrews, Judy A. -- Oregon Research Institute
Childhood and Adolescent Predictors of Substance Abuse in Emerging Adulthood

Aron, Adam Robert -- University of California (San Diego)
Fronto-Basal-Ganglia Circuits for Selective Stopping and Braking

Arria, Amelia M. -- University of Maryland (College Park Campus)
Drug Abuse Trajectories in the Transition to Adulthood: Risk Factors and Outcomes

Aston-Jones, Gary S. -- Medical University of South Carolina
Gene Transfer into Selected Brain Neurons In Vivo

Avison, Malcolm J. -- Vanderbilt University
High Resolution MRI Mapping of CNS Plasticity

Baker, David A. -- Marquette University
Targeting System XC- for the Treatment of Addiction

Barcelo, Helene -- Arizona State University (Tempe Campus)
Application of Discrete Homotopy Theory to the Study of Children's Social Network

Bardo, Michael T. -- University of Kentucky
Novelty, Dopamine and Response to Amphetamine

Barker, Eric L. -- Purdue University (West Lafayette)
Lipidomic Profile of Endocannabinoids from Neuronal Cells

Barres, Ben A. -- Stanford University
The Role of Glia in the Formation of Functional Synapses

Barth, Alison L. -- Carnegie-Mellon University
Experience Dependent Plasticity in a fosGFP Mouse

Bassell, Gary J. -- Emory University
Identification of Localized MiRNAS for Neuronal Development and Plasticity

Bazemore-Walker, Carthene R. -- Brown University
Proteomic Characterization of the Sigma-1 Receptor and Its Signaling Complex

Beauvais, Frederick -- Colorado State University (Fort Collins)
Drug Use among Young Indians: Epidemiology and Prediction

Becker, Jill B. -- University of Michigan at Ann Arbor
Gender Differences in Drug Abuse

Becker, Jill B. -- University of Michigan at Ann Arbor
Drug Abuse: Sex Differences in Developmental and Environmental Influences

Belenko, Steven -- Temple University
The Pennsylvania Research Center at Temple University

Berg, Kelly -- University of Texas Health Science Center (San Antonio)
Delta-Kappa Opioid Receptor Interactions: Ligand-Dependent Effects

Berman, Phillip -- University of California (Santa Cruz)
HIV Variation in Injection Drug Users: Mapping Broadly Neutralizing Antibodies

Berns, Gregory S. -- Emory University
Neurobiology of Uncertainty

Berns, Gregory S. -- Emory University
Neurobiological Circuits of Gain and Loss during Risky Decision Making

Berrettini, Wade H. -- University of Pennsylvania
Genetics of Nicotine Dependence

Berridge, Kent C. -- University of Michigan at Ann Arbor
Cue-Triggered Reward Seeking

Berwid, Olga G. -- Queens College
Impact of Stimulant Treatment on Neural Reward Circuitry Functioning in ADHD

Beveridge, Thomas J.R. -- Wake Forest University (Health Sciences)
Effect of Cocaine Self-Administration on Metabotropic Glutamate Systems

Bevins, Rick A. -- University of Nebraska (Lincoln)
Acquired Appetitive Properties of Nicotine

Bhagwagar, Zubin -- Yale University
A Pet Study of 5-HT1B Receptor Binding as a Novel Biomarker for Cocaine Dependency

Bibb, James A. -- University of Texas S.W. Medical Center (Dallas)
The Role of Cdk5 in Addiction

Bierut, Laura J. -- Washington University
Genetics Study of Nicotine Dependence in African Americans

Bisaga, Adam Mariusz -- Columbia University Health Sciences
Dronabinol Naltrexone Treatment for Opioid Dependence

Blanco, Carlos -- New York State Psychiatric Institute
Substance Use Comorbidity Care: Evidence-Based Stepped Strategies for Depression

Blough, Bruce E. -- Research Triangle Institute
Development of Potential Treatment Medications for Drug Abuse

Blow, Frederic C. -- University of Michigan at Ann Arbor
Optimizing SBIRT for Drug-Using Patients in an Inner-City Emergency Department

Bock, Beth C. -- Miriam Hospital
Examining a Text Message Intervention for Smoking Cessation

Boeri, Miriam W. -- Kennesaw State University
Older Drug Users: A Life Course Study of Turning Points in Drug Use and Injection

Bohn, Laura M. -- Scripps Research Institute
Agonist-Directed MOR Desensitization in Opioid Analgesic Tolerance

Bonci, Antonello -- Ernest Gallo Clinic and Research Center
CRF Modulation of NMDA Currents and Behavior in the VTA

Booth, Robert E. -- University of Colorado (Denver)
Understanding the Role of Power in Drug Use and HIV Risk Behaviors among...

Boyd, Carol J. -- University of Michigan at Ann Arbor
A Prospective Study of the Nonmedical Use of Prescription Medications by Adolescence

Bradesi, Sylvie S. -- Brentwood Biomedical Research Institute
Spinal Glia Activation in Chronic Stress-Induced Visceral Hyperalgesia

Branch, Marc N. -- University of Florida
Behavioral Determinants of Cocaine Tolerance

Braver, Todd -- Washington University
Negative Reinforcement Effects on Neural Mechanisms of Cognitive Control

Brecht, Mary-Lynn -- University of California (Los Angeles)
Methamphetamine Abuse: Long-Term Trajectories, Correlates, Treatment Effects

Brown, David R. -- University of Minnesota (Twin Cities)
Mucosal Defense Mechanisms in Substance Abuse

Brown, Joshua W. -- Indiana University (Bloomington)
Neural Mechanisms of Risky Behavior Avoidance

Brown, Richard A. -- Butler Hospital (Providence, RI)
Distress Tolerance Treatment for Smoking Cessation

Bruce, Jacqueline -- Oregon Social Learning Center, Inc.
Risk for Substance Use in Foster Adolescents: An fMRI Study of Inhibitory Control

Bruijnzeel, Adriaan W. -- University of Florida
Nicotine Dependence and Central Adiposity Signaling

Buch, Shilpa J. -- University of Kansas Medical Center
PLGA/Antisense IL-10: Gene Therapy for Cocaine Abusers with HAD

Burstein, Sumner H. -- University of Massachusetts Medical School (Worcester)
The Elmiric Acids: Biologically Active Anandamide Analogs

Carise, Deni -- Treatment Research Institute, Inc. (TRI)
Toolkits: Will Implementing An Evidence-Based Curriculum Improve Group Counseling?

Carr, Kenneth D. -- New York University School of Medicine
CNS Mechanisms That Modulate Reward

Carrasco, Gonzalo Andres -- University of Kansas (Lawrence)
Neuroendocrine Supersensitivity of 5-HT2A Receptors

Carroll, Frank I. -- Research Triangle Institute
Design and Development of Pharmacotherapies for Treating Stimulant Abuse

Case, Patricia L. -- Fenway Community Health Center
Feasibility of Pharmacy-Based HIV Interventions among IDUS: 2 New England Cities

Castillo, Pablo E. -- Yeshiva University
Presynaptic Forms of Long-Term Plasticity in the CNS

Chang, Sulie Lin -- Seton Hall University
Mechanisms of Nicotine's Behavioral Effects on the HIV-1 Transgenic Rat

Chen, Dong Feng -- Schepens Eye Research Institute
Glial Modulation of Cortical Development and Drug of Abuse-Induced Brain Damage

Chen, Hao -- University of Tennessee Health Science Center
Insular Cortex and Reinstatement of Nicotine Seeking Behavior

Chen, Kevin W. -- University of Maryland (Baltimore)
Treatment of Cocaine Addiction with Integrative Meditation

Chen, Rong -- University of Michigan at Ann Arbor
PKC-Beta Regulation of the Dopamine Transporter Trafficking

Cherner, Mariana -- University of California (San Diego)
COMT Genotype and Risky Decision Making in HIV and Methamphetamine Dependence

Childress, Anna Rose -- University of Pennsylvania
Extinction of Limbic Activation to "Unseen" Cocaine Cues

Cinciripini, Paul Michael -- University of Texas (M.D. Anderson Cancer Center)
Effectiveness of Varenicline vs. Varenicline plus Bupropion for Smoking Cessation

Cinciripini, Paul Michael -- University of Texas (M.D. Anderson Cancer Center)
Error Sensitivity as a Predictor of Nicotine withdrawal and Smoking Cessation

Clarke, Jennifer Grace -- Memorial Hospital of Rhode Island
Sustaining Tobacco Abstinence after Incarceration

Cochran, Bryan Neil -- University of Montana
Predicting the Development of Opioid Abuse or Dependence

Coffman, Donna Lynn -- Pennsylvania State University (University Park)
Causal Inference for Mediation Models in Substance Abuse Prevention Research

Collins, David -- Pacific Institute for Research and Evaluation
Mobilizing the Community to Reduce Teen Prescription Drug Abuse

Connett, Deborah Finfgeld -- University of Missouri (Columbia)
Optimal Treatment: Recovery Frameworks for Women with Substance Abuse Problems

Cooper, Hannah L. -- Emory University
Public Housing Relocations: Impact on Healthcare Access, Drug Use and Sexual Health

Cooper, Hannah L. -- Emory University
Exploring HIV Risk in Drug-Using Black Women with an Incarcerated Partner

Cosgrove, Kelly P. -- Yale University
Dopaminergic and Endocannabinoid Interactions in Nicotine Dependence

Cravatt, Benjamin F. -- Scripps Research Institute
Endocannabinoid Metabolic Enzymes: Structure, Function, In Vivo Inhibition

Crystal, Ronald G. -- Weill Medical College of Cornell University
Adenovirus-Based Nanoparticle Vaccines

Cubbins, Lisa Ann -- Battelle Centers/Public Health Research and Evaluation
Immigration Effects on Substance Abuse, Mental Health and Treatment Gaps

Cunningham, Rebecca M. -- University of Michigan at Ann Arbor
Substance Use among Violently Injured Youth in an Urban ER: Services and Outcome

Dafny, Nachum -- University of Texas Health Science Center (Houston)
How and Where Methylphenidate Exerts Effect in Adolescent and Adult Brains

Dallery, Jesse -- National Development and Research Institute
Technological Innovations in a Behavioral Treatment for Cigarette Smoking

Davies, Huw M. -- Emory University
Design of New Treatment Agents for Drug Abuse

De Biasi, Mariella -- Baylor College of Medicine
Stress, Anxiety, and Nicotine Withdrawal

De La Garza, Richard -- Baylor College of Medicine
Rivastigmine and Huperzine A as Potential Treatments for Cocaine Addiction

De Wit, Harriet -- University of Chicago
Determinants of Drug Preference in Humans

Des Jarlais, Don C. -- Beth Israel Medical Center (New York)
Risk Factors for HIV/AIDS in Drug Users

Desai, Rajeev I. -- Mc Lean Hospital (Belmont, MA)
Nicotinic Modulation of Methamphetamine's Behavioral and Neurochemical Effects

Deutch, Ariel Y. -- Vanderbilt University
The Role of Claustrum in Substance Abuse and Cognition

Deutsch, Dale G. -- State University New York (Stony Brook)
Endocannabinoid Inactivation: Plasma Membrane Uptake and Cellular Trafficking

Deutsch, Dale G. -- State University New York (Stony Brook)
The Biosynthesis of Anandamide

Deutsch, Dale G. -- State University New York (Stony Brook)
Endocannabinoid Intracellular Transporters

Dierker, Lisa C. -- Wesleyan University
Individual Differences in Smoking Exposure and Nicotine Dependence Sensitivity

Dileone, Ralph J. -- Yale University
Development of Neuronal Tracers to Study Leptin Modulation of Dopamine Circuits

Dillon, Glenn H. -- University of North Texas Health Science Center
Mechanisms of Carisoprodol Abuse

Dimmitt Champion, Jane -- University of Texas Health Science Center (San Antonio)
Translation of Interventions for Rural Mexican-American Adolescent Women

Dodge, Kenneth A. -- Duke University
Development and Prevention of Substance Abuse Problems

Doherty, Irene A. -- University of North Carolina (Chapel Hill)
The Nexus of Drugs, Sex Networks, HIV and Syphilis in Young African American MSM

Dominguez, Juan M. -- University of Texas (Austin)
A Role for the Medial Preoptic Area in Regulating Gender-Sensitive Differences...

Dorn, Lorah D. -- Children's Hospital Medical Center (Cincinnati)
Metabolic Consequences of Substance Use in Adolescent Girls

Dow-Edwards, Diana L. -- SUNY Downstate Medical Center
Binge Cocaine during Pregnancy in the Rat

Draine, Jeffrey N. -- University of Pennsylvania
Education and Empowerment Intervention for HIV Prevention In and Out of Jail

Drobes, David J. -- H. Lee Moffitt Cancer Center and Research Institute
Influence of Smoking Abstinence and Age on ERP Indices of Attentional Control

D'souza, Deepak Cyril -- Yale University
Imaging Nicotinic Acetylcholine Receptors in Schizophrenia

Dunlap, Laura J. -- Research Triangle Institute
Evaluation of a Web-Based Instrument for Service-Level Cost Estimation in Drug Abuse

Eby, Lillian T. -- University of Georgia (UGA)
Understanding the Adoption and Implementation of Tobacco-Free Regulation in..

Eisch, Amelia J. -- University of Texas S.W. Medical Center (Dallas)
Opiates and Adult Neurogenesis

El-Hage, Nazira -- Virginia Commonwealth University
Oxidative Damage and Proteasome Activity: Role of Opioid in HIV-HCV Infection

Elmer, Gregory I. -- University of Maryland (Baltimore)
Pattern Array: In Vivo Mining for Novel Psychoactive Drug Discovery

Engstrom, Malitta V. -- University of Chicago
Family Therapy Development for Incarcerated Mothers with Substance Use Disorders

Ettenberg, Aaron -- University of California (Santa Barbara)
Mechanisms of Opiate and Stimulant Drug Reinforcement

Evans, David E. -- H. Lee Moffitt Cancer Center and Research Institute
Automatic Attention to Smoking Cues: Neural Correlates

Evans, David E. -- H. Lee Moffitt Cancer Center and Research Institute
Genetic Moderation of Attentional Deficits Resulting from Nicotine Withdrawal

Everall, Ian Paul -- University of California (San Diego)
COMT Genotype and Executive Function in HIV Infection and Methamphetamine Use

Fals-Stewart, William S. -- University of Rochester
Cognitive Rehabilitation for Substance Abusing Adolescents

Fatemi, S. Hossein -- University of Minnesota (Twin Cities)
Varenicline and Smoking Cessation in Schizophrenia

Feinberg, Mark Ethan -- Pennsylvania State University (University Park)
Pilot Study of Sibling Prevention Program

Festinger, David S. -- Treatment Research Institute, Inc. (TRI)
Improving the Ethics of Consent in Drug Abuse Research

Flagel, Shelly Beth -- University of Michigan at Ann Arbor
Individual Differences in Incentive Salience Attribution: Relevance to Addiction

Flanagan, Constance A. -- Pennsylvania State University (University Park)
Friends Helping Friends: Socially Responsible ATOD Prevention

Flower, E. Keith -- California Pacific Medical Center Research Institute
A Pilot Trial of Naltrexone for Methamphetamine Addiction - Role of the A118G SNP

Floyd, Leah -- Johns Hopkins University
Race and HIV-Risk: Contextual and Neurocognitive Influences on Sex Partnerships

Foley, Kristie L. -- Davidson College
Implementation and Dissemination of Tobacco Cessation Strategies in Free Clinics

Franklin, Teresa R. -- University of Pennsylvana
Dopaminergic Variants Involved in Smoking Behavior: A Perfusion fMRI Study

Friedman, Samuel R. -- National Development and Research Institutes
Community Vulnerability and Responses to Drug-User-Related HIV/AIDS

Friedmann, Peter D. -- Rhode Island Hospital (Providence, RI)
Continuum of Care for Drug-Involved Offenders

Froeliger, Brett -- Duke University
Neuropharmacology of Emotion-Cognition Interaction in Nicotine Dependence

Galli, Aurelio Antonio -- Vanderbilt University
Molecular Mechanisms of Stimulant Abuse

Garofalo, Robert -- Children's Memorial Hospital (Chicago)
Syndemic Development and HIV Risk among Vulnerable Young Men

Gentry, W Brooks -- University of Arkansas Medical Sciences (Little Rock)
Monoamine Antagonist Therapies for Methamphetamine Abuse

George, Susan R. -- University of Toronto
Receptors Mediating Drug Dependence

Geppert, Cynthia Ann Martha -- Biomedical Research Institute of New Mexico
A Survey Study of Informed Consent Processes in Addiction Treatment

Girdler, Susan S. -- University of North Carolina (Chapel Hill)
Stress Responses, Psychosocial Stress and Pain Perception in African Americans

Glass, Michael J. -- Weill Medical College of Cornell University
Glutamate Receptors and Opioid Dependence: Molecules, Circuits and Behavior

Glass, Michael J. -- Weill Medical College of Cornell University
Amygdala AMPA GLuR2 Deletion and Opioid Dependence

Gold, Jeffrey Ira -- Children's Hospital (Los Angeles)
Virtual Reality Analgesia: Using fMRI to Explore the Central Mechanisms of..

Golub, Sarit A. -- Hunter College
Neurocognitive Deficits, Substance Use, and HIV Risk Behavior

Gonzalez-Haddad, Gerardo -- University of Massachusetts Medical School (Worcester)
Memantine-Enhanced Buprenorphine Treatment for Opioid-Dependent Young Adults

Goodwin, Amy K. -- Johns Hopkins University
Hallucinogen Self-Administration in Baboons

Grace, Anthony A. -- University of Pittsburgh at Pittsburgh
Stress-Induced Alterations in Amygdala-LC Interactions

Gray, Kevin M. -- Medical University of South Carolina
A Controlled Trial of N-Acetylcysteine (NAC) in Cannabis Dependent Adolescents

Green, Alan I. -- Dartmouth College
Cannabis and Schizophrenia: Self-Medication and Agonist Treatment?

Green, Kerry M. -- University of Maryland (College Park Campus)
Substance Use and Psychological Problems among African Americans into Midlife

Greenwald, Mark K. -- Wayne State University
Human Laboratory Model of Cocaine Treatment: Behavioral Economic Analysis

Grigson, Patricia Sue -- Pennsylvania State University (Hershey Medical Center)
Drugs of Abuse, Reward Comparison, and the Thalamus

Grucza, Richard A. -- Washington University
Early Substance Use and Addiction: Genes, Environment, and Epidemiology

Gu, Howard H. -- Ohio State University
Mechanism of Drug Addiction

Gu, Howard H. -- Ohio State University
Cocaine Degrading Enzymes from Pest Insects of Coca Plants

Guydish, Joseph R. -- University of California (San Francisco)
Impact of Core Implementation Components on Adoption

Halkitis, Perry N. -- New York University
Syndemic Production among Emergent Adult Men

Hammond, Donna L. -- University of Iowa
Opioid Mechanisms of Analgesia

Hampson, Robert E. -- Wake Forest University Health Sciences
Cannabinoid Effects on Sensory Processing in Brain

Hansen, William B. -- Tanglewood Research, Inc.
The Impact of Adaptation on Successful Implementation

Hao, Shuanglin -- University of Michigan at Ann Arbor
Pathogenesis and Therapy of HIV-Related Neuropathic Pain

Hao, Shuanglin -- University of Michigan at Ann Arbor
Gene Therapy of HIV-Neuropathic Pain with Morphine Tolerance

Harding, Wayne -- Hunter College
Synthesis and Evaluation of Aporphines as MDMA Antagonists

Hatsukami, Dorothy K. -- University of Minnesota (Twin Cities)
Innovative Interventions for Smoking Cessation

Haughey, Heather May -- University of Virginia (Charlottesville)
Medications Development for the Treatment of Cannabis Related Disorders

Hayes, Marie J. -- University of Maine (Orono)
Sleep, Arousal, and Spontaneous Movements in Opioid Exposed Infants

Heeger, David J. -- New York University
The Neural Correlates of Effective Drug Prevention Messages

Heinzerling, Keith Gregory -- University of California (Los Angeles)
Pilot Trial of Bupropion vs Placebo for Methamphetamine Abuse in Adolescents

Higgins, Stephen T. -- University of Vermont and State Agriculture College
Modeling Initial Smoking Abstinence and Relapse Risk

Hill, Karl G. -- University of Washington
Gene-Environment Interplay in the Development of Drug Abuse and Comorbid Problems

Ho, Wenzhe -- Children's Hospital of Philadelphia
Drug Abuse, Substance P and HIV

Hogue, Aaron -- National Center on Addiction/Substance Abuse
Evidence-Based Practices and Service Outcomes in Usual Care for ASA

Holahan, Carole K. -- University of Texas (Austin)
Depressive Symptoms and Smoking in Middle-Aged and Older Women

Holschneider, Daniel Philipp -- University of Southern California
Implantable Minipump for Tetherless Drug Self-Administration in Mice

Hong, Jiyong -- Duke University
PKC Zeta-Specific Inhibitors for Treatment of Methamphetamine Addiction

Hooten, W. Michael -- Mayo Clinic College of Medicine (Rochester)
Cognitive Behavioral Smoking Cessation Intervention for Adults with Chronic Pain

Horner, Kristen A. -- Mercer University (Macon)
The Role of Mu Opioid Receptor Activation in Psychostimulant-Induced Gene Express

Hoyle, Rick H. -- Duke University
Brain Imaging the Effects of High Sensation Value Anti-Drug PSAs

Hruby, Victor J. -- University of Arizona
New Modalities for Treatment of Pain and Drug Abuse

Hser, Yih-Ing -- University of California (Los Angeles)
A Long-Term Follow-Up Study of Drug-Dependent Mothers and Children

Hu, Xiu-Ti -- Rush University Medical Center
Chronic Cocaine Exposure and HIV-1 Tat: Dysregulation of the...

Huang, Weihua -- University of Virginia (Charlottesville)
Functional Characterization of ANKK1 and Its Genetic Variants

Hurd, Yasmin L. -- Mount Sinai School of Medicine of NYU
The Opioid Mesolimbic System in Heroin Abuse

Hussong, Andrea M. -- University of North Carolina (Chapel Hill)
Internalizing Pathways to Drug Use: A Multi-Sample Analysis

Iacono, William G. -- University of Minnesota (Twin Cities)
Twin Family Study of Vulnerability to Substance Abuse

Ilgen, Mark Andrew -- University of Michigan at Ann Arbor
Developing an Intervention to Address Suicide Risk during Substance Use Disorder

Isgor, Ceylan -- Florida Atlantic University
Individual Differences in Relapse to Nicotine

Ito, Tiffany A. -- University of Colorado at Boulder
Multilevel Analysis of Self-Regulation and Substance Abuse

Itzhak, Yossef -- University of Miami School of Medicine
Reconsolidation and Extinction Processes in the Treatment of Drug Addiction

Ivanov, Iliyan S. -- Mount Sinai School of Medicine of NYU
Activation of Neuronal Networks Related to Risk for Addiction: A fMRI Study

Jamison, Robert N. -- Brigham and Women's Hospital
Substance Abuse Treatment for Chronic Pain Patients on Opioid Therapy

Javitch, Jonathan A. -- Columbia University Health Sciences
Molecular Mechanisms of Bacterial Homologs of Neurotransmitter: Sodium Symporters

Jiang, Faming -- SRI International
Development of Photoaffinity Ligands for the Alpha3Beta4 Nicotinic Acetylcholine

Johnson, Knowlton -- Pacific Institute for Research and Evaluation
A Community Trial in Alaska to Prevent Youth's Use of Legal Products to Get High

Johnson, Matthew Wayne -- Johns Hopkins University
Development of a Novel Trial-By-Trial Consequence Human Delay Discounting Task

Johnson, Matthew Wayne -- Johns Hopkins University
Sexual HIV Risk Behavior and Impulsive Decision Making in Cocaine Dependence

Johnson, Renee M. -- Boston University Medical Campus
Correlates of the Co-Occurrence of Violence and Substance Use among Boston Youth

Jones, Hendree E. -- Johns Hopkins University
Reinforcement Based Treatment for Pregnant Drug Abusers

Joseph, Jane E. -- University of Kentucky
Exploring the Neurobiological Response to Anti-Drug Media Messages with fMRI

Kantak, Kathleen M. -- Boston University
Cognitive Aspects of Addiction-Related Behavior

Kelley, Michelle L. -- Old Dominion University
Secondary Effects of Parent Treatment for Drug Abuse on Children

Kelly, Brian C. -- Purdue University (West Lafayette)
Prescription Drug Abuse in Club Subcultures: Contexts and Risks

Kelly, Brian C. -- Purdue University (West Lafayette)
Community-Based Methamphetamine Use and HIV Risk in China

Kerr, Thomas -- University of British Columbia
Evaluating the Natural History of Injection Drug Use

Khan, Maria -- National Development and Research Institutes
Longitudinal Study of Substance Use, Incarceration, and STI in the US

Kinlock, Timothy W. -- Friends Research Institute, Inc.
Implementing Treatment Initiatives for Criminal Justice Clients

Kissinger, Patricia J. -- Tulane University of Louisiana
Epidemiology of Drugs and HIV Sex Risk among Latino Migrants

Koenig, Barbara A. -- Mayo Clinic College of Medicine (Rochester)
Translating Addiction Genomics Research into Practice: Examining Ethics and Policy

Kollins, Scott H. -- Duke University
Smoking Reinforcement in Adults With and Without ADHD

Kombe, Gilbert -- ABT Associates, Inc.
Feasibility of Pharmacy-Based HIV Interventions among IDUS: Ha Giang, Vietnam

Kornetsky, Conan -- Boston University Medical Campus
Interactions between the Brain Reward and Pain Systems

Kosten, Thomas R. -- Baylor College of Medicine
Developing Immunotherapeutics for Methamphetamine Abuse

Kral, Alexander H. -- Research Triangle Institute
International Feasibility Study of Pharmacy-Based HIV Prevention: San Francisco

Kral, Alexander H. -- Research Triangle Institute
Assessing Patterns of HIV Risk among IDUS in Neighborhood Environments Over Time

Krishnan-Sarin, Suchitra -- Yale University
Incentive-Based Intervention for Smoking Cessation and Prevention in High Schools

Kumar, Anil -- University of Missouri (Kansas City)
HIV, Drug Abuse and Neurotoxicity

Kutchan, Toni M. -- Donald Danforth Plant Science Center
Evolution of Pathways to Pharmaceuticals in the Poppy Family

Kuzhikandathil, Eldo V. -- University of Medicine and Dentistry of New Jersey
Regulation of D1 Dopamine Receptor Expression by NcRNA in Cocaine Addiction

Labar, Kevin S. -- Duke University
Brain Imaging Studies of Negative Reinforcement in Humans

Lalumiere, Ryan T. -- Medical University of South Carolina
Infralimbic Regulation of Memory Consolidation of Extinction of Cocaine-Seeking

Lankenau, Stephen E. -- Children's Hospital (Los Angeles)
Evaluation of Overdose Prevention Programs for Injection Drug Users

Lapinsky, David J. -- Duquesne University
Non-Tropane Irreversible Dopamine Transporter Ligands

Latimer, William W. -- Johns Hopkins University
Randomized Trial of IFCBT-HIVPI to Prevent HIV among Non-Injection Drug Users

Lee, Christine M. -- University of Washington
Indicated Marijuana Prevention for Frequently Using College Students

Lejuez, Carl W. -- University of Maryland (College Park Campus)
Novel Intervention for Drug Use and HIV Risk among Anxiety Sensitive Heroin Users

Lerman, Caryn -- University of Pennsylvania
Neural Substrates of Cognitive Deficits in Nicotine Withdrawal

Leve, Leslie Diane -- Oregon Social Learning Center, Inc.
Juvenile Justice Girls: Pathways to Adjustment and System Use in Young Adulthood

Leventhal, Adam Matthew -- University of Southern California
Mechanisms Linking Anhedonia and Tobacco Addiction

Li, Chiang-Shan Ray -- Yale University
Thalamic Processes of Self Control in Cocaine Dependence

Li, Guigen -- Texas Tech University
Searching for Novel Analgesic and Anti-Inflammatory Agents

Li, Ming D. -- University of Virginia (Charlottesville)
Fine Mapping Susceptibility Loci for Nicotine Dependence

Licata, Stephanie C. -- Mc Lean Hospital (Belmont, MA)
Neurochemical Substrates of Sedative/Hypnotic Action: Proton MRS Studies

Liddle, Howard A. -- University of Miami School of Medicine
Center for Implementing Juvenile Justice Drug Abuse and HIV Systems Interventions

Liddle, Howard A. -- University of Miami School of Medicine
Juvenile Offender HIV Prevention and Drug Abuse Services

Lindberg, Iris -- University of Maryland (Baltimore)
Deorphanizing the Peptidome

Ling, Walter -- University of California (Los Angeles)
Sustained-Release Methylphenidate for Management of Methamphetamine Use Disorders

Lisman, John E. -- Brandeis University
CRCNS: Quantitative Description of Initial Biochemical Steps in LTP

Liu, Christina H. -- Massachusetts General Hospital
In Vivo Profiling of Glial and Neuronal Activities in Psychostimulant Abuse

Liu, Jingyu -- The Mind Research Network
A Multilevel Vulnerability Study of Substance Abuse via CNV, Brain Activation..

Liu-Chen, Lee-Yuan -- Temple University
Cellular Pharmacology of Kappa Opioid Receptor

Lofwall, Michelle Renee -- University of Kentucky
Efficacy of Extended Release Tramadol for Treating Prescription Opioid Withdrawal

Lord, Sarah E. -- National Development and Research Institutes
Feasibility of Online Parent Training to Promote Parent-Adolescent Communication

Lowen, Steven Bradley -- Mc Lean Hospital (Belmont, MA)
fMRI Correlates of Olfactory and Visual Cues in Tobacco Smoking

Lukas, Scott E. -- Mc Lean Hospital (Belmont, MA)
Citicoline-Induced Modulation of Cannabis Effects: Imaging and Mechanism of Action

Lundahl, Leslie H. -- Wayne State University
Smoked Marijuana Discrimination and Marijuana Choice in Humans...

Lysle, Donald T. -- University of North Carolina (Chapel Hill)
Neural Mechanisms of Heroin-Induced Conditioned Immunomodulation

Mackenzie, Robert George -- Wayne State University
Inducible Regulation of Key Transcription Factors in Dopamine Neurons

Mackey, Sean C. -- Stanford University
Learned Control of Frontal and Limbic Systems via Real-Time fMRI

Mackinnon, David P. -- Arizona State University (Tempe Campus)
Estimating Mediation Effects in Prevention Studies

Madura, Jeffry D. -- Duquesne University
CRCNS: Computational and Experimental Study of Dopamine and Serotonin Transporter

Mahadevan, Anu -- Organix, Inc.
Development of CB2 Agonists for Treatment of Pain

Makriyannis, Alexandros -- Northeastern University
Novel Medications for Cannabis Dependence

Malter, James -- University of Wisconsin (Madison)
Pin1 in Synaptic Plasticity and Translation

Mark, Gregory P. -- Oregon Health and Science University
CRF System and Methamphetamine Extinction

Marks, Michael J. -- University of Colorado at Boulder
Genetics of Nicotine Tolerance: Role of Receptors

Marlatt, G. Alan -- University of Washington
Mindfulness-Based Relapse Prevention: Efficacy and Mechanisms

Marsch, Lisa A. -- National Development and Research Institutes
Computer-Delivered Psychosocial Treatment for Adolescent Substance Use Disorders

Martin, Eileen Margaret -- University of Illinois at Chicago
Decision Making and Drug Abuse in the Chicago MACS

Mason, Barbara J. -- Scripps Research Institute
Gabapentin Treatment of Cannabis Dependence

Mason, Graeme F. -- Yale University
GABA Effects of Nicotine in Men and Women

Mateu-Gelabert, Pedro -- National Development and Research Institutes
Staying Safe: Training IDUS in Strategies to Avoid HIV and HCV Infection

Matheson, Jennifer Lynne -- Colorado State University (Fort Collins)
Individual, Social and Educational Predictors of Program Completion for College Study

Mawhinney-Delson, Samantha M. -- University of Colorado (Denver)
Consequences of Drug Use and Informative Dropout on HIV/AIDS Outcomes in the MACS

Maxwell, Jane C. -- University of Texas (Austin)
Monitoring the Changing Methamphetamine Market in the Austin Area

Mayes, Linda Carol -- Yale University
ERP Neurobehavioral Assessment of Negative Reinforcement in Adolescents

Mayford, Mark R. -- Scripps Research Institute
Transgenic Probes of Active Circuits

McCaffrey, Daniel F. -- Rand Corporation
The Causal Effect of Community-Based Treatment for Youths

McCaul, Mary E. -- Johns Hopkins University
Gender Effects on Amphetamine-Induced Dopamine Release and Subjective Responses

McClernon, Francis Joseph -- Duke University
Neuropharmacology of Response Inhibition in Comorbid ADHD and Nicotine Dependence

McClung, Colleen A. -- University of Texas S.W. Medical Center (Dallas)
Addiction-Like Behavior in Models of Mood Disorders: Role of CLOCK and NPAS2

McMahon, Lance R. -- University of Texas Health Science Center (San Antonio)
Nicotine Dependence: Neuropharmacology in Monkeys

McMahon, Lance R. -- University of Texas Health Science Center (San Antonio)
Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical Studies

McMahon, Lance R. -- University of Texas Health Science Center (San Antonio)
Treatment of Cannabinoid Withdrawal in Rhesus Monkeys

McManus, Michael T. -- University of California (San Francisco)
Resolving MicroRNA Targets

McRae, Aimee L. -- Medical University of South Carolina
Buspirone Treatment for Marijuana Dependence

Meara, Ellen R. -- Harvard University (Medical School)
Parity, Child Mental Health, and Substance Abuse

Mehler, Ernest L. -- Weill Medical College of Cornell University
Functional Properties of Protein Segments in Receptors and Transporters

Merchant, Roland C. -- Rhode Island Hospital (Providence, RI)
Brief Intervention for Drug Misuse for the Emergency Department (BIDMED)

Meredith, Gloria E. -- Rosalind Franklin University of Medicine and Science
Mechanisms Underlying Reward-Related Synaptogenesis

Metzger, David S. -- University of Pennsylvania
Efficacy of Drug-HIV Counseling among IDU at Methadone Clinics in Jakarta

Meyerhoff, Dieter J. -- Northern California Institute Research and Education
Polysubstance Use and Chronic Smoking: Neuroimaging and Cognition

Miller, Brenda A. -- Pacific Institute for Research and Evaluation
Prevention of Young Adult Drug Use in Club Settings

Miller, Gregory M. -- Harvard University (Medical School)
TAAR1 Polymorphisms in Rhesus Monkeys

Milner, Teresa A. -- Weill Medical College of Cornell University
Stress-Opioid Interaction in Hippocampus

Minnes, Sonia -- Case Western Reserve University
The Effects of Prenatal Cocaine Exposure in Adolescence

Miranda, Robert -- Brown University
Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents

Mitchell, James E. -- Neuropsychiatric Research Institute
Longitudinal Assessment of Bariatric Surgery (LABS)

Mitchell, Suzanne H. -- Oregon Health and Science University
Imaging Temporal Discounting in Smokers and Nonsmokers

Montague, P. Read -- Baylor College of Medicine
Computational Substrates of Addiction and Reward

Moore, Richard Douglas -- Johns Hopkins University
HIV Disease Outcomes in Drug Users in Clinical Practice

Moore, Todd M. -- University of Tennessee (Knoxville)
Ecological Momentary Assessment of Relapse to Substance Use Following Treatment

Morgan, Michael M. -- Washington State University
Neural Mechanisms for Enhanced Cannabinoid/Opioid Antinociception

Morgan, Michael M. -- Washington State University
Cellular Mechanisms of Opioid Tolerance

Morikawa, Hitoshi -- University of Texas (Austin)
Calcium Signaling in the Brain Reward Circuit and Drug Addiction

Moron-Concepcion, Jose A. -- University of Texas Medical Branch at Galveston
Mechanisms Underlying Opiate-Induced Neuroplasticity at the Synapse

Morrell, Joan I. -- Rutgers The State University of New Jersey (Newark)
Maternal Rat Preferences for Pups versus Cocaine

Murphy, Sheigla B. -- Scientific Analysis Corporation
A Qualitative Study of Women Prescription Drug Sellers

Mutchler, Matt -- California State University (Dominguez Hills)
Sex-Drugs and HIV: How Substances Became Associated with Sex among...

Myers, Janet -- University of California (San Francisco)
Navigator Enhanced Case Management for Jail Inmates

Nair, Madhavan P. -- Florida International University
Polydrug Nanocarrier to Treat Opiate Addiction and HIV Disease

Narayan, Roger J. -- University of North Carolina (Chapel Hill)
Autonomous Treatment of Opioid Abuse

Narendran, Rajesh -- University of Pittsburgh at Pittsburgh
Imaging Dopamine D2 Agonist Binding Sites in Cocaine Dependence with [11C]NPA

Narendran, Rajesh -- University of Pittsburgh at Pittsburgh
Vesicular Monoamine Transporter 2 Imaging in Cocaine Abuse

Nefzi, Adel -- Torrey Pines Institute for Molecular Studies
Innovative Approaches to Oligoheterocyclic Peptidomimetics

Negus, Sidney S. -- Virginia Commonwealth University
Medications Development for Stimulant Abuse

Neighbors, Jeffrey D. -- University of Iowa
Pawhuskins: Potential Treatments for Stimulant Abuse

Nemoto, Tooru -- Public Health Institute
Substance Use and HIV Risk among Thai Women

Nesmith, Elizabeth Grooms -- Medical College of Georgia (MCG)
Inflammation and Sub-Clinical Renal Damage in Cocaine-Dependent African Americans

Neumaier, John F. -- University of Washington
The Role of 5-HT1B Receptors in Brain Reward Circuits

Newton, Philip M. -- Ernest Gallo Clinic and Research Center
Extinction Is Mediated By the Infralimbic Cortex and Protein Kinase C Epsilon

Newton, Thomas Frederick -- Baylor College of Medicine
N-Acetylcysteine as a Potential Treatment for Methamphetamine Dependence

Noel, Richard J. -- Ponce School of Medicine
Synergistic Neurotoxicity of Speedball and HIV Toxins

Nyamathi, Adeline M. -- University of California (Los Angeles)
HBV Prevention for Homeless at Risk for HBV/HCV/HIV

O'Banion, Michael Kerry -- University of Rochester
Neuroinflammation and Glial ROS in Methamphetamine Neurotoxicity

O'Farrell, Timothy J. -- Harvard University Medical School
Behavioral Couples Therapy for Female Drug-Abusing Patients

Olive, M. Foster -- Medical University of South Carolina
mGLuR5 Antagonists for Methamphetamine Addiction

Olmstead, Todd A. -- George Mason University
Estimating the Price Elasticities of Demand for Illicit Drugs

Oncken, Cheryl -- University of Connecticut School of Medicine and Dentistry
Exercise in Smoking Cessation in Postmenopausal Women

Orson, Frank M. -- Baylor College of Medicine
Vaccines for Sustainable Therapy of Opiate Addiction

Osterhout, John J. -- Angelo State University
Development of Therapeutics to Eliminate HIV

Ostrow, David G. -- National Opinion Research Center
Men's Assessment of Social Support and Risk Networks

Pagan, One R. -- West Chester University of Pennsylvania
Cocaine-Induced Planarian Behavior and Its Modulation by Sesquiterpene Lactones

Page-Shafer, Kimberly -- University of California (San Francisco)
Acute Hepatitis C Infection in Young Injectors

Paige, Mikell -- Georgetown University
Design and Synthesis of New Neuronal NACHr Silent Desensitizers for Drug Abuse

Pan, Zhizhong Z. -- University of Texas M.D. Anderson Cancer Center
Impact of Pain on Sensitivity to Opioid Reward

Pankratz, Melinda M. -- Pacific Institute for Research and Evaluation
Comparing Multiple Methods of Measuring Fidelity of Curriculum Implementation

Paradis, Suzanne -- Brandeis University
Identification of the Protein Kinases Which Regulate Mammalian Synapse Formation

Patten, Christi A. -- Mayo Clinic College of Medicine (Rochester)
Tobacco Cessation Treatment for Alaska Native Youth

Paulus, Martin P. -- University of California (San Diego)
Neurobiology of Transition to Stimulant Dependence

Paulus, Martin P. -- University of California (San Diego)
Negative Reinforcement and Interoceptive Dysfunction in Stimulant Dependence

Peoples, Laura Lynn -- University of Pennsylvania
The Role of Cocaine-Induced Changes in OMPFC Neurophysiology in Cocaine Addiction

Perry, David C. -- George Washington University
Chronic Nicotine Effects on Receptor Subtypes

Persidsky, Yuri -- Temple University
Mechanisms and Interventions for Methamphetamine and HIV-1 Induced CNS Injury

Peterson, Eric C. -- University of Arkansas Medical Sciences (Little Rock)
Antibody-Nanoparticle Conjugates for the Treatment of Methamphetamine Abuse

Peterson, Ruth D. -- Ohio State University
Spatial Patterns of Social Isolation, Youthful Marijuana Use, and Sexual/HIV Risk

Phillips, Kristina T. -- University of Northern Colorado
Reduction of Medical Complications Associated with Injection Drug Use

Pickel, Virginia M. -- Weill Medical College of Cornell University
EM-Transmitter Interactions of Striatal Opioid Neurons

Piomelli, Daniele -- University of California (Irvine)
Characterization of a Novel Brain Cannabinoid Ligand

Pleasure, Samuel Jeremy -- University of California (San Francisco)
Defective Forebrain Development in Mutant Mice

Polcin, Douglas L. -- Public Health Institute
Intensive Motivational Interviewing for Methamphetamine Dependence

Prado, Guillermo -- University of Miami School of Medicine
Familias Unidas Stage III Study: Preventing Substance Abuse in Hispanic Youth

Prado, Guillermo -- University of Miami School of Medicine
Preventing Drug Abuse and HIV in Hispanic First Offenders

Premkumar, Louis S. -- Southern Illinois University School of Medicine
A Novel Approach for Chronic Pain Treatment Using Resiniferatoxin

Prendergast, Michael L. -- University of California (Los Angeles)
Pacific Coast Research Center of CJ-DATS 2

Prendergast, Michael L. -- University of California (Los Angeles)
Using Incentives to Improve Parolee Participation and Attendance in Community

Prochaska, James O. -- University of Rhode Island
Comparing Population Cessation Services with Emphasis on Unmotivated Smokers

Quintero, Gilbert A. -- University of Montana
Information and Communication Technologies in Collegiate Drug Use Practices

Rademacher, David J. -- Rosalind Franklin University of Medicine and Science
The Role of Activity-Regulated Cytoskeletal-Associated Protein in Amphetamine Pla

Ramchand, Rajeev N. -- Rand Corporation
Behavioral Intentions and Associated Outcomes over Party-Oriented Vacations

Reggio, Patricia Hodapp -- University of North Carolina (Greensboro)
Molecular Determinants of Cannabinoid Activity

Reid, Malcolm S. -- New York University School of Medicine
Clinical Laboratory Evaluations of Aprepitant for the Tx of Opioid Dependence

Renshaw, Perry Franklin -- University of Utah
Citicoline Treatment of Methamphetamine Dependence

Repunte-Canonigo, Vez -- Scripps Research Institute
Role of MicroRNAs in Behavioral Sensitization to Cocaine

Reti, Irving M. -- Johns Hopkins University
The Role of NARP in Drug Abuse

Rhodes, Justin S. -- University of Illinois Urbana (Champaign)
The Functional Significance of Exercise-Induced Neurogenesis in Cocaine Reward

Rich, Josiah D. -- Miriam Hospital
A Randomized Trial of Continued Methadone Maintenance vs. Detoxification in Jail

Richards, Jerry B. -- State University of New York at Buffalo
Effects of Negative Consequences on Drug Self Administration in Rats

Richards, Jerry B. -- State University of New York at Buffalo
Drug Abuse and Impulsivity: Tests of Animal Models

Richardson, Gale A. -- University of Pittsburgh at Pittsburgh
Effects of Prenatal Cocaine Use: 21-Year Follow-Up

Ries, Richard K. -- University of Washington
Preventing Addiction Related Suicide

Riley, Barth B. -- Chestnut Health Systems, Inc.
Computer Adaptive Testing Methods

Roitman, Mitchell F. -- University of Illinois at Chicago
Modulation of NAc-DA Signaling By Learning, Motivational State and Peptides

Romero-Sandoval, Edgar Alfonso -- Dartmouth College
Cannabinoids and Neuroimmune Interactions

Rosen, Marc I. -- Yale University
Abstinence Linked Money Management

Rosenman, Robert Edward -- Washington State University
Development of Econometric Models for Improved Estimation of Prevention Program B

Rosenthal, Mark Z. -- Duke University
Randomized Controlled Trial Computer-Base Intervention to Augment Drug Counseling

Rothenberg, Richard B. -- Georgia State University
Combining Theoretical and Empirical Network Approaches to HIV Transmission

Rowe, Cynthia L. -- University of Miami School of Medicine
Long-Term Outcomes and Economic Impact of the Detention to Community Model

Rowlett, James K. -- Harvard University Medical School
Anxiolytic Effects and Abuse of BZ Receptor Ligands

Roy, Sabita -- University of Minnesota (Twin Cities)
Opioid Abuse, Opportunistic Infection and NeuroAIDS

Rudolph, Uwe -- Mc Lean Hospital (Belmont, MA)
GABAA Subtype-Specific Pharmacological Modulation of Reward-Related Behavior

Rudolph, Uwe -- Mc Lean Hospital (Belmont, MA)
Psychostimulant Actions: Essential Role of a2-GABA-A Receptors in the NAc

Ruger, Jennifer P. -- Yale University
Economic Evaluation of Drug Abuse Tx and HIV Prevention Services for Pregnant Women

Ruiz-Velasco, Victor -- Pennsylvania State University Hershey Medical Center
Coupling Mechanisms of NOP Receptors and Calcium Channels

Ruoho, Arnold E. -- University of Wisconsin (Madison)
Characterization of the Sigma-2 Receptor

Rusby, Julie C. -- Oregon Research Institute
Ecological Momentary Assessment of Peer Affiliation, Perceptions and Behavior

Rush, Craig R. -- University of Kentucky
Agonist Replacement Therapy for Methamphetamine Dependence: Human Lab Studies

Saccone, Nancy L. -- Washington University
Human Genetic Variation in Smoking and Addiction Risk

Sacks, Stanley -- National Development and Research Institutes
NDRI Rocky Mountain Research Center for CJ-DATS 2

Saggau, Peter -- Baylor College of Medicine
Optogenetic Tools for in Vivo Analysis of Cortical Circuit Plasticity

Salo, Ruth Eileen -- University of California (Davis)
Neural and Cognitive Correlates of Methamphetamine Use in Schizophrenia

Sanyal, Subhabrata -- Emory University
Transcriptional Regulation of Behavioral Adaptation in Drosophila

Sato-Bigbee, Carmen -- Virginia Commonwealth University
Buprenorphine Effects on Oligodendrocyte Development and Axonal Growth

Schackman, Bruce R. -- Weill Medical College of Cornell University
Economic Analysis of Rapid HIV and HCV Testing in Drug Abuse Treatment Programs

Schinke, Steven P. -- Columbia University (New York Morningside)
Drug Abuse, Adolescent Girls, and Prevention: YMCA Community Collaboration

Schnoll, Robert A. -- University of Pennsylvania
An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence

Schnoll, Robert A. -- University of Pennsylvania
Assessment of High Dose Transdermal Nicotine for Fast Metabolizers of Nicotine

Schoenbaum, Geoffrey M. -- University of Maryland (Baltimore)
Corticolimbic Encoding of Conditioned Reinforcers: Relevance to Addiction

Schottenfeld, Richard S. -- Yale University
Pain and Opioid Dependence (POD)

Schwartz, Seth J. -- University of Miami School of Medicine
The Role of Culture in Thriving and Risk Behavior in Hispanic Adolescents

Selley, Dana E. -- Virginia Commonwealth University
CB1 Receptor Regulation by Cannabinoid Receptor Interacting Protein CRIP1a

Selley, Dana E. -- Virginia Commonwealth University
Role of G-Gamma-7 in Striatal Cannabinoid and D2 Dopamine

Setlow, Barry -- Texas A&M University System
Neural Mechanism of Enduring Cocaine Effects on Impulsive Choice

Shahan, Timothy A. -- Utah State University
Behavioral Momentum of Cocaine Self-Administration

Shane, Matthew -- The Mind Research Network
Using rt-fMRI to Modulate Neural Responses to Drug and Nondrug Rewards in Cocaine

Sharar, Sam R. -- University of Washington
Identifying Virtual Reality Analgesia Mechanisms by Pharmacologic Manipulation

Shaw, Daniel S. -- University of Pittsburgh at Pittsburgh
Substance Use in Young Men: Genes, Brain Function and Early Social Development

Sheidow, Ashli J. -- Medical University of South Carolina
Stage II Research on Outpatient Treatment for Adolescents with Comorbidity

Sherman, Steven J. -- Indiana University (Bloomington)
Teen and Adult Smoking: Intergenerational Transmission and Prevention Applications

Shiflett, Michael William -- Rutgers The State University of New Jersey (Newark)
Pavlovian Influences on Reward-Seeking Behavior

Shohamy, Daphna -- Columbia University (New York Morningside)
Neural Systems of Learning and Memory in Addiction

Shuter, Jonathan -- Montefiore Medical Center (Bronx, NY)
A Trial to Test the Efficacy of a Tailored Intensive Smoking Cessation Intervention

Sim-Selley, Laura J. -- Virginia Commonwealth University
Brain Cannabinoid Signaling: Selectivity and Adaptation

Sinha, Rajita -- Yale University
Development of Guanfacine to Decrease Drug Craving, Anxiety and Cocaine Relapse

Slesinger, Paul A. -- Salk Institute for Biological Studies
Molecular Changes in Mesolimbic Dopamine Signaling with Psychostimulants

Slesnick, Natasha -- Ohio State University
Stage 1 Treatment Development with Homeless Mothers and Their 2-6 Year Old Children

Slesnick, Natasha -- Ohio State University
Adolescent Involvement in Parental Substance Abuse Treatment: Evaluation of EBFT

Smith, Courtney Elizabeth -- Virginia Commonwealth University
Indirect Screening: Enhancing Identification of Illicit Drug Use during Pregnancy

Smith, Dana K. -- Oregon Social Learning Center, Inc.
Preventing Drug Abuse and HIV/AIDS in Delinquent Youths: An Integrated Intervention

Spigelman, Igor -- University of California (Los Angeles)
Development of Peripherally-Acting Cannabinoid 1 Receptor Ligands

Stein, Michael D. -- Butler Hospital (Providence, RI)
Linkage of Hospitalized Opioid Users to Buprenorphine

Sterk, Claire E. -- Emory University
Neighborhood Effects on Drug Use among African American Adults

Stitzer, Maxine L. -- Johns Hopkins University
Improving Care Continuity in Drug Abuse Treatment

Stone, Kristen C. -- Women and Infants Hospital (Rhode Island)
Postpartum Sleep Effects on Smoking Relapse

Stoops, William Walton -- University of Kentucky
Neuropharmacology of Tramadol: Clinical Efficacy and Abuse Potential

Strathdee, Steffanie A. -- University of California (San Diego)
Proyecto Parejas: HIV/STI Risks among FSWs and Their Non-Commercial Partners

Straubinger, Robert M. -- State University of New York at Buffalo
Peripheral Biomarkers of Cocaine Dependence and Relapse

Sumikawa, Katumi -- University of California (Irvine)
Maternal Smoking and Hippocampal Circuits

Sumikawa, Katumi -- University of California (Irvine)
Nicotine Abuse and Memory Mechanisms

Surratt, Christopher K. -- Duquesne University
Dopamine Transporter Structure and Function

Surratt, Hilary L. -- University of Delaware
The Diversion of Antiretroviral Medications to Street Markets

Tanabe, Jody Lee -- University of Colorado (Denver)
Neural Correlates of Avoidance Learning in Substance Abuse

Tang, Wan -- University of Rochester
Analysis of Count Data with Structural Zeros: CTN0018 and CTN0019

Tapper, Andrew R. -- University of Massachusetts Medical School (Worcester)
The Role of Nicotinic Receptors in Nicotine Withdrawal

Tarantino, Lisa M. -- University of North Carolina (Chapel Hill)
Organismal and Genetic Networks in Drug Reward and Reinforcement

Taxman, Faye S. -- George Mason University
Action Research to Advance Implementation in the CJS: CJ-DATS 2 Continuation

Taylor, Jane R. -- Yale University
Incentive Motivation and Addiction: PKA Mechanisms

Terman, Gregory W. -- University of Washington
Modulation of Pruritus by Spinal Cannabinoids

Teruya, Cheryl -- University of California (Los Angeles)
Exploring Proposition 36 as a Turning Point in Life Course Drug Use Trajectories

Tesche, Claudia Denke -- University of New Mexico
The Neuroscience of Motivational Interviewing Change Talk

Thakur, Ganeshsingh Arjunsingh -- Northeastern University
Allosteric Modulators of CB1 Cannabinoid Receptor

Tidey, Jennifer W. -- Brown University
Smoking Abstinence and Lapse Effects in Smokers with Schizophrenia and Controls

Tiedge, Henri -- SUNY Downstate Medical Center
Small RNAs in Neurons

Tolma, Eleni L. -- University of Oklahoma Health Sciences Center
A Longitudinal Analysis of Gender, Youth Assets and Adolescent Substance Use

Tracy, Elizabeth M. -- Case Western Reserve University
Role of Personal Social Networks in Post Treatment Functioning

Trickett, Penelope K. -- University of Southern California
From Child Maltreatment to Adolescent Substance Abuse: Risks, Protective Factors

Tsao, Jennie C. -- University of California Los Angeles
Pain, Psychological Symptoms, and Prescription/Illicit Drug Use in the MACS

Vandrey, Ryan G. -- Johns Hopkins University
Efficacy and Safety of Dronabinol (Oral THC) for Treating Cannabis Dependence

Vaughan, Roxanne A. -- University of North Dakota
Phosphorylation and Regulation of Dopamine Transporters

Visher, Christy A. -- University of Delaware
Implementing Effective HIV/Drug Treatment in Corrections - MidStates CJ-DATS Center

Vitaliano, Gordana D. -- Mc Lean Hospital (Belmont, MA)
New Dopamine Transporter MRI Nanoprobes for Addiction Research

Vorel, Stanislav R. -- New York State Psychiatric Institute
NMDA Glutamate Receptor Transmission in Extinction of Cocaine-Seeking Behavior

Vulchanova, Lyudmila H. -- University of Minnesota (Twin Cities)
The Neurosecretory Protein VGF: Contributions to Pain

Wagner, Eric F. -- Florida International University
Brief Intervention for Marijuana Use among Latino Youth

Wagner, John J. -- University of Georgia (UGA)
Cocaine-Induced Metaplasticity in the Hippocampus

Wakschlag, Lauren S. -- University of Illinois at Chicago
Prenatal Smoking and the Substrates of Disruptive Behavior in Early Life

Walker-Schramm, Denise D. -- University of Washington
Marijuana Dependence Treatment PRN

Walsh, Sharon L. -- University of Kentucky
New Neural Targets for Opioid Use Disorders: Human Studies

Wang, Fan -- Duke University
Genetically Encoded Anatomical Probes for Neuronal Activity and Plasticity

Wang, Gene-Jack -- Brookhaven Science Associates - Brookhaven Lab
Studies in Cocaine Abuse

Warren, Keith Leverett -- Ohio State University
Maintenance and Correlates of Cooperative Behavior in Therapeutic Communities

Weiss, Stanley Jerome -- American University
Incentive Properties of Abused Drugs

Werch, Chudley E. -- University of Florida
Multiple Behavior SBIRT Model of Drug Abuse among Emerging Adults in Primary Care

Whistler, Jennifer L. -- Ernest Gallo Clinic and Research Center
Trafficking and Signaling of Opioid Receptor Subtypes and Heterodimers

Whiteaker, Paul -- St. Joseph's Hospital and Medical Center
Construction & Expression of Concatemeric Alpha6beta2 Nicotinic Acetycholine Recept

Wiebe, Sandra A. -- University of Nebraska (Lincoln)
Prenatal Tobacco Exposure, Self Regulation, Externalizing Behaviors in Early Childhood

Wilcox, George Latimer -- University of Minnesota (Twin Cities)
Phosphoproteomics of Opioid Tolerance

Wiley, Jenny L. -- Virginia Commonwealth University
Endogenous Cannabinoids and Brain Function

Williams, Chyvette -- University of Illinois at Chicago
Formative Research to Understand High-Risk Community Sex Networks

Williams, Jill M. -- University of Medicine/Dentistry of New Jersey
Double-Blind Placebo-Controlled Trial of Nicotine Nasal Spray

Williams, John T. -- Oregon Health and Science University
Agonist Selective Activation of Mu-Opioid Receptors

Winder, Danny G. -- Vanderbilt University
Physiology of Periaqueductal Gray Dopamine Neurons

Wood, David A. -- Beth Israel Deaconess Medical Center
Neural Mechanisms of the Methamphetamine-Sensitive Circadian Oscillator

Woodall, W. Gill -- University of New Mexico
Web-Based Substance Abuse STD/HIV Prevention

Woodward, John J. -- Medical University of South Carolina
Neural Actions of Toluene

Woody, George E. -- University of Pennsylvania
Suboxone and Methadone for HIV Risk Reduction in Subutex Injectors

Woolverton, William L. -- University of Mississippi Medical Center
Temporal Discounting of Punishment of Drug Choice

Wu, Li-Tzy T. -- Duke University
Classification of Substance Use Severity and Treatment Outcomes: NIDA CTN Studies

Wu, Ping -- New York State Psychiatric Institute
Drug Abuse, Criminal Justice System Involvement and Health Disparities in Youth

Xu, Ming -- University of Chicago
Extinction of Cue-Elicited Cocaine Seeking

Yang, Xinmai -- University of Kansas (Lawrence)
The Assessment of Brain Functional Alterations Due to Drug Abuse/Addiction with PAI

Yin, Hang -- University of Colorado at Boulder
Transforming Clinical Pain Control by Targeting a Novel Non-Neuronal Receptor

Yin, Hang -- University of Colorado at Boulder
Optimizing the Clinical Efficacy of Opioids by TLR4 Blockade

Yoder, Karmen K. -- Indiana University (Purdue University at Indianapolis)
Assessment of the Dopamine System in Fibromyalgia

Zahniser, Nancy Rutledge -- University of Colorado Denver
Individual Differences in Cocaine Activation/Reward and the Dopamine Transporter

Zhang, Yan -- Virginia Commonwealth University
Non-Peptide Mu Opioid Receptor Selective Antagonists

Zhang, Yanan -- Research Triangle Institute
Bivalent Ligands as Molecular Probes for CB1/OX1 Receptor Heterodimers

Zhdanova, Irina V. -- Boston University Medical Campus
Circadian System and Prenatal Cocaine in Zebrafish

Zheng, Guangrong -- University of Kentucky
Development of Antagonists for M5 Muscarinic Acetylcholine Receptor

Zhu, Jun -- University of South Carolina at Columbia
Role of Dopamine Transporter: HIV-1 Tat Protein and Nicotine Sensitization

Zhu, Jun -- University of South Carolina at Columbia
Role of DARPP-32: Individual Responsiveness to Nicotine

Zjawiony, Jordan K. -- University of Mississippi
Chemistry and Pharmacology of Newly Emerging Psychoactive Plants

Zucker, Robert A. -- University of Michigan at Ann Arbor
Brain Endophenotypes Modulating Drug Abuse Risk

Zule, William A. -- Research Triangle Institute
The Role of Dead Space Syringes in HIV Epidemics Amount IDU's - Drug Abuse Aspect

Zule, William A. -- Research Triangle Institute
A Tailored Cue-Card Driven HIV/STI Intervention for High Risk Groups Pilot Study


Index

Research Findings

Program Activities

Extramural Policy and Review Activities

Congressional Affairs

International Activities

Meetings and Conferences

Media and Education Activities

Planned Meetings

Publications

Staff Highlights

Grantee Honors



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