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NIDA Home > Publications > Director's Reports > September, 2007 Index    

Director's Report to the National Advisory Council on Drug Abuse - September, 2007



Program Activities

New NIDA PAs and RFAs

On April 24, 2007, NIDA issued two Program Announcements entitled Medications Development for the Treatment of Cannabis-Related Disorders (R01) PA-07-365 and Medications Development for the Treatment of Cannabis-Related Disorders (R21) PA-07-366. Through this FOA, NIDA solicits grant applications from institutions/organizations that propose to conduct preclinical and/or clinical research directed towards the identification, evaluation, and development of safe and effective medications for the treatment of Cannabis Related Disorders, and their medical and psychiatric consequences.

On July 13, 2007, NIDA issued an RFA entitled Criminal Justice Drug Abuse Treatment Studies 2 (CJ-DATS 2) (U01) (RFA-DA-08-002). Through this RFA, NIDA invites cooperative agreement applications to participate as Research Centers in the second phase of the national Criminal Justice Drug Abuse Treatment Studies (CJ-DATS 2). The goal of this cooperative research program is to develop and test systems-level models that integrate public health and public safety approaches for criminal justice-involved adults and adolescents with drug abuse and addictive disorders. Letter of Intent Receipt Date for this RFA: September 26, 2007; Application Receipt Date: October 26, 2007.

PAs and RFAs with Other NIH Components/Agencies

On June 4, 2007, NIDA, in conjunction with the National Institute of Environmental Health Sciences (NIEHS) issued a Program Announcement entitled Psychopharmacology of Widely Available Psychoactive Natural Products (R01) (PA-07-374). This Funding Opportunity Announcement (FOA) solicits research grant applications that characterize the chemistry, psychopharmacology, and/or toxicology of acute and chronic exposure to psychoactive natural products, as well as the transition in the use of these products to licit or illicit drugs of abuse.

On June 4, 2007, NIDA, in conjunction with the National Institute of Environmental Health Sciences (NIEHS) issued a Program Announcement entitled Psychopharmacology of Widely Available Psychoactive Natural Products (R03) (PA-07-375). This Funding Opportunity Announcement (FOA) solicits research grant applications that characterize the chemistry, psychopharmacology, and/or toxicology of acute and chronic exposure to psychoactive natural products, as well as the transition in the use of these products to licit or illicit drugs of abuse.

On June 7, 2007, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R01) (PAR-07-379). The Purpose of this PA is to encourage behavioral and social science research on the causes and solutions to health and disabilities disparities in the U. S. population. Health disparities between, on the one hand, racial/ethnic populations, lower socioeconomic classes, and rural residents and, on the other hand, the overall U.S. population are major public health concerns. Emphasis is placed on research in and among three broad areas of action: 1) Public policy, 2) health care, and 3) disease/disability prevention. Particular attention is given to reducing "health gaps" among groups. Proposals that utilize an interdisciplinary approach, investigate multiple levels of analysis, incorporate a life-course perspective, and/or employ innovative methods such as system science or community-based participatory research are particularly encouraged.

On June 7, 2007, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R21) (PAR-07-380). The Purpose of this PA is to encourage behavioral and social science research on the causes and solutions to health and disabilities disparities in the U. S. population. Health disparities between, on the one hand, racial/ethnic populations, lower socioeconomic classes, and rural residents and, on the other hand, the overall U.S. population are major public health concerns. Emphasis is placed on research in and among three broad areas of action: 1) Public policy, 2) health care, and 3) disease/disability prevention. Particular attention is given to reducing "health gaps" among groups. Proposals that utilize an interdisciplinary approach, investigate multiple levels of analysis, incorporate a life-course perspective, and/or employ innovative methods such as system science or community-based participatory research are particularly encouraged.

On June 11, 2007, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Advancing Novel Science in Women's Health Research (ANSWHR) (R21) (PAS-07-381). The purpose of this Funding Opportunity Announcement (FOA), issued by the Office of Research on Women's Health (ORWH) and co-sponsoring NIH institutes and centers (ICs), is to promote innovative, interdisciplinary research that will advance new concepts in women's health research and the study of sex/gender differences. Recent research reports have established the importance of studying issues specific to women, including the scientific and clinical importance of analyzing data separately for females and males. ORWH is particularly interested in encouraging extramural investigators to undertake new interdisciplinary research to advance studies on how sex and gender factors affect women's health; however, applications in all areas of women's health and/or sex/gender research are invited.

On June 11, 2007, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Advancing Novel Science in Women's Health Research (ANSWHR) (R03) (PAS-07-382). The purpose of this Funding Opportunity Announcement (FOA), issued by the Office of Research on Women's Health (ORWH) and co-sponsoring NIH institutes and centers (ICs), is to promote innovative, interdisciplinary research that will advance new concepts in women's health research and the study of sex/gender differences. Recent research reports have established the importance of studying issues specific to women, including the scientific and clinical importance of analyzing data separately for females and males. ORWH is particularly interested in encouraging extramural investigators to undertake new interdisciplinary research to advance studies on how sex and gender factors affect women's health; however, applications in all areas of women's health and/or sex/gender research are invited.

On June 29, 2007, NIDA, in conjunction with a number of other NIH components, issued a PA entitled Neurotechnology Research, Development, and Enhancement (SBIR [R43/R44]) PA-07-389). Advances in the brain and behavioral sciences are being made rapidly, vastly improving our understanding of healthy brain function and offering promise to the millions suffering from brain and behavioral disorders. This Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to enable neuroscience and behavioral research through the development of novel, or the significant enhancement or improvement of currently existing, tools and approaches to be used in brain and behavioral research. Such tools and approaches could include those used in basic or clinical research, or for clinical treatment and care (e.g., assessment, diagnosis, and treatment of brain disorders). Research solicited under this funding opportunity announcement is not limited to any particular type of technology, level of analysis, or approach. Multidisciplinary teams of researchers are especially encouraged to apply. Technologies appropriate for study, development and enhancement under this FOA include hardware, software, and wetware (and combinations thereof).

On June 29, 2007, NIDA, in conjunction with a number of other NIH components, issued a PA entitled Neurotechnology Research, Development, and Enhancement (SBIR [R41/R42] PA-07-390). Advances in the brain and behavioral sciences are being made rapidly, vastly improving our understanding of healthy brain function and offering promise to the millions suffering from brain and behavioral disorders. This Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to enable neuroscience and behavioral research through the development of novel, or the significant enhancement or improvement of currently existing, tools and approaches to be used in brain and behavioral research. Such tools and approaches could include those used in basic or clinical research, or for clinical treatment and care (e.g., assessment, diagnosis, and treatment of brain disorders). Research solicited under this funding opportunity announcement is not limited to any particular type of technology, level of analysis, or approach. Multidisciplinary teams of researchers are especially encouraged to apply. Technologies appropriate for study, development and enhancement under this FOA include hardware, software, and wetware (and combinations thereof).

On June 29, 2007, NIDA, in collaboration with NIMH and NIAAA, issued a PA entitled Mentoring Programs to Diversify the Mental Health and Substance Abuse HIV/AIDS Workforce through Innovative Educational Initiatives (R25) (PAR-07-386). This funding opportunity announcement (FOA) was developed in response to: (i) simultaneous overrepresentation of individuals from racial and ethnic groups with HIV/AIDS, yet underrepresentation of individuals from racial and ethnic groups, individuals with disabilities, and individuals from disadvantaged backgrounds as HIV/AIDS researchers; (ii) insufficient scientific information about HIV/AIDS disparities experienced by members of underrepresented racial and ethnic groups; (iii) the paucity of HIV/AIDS mental health, and substance abuse research by investigators from underrepresented racial and ethnic groups; and (iv) the limited number of individuals from underrepresented racial and ethnic groups who are pursuing careers in HIV/AIDS mental health and/or substance abuse research. Through this PA participating Institutes encourage the development of research mentoring programs for graduate students, postdoctoral fellows, and early career faculty from underrepresented groups to improve the capacity for high quality HIV research and to facilitate the research career development of investigators in HIV/AIDS fields, particularly as they relate to mental health and substance abuse. This FOA solicits grant applications from applicant organizations that propose to: (i) develop a special summer institute for new and improved research mentorship programs--targeting individuals from underrepresented racial and ethnic groups, individuals with disabilities, or individuals from disadvantaged backgrounds--relevant to the HIV/AIDS research missions of NIMH, NIAAA and NIDA and/or (ii) establish a central network of senior mentors in HIV/AIDS research for mentees from underrepresented groups (for the purpose of this FOA, "underrepresented groups" is defined as individuals from racial and ethnic groups, individuals with disabilities, and individuals from disadvantaged backgrounds). These mentoring programs should have a thematic focus on research/educational activities that relate to the mental health, substance abuse or CNS aspects of HIV infection (e.g., disparities, neuropsychiatry, neuropathogenesis, prevention, treatment, services).

On July 19, 2007, NIDA, in conjunction with several other NIH Institutes, issued a PA entitled Health Research with Diverse Populations (R01) (PA-07-409). The purpose of this Funding Opportunity Announcement (FOA) is to invite grant applications for biological, behavioral, social, addictive, and mental health research related to the health of lesbian, gay, bisexual, transgender, intersex, and other diverse populations. Proposed research should be appropriate for the missions of one or more of the participating Institutes.

On July 24, 2007, NIDA and NIAAA jointly issued a PA entitled Genetic Epidemiology of Substance Use Disorders (R01) (PA-07-413). This funding opportunity announcement (FOA) solicits research to expand the application of genetic epidemiologic methods to studies of substance and alcohol use disorders (SUDs/AUD, drug and alcohol abuse and dependence) by applying genetic epidemiologic approaches to advance our understanding of developmental trajectories of SUD/AUD, differentiate genetic and environmental factors in the development and maintenance of SUD/AUD, broaden and refine phenotypic definitions of SUDs/AUD, guide the translation of etiologic findings to treatment, prevention, gene-finding and molecular studies, and meet the methodologic challenges of the field.

On July 24, 2007, NIDA and NIAAA jointly issued a PA entitled Genetic Epidemiology of Substance Use Disorders (R03) (PA-07-414). This funding opportunity announcement (FOA) solicits research to expand the application of genetic epidemiologic methods to studies of substance and alcohol use disorders (SUDs/AUD, drug and alcohol abuse and dependence) by applying genetic epidemiologic approaches to advance our understanding of developmental trajectories of SUD/AUD, differentiate genetic and environmental factors in the development and maintenance of SUD/AUD, broaden and refine phenotypic definitions of SUDs/AUD, guide the translation of etiologic findings to treatment, prevention, gene-finding and molecular studies, and meet the methodologic challenges of the field.

On July 24, 2007, NIDA and NIAAA jointly issued a PA entitled Genetic Epidemiology of Substance Use Disorders (R21) (PA-07-415). This funding opportunity announcement (FOA) solicits research to expand the application of genetic epidemiologic methods to studies of substance and alcohol use disorders (SUDs/AUD, drug and alcohol abuse and dependence) by applying genetic epidemiologic approaches to advance our understanding of developmental trajectories of SUD/AUD, differentiate genetic and environmental factors in the development and maintenance of SUD/AUD, broaden and refine phenotypic definitions of SUDs/AUD, guide the translation of etiologic findings to treatment, prevention, gene-finding and molecular studies, and meet the methodologic challenges of the field.

On July 24, NIDA, in collaboration with several other NIH Institutes, issued a PA entitled Developmental Pharmacology (R01) (PAR-07-416). The purpose of this PA is to encourage multidisciplinary, investigator-initiated basic and translational research in developmental pharmacology with particular emphasis on the role of ontogeny on drug metabolizing enzymes, transporters, receptors and signaling pathways activity across developmental periods from fetal life to adolescence.

On July 25, 2007, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Neuroimaging Informatics Software Enhancement for Improved Interoperability and Dissemination (R03) (PAR-07-417). This FOA intends to support modification and enhancement of existing neuroimaging informatics tools and resources that are hosted or being considered for inclusion into the NIH Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC, www.nitrc.org, public release scheduled for October 2007). Examples of such tools include image segmentation, image registration, image processing pipelines, statistical analysis packages, spatial alignment and normalization algorithms, and data format translators. Resources include well-characterized test datasets, data formats, and databases, among others. The proposed work shall significantly improve the interoperability and adoptability of neuroimaging informatics tools and resources and result in enhanced dissemination, adoption, and evolution of such tools and resources by the broader neuroimaging research community.

On August 3, 2007, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Data Ontologies for Biomedical Research (R01) (PAR-07-425). The NIH Blueprint for Neuroscience Research is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the nervous system. This FOA is released in affiliation with the Neuroscience Blueprint, with Institutes and Centers participating independently, and with participation by Institutes that are not part of the Neuroscience Blueprint.

On August 3, 2007, NIDA, in collaboration with numerous other NIH components, issued a PA entitled Sharing Data and Tools: Federation using the BIRN and caBIG Infrastructures (R01) (PAR-07-426). The NIH Blueprint for Neuroscience Research is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the nervous system. This FOA is released in affiliation with the Neuroscience Blueprint, with Institutes and Centers participating independently, and with participation by Institutes that are not part of the Neuroscience Blueprint. Sharing data and tools across a research community adds tremendous value to the efforts of that community. Search engines like Google show the power of sharing text based data. While strides have been made, the infrastructure necessary to share and query data sets that have more than just textual biomedical data is still under development. Examples of such heterogeneous data sets include those that contain images, clinical data, or genomic/gene expression data. Two large NIH supported infrastructure projects to allow data and tool sharing are the caBIG(TM) program and the Biomedical Informatics Research Network (BIRN). Many of the communities involved in neuroscience research embrace the data/tool sharing idea. Some communities, such as neuroimaging researchers, have seized it, and in so doing, have accrued scientific benefits that would have been otherwise out of reach. As a specific example, three neuroimaging research communities are serving as the biological test beds for the BIRN infrastructure (http://www.nbirn.net). The BIRN infrastructure has now matured to the point where it can serve as a platform for data sharing and informatics tool sharing that extends beyond the neuroimaging researchers involved in the test beds, to include other areas of neuroscience beyond imaging, and to include biomedical research beyond neuroscience. The caBIG(TM) program has goals that are related to those of the BIRN program, but has chosen a different development path. caBIG(TM) aims to develop applications and underlying architecture that connects data and tools in an open, federated environment. Interoperability in caBIG(TM) is based on standardizing interfaces and data, rather than on specific software systems used in BIRN. General information concerning caBIG can be found at https://cabig.nci.nih.gov/.

On August 21, 2007, NIDA, in collaboration with other NIH components and with the Administration for Children and Families (ACF) and CDC and SAMHSA, issued a PA entitled Research on Interventions for Child Abuse and Neglect (R01) (PA-07-437). This Funding Opportunity Announcement (FOA) solicits research project grant (R01) applications focused on conducting efficacy and effectiveness trials of child abuse and neglect interventions. Specifically, this FOA solicits grant applications that include various levels of interventions. For those interventions that need preliminary research, applicants should consider additional mechanisms, which are used to establish efficacy, including the R21 and R34, as appropriate. However, given the public health need for children and families who experience the negative effects of child abuse and neglect, interventions in which preliminary developmental/exploratory work has already been undertaken, and pilot studies, or in some cases efficacy trials, have demonstrated positive change are strongly encouraged for R01 grant applications under this FOA. Of particular interest is the development of large scale trials designed to target either or both the victims or perpetrators of child abuse and neglect, including preventive interventions. Child abuse and neglect is a complex public health issue likely caused by a myriad of factors, including individual-, family-, and community-level elements. Thus, a research program focused on understanding and addressing these problems must necessarily draw upon interdisciplinary theories and approaches. One of the goals of this FOA is to bring together multi-disciplinary and translational perspectives encompassing basic biomedical, behavioral and social science research in mental health, physical health, public health and prevention, alcohol and substance abuse, neurology, injury, trauma and child development, to advance our knowledge of child abuse and neglect. Only projects proposing rigorous scientific research designs will be considered; service demonstrations or other types of service programs are not eligible for funding under this FOA.

On July 18, 2007, NIDA, in collaboration with a number of other NIH components, issued an RFA entitled U.S.-India Bilateral Collaborative Research Partnerships (CRP) on the Prevention of HIV/AIDS (R21) (RFA-AI-07-031). This Funding Opportunity Announcement (FOA) solicits Exploratory/Developmental (R21) applications from United States (U.S.)-funded institutions with an Indian-institution partner to establish Collaborative Research Partnerships (CRP) in the field of HIV/AIDS prevention with an emphasis on topical microbicides as well as other modes of HIV/AIDS prevention. The U.S.-India Bilateral CRP Program is designed to develop collaborations between scientists and institutions in the U.S. and India to conduct high quality HIV/AIDS prevention research of mutual interest and benefit to both countries while developing the basis for future institutional and individual scientific collaborations. This FOA will utilize the research capacity of the institutions and scientists in both countries to advance the field of HIV/AIDS prevention and develop preliminary data that may support a research proposal to test an HIV/AIDS prevention program with public health significance.

On July 17, 2007, NIDA, in collaboration with numerous other NIH components, issued an RFA entitled Tools and Techniques for Elucidating and Manipulating Neural Circuit Development (R21) (RFA-MH-08-060). The NIH Blueprint for Neuroscience Research is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the central and peripheral nervous systems. In fiscal year 2008, the Blueprint is emphasizing neural development. This Funding Opportunity Announcement (FOA) solicits applications directed toward the discovery of novel and/or improved means for precise spatiotemporal analysis or manipulation of circuit assembly in the developing central and peripheral nervous systems. For the purposes of this FOA, neural circuit development is defined as processes occurring during prenatal and postnatal development (through adolescence) that begin with axon and dendrite formation and continue through axon guidance and pathfinding, myelination, synapse formation and synapse refinement. Tools and technologies for the study of invertebrates, vertebrates and/or humans are acceptable if the resulting resources will accelerate research in the area of neural circuit development.

On July 23, 2007, NIDA, in collaboration with several other NIH Institutes, issued an RFA entitled Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) (R01) (RFA-GM-08-002). This FOA solicits Research Project Grant (R01) applications from institutions/organizations proposing exceptionally innovative research on novel hypotheses or difficult problems, solutions to which would have an extremely high impact in biomedical or biobehavioral research that is germane to the mission of one or more of the participating NIH Institutes.

On August 8, 2007, NIDA, in collaboration with several other NIH Institutes, issued an RFA entitled Collaborative Research to Explore New Uses for Existing Radioligands (R21/R33) (RFA-DA-08-001). Through the issuance of this RFA, participating Institutes seek to encourage broader uses of established PET/SPECT radioligands by reducing barriers to their wider distribution, and expanding their utility to the study of diseases or organs for which the radioligand has not previously been studied. Applications for this RFA should demonstrate a high degree of innovation and novelty with regard to the new uses for existing radioligands. Although there is no requirement for preliminary data, a clear scientific rationale is essential. Applications for this RFA are expected to propose multi-institutional collaborations between investigators who have the capacity for routine production of a given radioligand for human use, and investigators who lack access to the radioligand but wish to demonstrate the feasibility of an innovative use for the radioligand in a novel patient population. The primary focus of the proposal must be on human studies; animal studies are allowable only if required to obtain regulatory approval for the ligands.

On August 9, 2007, NIDA, in collaboration with numerous other NIH components, issued an RFA entitled Genome-wide Association Studies in the Genes, Environment, and Health Initiative - Study Investigators (U01) (RFA-HG-07-012). The purpose of this funding opportunity is to provide support for investigative groups to conduct genome-wide association (GWA) genotyping and/or replication studies, using data and specimens from human subjects on whom information is available for conditions/traits of public health importance and relevant environmental exposures. It includes support for sharing the specimens and data and analyzing the resulting data as part of the NIH-wide Genes, Environment, and Health Initiative (GEI).

On August 9, 2007, NIDA, in collaboration with a number of other NIH components, issued and RFA entitled Clinical Research Education and Career Development (CRECD) in Minority Institutions (R25) (RFA-RR-07-005). This Funding Opportunity Announcement (FOA) is intended to encourage both current CRECD awardee institutions in the final year of funding and eligible institutions that have not received previous CRECD award to apply. These awards are intended to support development and implementation of curriculum-dependent programs in minority institutions to train selected doctoral and postdoctoral candidates in clinical research leading to a Master of Science in Clinical Research or Master of Public Health in a clinically relevant area. A successful program will result in an accredited master's degree program to produce trained clinical researchers who can become part of translational and/or patient-oriented research projects. This FOA has two phases: (1) an initial two-year Phase I to develop and offer a structured didactic course work and mentored clinical research training leading to a degree in Master of Science in Clinical Research or Master of Public Health for qualified and selected candidates; (2) Phase II of the program will provide continued mentoring and career development to the selected CRECD graduates for up to three years in clinical research as part of their training and skill development to become independent clinical investigators.

NIDA has spearheaded, in conjunction with OBSSR, the RFA entitled Facilitating Interdisciplinary Research via Methodological and Technological Innovation in the Behavioral and Social Sciences (R21) http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-07-004.html, a trans-NIH Roadmap RFA intended to support new developments in methodologies and technologies that will facilitate interdisciplinary research involving the behavioral and social sciences. The applications received were reviewed on July 9-10, 2007.

Other Program Activities

Clinical Trials Network (CTN) Update

The CCTN received proposals in response to a NIH SBIR Contract Solicitation for Topic 089, Development of Practical Training Materials for Evidence-Based Treatment. A review meeting was held on March 13, 2007. Two awards are planned for this solicitation.

A total of 27 protocols have been initiated since 2001. Over 8,100 participants have enrolled in studies. Of these studies, 20 have completed enrollment and locked the data; one completed enrollment and is in the data-lock phase; and four are currently enrolling. Two new protocols are in the development phase.

Primary outcome papers are published and dissemination materials have been developed with CSAT's ATTC on the following:

Protocol CTN 0001, Buprenorphine/Naloxone versus Clonidine for Inpatient Opiate Detoxification

Protocol CTN 0002, Buprenorphine/Naloxone versus Clonidine for Outpatient Opiate Detoxification

Protocol CTN 0005, MI (Motivational Interviewing) To Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse

Protocol CTN 0006, Motivational Incentives for Enhanced Drug Abuse Recovery: Drug Free Clinics

Protocol CTN 0007, Motivational Incentives for Enhanced Drug Abuse Recovery: Methadone Clinics

The following protocols have locked the data:

Protocol CTN 0003, Bup/Nx: Comparison of Two Taper Schedules

Protocol CTN 0004, MET (Motivational Enhancement Treatment) To Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse

Protocol CTN 0008, A Baseline for Investigating Diffusion of Innovation

Protocol CTN 0009, Smoking Cessation Treatment with Transdermal Nicotine Replacement Therapy in Substance Abuse Rehabilitation Programs

Protocol CTN 0010, (Buprenorphine/Naloxone Facilitated Rehabilitation for Opioid Dependent Adolescents/Young Adults)

Protocol CTN 0011, A Feasibility Study of a Telephone Enhancement Procedure (TELE) to Improve Participation in Continuing Care Activities

Protocol CTN 0012, Characteristics of Screening, Evaluation, and Treatment of HIV/AIDS, Hepatitis C Viral Infection, and Sexually Transmitted Infections in Substance Abuse Treatment Programs

Protocol CTN 0013, (Motivational Enhancement Therapy to Improve Treatment Utilization and Outcome In Pregnant Substance Abusers)

Protocol CTN 0015, Women's Treatment for Trauma and Substance Use Disorder: A Randomized Clinical Trial

Protocol CTN 0016, Patient Feedback: A Performance Improvement Study in Outpatient Addiction Treatment

Protocol CTN 0017, (HIV and HCV Intervention in Drug Treatment Settings)

Protocol CTN 0018, (Reducing HIV/STD Risk Behaviors: A Research Study for Men in Drug Abuse Treatment)

Protocol CTN 0019, (Reducing HIV/STD Risk Behaviors: A Research Study for Women in Drug Abuse Treatment)

Protocol CTN 0020, (Job Seekers Training for Substance Abusers). This study was also conducted in a Navajo American Indian site, the Na'nizhoozhi Center, Inc. in Gallup, New Mexico, the first CTN study to be conducted there.

Protocol CTN 0021, (Motivational Enhancement Treatment to Improve Treatment Engagement and Outcome for Spanish-Speaking Individuals Seeking Treatment for Substance Abuse). This is the first Spanish-only protocol in the CTN.

The following protocol has ended new enrollment and is in follow-up phase:

Protocol CTN 0014, Brief Strategic Family Therapy for Adolescent Drug Abusers (BSFT), has been implemented at eight sites. The study reached its enrollment target of 480 randomized participants in January 2007.

Four protocols are currently enrolling:

Protocol CTN 0027, Starting Treatment with Agonist Replacement Therapies (START) is a randomized, open-label, multi-center study that was developed in collaboration with the Division of Pharmacotherapies & Medical Consequences of Drug Abuse (DPMCDA). Enrollment began in April 2006. As of August 3, 2007, there were 408 randomized participants.

Protocol CTN 0028, Randomized Controlled Trial of Osmotic-Release Methylphenidate (OROS MPH) for Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents with Substance Use Disorders (SUD). Enrollment is now open at 11 sites. As of August 3, 2007, 145 participants have been randomized.

Protocol CTN 0029, A Pilot Study of Osmotic-Release Methylphenidate (OROS MPH) in Initiating and Maintaining Abstinence in Smokers with Attention Deficit Hyperactivity Disorder (ADHD). This study is being carried out at six community treatment sites across five Nodes. There are a total of 226 randomized participants.

Protocol CTN 0030, Prescription Opioid Addiction Treatment Study (POATS) is a randomized 2-phase, open-label, multi-center study in outpatient treatment settings. Pre-screening began in May 2006. The study is being carried out in 11 sites. There are 217 randomized participants.

Two protocols are in the development phase:

Protocol CTN 0031, Stimulant Abuser Groups to Engage in 12-Step (STAGE-12): Evaluation of a Combined Individual-Group Intervention to Reduce Stimulant and Other Drug Use by Increasing 12-Step Involvement. On June 20-21, 2007, the protocol development team met with staff from the Data and Statistics Coordinating Center (Duke Clinical Research Institute) in Durham NC to discuss specific procedures for the Electronic Data Capture being utilized in this study. This face-to-face meeting was the first of its kind during protocol development in the CTN. The initial Investigators' meeting to train staff from the three Wave 1 sites (Maryhaven - Ohio Valley Node, ChangePoint - Oregon/Hawaii Node, and Recovery Centers of King County - Washington Node) will take place in Bethesda, MD on December 3-5, 2007. The protocol development team is also collaborating with other CTN investigators (Dennis McCarty - Oregon/Hawaii Node and Joseph Guydish - California/Arizona Node) to incorporate an ancillary study on Health Services Research to be supported by supplementary funds from DESPR.

Protocol CTN 0032, HIV Rapid Testing and Counseling Protocol. This protocol is under development. This study seeks to evaluate the most effective strategy to ensure that persons in drug treatment programs are tested for HIV and receive their HIV test results. The Centers for Disease Control (CDC) have made a priority to bring HIV rapid testing and counseling into outpatient health care settings for high-risk populations. Protocol 0032 was approved for development late November, 2006, and the protocol team meets regularly by conference call. The DSMB met on July 13, 2007 to review and discuss the protocol, and made recommendations to NIDA

In addition to the primary CTN trials, there are currently 30 funded studies supported by independent grants that use CTN studies as a platform.

NIDA has awarded Brandeis University's NIDA Research Center on Managed Care and Drug Abuse Treatment with an ancillary study to conduct an economic analysis of the interventions examined in the Prescription Opioid Addiction Treatment Study (POATS - CTN 0030). In September 2007, Brandeis University will be collecting data to assess the costs and benefits of the two treatment approaches EMM (Enhanced Medical Management) and SMM (Standard Medical Management).




NIDA's New and Competing Continuation Grants Awarded Since May 2007

Abi-Dargham, Anissa -- Columbia University Health Sciences
Imaging Dopamine Transmission in Cannabis Dependence

Abood, Mary E. -- California Pacific Medical Center Research Institute
Molecular Characterization of Gpr35 and Gpr55, Putative Cannabinoid Receptors

Adinoff, Bryon H. -- University of Texas Southwest Medical Center, Dallas
Impulsivity, Neural Deficits, and Cocaine Relapse

Adler, Martin W. -- Temple University
Opioids, Cannabinoids, Chemokines: Functional Implications of Cross-Talk

Agrawal, Arpana -- Washington University
Cannabis and Tobacco Involvement: A Twin Study

Aharonovich, Efrat -- New York State Psychiatric Institute
Modified Behavioral Treatment for Cocaine Patients with Cognitive Deficits

Aidala, Angela A. -- Columbia University Health Sciences
Drug Abuse, Mental Illness, Homelessness, and HIV: Evaluating Models of Care

Ait-Daoud, Nassima -- University of Virginia, Charlottesville
New Medication Treatments for Stimulant Dependence

Akins, Chana K. -- University of Kentucky
Prenatal Cocaine Effects on Sexual Motivation

Akins, Michael R. -- Brown University
Syncam Family Interactions in Synapse Formation

Alexandre, Pierre K. -- Johns Hopkins University
Economic Aspects of Ecstacy Use

Ambrose Lanci, Lisa M. -- Thomas Jefferson University
Anxiety in Females During Cocaine Withdrawal

Back, Sudie E. -- Medical University of South Carolina
Translational Research Training: Stress and Addiction

Baldwin, Gayle C. -- University of California Los Angeles
Cocaine Synergizes with T Cell Activation as a Cofactor for HIV Infection

Baumann, Steven -- Psychology Software Tools, Inc.
Stimulus Delivery and Response Hardware for FMRI Studies in Substance Abuse

Becker, Jill B. -- Gordon Research Conferences
2007 Catecholamines Gordon Research Conference

Beckwith, Curt G. -- Miriam Hospital
Comprehensive HIV Testing Strategies for Jails

Bickel, Warren K. -- University of Arkansas Medical Sciences Little Rock
The Behavioral Economics of Relapse

Bidlack, Jean M. -- International Narcotics Research Conference, Inc.
38th Annual International Narcotics Research Conference

Bidlack, Jean M. -- University of Rochester
Pharmacology of Drug Abuse

Bierut, Laura J. -- Washington University
Human Genetics of Addiction: A Study of Common and Specific Factors

Bogenschutz, Michael P. -- University of New Mexico Albuquerque
Clinical Trial Network: Southwest Node

Booth, Robert E. -- University of Colorado Denver/Health Sciences Center Aurora
Intervention to Reduce injection Drug Use

Boudreaux, Edwin D. -- University of Medicine/Dentistry of New Jersey-Robert Wood Johnson Medical School
Multicenter Pilot Studies for Educational Tobacco Interventions

Bowen, Anne M. -- University of Wyoming
Wyoming Meth Use and AIDS Risk: Exploring Rural Culture and Context

Braine, Naomi -- Beth Israel Medical Center, New York
MSM Communities in NYC Respond to HIV and Methamphetamine

Brigham, Gregory S. -- University of Cincinnati
Community Reinforcement and Family Training for Treatment Retention/HIV Risk

Britt, Jonathan P. -- University of Chicago
The Processing of Tonic and Burst Activity Patterns in DA Terminals in the Nacc

Bromberg, Jonas -- Inflexxion, Inc.
Internet Support for Self-Managing Neuropathic Pain

Brookshire, Bethany R. -- Wake Forest University Health Sciences
The Effects of Chronic Methylphenidate on Dopamine and Serotonin Interactions

Brown, Ana C. -- Arizona State University
Explaining Program Effects on Youth Substance Use: Role of Negative Cognitions

Brunzell, Darlene H. -- Yale University
nAChR Subunit Contributions to Nicotine Dependent Behaviors

Budney, Alan J. -- University of Arkansas Medical Sciences Little Rock
Behavioral Treatment of Adolescent Marijuana Use

Budney, Alan J. -- University of Arkansas Medical Sciences Little Rock
Development and Efficacy Test of Computerized Treatment for Marijuana Dependence

Cance, Jessica D. -- University of North Carolina Chapel Hill
Pubertal Timing and Adolescent Substance Use: Psychological and Social Mediators

Carelli, Regina M. -- University of North Carolina Chapel Hill
Neurophysiological Study: Cocaine and Natural Reinforcers

Cass, Wayne A. -- University of Kentucky
Calcitriol and Methamphetamine Neurotoxicity

Chawla, Neharika -- University of Washington
Experiential Avoidance and Substance Use Relapse

Childers, Steven R. -- Wake Forest University Health Sciences
Neuroscience of Drug Abuse Training Program

Chowdhury, Parimal -- University of Arkansas Medical Sciences Little Rock
Sixth Annual Meeting of the Internatioanl Society for the Prevention of Tobacco

Clark, David J. -- Palo Alto Institute for Research & Education, Inc.
Genetic Determinants of Opioid-induced Hyperalgesia

Cloak, Christine C. -- University of Hawaii at Manoa
Impact of Marijuana Exposure on Brain Maturation

Cole, Shannon H. -- Vanderbilt University
Identifying Dopamine Transporter Regulator Proteins in C. Elegans

Collins, Stephanie L. -- Columbia University Health Sciences
Sex Differences & Impulsivity: Effect of Drug History & Stimulant Administration

Cowan, Ronald L. -- Vanderbilt University
Genetic Factors in Human MDMA Toxicity: A PET Study

Cropsey, Karen L. -- Virginia Commonwealth University
Relapse Prevention to Reduce HIVAmong Women Prisoners

Czoty, Paul W. -- Wake Forest University Health Sciences
Cocaine Discrimination, Self-Administration and Microdialysis in Monkeys

Dalva, Matthew B. -- University of Pennsylvania
Cell-Contact Mediated Mechanisms Assembling Synapses

Davidson, Leslie L. -- Columbia University Health Sciences
Health & Psychosocial Need: Children with Developmental Disorder in a Time of HIV

De Wit, Harriet -- University of Chicago
Craving During Smoking Abstinence: Does It Abate Or incubate?

Deadwyler, Samuel A. -- Wake Forest University Health Sciences
Neuronal Analysis of Cocaine Effects on Cognition

Delisi, Lynn E. -- New York University School of Medicine
World Congress of Psychiatric Genetics with Emphasis on Genes for Drug Abuse

Dematteo, David S. -- Treatment Research Institute, Inc. (TRI)
Development of a Prevention Intervention for Low-Risk Drug Court Clients

Dewey, Stephen L. -- Brookhaven Science Assoc., Brookhaven National Laboratory
Treating Adolsecent and Adult Methamphetamine or Inhalant Abuse with S-(+)-GVG

Donny, Eric C. -- University of Pittsburgh at Pittsburgh
Are Some Regular Smokers Resistant to Nicotine Dependence?

Donovan, Dennis M. -- University of Washington
Clinical Trials Network: Pacific Northwest Node

D'souza, Deepak C. -- Yale University
Cannabinoids, Neural Synchrony and Information Processing

Du, Congwu -- State University New York Stony Brook
Optical and fMRI Studies of Cocaine in the Rat Brain

Dubocovich, Margarita L. -- Northwestern University
Modulation of Methamphetamine Actions in the CNS

Dymecki, Susan M. -- Harvard University Medical School
Developmental Genetics of Serotonin Neuron Subtypes in Brain Reward Circuits

Eiden, Rina D. -- State University of New York at Buffalo
Maternal Substance Use and Toddler Self-Regulation

Eisch, Amelia J. -- University of Texas Southwest Medical Center, Dallas
New Horizons in Adult Neurogenesis

Eldridge, Gloria D. -- University of Alaska Anchorage
HIV, Drugs, and Prisoners: Barriers to Epidemiologic and Intervention Research

Ernst, Thomas M. -- University of Hawaii at Manoa
Rgr-Based Motion Tracking for Real-Time Adaptive MRI and Spectroscopy

Evans, Christopher J. -- University of California Los Angeles
Center for Study of Opioid Receptors and Drugs of Abuse (CSORDA)

Evans, Suzette M. -- Columbia University Health Sciences
Sex Differences in Stress & Impulsivity in Cocaine Abusers

Evans, Suzette M. -- New York State Psychiatric Institute
Progesterone Treatment for Cocaine-Dependent Women

Evins, A. Eden -- Massachusetts General Hospital
Smoking Cessation and Smoking Relapse Prevention in Patients with Schizophrenia

Fawcett, Stephen B. -- University of Kansas Lawrence
Testing the Community Change Model with Substance Abuse Coalitions

Febo, Marcelo -- Northeastern University
Brain Imaging of Cocaine and Maternal Reward

Fiellin, David A. -- Yale University
Buprenorphine Maintenance Vs. Detoxification in Prescription Opioid Dependence

Filbey, Francesca -- The Mind Institute
The Effects of CNR1 on Brain Function in Cannabis Users

Foltin, Richard W. -- New York State Psychiatric Institute
Translational Approach to Models in Relapse

Frangakis, Constantine -- Johns Hopkins University
Statistical Designs and Methods for Partially Controlled HIV/AIDS Studies

Friedmann, Peter D. -- Association for Medical Education & Research in Substance Abuse
AMERSA Annual National Conference

Fuller, Crystal M. -- New York Academy of Medicine
Pharmacy Referral Intervention: IDU Access to Services

Gale, Michael J. -- University of Washington
Inate Immune Defense Against HCV and HIV: The Chimeric Mouse Model

Gauda, Estelle B. -- Johns Hopkins University
Immersion in Drug Abuse

Gillette, Rhanor -- University of Illinois Urbana-Champaign
Toggling a Switch for Appetance and Avoidance

Ginsburg, Brett C. -- University of Texas Health Science Center San Antonio
Age, Ethanol, and Strain Effects on the Behavioral Pharmacology of Cannabinoids

Gintzler, Alan R. -- Suny Downstate Medical Center
Adenylyl Cyclase Gbetagamma Stimulation and Opioid Tolerance

Go, Vivian F. -- Johns Hopkins University
Prevention for Positives: A Randomized Controlled Trial Among Vietnamese HIV

Golik, Jerzy -- Makscientific, LLC
New Drugs to Enhance Endocannabinoid Responses for Treating Excitotoxicity

Gorbach, Pamina M. -- University of California Los Angeles
Transmission Behavior in Partnerships of Newly HIV Infected Southern Californians

Gourevitch, Marc N. -- New York University School of Medicine
Substance Abuse Research Education and Training (SARET)

Griffiths, Roland R. -- Johns Hopkins University
Human Clinical Pharmacology of Emerging Drugs of Abuse (Club Drugs)

Grimm, Jeffrey W. -- Western Washington University
Incubation of Craving: Neural Substrates

Gruber, Staci A. -- Mc Lean Hospital, Belmont, MA
Marijuana and Mood: Frontal Predictors of Behavior

Grueter, Brad A. -- Stanford University
Role of Psd-95 in Synaptic and Drug induced Plasticity in Dopamine Neurons

Guo, Xiaohui -- University of Miami-Medical School
Measurement Invariance Analysis on ASI-Lite

Hagan, Holly C. -- National Development & Research Institutes
Reducing HIV Transmission By Promoting Sexual Health Among Drug Users

Hahn, Judith A. -- University of California San Francisco
Dynamic Modeling of the HCV Epidemic in IDU

Heimer, Robert -- Yale University
Environmental Factors in HIV Transmission Among Suburban IDUs

Henderson, Leslie P. -- Dartmouth College
Steroid Regulation of Ion Channels

Henry, Loren K. -- Vanderbilt University
Integration of Computational and Biological Analysis of Serotonin Transporters

Herin, David V. -- University of Texas Health Science Center Houston
Dextroamphetamine Treatment for Comorbid Cocaine Dependence and ADHD

Herrold, Amy A. -- Loyola University Chicago
Mglur5 Regulation of METH Reward and Sensorimotor Gating

Heslin, Kevin C. -- Charles R. Drew University of Medicine & Science
Racial/Ethnic Disparities in Mental Healthcare Use by Substance Abuse Clients

Ho, Wenzhe -- Children's Hospital of Philadelphia
Opioids, HIV/HCV and Host Cell Innate Immunity

Houghten, Richard A. -- Torrey Pines Institute for Molecular Studies
In Vivo Screening of Mixture-Based Combinatorial Libraries

Hoven, Christina W. -- New York State Psychiatric Institute
Maternal Incarceration and Course of Child Psychopathology in the South Bronx

Hurt, Hallam -- Children's Hospital of Philadelphia
In Utero Cocaine Use: Adolescent and Young Adult Neurocognitive Outcome

Inturrisi, Charles E. -- Weill Medical College of Cornell University
Pharmacology and Neuroscience of Drug Abuse

Jarbe, Torbjorn U. -- Northeastern University
Endogenous/Exogenous Cannabinoids: A Comparison

Jason, Leonard A. -- De Paul University
Evaluating Alternative Aftercare Models for Ex-offenders

Javitt, Daniel C. -- Nathan S. Kline Institute for Psychiatric Research
Phencyclidine Abuse & Psychosis: Biomedical Mechanisms

Johnson, Kenneth M. -- University of Texas Medical Branch Galveston
Neural and Pharmacological Mechanisms of Abused Drugs

Jones, Joshua L. -- University of North Carolina Chapel Hill
Amygdalar Regulation of Nucleus Accumbens Reward Signaling

Jones, Sara R. -- Wake Forest University Health Sciences
Dopamine Transporter Changes Following Cocaine Self-Administration

Kamarck, Thomas W. -- University of Pittsburgh at Pittsburgh
Psychosocial Stress Exposure: Real-Time and Structured Interview Technologies

Kandel, Denise B. -- Columbia University Health Sciences
Epidemiological/Familial Aspects of Drug Use

Kang, Sung-Yeon -- National Development & Research Institutes
Gender Differences in Healthcare and Drug Treatment Utilization among Drug Users

Keefe, Kristen A. -- University of Utah
Neural Substrates of Stimulus-Induced Drug Seeking

Kelly, Brian C. -- Purdue University West Lafayette
Emerging Trends of Tryptamine Use: Contexts & Risks

Kinlock, Timothy W. -- Friends Research Institute, Inc.
Buprenorphine for Prisoners

Kirk, Gregory -- Johns Hopkins University
Real Time Methods for Quantifying Exposure to Illicit Drugs & Psychosocial Stress

Kollins, Scott H. -- Duke University
Mechanisms of Nicotine Dependence in ADHD Adults

Korthuis, Philip T. -- Oregon Health & Science University
Quality Outcomes for Patients with Drug Abuse and HIV

Kral, Alexander H. -- Research Triangle Institute
Qualitative Exploration of Low-Frequency Heroin Injectors not in Drug Treatment

Kumar, Santosh -- University of Memphis
Autosense: Quantifying Exposures to Addictive Substances and Psychosocial Stress

Lachance, Heather R. -- National Jewish Medical & Research Center
Development of Behavioral Couples Treatment for Smoking Cessation

Lariviere, William R. -- University of Pittsburgh at Pittsburgh
Genetics of Neuropathic & Inflammatory Hypersensitivity

Ledgerwood, David M. -- Wayne State University
Prize Reinforcement for Smoking Cessation

Lee, Debora -- University of California Los Angeles
Long-Term Follow Up of Community Intervention in Yunnan, China

Leung, Hoi-Chung -- State University New York Stony Brook
The Role of Frontostriatal Circuits in Multimodal Response Inhibition

Levine, Allen S. -- University of Minnesota Twin Cities
Effect of Sweet Tastants on Opioid-Melanocortin Interactions

Levitt, Pat R. -- Vanderbilt University
Development of Reciprocal Neural Circuitry

Liberto, Joseph -- American Academy of Addiction Psychiatry
18th-22nd Annual Meetings and Symposium

Liberty, Hilary James -- Social Sciences Innovations Corporation
Using CAI to Enhance Drug Tx Staff HCV Knowledge and Communication Skills

Licata, Stephanie C. -- Mc Lean Hospital, Belmont, MA
FMRI Studies Investigating the Choice Effects of Sedative/Hypnotics

Lin, Zhicheng -- Mc Lean Hospital, Belmont, MA
Human Dopamine Transporter Gene: Variations and Transcriptional Regulation

Lindsey, Kimberly P. -- Mc Lean Hospital, Belmont, MA
FMRI of Cigarette Smoking: Effects of Dependence, Withdrawal, and Conditioned Reinforcement

Loh, Horace H. -- University of Minnesota Twin Cities
Structural and Functional Studies of Mu Opiate Receptors

Lowe, John R . -- Florida Atlantic University
Community Partnership to Affect Cherokee Adolescent Substance Abuse

Lukas, Scott E. -- Mc Lean Hospital, Belmont, MA
Training in Drug Abuse and Brain Imaging

Mackie, Kenneth P. -- Indiana University Bloomington
Cannabinoid Modulation of Cell Function

Mackie, Kenneth P. -- Indiana University Bloomington
2007 CB2 Cannabinoid Meeting

Mackler, Scott A. -- University of Pennsylvania
NaC1, A Cocaine Regulated mRNA in the Rat Brain

Makriyannis, Alexandros -- Northeastern University
Endocannabinoid Active Sites as Therapeutic Targets

Makriyannis, Alexandros -- Northeastern University
Training Program in Medications Development for Drugs of Abuse

Malison, Robert T. -- Yale University
Patient-Oriented Research and Mentoring in the Translational Neurobiology/Genetic

Mandyam, Chitra D. -- Scripps Research Institute
Regulation of Adult Neurogenesis by Methamphetamine

Markowitz, John S. -- Medical University of South Carolina
Drug Transporters and the Disposition of ADHD therapeutic Agents

Martin, Billy R. -- Virginia Commonwealth University
Center for Drug Abuse Research

Martin, Laura E. -- University of Kansas Medical Center
Nicotine Addiction and Reward Processing: An fMRI Investigation

Martins, Silvia Saboia -- Johns Hopkins University
Trends in Problems Related to Extramedical Use of Analgesics

Mason, Graeme F. -- Yale University
Neuroimaging Sciences Training Program

Mason, Michael J. -- Villanova University
Social Ecology of Urban Adolescent Substance Abuse: A Multiple Domain Approach

Mason, Peggy -- University of Chicago
Physiology of Raphe Magnus Cells During Wake and Sleep

Massey, Kerri A. -- University of California San Diego
Nicotinic and GABAergic Interactions in Hippocampal Development

Matell, Matthew S. -- Villanova University
Neuroanatomical Localization of the Dopaminergic Modulation of Clock Speed

Matsumoto, Rae R. -- University of Mississippi
Synthesis and Evaluation of Sigma-Active Cocaine Antagonists

Mayer, Andrew Robert -- The Mind Institute
Multimodal Imaging of the Sensory Gating Deficit in Chronic Cocaine Abusers

Mcginty, Jacqueline F. -- Medical University of South Carolina
Drug Abuse Training Program

Mechlin, M. Beth -- University of North Carolina Chapel Hill
Ethnicity and Pain: Psychosocial Stress and Stress Responses

Mendelson, Jack H. -- Mc Lean Hospital, Belmont, MA
Drug Abuse Research Training Program

Meng, Ian D. -- University of New England
Chronic Morphine-Induced Sensitization of Trigeminal Dura Sensitive Neurons

Mertens, Jennifer -- Kaiser Foundation Research Institute
Brief Intervention to Reduce Substance Use in South African Primary Care

Metrik, Jane -- Brown University
Marijuana's Acute Effects on Risk Taking, Sexual/HIV Risk, and Impulsivity

Midgley, A. Rees -- Indepthlearning
Drug Scene Investigators

Miech, Richard A. -- University of Colorado Denver/Health Sciences Center Denver
The Growing Disparity in Illegal Drug Use Across Socioeconomic Strata

Miller, Gregory M. -- Harvard University Medical School
Methamphetamine Effects Via Trace Amine Associated Receptor 1

Miller, Leslie M. -- Rice University
Web Adventures to Teach Adolescents About Inhalant Abuse

Miller, Matthew J. -- Harvard University School of Public Health
Prescription Opioid Use and the Risk of Injury Among Elderly Americans

Molitor, Thomas W. -- University of Minnesota Twin Cities
Training in Neuroimmune/Neurobehavior Addiction Research

Molitor, Thomas W. -- University of Minnesota Twin Cities
Opiate Modulates Lymphocyte Trafficking into the CNS in TB Meningitis

Monterosso, John R. -- University of California Los Angeles
Neural Recruitment During Self-Control of Smoking: An fMRI Paradigm

Morgan, Drake -- University of Florida
Chronic Opioids and Aging

Morgenstern, Jonathan -- National Center on Addiction/Substance Abuse
Disease Management for Chronic Drug Abuse

Moron-Concepcion, Jose A. -- University of Texas Medical Branch Galveston
Protein Expression in Extinction of Morphine-Dependent Conditioned Behavior

Moyers, Theresa B. -- University of New Mexico Albuquerque
Testing Theory-Based Training in Motivational Interviewing

Nation, Jack R. -- Texas A&M University System
Heavy Metal and Drug Self-Administration: Mechanisms

Nunes, Edward V. -- New York State Psychiatric Institute
Clinical Trials Network: Long Island Regional Node

O'Dell, Laura E. -- University of Texas El Paso
Nico-Teen: Mechanisms of Nicotine Reward and Withdrawal During Adolescence

Olsen, Dale E. -- Simmersion, LLC
Interactive Multimedia Simulation to Train Motivational Interviewing Skills

Ondersma, Steven J. -- Wayne State University
The WIDUs: Indirect Screening for Perinatal Drug Use

O'Neill, Joseph -- University of California Los Angeles
Magnetic Resonance Spectroscopic Imaging of the Brain in Methamphetamine Abuse

O'Phelan, Kristine Hazel -- Queen's Medical Center
Effects of Methamphetamine in Traumatic Brain injury

Oser, Carrie B. -- University of Kentucky
Rural Drug Abuse Treatment: Organizations, Counselors, and Client Outcomes

Osgood, D. Wayne -- Pennsylvania State University
Friendship Networks and Emergence of Substance Use

Overman, William H. -- University of North Carolina Wilmington
A Novel Method to Improve Decision-Making in Young Adults and Adolescents

Owens, Douglas K. -- Stanford University
Making Better Decisions: Policy Modeling for AIDS and Drug Abuse

Ozechowski, Timothy J. -- Oregon Research Institute
A Pilot Test of the Functional Family Therapy Coding and Rating Scale

Paulus, Martin P. -- University of California San Diego
Time Processing in Stimulant Users: Impulsivity and Temporal Discounting

Petry, Nancy M. -- University of Connecticut School of Medicine and Dentistry
Brief Therapies for Problem Gambling Substance Abusers

Podus, Deborah L. -- University of California Los Angeles
Emergency Management for Disruptions in Methadone Treatment

Polcin, Douglas L. -- Public Health Institute
Measuring Confrontation During Recovery

Poling, James C. -- Yale University
Pharmacotherapy & CM for Opioid and Cocaine Dependence

Pollio, David E. -- Washington University
Social Work Training in Addictions Research

Porreca, Frank F. -- University of Arizona
Mechanisms of Opioid Induced Hyperalgesia

Porrino, Linda J. -- Wake Forest University Health Sciences
Neurobiological Correlates of Cocaine Abuse

Portoghese, Philip S. -- University of Minnesota Twin Cities
Selective Opioid Ligands

Rawls, Scott M. -- Temple University
Cannabinoid Regulation of Basal Ganglia Glutamate and GABA

Ray, Stuart C. -- Johns Hopkins University
Mechanisms of Hepatitis C Virus Evolution

Razdan, Raj K. -- Organix, Inc.
Synthesis of Delta9-Tetrahydrocannabinol Related Compounds

Rea, Mark S. -- Rensselaer Polytechnic Institute
Light Measuring Device for Correcting Circadian Disruption

Rende, Richard -- Butler Hospital, Providence, RI
Sibling Contagion for Smoking: Social & Genetic Influences in Early Adulthood

Renshaw, Perry F. -- Mc Lean Hospital, Belmont, MA
Mentoring in Drug Abuse Neuroimaging

Richter, Kimber P. -- University of Kansas Medical Center
Describing and Measuring Tobacco Treatment in Drug Treatment

Rieger, Jayson Michael -- Adenosine Therapeutics, LLC
Adenosine A2a Receptor Antagonists for the Treatment of Cocaine Addiction

Riley, Elise D. -- University of California San Francisco
Effects of Housing and HIV on Risk Behavior and Victimization of indigent Women

Robles, Rafaela R. -- Universidad Central Del Caribe
Puerto Rico Drug Abuse Research Development Program (PRDARDP II)

Roesch, Matthew R. -- University of Maryland Baltimore
Orbitofrontal-Accumbens Interactions, Dopamine Modulation and Impulsive Choice

Roiko, Samuel A. -- University of Minnesota Twin Cities
Effects of Passive Immunization on Nicotine Dependence in Rats

Roy, Sabita -- University of Minnesota Twin Cities
Role of Mu Opioid Receptor in Immune Function

Saldana, Lisa -- Oslc Community Programs
Integrating interventions for Maternal Substance Abuse and Child Neglect

Salo, Ruth E. -- University of California Davis
Neural Correlates of Methamphetamine Use in Schizophrenia: An MRS Study

Salzman, C. Daniel -- New York State Psychiatric Institute
Neural Mechanisms Underlying Reinforcement Learning

Scavone, Jillian L. -- Thomas Jefferson University
Cannabinoid and Opioid Interactions in Noradrenergic Cells

Schensul, Jean J. -- Institute for Community Research
MDMA and STD/HIV Risk Among Hidden Networks of Ecstasy-Using Young Adults

Schmitz, Joy M. -- University of Texas Health Science Center Houston
Contingency Management Plus Levodopa/Carbidopa for Treatment of Cocaine Dependence

Schottenfeld, Richard S. -- Yale University
Drug Counseling and Abstinent-Contingent Take Home Buprenorphine in Malaysia

Schwartz, Robert P. -- Friends Research Institute, Inc.
Entry into Comprehensive Methadone Treatment Via interim Maintenance

Scott, Christy K. -- Chestnut Health Systems, Inc.
Recovery Management Checkups for Women Offenders (RMC-WO) Experiment

Sesack, Susan R. -- University of Pittsburgh at Pittsburgh
Persistent Impact of Developmental Nicotine on Cholinergic Input to DA Cells

Seybold, Virginia S. -- University of Minnesota Twin Cities
Neuroscience Training in Drug Abuse Research

Shaw, Daniel S. -- University of Pittsburgh at Pittsburgh
Parental Involvement, Extra-Familial Contexts and Prevention of Drug Use Risk

Sheth, Christopher M. -- Virginia Commonwealth University
Tolerance to the Immunosuppressive Effects of Delta-9 Tetrahydrocannabinol

Shetty, Vivek -- University of California Los Angeles
Refinement and Validation of A Portable, Salivary Biosensor of Psychosocial Stress

Sigmon, Stacey C. -- University of Vermont & State Agricultural College
Incentive-Based Smoking Cessation for Methadone Patients

Simmons, Janie E. -- National Development & Research Institutes
Barriers to Treatment-Based HIV Prevention for IDU Couples

Sipe, Jack C. -- Scripps Research Institute
Endocannabinoid Biomarkers of Obesity Using integrated Genomics and Metabolomics

Snyder, Solomon H. -- Johns Hopkins University
Drug Abuse Research Center

Sofuoglu, Mehmet -- Yale University
Cocaine Withdrawal and Pharmacotherapy Response

Sorensen, James L. -- University of California San Francisco
California-Arizona Clinical Trials Network Node

Spealman, Roger D. -- Harvard University Medical School
Nonhuman Primate Models of Reinstated Cocaine Seeking

Spoth, Richard L. -- Iowa State University
Partnership Model for Diffusion of Proven Prevention

Sprague, Jon E. -- Ohio Northern University
Hyperthermia: Uncoupling the Agony From Ecstasy

Staley, Julie K. -- Yale University
Neuroreceptor Imaging of Tobacco Smokers

Stall, Ronald -- University of Pittsburgh at Pittsburgh
Long Term Health Effects of Methamphetamine Use in the Macs

Stein, Lynda A. -- University of Rhode Island
Motivation and Skills for Detained Teen Smokers

Stella, Nephi -- University of Washington
Novel CB Receptors

Stenger, Victor A. -- University of Hawaii at Manoa
Parallel MRI for High Field Neuroimaging

Stitzel, Jerry A. -- University of Colorado at Boulder
Circadian Variations in Nicotine Sensitivity in Mice

Stolerman, Ian P. -- King's College London
Comprehensive Database of Drug Discrimination and Self-Administration Research

Strain, Eric C. -- Johns Hopkins University
Mentoring of Clinical investigators in Patient Oriented Research

Strathdee, Steffanie A. -- University of California San Diego
Training Program in Substance Use, HIV and Related Infections

Sulzer, David L. -- Columbia University Health Sciences
Presynaptic Mechanisms in Dopamine Neurotransmission

Surratt, Christopher K. -- Duquesne University
Monoamine Transporter Structure-Function Studies

Sussman, Steven Y. -- University of Southern California
Drug Abuse Prevention for High Risk Emerging Adults

Tarantino, Lisa M. -- Novartis Institute for Functional Genomics
Fine Mapping Genes for Cocaine Locomotor Response in Enu Mutagenized Mice

Terrell, Heather K. -- Arizona State University
Substance Abuse in Women: the Role of Stressful Pregnancy Outcomes

Thomas, David L. -- Johns Hopkins University
The Progression of Hepatitis C Among IDUs

Thomas, David M, -- Wayne State University
Molecular Mechanisms of Methamphetamine Neurotoxicity

Tolan, Patrick H. -- University of Illinois at Chicago
Developmental Evalulation of Prevention Effects of the Safe Children Intervention

Torres, Gonzalo E. -- University of Pittsburgh at Pittsburgh
Physical and Functional Link of the Dopamine Transporter with Synaptic Proteins

Traynor, John R. -- University of Michigan at Ann Arbor
Postdoctoral Training in the Biology of Drug Abuse

Traynor, John R. -- University of Michigan at Ann Arbor
Role of Lipid Rafts in Adenylyl Cyclase Sensitization

Ursu, Stefan -- University of California Davis
The Human PFC Response to Drug Cues: Outcome Representation Vs. Cognitive Control

Valdez, Avelardo -- University of Houston
Drug Abuse Research Development Program

Vezina, Paul R. -- University of Chicago
Neuropsychopharmacology Training for Drug Abuse Research

Waldron, Holly B. -- Oregon Research Institute
Adolescent Substance Abuse: Progressive Treatment

Waldron, Holly B. -- Oregon Research Institute
Development of A Family-Based Treatment for Adolescent Methamphetamine Abuse

Wang, Zuoxin -- Florida State University
Dopamine Regulates Drug and Social Reward interactions

Wasan, Ajay D. -- Brigham and Women's Hospital
Oral Opioid Treatment and Psychiatric Comorbidity

Wassum, Kate M. -- University of California Los Angeles
Opioid and Glutamate Modulation of Reward Value During Goal-Directed Behavior

Waterhouse, Barry D. -- Drexel University
Neurochemistry and Neurophysiology of MDMA (Ecstasy)

Weinstein, Harel -- Weill Medical College of Cornell University
Hallucinogens and 5-Ht Receptors: Mechanisms and Effects

Weiss, Roger D. -- Mc Lean Hospital, Belmont, MA
CTN: Northern New England Node

Wentland, Mark P. -- Rensselaer Polytechnic Institute
Aminobenzomorphan: Potential Cocaine Abuse Medications

White, Tara L. -- Brown University
Imaging Individual Differences in Amphetamine Effects

White, Wesley O. -- Morehead State University
Mechanisms of Amphetamine Withdrawal and Recovery

Wightman, Robert M. -- University of North Carolina Chapel Hill
Dynamics of In Vivo Dopamine Release

Winger, Gail D. -- University of Michigan at Ann Arbor
Behavioral Economic Analysis of Polydrug Abuse

Young, Paul A. -- Nova Research Company
Qds(Tm)-Web Interview Administering System

Yu, Aiming -- State University of New York at Buffalo
Pharmacogenetics in Indolealkylamine Metabolism and Drug interactions

Yudowski, Guillermo A. -- University of California San Francisco
Regulation of GPCR Recycling At the Plasma Membrane

Yurgelun-Todd, Deborah A. -- Mc Lean Hospital, Belmont, MA
Brain Changes with Cannabis and Methamphetamine

Zarkin, Gary A. -- Research Triangle Institute
Modeling Benefits and Costs of Prison-Based Substance Abuse Treatment

Zaveri, Nurulain T. -- SRI International
Discovery of Small-Molecular Orphanin FQ Receptor Ligands

Zhou, Fu-Ming -- University of Tennessee Health Science Center
Non-Transporter Cocaine Mechanisms in Dopamine System


Index

Research Findings

Program Activities

Extramural Policy and Review Activities

Congressional Affairs

International Activities

Meetings and Conferences

Media and Education Activities

Planned Meetings

Publications

Staff Highlights

Grantee Honors



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