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Director's Report to the National Advisory Council on Drug Abuse
September, 2001


Publications

Epidemiologic Trends in Drug Abuse - Community Epidemiology Work Group, Volume I- December 2000
NIH Pub. No. 01-4916

This report provides an ongoing assessment of drug abuse in major metropolitan areas of the United States with the purpose of keeping both public and private sector policymakers and researchers informed with current and accurate data.

Monitoring the Future National Survey Results on Adolescent Drug Use - Overview of Key Findings, 2000
NIH Pub. No. 01-4923

This report will provide systematically recurring annual estimates of drug use among students. The trends are useful for understanding the changing drug abuse problems and for formulating the appropriate intervention (both prevention/treatment) policies.

Monitoring the Future National Survey Results on Drug Use, 1975-2000, Volume I: Secondary School Students, 2000
NIH Pub. No. 01-4924

This annual monograph reports the prevalence of drug use among American secondary students (specifically 8th, 10th & 12th graders). The trends are used for understanding the changing drug abuse problems and for formulating the appropriate intervention (prevention/treatment) policies.

Monitoring the Future National Survey Results on Drug Use, 1975-2000, Volume II: College Students and Young Adults, 2000
NIH Pub. No. 01-4925

This annual monograph reports trends in drug use by populations based on gender, college plans, regions of the country, population density, race/ethnicity, and parents' education. The trends are used for understanding the changing drug abuse problems and for formulating the appropriate intervention (prevention/treatment) policies.

Native American/Alaska Natives Calendar 2002
NIH Pub. No. 01-499

This calendar encourages Native Americans/Alaska Natives to reject illicit drugs; the purpose of the material is to increase the audience's knowledge and awareness of the signs, symptoms and physiological effects of various drugs. To ensure cultural relevancy of the material, the calendar will integrate images and quotations that convey and reinforce Indian pride with its drug education messages.

Brain Power: Student Magazine; Teacher's Guide; Parent's Guide and Video (Grades 2-3)
NIH Pub. No. 01-4575

These materials are designed to interest and educate students in an age appropriate manner about their brain, why they should protect it, and how drugs such as nicotine and inhalants can hurt their brain. The materials are designed to accompany a short video on these topics. The teacher's guide will provide more in depth information, suggestions for activities that can be done in the classroom and a listing of resources. The parent's guide will include activities that can be done with the whole family and a listing of resources.


NIDA NOTES

NIDA NOTES, Volume 16, Issue 3
NIH 01-3478

The lead story in this issue reports on NIDA's prescription drug abuse initiative and the information presented by the scientific panel at the kickoff event. In a Director's Column titled "Understanding the Risks of Prescription Drug Abuse," Dr. Leshner describes this problem, as well as NIDA's efforts to address it. Other stories report on the negative effect of nicotine on the brains of rat pups and how this might translate to prenatal nicotine exposure of fetuses by mothers who smoke during pregnancy; injection drug users' risks of acquiring hepatitis C through sharing cookers and filtration along with information on the prevalence of hepatitis C; and how the brain chemical agmatine may offer promise for treatment of chronic pain. Other stories highlight NIDA's newly designed Web site and this year's PRISM award winners. The Tearoff describes NIDA's new Research Report on prescription drug abuse. The Bulletin Board reports on an addiction studies program at Wake Forest University for journalists who cover drug abuse and addiction issues.


Other Publications

United States-Eastern Europe Regional Meeting on Methamphetamine and Ecstasy Research

This volume summarizes the oral presentations and includes the agenda and participant list from the March 2000 meeting cosponsored by NIDA and the Hungarian Ministry of Youth and Sports to exchange information about the growing abuse of methamphetamine and MDMA (Ecstasy) by young people and the potential for research cooperation in this area.

Street Children and Drug Abuse: Social and Health Consequences

This volume provides summaries of oral presentations, panel discussions, and workgroup reports; participant recommendations; the agenda; and the participant list from the September 2000 meeting cosponsored by NIDA and the World Health Organization to discuss the numerous challenges, including substance abuse, that face the world's vulnerable children and youth.

Vaccines Against Nicotine: How Effective are They Likely to Be in Preventing Smoking? Vocci, F.J. and Chiang, N. CNS Drugs, 15(7), pp. 505-514, 2001.

Elkashef, A., Doudet, D., Bryant, T.,Cohen, R., Li, S. and Wyatt, R.J. 6-18F-DOPA PET Study in Patients with Schizophrenia. Psychiatry Research: Neuroimaging, 100, pp. 1-11, 2000.

Ten editions of the CTN Bulletin Board were distributed this period. The Bulletin Board is an electronic report on the activities of the various protocol teams and subcommittees of the CTN. Patient and clinician brochures for the protocol entitled "Buprenorphine/Naloxone: Comparison of Three Taper Schedules for Opiate Detoxification" were approved and published this period. Copies were distributed to all community treatment sites participating in that study.

Tai, B. NIDA's Clinical Trials Network: Overview and Challenges. In Sorensen, J.L., Rawson, R.A., Guydish, J. and Zweben, J.E. (Eds.), Research to Practice, Practice to Research: Promoting Scientific-Clinical Interchange in Drug Abuse Treatment. Washington, DC: American Psychological Association, 2001.

Cadet, J.L., Jayanthi, S., McCoy, M.T., Vawter, M., and Ladenheim, B. Temporal Profiling of Methamphetamine-induced Changes in Gene Expression in the Mouse Brain: Evidence from cDNA Array. Synapse. 41(1), pp. 40-48, 2001.

Herning, R.I., Better, W.E., Tate, K., and Cadet, J.L. Marijuana Abusers are at Increased Risk for Stroke. Preliminary Evidence from Cerebrovascular Perfusion Data. Ann N Y Acad Sci. 939, pp. 413-415, 2001.

Herning, R.I., Better, W.E., Tate, K., and Cadet, J.L. Antiviral Medications Improve Cerebrovascular Perfusion in HIV+ Non-drug Users and HIV+ Cocaine Abusers. Ann N Y Acad Sci., 939, pp. 405-412, 2001.

Imam, S.Z., Itzhak, Y., Cadet, J.L., Islam, F., Slikker, W., and Ali, S.F. Methamphetamine-induced Alteration in Striatal p53 and bcl-2 Expressions in Mice. Brain Res Mol Brain Res. 13,91(1-2), pp. 174-178, 2001.

Imam, S.Z., el-Yazal, J., Newport, G.D., Itzhak, Y., Cadet, J.L., Slikker, W. Jr., and Ali, S.F. Methamphetamine-induced Dopaminergic Neurotoxicity: Role of Peroxynitrite and Neuroprotective Role of Antioxidants and Peroxynitrite Decomposition Catalysts. Ann N Y Acad Sci., 939, pp. 366-380, 2001.

Jayanthi, S., Deng, X., Bordelon, M., McCoy, M.T., and Cadet, J.L. Methamphetamine Causes Differential Regulation of Pro-death and Anti-death Bcl-2 Genes in the Mouse Neocortex. FASEB J., 15(10), pp. 1745-1752, 2001.

Jayanthi, S., Lewis, B.D., and Cadet, J.L. Fas-induced Apoptosis of Glioma Cells is Associated with Down-Regulation of the hSCO1 Protein, a Subunit of Complex IV. Vol Brain Res., 13, 91(1-2), pp. 131-136, 2001.

Thiriet, N., and Subramanian, J. Involvement of Free Radicals in MDMA-induced Neurotoxicity in Mice. Ann Med Interne (Paris), 152 Suppl 3, pp. 57-59, 2001.

Ernst, M., Matochik, J.A., Heishman, S.J., Van Horn, J.D., Jons, P.H., Henningfield, J.E., and London, E.D. Effect of Nicotine on Brain Activation during Performance of a Working Memory Task. Proceedings of the National Academy of Sciences, USA, 98, pp. 4728-4733, 2001.

Radzius, A., Moolchan, E.T., Henningfield, J.E., Heishman, S.J., and Gallo, J.J. A Factor Analysis of the Fagerstršm Tolerance Questionnaire. Addictive Behaviors, 26, pp. 303-310, 2001.

Heishman, S.J., Singleton, E.G., and Liguori, A. Marijuana Craving Questionnaire: Development and Initial Validation of a Self-report Instrument. Addiction, 96, pp. 1023-1034, 2001.

Witt, L.A., Hilton, T.F., and Hochwarter, W.A. Addressing Politics in Matrix Teams. Group and Organization Management, 26(2), pp. 230-247, 2001.


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