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National Institute on Drug Abuse

Director's Report to the National Advisory Council on Drug Abuse

May, 1999


Publications


Research Report Series: Cocaine Abuse and Addiction
NIH pub. No. 99-4166
This issue will explore what cocaine is like, how it is used, what the short- and long-term effects are, how cocaine abuse can affect pregnancy, and what treatment is available. A glossary and a resource list will help stimulate further study.

Epidemiologic Trends in Drug Abuse, Proceedings of the Community Epidemiology Work Group - Volume I: Highlights and Executive Summary - December 1998
NIH Pub. No. 99-4526
This report provides program administrators and officials with specific indicators and ethnographic information on current patterns and trends as well as emerging problems.

An Individual Drug Counseling Approach: Treating Cocaine Addiction
NIH Pub. No. 99-4380
This publication describes a specific behavioral model of counseling, which can be implemented in a wide range of different drug abuse treatment settings. It is a component of NIDA's Treatment Initiative one of the goals of which includes dissemination of behavioral and cognitive treatment approaches which have been proved effective through research to agencies and service providers in order to improve drug abuse treatment services and outcomes.


Videos


Treatment Solutions - Video
NCADI DD110 (19 minutes)
NCADI DD111 (10 Minutes)
Viewer's Guide, NCADI DD110G
This is a 19-minute-long videotape, which describes the latest developments in treatment research. Expertly produced, and highly engaging, the program covers such issues as treatment medications and behavior modification techniques. It also stresses the benefits of drug abuse treatment, both to the patient and to the greater economy. A 10-minute version of Treatment Solutions is also available. A comprehensive viewer's guide to the videotape is enclosed.

Drug Abuse and Addiction: Bridging the Great Disconnect Between Myths and Realities - Video
NCADI VHS109
Viewer's Guide, VHS109G
A new videotape produced by NIDA shatters those myths in an entertaining and informative way. The 10-minute presentation employs high-tech computer-generated graphics and special effects. It shows, in easily understood terms, the dramatic changes in brain function occurring in drug abusers and addicts. A comprehensive viewer's guide to the videotape is enclosed.


NIDA NOTES


NIDA NOTES, Vol. 13, Issue No. 5
NCADI NN0033
The lead story in this issue of NIDA NOTES reports on NIDA's Nicotine Conference. The Director discusses NIDA's health services research in conjunction with a report on a NIDA symposium on the subject. Another story covers an imaging study that has identified areas of the brain activated by cocaine. This issue also highlights NIDA's new Center on AIDS and Other Medical Consequences of Drug Abuse and the Institute's new Global Research Network on HIV Prevention in Drug-Using Populations.

NIDA NOTES, Vol. 13, Issue No. 6
NCADI NN0034
The front-page story and the Director's Column in this issue both highlight NIDA's Vulnerability to Addiction Initiative. Research on a gene variant that makes people less likely to become addicted to nicotine is covered as is a study of a compound that enhances memory in mice with Alzheimer-like symptoms. This issue also reports on research into treating mood disorders in drug abuse patients. The "NIDA Goes to School" campaign is described as well.

NIDA NOTES, Vol. 14, Issue 1
NCADI NN0035
Establishment of NIDA's National Drug Abuse Treatment Clinical Trials Network is highlighted in this issue, which also commemorates "NIDA's 25th Anniversary with a Special Report, "NIDA Marks 25 Years of Progress in Drug Abuse Research." The Director reflects on the next generation of drug abuse research with an emphasis on speeding the adoption of science-based drug abuse prevention and treatment programs in the Nation's communities. The Institute's collaboration with the National Cancer Institute to create tobacco research centers is also featured. Other articles look at teen drug use, the long-term effects of drug use, and the role of stress in drug abuse relapse.


Other Publications


Needle, R.N., Lambert, E.Y., Coyle, S., and Haverkos, H.W. "Drug Abuse and Infectious Disease." In: Ammerman, R.T., Ott, P.J., & Tarter, R. E. (Eds.). Prevention and Societal Impact of Drug and Alcohol Abuse. Mahwah, N.J.: Lawrence Erlbaum Associates, Inc., pp. 125-149, 1999.

In March, 1999, a special issue of Clinics in Perinatology was published on Prenatal Drug Exposure and Child Outcome. This special issue covers topics including historical trends in the research; mechanisms of action of the drugs; methodological considerations; status of knowledge about maternal and obstetrical effects, perinatal effects, early development, and longer-term outcomes; and intervention strategies for drug-exposed infants. Several NIDA-supported researchers were involved in the preparation of this volume, including Barry Lester, who was guest editor for the issue. The Foreword was prepared by Dr. Leshner, and one of the chapters was written by Vincent Smeriglio and Holly Wilcox (Center on AIDS and Other Medical Consequences of Drug Abuse [CAMCODA]).

De La Rosa, M.R., Segal, B., and Lopez, R.E., (Eds.) Conducting Drug Abuse Research with Minority Populations: Advances and Issues. Binghamton, NY: Haworth Press, Inc., 1999. Simultaneous publication as a monograph, Drugs & Society 14, 1/2, 1999.

Katz, J.K., Izenwasser, S., Kline, R.H., Allen, A.C., and Newman, A H. Novel 3 -Diphenylmethoxytropane Analogs: Selective Dopamine Uptake Inhibitors with Behavioral Effects Distinct from those of Cocaine. J. Pharmacol. Exp. Ther. 288, pp. 302-315, 1999.

Vaughan, R.A., Agoston, G.E., Lever, J R., and Newman, A.H. Differential Binding Sites of Tropane-Based Photoaffinity Ligands on the Dopamine Transporter. J. Neurosci. 19, pp. 630-636, 1999.

Preston, K.L., and Bigelow, G.E. Opioid Discrimination in Humans: Discriminative and Subjective Effects of Progressively Lower Training Dose. Behavioural Pharmacology, 9, pp. 533-543, 1998.

Asanuma, M. and Cadet, J.L. Methamphetamine-Induced Increase in Striatal NF-kappaB DNA-Binding Activity is Attenuated in Superoxide Dismutase Transgenic Mice. Brain Res Mol Brain Res 60(2), pp. 305-309, 1998.

Bolla, K.I., Cadet, J.L., and London, E.D. The Neuropsychiatry of Chronic Cocaine Abuse. J Neuropsychiatry Clin Neurosci 10(3), pp. 280-289, 1998.

Goodman, C.B., Heyliger, S., Emilien, B., Partilla, J.S., Yang, H.Y., Lee, C.H., Cadet, J.L. and Rothman, R.B. Regulation of Mu Binding Sites after Chronic Administration of Antibodies Directed Against Specific Anti-Opiate Peptides. 19(10), pp. 1703-9, 1998.

Haverkos, H.W., Turner, J.F., Jr, Moolchan, E.T., and Cadet, J.L. Relative Rates of AIDS Among Racial/Ethnic Groups by Exposure Categories. J Natl Med Assoc. 91(1), pp. 17-24, 1999.

Hayashi, T., Tsao, L.I., Cadet, J.L., and Su, T.P. [D-Ala2, D-Leu5]enkephalin Blocks the Methamphetamine-Induced C-Fos mRNA Increase in Mouse Striatum. Eur J Pharmacol 5;366 (2-3), 1999.

Tsao, L.I., Ladenheim, B., Andrews, A.M., Chiueh, C.C., Cadet, J.L. and Su, T.P. Delta Opioid Peptide [D-Ala2,D-leu5]Enkephalin Blocks the Long-Term Loss of Dopamine Transporters Induced by Multiple Administrations of Methamphetamine: Involvement of Opioid Receptors and Reactive Oxygen Species. J Pharmacol Exp Ther 287(1), pp. 322-331, 1998.


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