Research Report Series: Comorbidity of Drug Abuse and Mental Illness
NIH Pub. No: 08-5771
When two disorders or illnesses occur simultaneously in the same person, they are called comorbid. This new research report addresses the comorbidity of drug abuse and addiction and other mental disorders. It explores the complex ways in which genetic, developmental and environmental factors appear to interact to predispose individuals to develop both diseases or to have a greater risk of the second disorder after the first appears. The report describes the prevalence of, as well as the diagnostic and treatment challenges posed by comorbid conditions that involve drug abuse, addiction and other mental disorders.
Addiction Science & Clinical Practice
Volume 4, Issue No. 1
NIH Pub. No. 08-6172
In this issue, Dr. Alan J. Budney and colleagues review recent research on marijuana dependence withdrawal, and treatment. Dr. Sharon Samet and colleagues discuss instruments used to diagnose psychiatric disorders and their utility in diagnosing abuse and addiction. Dr. Diana Sylvestre explains the disease process, screening methods, and treatment of hepatitis C in the context of addiction medicine. Finally, Drs. Michael Dennis and Christy Scott explore the discrepancy between acute-care models of addiction treatment and the compelling evidence that addiction is a chronic condition.
Monitoring the Future - National Results on Adolescent Drug Use, Overview of Key Findings: 2007
NIH Pub. No.: 08-6418
Provides a summary of drug use trends from a survey of 8th-, 10th-, and 12th grade students nationwide. Also includes perceived risk, personal disapproval, and perceived availability of each drug by this group.
Epidemiologic Trends in Drug Abuse - Community Epidemiology Work Group - June 2007
NIH Pub. No.: 08-6200A
This report is a synthesis of findings and highlights of data reported at the semiannual meeting of the CEWG.
Epidemiologic Trends in Drug Abuse - Community Epidemiology Work Group - Volume II - June 2007
NIH Pub. No. 08-6204A
This report provides an in-depth analysis of the epidemiologic trends and special reports for a limited audience made up primarily of drug abuse researchers who utilize this volume to identify potential areas for further research.
NIDA NOTES, Vol. 21, No. 6
The lead story explores a new therapy, Behavioral Treatment of Substance Abuse in Severe and Persistent Mental Illness, which boosted attendance at treatment sessions, reduced drug abuse, and improved quality of life for substance abusers whose mental illnesses greatly complicate their recovery. Also included are features on mice whose dopamine receptors have been genetically altered, rendering them insensitive to the rewarding effects of cocaine; the link between opioid use and immune system inhibition; the effects of the often-abused solvent toluene on the brain; and the relationship between a mother's cigarette smoking when pregnant and the early manifestation of behavioral problems and disorders in her child. The Director's Column reports on the NIH Blueprint for Neuroscience Research, a knowledge- and resource-sharing system for NIH-funded neuroscientists. This issue also includes a complete index to NIDA Notes Volume 21.
NIDA NOTES, Volume 22 Innovations Special Issue
This special issue features recent groundbreaking discoveries in drug abuse research that connect to the work of scientists across many disciplines. The lead story describes findings about receptors on neurons and glial cells that offer promise for pain relief without the negative side effects of currently used opioids. The Director's Perspective looks at how NIDA fosters interdisciplinary, breakthrough work; it describes two innovative NIDA programs: Cutting-Edge Basic Research Awards (CEBRA) and the Translationally Oriented Approaches, Devices and Strategies (TOADS) Workgroup. Other research reports discuss optical technologies that expand research and therapeutic possibilities by revealing neural circuits in living animals; discoveries of an unexpected role for the immune system in eliminating extra synapses during brain development; and work in genetics that identifies dozens of genes that influence vulnerability to drug dependence and indicates parts of the brain beyond the dopamine reward system that may contribute to addiction risk.
Brain Power! NIDA Junior Scientists
NIDA is reprinting both Brain Power! NIDA Junior Scientists for grades 2-3 and Brain Power! NIDA Junior Scientists for grades 4-5. Both sets of materials were designed for use in the classroom and include about 5 days worth of lessons. The materials have been extremely popular among teachers.
Seven editions of the CTN Bulletin Board were distributed. The Bulletin Board is an electronic report on the progress of the protocols, committees, and node activity in the CTN. The Bulletin has wide readership within and outside the CTN and NIDA.
Data from eleven CTN trials are now available on the CTN Data Sharing Web Site http://www.ctndatashare.org/. Another three data sets will be available by the end of June 2008. Currently more than 115 research scientists have downloaded one or more data sets. These data sets are in compliance with HIPAA and CDISC (Clinical Data Interchange Standards Consortium) standards in support of the interoperability required by the NIH Roadmap. Starting this summer, flat file postings of the current data sets will also be available on the CTN Data Sharing website.
New Look for International Program Web Site, E-News
The NIDA International Program launched a redesigned Web site in March, www.international.drugabuse.gov, improving the site's navigation and visual design.
NIDA International Program E-News Letter
January 2008 - This issue reported on the formation of an Inhalant Abuse Working Group in East and Southern Africa, a NIDA Director's Award presented to Dr. Ivan Montoya for his efforts to help implement the Institute's Latin American Initiative, and binational research teams in Argentina, Brazil, and Syria who have been awarded NIDA R01 research project grants through the Fogarty International Center International Tobacco and Health Research and Capacity Building Program. The issue also announced extended deadlines for abstract submission and links to the online registration site for the 2008 NIDA International Forum.
April 2008 - This issue announced the Indo-US binational agreement to cooperate on research into mental health, neurology, and addiction; the results of DISCA-supported research on intravenous self-administration studies in mice and the role of stress hormones in relapse to cocaine use; and a NIDA meeting on anti-smoking efforts that featured the U.S. Surgeon General and NIDA staff briefing Russian public health experts. The issue also reported on the selection of Octavio Campolo, Ph.D., University of Guadalajara, as a DISCA awardee; and the 2008 WHO/NIDA/CPDD International Traveling Fellows: Yu Liu, Ph.D., Chinese National Institute on Drug Dependence, Peking University; and Rasmon Kalayasiri, M.D., Chulalongkorn University, Thailand.
Acri, J.B., Chiang, N., McCann, D.J., Shih, M.L., and Vocci, F.J. Summary of NIDA Medications Workshop: New Opportunities for Chemists and Pharmacologists. Drug Alcohol Depend., 92, pp. 307-311, 2008.
Somoza, E., Somoza, P., Lewis, D., Li, S.H., Winhusen, T., Chiang, N., Vocci, F., Horn, P., and Elkashef, E. The SRPHK1 Outcome Measure for Cocaine Dependence Trials Combines Self- Report, Urine Benzoylecgonine Levels, and the Concordance between the Two to Determine a Cocaine-Use Status for each Study Day. Drug Alcohol Depend., 93, pp.132-140, 2008.
McCann, D.J. Potential of Buprenorphine/Naltrexone in Treating Polydrug Addiction and Co-occuring Psychiatric Disorders. Clinical Pharmacology and Therapeutics 83(4), pp. 627-630, 2008.
White, D.A., Michaels, C.C., and Holtzman, S.G. Periadolescent Male but not Female Rats have Higher Motor Activity in Response to Morphine Than Do Adult Rats. Pharmacology, Biochemistry and Behavior 89, pp. 188-199, 2008.
Khalsa, J.H. and Vocci, F. Clinical Management of Drug Addicts Infected with Human Immunodeficiency Virus and Hepatitis C Virus, J. Addictive Diseases, 27(2), pp. 1-10, 2008.
Bjork, J.M., Momenan, R., Smith, A.R., and Hommer, D.W. Reduced Posterior Mesofrontal Cortex Activation by Risky Rewards in Substance-Dependent Patients. Drug and Alcohol Dependence, 95, pp. 115-128, 2008.
Singh, H.H., Rapaka, R.S., and Shurtleff, D. NIDA Drug Supply and Analytical Services Program: Providing Research Resources and Tools to the Scientific Community. Drug and Alcohol Dependence 95, pp. 182-186, 2008.
Sharp C.W., Rosenberg N., and Beauvais, F. Substance Abuse: Inhalant-Related Disorders. Psychiatry, 3rd Edition. A. Tasman M. Maj, M.B. First, J. Kay, and J. A. Lieberman (Eds) Wiley: 2008.
Thomas, Y.F., and Compton, W.M. Rural Populations Are Not Protected from Drug Use and Abuse. The Journal of Rural Health, 23, pp. 1-3, 2007.
Bukoski, W.J., and Compton, W.M. Drug Abuse Research Collaboration in the 21st Century. In: Scheier, L.M. and Dewey, W.L. (Editors): The Complete Writing Guide to NIH Behavioral Science Grants. New York: Oxford University Press, 2008.
Dr. Redonna Chandler, Chief of the Services Research Branch of DESPR was a lead editor of a Special Edition of the Journal of Substance Abuse Treatment. Sacks, S., Chandler, R., and Gonzales, J. Responding to the Challenge of Co-Occurring Disorders: Suggestions for Future Research. Journal of Substance Abuse Treatment 24, pp. 139-146.
Graham, D.L., Noailles, P.A. and Cadet, J.L. Differential Neurochemical Consequences of an Escalating Dose-binge Regimen followed by Single-day Multiple-dose Methamphetamine Challenges. J. Neurochem., 2008. [Epub ahead of print]
Herning, R., Better, W. and Cadet, J.L. EEG of Chronic Marijuana Users During Abstinence: Relationship to Years of Marijuana Use, Cerebral Blood Flow and Thyroid Function. Clin. Neurophysiol. 119(2), pp. 321-331, 2008.
Krasnova, I.N., Li, S.M., Wood, W.H., McCoy, M.T., Prabhu, V.V., Becker, K.G., Katz, J.L. and Cadet, J.L. Transcriptional Responses to Reinforcing Effects of Cocaine in the Rat Hippocampus and Cortex. Genes Brain Behavior 7(2), pp. 193-202, 2008.