Epidemiologic Trends in Drug Abuse - Community Epidemiology Work Group - January 2007
NIH Pub. No.: 07- 6200
This report is a synthesis of findings and highlights of data reported at the semiannual meeting of the CEWG.
Monitoring the Future - National Results on Adolescent Drug Use, Overview of Key Findings: 2006
NIH Pub. No.: 07- 6202
Provides a summary of drug use trends from a survey of 8th-, 10th-, and 12th grade students nationwide. Also includes perceived risk, personal disapproval, and perceived availability of each drug by this group.
Science of Addiction
NIH Pub. No.: 07-5605
New advances in science demonstrate that addiction is a brain disease--a disease that is accompanied by disruption of the mechanisms responsible for generating, modulating and controlling an individual's cognitive, emotional, and social behavior.
Commonly Abused Drugs Chart (Revised)
Laminated 8.5" x 11" color chart lists drugs most widely abused, their trade names and street names, effects of intoxication, and long-term health consequences. Includes 13 "Principles of Drug Abuse Treatment" and graphs on drug use by students.
NIDA Notes Volume 21 Issue No. 2
NIH Pub. No. 07-3478
The lead story looks at the correlation of response to novel objects and cocaine-induced dopamine release in rats. The Director's Perspective reports on the interplay of addiction and co-occurring mental disorders. Other research looks at cue responses in cocaine abusers; nicotine's effects on the developing rat brain; and cocaine craving and cocaine high's effects on brain reward structures. A NIDA at Work feature discusses the Division of Basic Neuroscience and Behavioral Research. Brief features look at acculturation studies, the impact of medical care during addiction treatment, and brain changes that accompany cocaine withdrawal.
NIDA Notes Volume 21 Issue No. 3
NIH Pub. No. 07-3478
The Director's Perspective will examine genes and smoking, and NIDA's work with Perlegen Sciences. Research findings will include how regional brain development contributes to adolescent risk-taking; animal studies looking at the serotonin system as a potential target for cocaine medications; endorphin derivative inhibiting reward from morphine and nicotine in rats; depot naltrexone's safety and efficacy for heroin addiction; and the use of standard treatments to help depressed smokers quit. The Bulletin Board discusses the NIDA International Program-sponsored special supplement to Drug and Alcohol Dependence, and What the Numbers Say will look at cocaine abstinence rates. The Bulletin Board will report on the recent Waletzky award presentation, the Blending Conference, and methadone research centers.
Science and Practice Perspectives
Science and Practice Perspectives Volume 3, Issue No. 2
Research Review articles will include "Assessing Organizational Functioning as a Step toward Innovation," by Drs. D. Dwayne Simpson and Donald F. Dansereau; "Imaging the Addicted Human Brain," by Dr. Joanna Fowler and NIDA Director Dr. Nora D. Volkow; "Clinical Perspectives: One Program's Experience Incorporating Research-Based Strategies into Methamphetamine Treatment," by Jay Hansen; "Quality and Performance Improvement: What's a Program to Do?" by Dr. Frank McCorry. The Science and Practice in Action feature is "Attending to Emotional Cues for Drug Abuse: Bridging the Gap between Clinic and Home Behaviors" by Drs. Michael Otto, Conall O'Cleirigh, and Mark Pollack.
Seven editions of the CTN Bulletin Board were distributed. The Bulletin Board is an electronic report on the progress of the protocols, committees, and node activity in the CTN.
The CTN Data Sharing Web Site was established to support the NIH data sharing policy. The data sets of six protocols are available for public use; another five data sets will be available before the end of August 2007. Currently more than 30 research scientists have downloaded one or more data sets. These data sets are in compliance with HIPAA and CDISC (Clinical Data Interchange Standards Consortium) standards in support of the interoperability required by the NIH Roadmap.
CCTN developed two bookmarks for distribution to participants throughout the CTN: Informed Consent and Data Sharing.
International Program E-News Letter
The NIDA International Program issues an E-News Letter every other month to inform the international drug abuse research community about recent events, funding opportunities, NIDA's the research training and exchange programs for international scientists, and forthcoming meetings.
February 2007 - This issue announced the expansion of NIDA's Program Announcement on International Research Collaboration on Drug Abuse to the R01, R03, and R21 grants mechanisms; the new Methadone Research Web guide; and results of a NIDA-Dutch Addiction Program binational research project that concluded that children diagnosed with Disruptive Behavior Disorder in middle childhood benefit from a cognitive-behavioral intervention, the Coping Power Program (CPP), which may prevent the children from progressing to substance abuse in early adolescence.
Compton, W.M., Thomas, Y.F., Stinson, F.S., and Grant, B.F. Prevalence, Correlates, Disability, and Comorbidity of DSM-IV Drug Abuse and Dependence in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Archives of General Psychiatry, May 2007.
Goldstein, R.B., Dawson, D.A., Saha, T.D., Ruan, W.J., Compton, W.M., and Grant, B.F. Antisocial Behavioral Syndromes and DSM-IV Alcohol Use Disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Alcoholism: Clinical and Experimental Research, 31(5), pp. 814-828, 2007.
Ingraham, S.E., Lynch, R.A., Surti, U., Rutter, J.L., Buckler, A.J., Khan, S.A., Menon, A.G., and Lepont, P. Identification and Characterization of Novel Human Transcripts Embedded Within HMGA2 in t(12;14)(q15;q24.1) Uterine Leiomyoma. Mutation Res. 602, pp. 43-53, 2006.
Swan, G.E., Bierut, L.J., Li, M.D., Bergen, A., Lachman, H., Rutter, J.L., Pollock, J.D., and Caporaso, N. Letter to the Editor of JAMA Genetic Research and Smoking Behavior. JAMA, 297, p. 809, 2007.
International Mouse Knockout Consortium; Collins, F.S., Rossant, J., and Wurst, W. A Mouse For All Reasons. Cell, 128(1), pp. 9-13, January 12, 2007.
Vocci, F.J., Jr., and Appel, N.M. Approaches to the Development of Medications for the Treatment of Methamphetamine Dependence. Addiction 102(S1), pp. 96-106, 2007.
Elkashef, A., Rawson, R.A., Smith, E., Pearce, V., Flammino, F., Campbell, J., Donovick, R., Gorodetzky, C., Haning, W., Mawhinney, J., McCann, M., Weis, D., Williams, L., Ling, W. and Vocci, F. The NIDA Methamphetamine Clinical Trials Group: A Strategy to Increase Clinical Trials Research Capacity. Addiction 102(S1), pp. 107-113, 2007.
Vocci, F.J. Opiates and Addiction. In Handbook of Contemporary Neuropharmacology, eds. Sibley, D., Hanin, I., Kuhar, M., and Skolnick, P. .John Wiley and Sons, Inc, Vol. 2, pp. 691-705, 2007.
Tanda, G., Ebbs, A., Kopajtic, T., Campbell, B., Newman, A.H., and Katz, J.L. Effects of Muscarinic M1 Receptor Blockade on Cocaine-Induced Elevations of Brain Dopamine Levels and Locomotor Behavior in Rats. J. Pharmacol. Exp. Ther. 321, pp. 332-344, 2007.
Kulkarni, S.S. and Newman, A.H. Design and Synthesis of Novel Heterobiaryl Amides as Metabotropic Glutamate Receptor Subtype 5 Antagonists. Bioorg. Med. Chem Lett. 17, pp. 2074-2079, 2007.
Heinz, A., Waters, A.J., Taylor, R.C., Myers, C.S., Moolchan, E.T., and Heishman, S.J. Effect of Tobacco Deprivation on the Attentional Blink in Rapid Serial Visual Presentation. Human Psychopharmacology: Clinical and Experimental 22, pp. 89-96, 2007.