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Director's Report to the National Advisory Council on Drug Abuse - May, 2005



Program Activities

New NIDA PAs and RFAs

On March 10, 2005, NIDA issued a Program Announcement (PA) entitled Collaborative Multisite Research in Addiction (COMRAD) (PA-05-067). The purpose of this PA is to increase the collaboration of investigators at two or more sites in order to address critical issues in the epidemiology, services and prevention of substance abuse and related disorders that require sample sizes greater than a single site can reasonably attain.

On March 15, 2005, NIDA issued a Program Announcement entitled Minority Institutions' Drug Abuse Research Development Program (MIDARP) (PAR-05-069). The purpose of this PA is to increase research capacity of minority institutions to conduct research in drug abuse and addiction. Through this announcement, grants will be provided to foster research career development of racial/ethnic minority faculty, student and staff who are underrepresented in drug abuse research, and to enhance research infrastructure at minority institutions. This is a reissue of PAR-02-016, released October 22, 2001.

On April 1, 2005, NIDA issued a Program Announcement entitled Drug Abuse Dissertation Research: Epidemiology, Prevention, Treatment, Services and Women and Sex/Gender Differences (PAR-05-083). The purpose of this PA is to invite applications for support of drug abuse doctoral dissertation research in epidemiology, prevention, treatment, services and women and sex/gender differences. This PA provides funding support of dissertation research through the NIH Dissertation Award (R36) mechanism. This is a reissue of PA-02-055, released February 5, 2002.

On May 3, 2005, NIDA issued a Program Announcement entitled Inhalant Abuse: Supporting Broad-Based research Approaches (PA-05-099). The goal of this PA is to encourage research on all aspects of inhalant abuse (i.e., epidemiology; prevention, treatment and service delivery; antecedents, consequences and neurobiological mechanisms).

On February 9, 2005, NIDA issued an RFA entitled Strategic Program for Innovative Research on Drug Addiction Pharmacotherapy (SPIRDAP) (RFA-DA-05-009). Through this RFA, NIDA invites applications to support innovative, integrated preclinical and clinical research to validate novel pharmacotherapeutic approaches and to identify potential compounds that are safe and effective, short-term (to reduce and stop drug use) and long-term (to prolong abstinence) pharmacotherapies for cocaine, methamphetamine and cannabinoid addiction. Letter of Intent Receipt Date for this RFA: March 18, 2005;Application Receipt Date: April 18, 2005.

PAs and RFAs Issued With Other NIH Components/Agencies

On February 9, 2005, NIDA, in conjunction with numerous other NIH components, issued a Program Announcement (PA) entitled Research on Sleep and Sleep Disorders (PA-05-046). Through this PA co-sponsoring ICs invite grant applications proposing research to advance biomedical knowledge related to sleep disorders, improve understanding of the neurobiology or functions of sleep over the lifespan, enhance timely diagnosis and effective treatment for individuals affected by sleep-related disorders or implement and evaluate innovative community-based public health education and intervention programs. This is a reissue of PA-95-014, released December 23, 1994.

On February 14, 2005, NIDA, in conjunction with numerous other NIH components, issued a Program Announcement (PA) entitled Functional Links Between the Immune System, Brain Function and Behavior (PA-05-054). Through this PA co-sponsoring ICs invite grant applications proposing research to study neuroimmune molecules and mechanisms involved in regulating normal and pathological central nervous system (CNS) function. This is a reissue of PA-02-045, released January 16, 2002.

On February 18, 2005, NIDA, in conjunction with numerous other NIH components, issued a Program Announcement (PA) entitled Jointly Sponsored Ruth L. Kirschstein National Research Service Award Institutional Predoctoral Training Program in the Neurosciences (PAR-05-055). Through this PA co-sponsoring ICs support broad and fundamental, early-stage graduate research training in the neurosciences via institutional training grants. This is a reissue of PAR-02-017, released November 6, 2001.

On February 25, 2005, NIDA, in conjunction with numerous other NIH components, issued a Program Announcement (PA) entitled Continued Development and Maintenance of Software (PAR-05-057). The goal of this PA is to support the continued development, maintenance, testing and evaluation of existing software. This is a reissue of PA-02-141.

On March 4, 2005, NIDA, in conjunction with numerous other NIH components, issued a Program Announcement (PA) entitled Collaborations with National Centers for Biomedical Computing (PAR-05-063). Through this PA co-sponsoring ICs invite grant applications for projects from individual investigators or small groups to collaborate with the recently-formed NIH Roadmap for Medical Research National Centers for Biomedical Computing (NCBCs).

On March 18, 2005, NIDA, in conjunction with numerous other NIH components, issued a Program Announcement entitled International Research Collaboration-Basic Biomedical (FIRCA-BB) (PAR-05-072). This PA is intended to facilitate collaborative basic biomedical research between scientists supported by the NIH and investigators in developing countries. This is a modification of PA-02-057, released February 6, 2002.

On March 22, 2005, NIDA, in conjunction with numerous other NIH components, issued a Program Announcement entitled International Research Collaboration-Behavioral, Social Sciences (FIRCA-BSS) (PAR-05-073). This PA is intended to facilitate collaborative behavioral and social science research between scientists supported by the NIH and investigators in developing countries. This is a modification of PA-02-057, released February 6, 2002.

On March 25, 2005, NIDA, in conjunction with the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH), issued a Program Announcement (PA) entitled Non-Human Lentiviral Models of the Neurological Complications of AIDS (PAS-05-078). Through this PA co-sponsoring ICs invite grant applications aimed at developing non-human lentiviral in vivo model systems for study of the neurologic complications of AIDS, with or without a history of drug use.

On March 30, 2005, NIDA, in conjunction with numerous other NIH components, issued a Program Announcement (PA) entitled Tools for Zebrafish Research (PAR-05-080). The goal of this PA is to support investigator-initiated applications designed to exploit the power of the zebrafish as a vertebrate model for biomedical and behavioral research. This is a reissue of PAR-02-142 released August 2, 2002.

On March 31, 2005, NIDA, in conjunction with numerous other NIH components, issued a Program Announcement (PA) entitled Global Research Initiative Program, Social Science (PAR-05-082). The goal of this PA is to provide funding opportunities for the increasing pool of foreign biomedical and behavioral scientists, clinical investigators, nurses and other health professionals with state-of-the-art knowledge of research methods to advance critical issues in global health upon their return to their home countries through behavioral and social science research. This is a modification of PAR-03-118 released May 16, 2003.

On April 21, 2005, NIDA, in conjunction with numerous other NIH components, issued a Program Announcement (PA) entitled Interactions between Stem and Progenitor Cells and the Microenvironment In Vivo (PAS-05-092). The goal of this PA is to support studies on the cellular and molecular signaling between the local environment within organisms and stem and progenitor cells that are either introduced as transplants or are normally resident within host tissues and organs. The objective of this initiative is to promote a thorough exploration and characterization of the bi-directional communication between multipotent cells and the three-dimensional local milieu or niche that they encounter in vivo under normal and compromised states, such as with aging or following injury, disease, or drug exposure. This is a reissue of PAS-03-172.

On April 26, 2005, NIDA, in conjunction with the National Institute on Alcohol Abuse and Alcoholism (NIAAA), issued a Program Announcement (PA) entitled Complementary and Alternative Medicine for Substance and Alcohol Related Disorders (PA-05-097). The goal of this PA is to identify, evaluate and develop safe and effective Complementary and Alternative Medicine therapies for the treatment of substance use disorders (SUD) and alcohol use disorders (AUD), including abuse or dependence on licit (alcohol and tobacco) and illicit drugs, and for the treatment of neurological, psychiatric and medical consequences of drug and alcohol addiction.

On May 3, 2005, NIDA, in conjunction with numerous other NIH components and the Canadian Institutes of Health Research (CIHR), issued a Program Announcement (PA) entitled Brain Disorders in the Developing World: Research Across the Lifespan (PAR-05-100). This PA solicits applications for collaborative research projects involving investigators in developed and developing countries, focusing on brain disorders throughout life relevant to developing nations. This PA is a modification of RFA-TW-03-007, released November 7, 2002.

On February 2, 2005, NIDA, in conjunction with the NIAAA, issued an RFA entitled Consequences of Drug Abuse and Alcohol Exposure on Brain and Behavioral Development (RFA-DA-05-007). The goal of this RFA is to support research on the consequences of drug and alcohol use, abuse, and addiction on human brain and behavioral development. Letter of Intent Receipt Date for this RFA: March 18, 2005; Application receipt Date: April 18, 2005.

On February 10, 2005, NIDA, in conjunction with numerous other NIH components, issued an RFA entitled Units for HIV/AIDS Clinical Trials Networks (RFA-AI-05-002). The objective of this RFA is to solicit applications for Clinical Trials Units (CTUs) to implement the clinical research plans of one or more of the HIV/AIDS Clinical Trials Networks. Letter of Intent Receipt Date for this RFA: June 10, 2005; Application Receipt Date: July 11, 2005.

On February 18, 2005, NIDA, in conjunction with NIMH, issued an RFA entitled HIV and Psychiatric Comorbidity Research Project (RFA-MH-05-010). The goal of this RFA is to support research addressing the cellular, molecular, and genetic factors underlying the high comorbidity between HIV-1 infection and psychiatric disorders. Letter of Intent Receipt Date for this RFA: March 29, 2005; Application Receipt Date: April 26, 2005.

On March 23, 2005, NIDA, in conjunction with numerous other NIH components, issued an RFA entitled Course Development in the Neurobiology of Disease (RFA-MH-05-011). The goal of this RFA, an initiative of the NIH Blueprint for Neuroscience Research, is to support the development and initiation of the significant expansion of courses on the neurobiology of disease for graduate students receiving basic neuroscience training. Letter of Intent Receipt Date for this RFA: April 25, 2005; Application Receipt Date: May 25, 2005.

NIH Roadmap Administrative Supplements to Support Interdisciplinary Research in the Behavioral/Social and Biological Sciences--NOT-RM-05-007. Several NIDA Divisions, including DCNDBT contributed to this announcement. Applications are due June 15, 2005.

Administrative Supplements for Research on the Intersection of Drug Use and Criminal Justice Consequences in the African American Population
The purpose of this administrative supplement solicitation is to give NIDA-funded researchers the opportunity to pursue research that will help clarify the relationship between drug use and addiction and criminalization/criminal justice involvement in the African American population. It is expected that recruitment of additional participants and/or the secondary analysis of existing data sets will lead to better understanding of the drug abuse and criminalization nexus in African Americans and lead to the development of effective prevention and intervention strategies.

NIDA has reissued its Science Education Drug Abuse Partnership Award program announcement. This R25 grant mechanism funds the development and evaluation of innovative model programs and materials for enhancing knowledge and understanding of neuroscience and the biology of drug abuse and addiction among K-12 students, teachers, the general public, health care practitioners, and other groups. The award provides support for the formation of partnerships between scientists and educators, media experts, community leaders and other interested organizations for the development and evaluation of programs and materials that will enhance knowledge and understanding of science related to drug abuse. The intended focus is on topics not well addressed in existing efforts by educational, community, or media activities.

Response to NIDA RFAs

Neurobiology of Behavioral Treatment: Recovery of Brain Structure and Function —RFA-DA-05-006 — 22 grant applications were received in response to this RFA. http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-05-006.html.

HIV and Drug Abuse Interventions among Pregnant Women in Drug Abuse Treatment--RFA-DA-05-008 — 16 applications were received in response to this RFA. http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-05-008.html.

Other Program Activities

CTN Update

The proposals for the Request for Applications (RFA) DA-05-001 for the fourth solicitation for the CTN were reviewed April 11-12, 2005. This RFA includes both new applications (new Nodes) and competing continuations. The anticipated award date is September 2005.

Two new Requests for Proposal (RFPs) were issued: DA-5-2207 for the Data and Statistics Center for the CTN, and DA-5-2208 for the Clinical Coordinating Center for the CTN. Both contracts are to be awarded in May 2005.

  • A total of eleven protocols that started since 2001 have completed enrollment. These studies enrolled 2,670 patients who were randomized in 53 community treatment programs located in 16 states.
  • Ten additional protocols are currently recruiting & enrolling patients. These protocols plan to enroll over 4,000 patients across 88 Community Treatment Programs when completed. Highlights of the active protocols include:
    • Protocol CTN 0003 (Bup/Nx: Comparison of Two Taper Schedules) began enrollment June 30, 2003. Participation has reached 86% of the targeted enrollment.
    • Protocol CTN 0010 (Buprenorphine/Naloxone Facilitated Rehabilitation for Opioid Dependent Adolescents/Young Adults) began enrollment in July 2003. This is the first protocol in the CTN that targets adolescent substance abusers. Enrollment is at 40% of the projected target.
    • Protocol CTN 0013 (Motivational Enhancement Therapy to Improve Treatment Utilization and Outcome In Pregnant Substance Abusers) began enrollment in November 2003 and has enrolled 50% of the projected target.
    • Protocol CTN 0014, Brief Strategic Family Therapy for Adolescent Drug Abusers (BSFT), has been implemented at 4 sites. The remaining 4 sites have finished the provider training and overall site preparation and will start patient enrollment in April/May 2005. This intervention is the first CTN study to target adolescents and their families.
    • Protocol CTN 0015 (Women's Treatment for Trauma and Substance Use Disorder: A Randomized Clinical Trial) began in March 2004. The study has reached nearly 61% of the targeted patient enrollment.
    • Protocol CTN 0017 (HIV and HCV Intervention in Drug Treatment Settings). The study began enrollment in November 2004 and enrollment has reached 25% of the target.
    • CTN 0018 (Reducing HIV/STD Risk Behaviors: A Research Study for Men in Drug Abuse Treatment) began enrolling in April 2004 and has reached 57% of the target.
    • CTN 0019 (Reducing HIV/STD Risk Behaviors: A Research Study for Women in Drug Abuse Treatment) began enrollment in April 2004 and has reached 60% of the target.
    • CTN 0020 (Job Seekers Training for Substance Abusers). The protocol began enrollment in October 2004 and has reached nearly 30% of the goal.
    • Protocol CTN 0021(Motivational Enhancement Treatment to Improve Treatment Engagement and Outcome for Spanish-Speaking Individuals Seeking Treatment for Substance Abuse) began enrollment in November 2003. This is the first Spanish-only protocol in the CTN. The study has reached nearly 2/3 of the target.
  • Two protocols have recently completed all data collection phases and are pending data lock (April/May 2005). Those include:
    • Protocol CTN-0004 (Motivational Enhancement Treatment to Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse).
    • Protocol CTN 0008 (Assessment of the National Drug Abuse Clinical Trials Network: A Baseline for Investigating Diffusion of Innovation) has completed all data collection phases.
  • Two protocols have recently locked their data sets and are at the analysis stage. Those include:
    • Protocol CTN 0012 (Characteristics of Screening, Evaluation, and Treatment of HIV/AIDS, Hepatitis C Viral Infections, and Sexually Transmitted Infections in Substance Abuse Treatment Programs).
    • Protocol CTN 0016 (Patient Feedback: A Performance Improvement Study in Outpatient Addiction Treatment Settings).
  • Four additional Protocols are currently being developed for the Network. Highlights of those protocols include:
    • Protocol CTN 0023: Twelve Step Facilitation: Evaluation of Two Interventions to Increase 12-Step Involvement and Improve Outcomes among Substance Dependent Individuals.
    • Protocol CTN 0028: Randomized Controlled Trial of Osmotic-Release Methylphenidate (OROS MPH) for Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents with Substance Use Disorders (SUD). Protocol is under review by the DSMB/PRB.
    • Protocol CTN-0029: A Pilot Study of Osmotic-Release Methylphenidate (OROS MPH) in Initiating and Maintaining Abstinence in Smokers with Attention Deficit Hyperactivity Disorder (ADHD). The protocol has been reviewed and approved to start implementation planning.
    • Protocol CTN 0030: Prescription Opioid Addiction Treatment Study (POATS) is a randomized 2-phases, open-label, multi-center study in outpatient treatment settings. Protocol is submitted for DSMB/PRB review.
  • In addition to the primary CTN trials, there are 12 studies supported by independent grants or as supplements that use CTN studies as a platform.
  • New Collaborative Study: Starting Treatment with Agonist Replacement Therapies (START) Study: The CTN will participate with the Division of Pharmacotherapies & Medical Consequences of Drug Abuse on a multi-centered trial to compare the effect of buprenorphine/naloxone (Bup/Nx) and methadone (MET) on liver function. This is a randomized, open-label, multi-center, Phase 4 study in participants entering opioid agonist treatment programs at community centers (methadone centers) throughout the country. It is anticipated that 1,000 patients will be entered into the trial starting January 2006 across 8 CTN nodes.

Review Activities:

  • Data and Safety Monitoring Boards (DSMB) met March 11, 2005, March 29, 2005, and April 11, 2005, in Bethesda, Maryland. The DSMB group reviewed developing and ongoing protocols.

NIDA's New and Competing Continuation Grants Awarded Since February 2005

Ahijevych, Karen L. -- Ohio State University
Menthol, Ethnicity and Nicotine Dependence

Aldrich, Jane V. -- University of Kansas Lawrence
Peptidic Ligands for Kappa Opioid Receptors

Aldridge, J. Wayne -- University of Michigan at Ann Arbor
Neural Coding of Reward in Ventral Forebrain

Ananthan, Subramaniam C. -- Southern Research Institute
Novel Nonpeptide Ligands for the Opioid Receptors

Aston-Jones, Gary -- University of Pennsylvania
Alterations In Reward Processing During Drug Abstinence

Bank, Lewis L. -- Oregon Social Learning Center, Inc.
Motivational Parent Training In Community Corrections

Ben-Shahar, Osnat M. -- University of California Santa Barbara
Neuroadaptations Underlying the Transition to Addiction

Bevins, Rick A. -- University of Nebraska Lincoln
Reference-Dose Method and Cocaine-Conditioned Choice

Biederer, Thomas -- Yale University
Mechanisms of Syncam-Induced Synapse Formation

Bisaga, Adam M. -- New York State Psychiatric Institute
Memantine Naltrexone Treatment for Opioid Dependence

Blakely, Randy D. -- Vanderbilt University
Regulation of Serotonin Transporters

Bolanos, Carlos A. -- Florida State University
Adolescent Antidepressant Treatment and Drug Reward

Booth, Brenda M. -- University of Arkansas Medical Sciences Little Rock
Cost-Effectiveness of Reducing Drug Treatment Barriers

Brook, Judith S. -- New York University School of Medicine
Childhood Determinants of Adolescent /Adult Drug Use

Butelman, Eduardo R. -- Rockefeller University
Kappa-Agonist Effects of The Hallucinogen Salvinorin A

Callaway, Edward M. -- Salk Institute for Biological Studies
Fugu Promoters for Mammalian Cortical Neurons

Carroll, Kathleen M. -- Yale University
Maximizing CBT's Efficacy With Medication & CM

Clark, Ann S. -- Dartmouth College
AAS and yhe Neurobiology of Social Behaviors

Clatts, Michael C. -- National Development & Research Institutes
Ethno-Epidemiology In An Emergent MSM Risk Environment

Day, Nancy L. -- University of Pittsburgh at Pittsburgh
Prenatal Marijuana Exposure: Long-Term Outcomes

De Leon, George -- National Development & Research Institutes
Generalization of the Client Matching Protocol

De Wit, Harriet -- University of Chicago
Drug Abuse and Impulsivity: Human Laboratory Models

Donny, Eric C. -- University of Pittsburgh at Pittsburgh
Mechanisms of Smoking Reinforcement

Dykstra, Linda A. -- University of North Carolina Chapel Hill
Opioid Analgesics: Pharmacological & Behavioral Factors

Filizola, Marta -- Weill Medical College of Cornell University
Informatics of Gpcr Dimers In Drug Abuse Mechanisms

Finn, Peter R. -- Indiana University Bloomington
Attention-Biases and Hot Cognition In Drug Dependence

French, Michael T. -- University of Miami Coral Gables
Economic Evaluation Methods: Development and Application

Friedman, Jeffrey M . -- Rockefeller University
Mapping Neural Circuits Using Pseudorabie Virus Vectors

Fuchs Lokensgard, Rita A. -- Medical University of South Carolina
Neural Bases of Drug Context-Induced Cocaine Seeking

Gahring, Lorise C. -- University of Utah
Nicotine Modulation of Caspases In Non-Neuronal Cells

Galea, Sandro -- New York Academy of Medicine
The HIV Risk Behavior and the Urban Environment

Gerak, Lisa R. -- Louisiana State University Health Science Center New Orleans
Behavioral Effects of Neuroactive Steroids

Geyer, Mark A. -- University of California San Diego
Monoamine and Hallucinogen Effects on Rodent Behavior

Gottdiener, William H. -- John Jay College of Criminal Justice
Therapy of Comorbid Substance Use Disorders and PTSD

Gulley, Joshua M. -- University of Illinois Urbana-Champaign
Amphetamine Sensitization and Prefrontal Cortex Function

Hao, Shuanglin -- University of Michigan at Ann Arbor
Transgene for Morphine Tolerance and Withdrawal

Howlett, Allyn C. -- North Carolina Central University
Cannabinoid Receptors In Neuronal Cells and Brain

Johnson, Bankole A. -- University of Virginia Charlottesville
Medication Development for Cocaine Dependence

Kaiyala, Karl J. -- University of Washington
Neuroadaptive Substrates for Nitrous Oxide Tolerance

Kalivas, Peter W. -- Medical University of South Carolina
Glutamate and Craving for Cocaine

Kalman, David W. -- Boston University Medical Campus
Double-Blind Placebo Controlled Study: Bupropion Treatment Smokers In Recovery

Kendler, Kenneth S. -- Virginia Commonwealth University
A Twin-Family Study of Drug Use, Abuse and Dependence

Kish, Stephen J. -- Centre for Addiction and Mental Health
Brain Serotonin Transporter In Ecstasy and MDA Users

Kollins, Scott H. -- Duke University
Methylphenidate Abuse Potential In ADHD Adults

Kuhn, Donald M. -- Wayne State University
Methamphetamine Neurotoxicity and Microglial Activation

Kurtz, Steven P. -- University of Delaware
Prevention For At-Risk Men: A Mixed Serostatus Approach

Lee, Juliet P. -- Pacific Institute for Research and Evaluation
Social Meanings of Drugs for Asian American Youth

Lipton, Jack W. -- University of Cincinnati
Neurochemical Sequelae of Prenatal MDMA

Liu, Xiu -- University of Pittsburgh at Pittsburgh
Neuropharmacology of Cue-Induced Nicotine Relapse

Mahata, Sushil K. -- University of California San Diego
Chromaffin Cell Physiology: Novel Molecular Approaches

Malenka, Robert C. -- Stanford University
Drugs of Abuse and Synaptic Processes In Dopamine Systems

Markou, Athina -- Scripps Research Institute
Neurobiology of Nicotine Reward and Withdrawal

Marsh, Jeanne C. -- University of Chicago
Gender Differences In Treatment Services Effectiveness

Martinez, Charles R. -- Oregon Social Learning Center, Inc.
Linking Acculturation To Latino Adolescent Substance Use

Matsumoto, Rae R. -- University of Mississippi
Cocaine, Sigma Receptors and Fra-2

Mccabe, Sean E. -- University of Michigan at Ann Arbor
Nonmedical Prescription Drug Use Among College Students

McMahon, James M. -- National Development & Research Institutes
Hepatitis C Virus Intranasal Transmission: Pilot Study

Michelhaugh, Sharon K. -- Wayne State University
Analysis of Nurr1 Isoforms In Rat Ventral Midbrain

Mitchell, Suzanne H. -- Oregon Health and Science University
Reinforcer Efficacy: Measures and Neural Mechanisms

Murphy, Sheigla B. -- Scientific Analysis Corporation
A Qualitative Study Of Women In Drug Markets

Nielsen, Darci M. -- Brown University
Nicotine Addiction and Gating Deficits In Schizophrenia

Pavlopoulos, Spiro -- University of Connecticut Storrs
Receptor Structural Features Determining Drug Tolerance

Petry, Nancy M. -- University of Connecticut School of Medicine and Dentistry
Vouchers Vs. Prizes: Cocaine-Dependent Methadone Patients

Pierce, Robert Christopher -- Boston University Medical Campus
Ephrins and Repeated Cocaine

Piomelli, Daniele -- University of California Irvine
Characterization of a Novel Cannabinoid Ligand

Pope, Harrison G. -- Mc Lean Hospital, Belmont, MA
Risk Factors for Anabolic-Androgenic Steroid Abuse

Rebec, George V. -- Indiana University Bloomington
Neuropharmacology of Drugs of Abuse: Amphetamine

Reynolds, James D. -- Duke University
Maternal MDMA (Ecstasy) Exposure and Fetal Physiology

Schoenwald, Sonja K. -- Medical University of South Carolina
Testing Context Effects on Treatment of Drug-Using Youth

Self, David W. -- University of Texas Southwest Medical Center, Dallas, TX
VTA Ionotropic Glutamate Receptors In Cocaine Addiction

Sharp, Burt M. -- University of Tennessee Health Science Center
Interaction Between Nicotine and Stress

Shepard, Paul D. -- University of Maryland Baltimore Professional School
Dopamine Cell Impulse Flow, Reward and Schizophrenia

Silverman, Kenneth -- Johns Hopkins University
Employment-Based Addiction Pharmacotherapy

Simone, Donald A. -- University of Minnesota Twin Cities
Cannabinoid Modulation of Hyperalgesia

Stanwood, Gregg -- Vanderbilt University
Dopaminergic Influences on Brain Formation and Function

Steiner, Heinz -- Rosalind Franklin University of Medicine & Science
Basal Ganglia Output and Psychostimulant Abuse

Stout, Julie C. -- Indiana University Bloomington
Cognitive Modeling of Risky Decisions In Drug Abusers

Taffe, Michael A. -- Scripps Research Institute
Behavioral Toxicity of MDMA In Rhesus Monkeys

Terwilliger, Ernest F. -- Beth Israel Deaconess Medical Center
SiRNA Suppression of Genes Mediating Addictive Behaviors

Thomas, Janet L. -- University of Kansas Medical Center
Supportive Behaviors To Assist In Smoking Cessation

Tietz, Elizabeth I. -- Medical College of Ohio At Toledo
Benzodiazepine-Induced Glutamate Receptor Plasticity

Tildesley, Elizabeth A. -- Oregon Research Institute
Modeling the Sequence of Depression and Substance Use

Unterwald, Ellen M. -- Temple University
Regulation of Delta Opioid Receptor Function By Cocaine

Venanzi, Carol A. -- New Jersey Institute of Technology
Multivariate, Cluster, and Comfa Analysis of GBR Analogs

Vorhees, Charles V. -- Children's Hospital Med Center, Cincinnati, OH
Developmental Effects of Methamphetamine-Like Stimulants

Walker, J. Michael -- Indiana University Bloomington
Role of Endogenous Vanilloids and Cannabinoids In Pain

Wang, Zuoxin -- Florida State University
Dopamine Regulates Drug and Social Reward Interactions

Watkins, Linda R. -- University of Colorado at Boulder
Pain Facilitation Via Neuron-To-Glia Signaling

Weed, Michael R. -- Johns Hopkins University
Pupillometry and Gaze-Tracking In Unrestrained Monkeys

Weinstein, Harel -- Weill Medical College of Cornell University
Structure and Function of Neurotransmitter Transporters

Wellman, Paul J. -- Texas A&M University System
Psychostimulants and Alpha-1 Adrenoceptor Subtypes

Whiteaker, Paul -- University of Colorado at Boulder
Immunochemical Protocols for Nicotinic Receptors

Willging, Cathleen E. -- Behavioral Health Research Center-Southwest
Drug Use, Ethnicity and Help Seeking Among Rural Youth

Williams, John T. -- Oregon Health & Science University
Cocaine Effects on Single Neurons

Williams, Mark -- University of Texas Health Science Center, Houston TX
Tanzania Injection Drug Use/HIV Prevention Project

Wu, Ping -- New York State Psychiatric Institute
Adolescent Use of Substance Use Treatment Services

Yaksh, Tony L. -- University of California San Diego
The Pharmacology of Spinal Analgesics


Index

Research Findings

Program Activities

Extramural Policy and Review Activities

Congressional Affairs

International Activities

Meetings and Conferences

Media and Education Activities

Planned Meetings

Publications

Staff Highlights

Grantee Honors

In Memoriam



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