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National Institute on Drug Abuse

Director's Report to the National Advisory Council on Drug Abuse

February, 1997


Meetings/Conferences


NIDA organized a "Town Meeting " in St. Louis, Missouri entitled "Understanding Drug Abuse and Addiction: Myths Vs. Reality" on October 29. Dr. Leshner and NIDA researchers discussed ways that state policy makers, organizations, schools and communities can utilize the latest scientific research to assess state and local drug problems and develop programs to meet these needs.

In conjunction with the St. Louis Town Meeting, a community meeting was held with parents, teachers, and community leaders at the Kirkwood School in Kirkwood, Missouri, on October 29, to discuss the current state of scientific knowledge on drug abuse and addiction.

NIDA recently sponsored a trans-NIH symposium entitled " Unique Contributions of Nonhuman Primate Research to Neuroscience " on November 15, as a satellite symposium to the Society for Neuroscience Meeting in Washington, D.C. The symposium explored the role of nonhuman primates in neuroscience research; the unique contributions made through the use of primates in neuroscience research; and current areas of neuroscience research in which there is a critical need for primate research. The symposium featured an outstanding cadre of scientists, including a nobel laureate. Other participating institutes included: NIAAA, NIMH, NINDS, NIA, NCRR, NICHD, NEI, and NIDCD.

On November 16, 1996, a Satellite Symposium on "Cognitive Functions and Drug Abuse" was held at the annual Society for Neuroscience meeting in Washington D.C. The purpose of this symposium was to explore advances in cognitive neuroscience and in addictions research with the goal of identifying common scientific challenges and opportunities for synergistic interactions between these fields. Leading researchers in both areas of research discussed topics of mutual interest, such as the formation of different types of memory in different regions of the brain and the factors that influence memory formation in these brain regions, as well as the brain circuits that are activated during cocaine craving. Following Dr. Alan I. Leshner's opening address, Dr. Stephen R. Zukin delivered introductory remarks. The morning session included presentations from Drs. Nora Volkow, Mortimer Mishkin, Edythe London, and Steven Petersen, and was chaired by Dr. Zukin. The afternoon session, chaired by Dr. Steven J. Grant, included presentations from Drs. James McGaugh, Barry J. Everitt, P. Read Montague, Bruce R. Rosen, and Michael Gazzaniga. The organizers of this meeting were Drs. T. Aigner, C. Asanuma, R. Brown, J. Frascella, S.J. Grant, A.I. Leshner, K. Skinner, and S.R. Zukin.

NIDA's Special Populations Office co-sponsored the Minorities in Neuroscience Forum that was held November 19, 1996 in Washington, DC as part of the Society for Neuroscience Annual Meeting. The work of minority supplement recipients was highlighted in a poster session, and attendees included NIDA training directors, high school students, and college and university students interested in drug abuse research.

NIDA hosted its Third Annual Constituent Conference on November 25-26 at the Lansdowne Conference Center in Lansdowne, Virginia. Dr. Alan Leshner presented the "Report Card" highlighting specific actions taken by NIDA in response to constituent group recommendations. Laurie Flynn, Executive Director of the National Alliance for the Mentally Ill addressed the participants concerning the recent success of the mental health community in obtaining parity through legislation.

On December 2-3, 1996 NIDA's Office of Science Policy and Communications held a regional meeting in San Francisco entitled "Methamphetamine: Abuse, Treatment, and Prevention." The meeting was opened by Congresswoman Nancy Pelosi and brought together scientists, practitioners, policy makers, and the community to discuss the most current research on the growing problem of methamphetamine abuse in the western United States.

Dedication of the NIDA Brain Imaging Center took place on December 16, 1996. General Barry McCaffrey, Director, Office of National Drug Control Policy, Dr. Harold Varmus, Director, National Institutes of Health (NIH), and Dr. Ruth L. Kirschstein, Deputy Director, NIH, joined Dr. Alan Leshner, Director, National Institute on Drug Abuse (NIDA), Dr. Barry Hoffer, Director, Division of Intramural Research, Mr. Richard Millstein, Deputy Director, NIDA, and Dr. Roy Pickens, Chief, Clinical Neurogenetics Section in a tour of the facility, scientific presentations, and the Center dedication. A state-of-the-art Exact HR+ Positron Emitting Tomography (PET) scanner (Siemens) and a RDS-111 cyclotron (Computers Technology Incorporated) are the primary instruments, which will permit the acquisition of high resolution PET images of the brain using fluorine-18, carbon-11 and oxygen-15 labeled tracers. This capability will permit the neuroanatomical exploration and identification of physiological and cognitive substrates underlying drug abuse in humans, and has the potential to provide new directions for the development of pharmacological and behavioral therapies. Dr. Edythe London is the director of the new Brain Imaging Center.

A meeting of the NIDA Scientific Review Group (SRG) Chairpersons and additional representatives was held on January 6 at NIH. NIDA Director, Dr. Alan Leshner, provided a State of the Institute report and discussed developments in the integration of NIDA's peer review structure into the broader NIH structure. He also requested input from the SRG members on several peer review issues that are under discussion by the Peer Review Oversight Group (PROG), particularly the rating criteria. Dr. Wendy Baldwin, NIH Deputy Director for Extramural Research, also attended and discussed activities of the PROG, which she chairs. Dr. Elvira Ehrenfeld, newly appointed Director, Division of Research Grants (DRG), also met with the group. She noted that she is looking forward to working with NIDA. There was a positive dialogue between the NIH leadership and the NIDA SRG members.

A meeting on "Measurements in Family Prevention Intervention" held on October 13-15, 1996 in Salt Lake City was sponsored by the Prevention Research Branch and chaired by Dr. Rebecca Ashery. The meeting explored family functioning and parenting instruments that would be useful to researchers in the field.

On December 3-4, Drs. Robert Battjes and Lisa Onken, DCSR, chaired a NIDA meeting entitled "Treatment Readiness: Factors Influencing Entry and Engagement." The meeting brought together ethnographers who are studying drug abusers perspectives on treatment, researchers who focus on motivation to change, and researchers studying alternative treatment approaches. It was designed to clarify factors that impact acceptability and accessability of treatment and also to consider directions for future research that will lead to improved recruitment strategies, treatment approaches, and more acceptable treatment environments.

The Behavioral Science Working Group hosted a master-class lecture (L.E.A.D.E.R.S.) by Dr. Steven Hursh entitled "Behavioral Economics, A Conceptual Framework for Drug Abuse Research, Intervention and Policy."

As part of NIDA's HBCU initiative, a technical assistance meeting was held with faculty and staff from HBCUs on September 9-12, 1996 in Washington, DC.

NIDA's Special Populations Office co-sponsored the 4th Annual Conference on Psychopharmacology, Psychopathology, Substance Abuse and Culture on October 10-12, 1996 in Los Angeles, CA.

With support from the NIH Office of Research on Minority Health, a meeting was held October 9, 1996 in Los Angeles, CA, to develop strategies for promoting collaborative research between majority and minority institutions. The meeting was coordinated and chaired by Dr. Tony Strickland and attended by NIDA grantees and interested minority investigators and institutions.

A NIDA-sponsored Policy Workshop on Research Development For Hispanic Drug Abuse Researchers was held in Washington, D.C. January 27-28,1997. The meeting was chaired by Dr. Mario De La Rosa.

On November 21-22, 1996, Howard University Research Center sponsored a meeting of faculty and staff from HBCUs who are forming a consortium to research substance abuse and other health issues of women on Black college campuses. This is a joint project with CSAP and the National Black Women's Health Project.

As part of NIDA's HBCU initiative, a technical assistance meeting for HBCUs was held December 16 -19, 1996 in Washington, DC.

Dr. Alan Leshner, Director, NIDA, was keynote speaker and co-chaired a day-long Institute on adolescent substance abuse and treatment at the American Academy of Child and Adolescent Psychiatry Annual Meeting held in Philadelphia on October 24 - 25, 1996.

Richard A. Millstein, Deputy Director, NIDA, spoke at and moderated the session "Effective Drug Treatment- What Works" at the Fourth Annual Conference on Psychopathology, Psychopharmacology, Substance Abuse and Culture held in Los Angeles, CA on October 11, 1996.

Richard A. Millstein and Dr. William Bukoski, DEPR, presented on NIDA prevention research at the Center for Substance Abuse Prevention (CSAP) senior staff meeting held in Rockville, MD on October 23, 1996. CSAP senior staff then presented to NIDA senior staff in December. Development of an MOU between NIDA and CSAP is currently being pursued to formalize discrete areas of cooperation and collaboration.

Richard A. Millstein represented NIDA at the presentation of the Dana Foundation Awards for Pioneering Achievements in Health and Education on November 6, 1996 in New York, NY.

Richard A. Millstein served as a panelist at a special presentation on the integration of peer review entitled "New Directions in Neuroscience Grant Review at NIH--A Discussion with the Directors" at the Society for Neuroscience Annual Meeting held in Washington, DC on November 18, 1996.

Richard A. Millstein spoke at the NIDA Minority Fellows Forum, "Neuroscience Research in Drugs of Abuse" at the Society for Neuroscience Annual Meeting in Washington DC on November 19, 1996.

Richard A. Millstein spoke at the symposium, "NIDA: The Next Generation," a satellite to the Society for Neuroscience Annual Meeting held in Washington DC on November 20, 1996.

Richard A. Millstein presented to the Hubert Humphrey Fellows in Rockville, MD on December 6, 1996.

Dr. Timothy Condon, Associate Director for Science Policy, and Director, OSPC, chaired a Grant Writing Workshop with Dr. Vince Smeriglio, DCSR and Dr. Naimah Weinberg, DEPR, at the American Academy of Child and Adolescent Psychiatry Annual Meeting held in Philadelphia on October 24 - 25, 1996. The aim of the workshop was to encourage attending psychiatrists interested in a career in drug abuse and addiction research.

Dr. Joseph Frascella, Chief of the Etiology and Clinical Neurobiology Branch, DCSR, attended the Winter Brain Conference in Breckenridge, Colorado, January 25-February 1, 1997. He represented NIDA on two panels that discussed issues related to the integration of the neurosciences at the DRG.

Dr. Meyer Glantz presented a paper entitled "Women and Substance Abuse" at the American Psychological Association - 1996 Women's Health Conference, Washington, D.C., September 1996. The paper explored some of the unique characteristics of women substance abusers, particularly those related to comorbidity.

Richard H. Needle, Ph.D., M.P.H., DEPR, gave a seminar entitled "Community-Based HIV Epidemiology and Prevention Research: 1987-1997" at the Centers for Disease Control and Prevention (CDC) on September 18, 1996. He described risk factors and rates of HIV seroprevalence among out-of-treatment injection drug users and crack smokers from NADR to NIDA's CA; research findings on the efficacy of interventions designed to prevent, eliminate, or reduce HIV risk behaviors; and future directions in community-based HIV research.

Richard H. Needle, Ph.D., M.P.H., served as discussant for a session entitled "Ethnographic Investigation: Drug Abusers Perspectives on Treatment," at DCSR's December 3-4 review meeting on "Treatment Readiness: Factors Influencing Entry and Engagement." Five ethnographers whose research NIDA supports gave presentations for the session, including Drs. Koester, Carlson, Dunlap, Murdoch, and Bourgois.

Helen Cesari, M.S., Community Research Branch, DEPR, provided an overview of the Drug- Using Men Who Have Sex with Men Multi-Site Study at the Centers for Disease Control and Prevention (CDC) on September 18. CRB/DEPR initiated this collaborative study with CDC's Division of STD/HIV Prevention to address the increasing incidence of HIV among DU MSM. Following the overview, Sherry Deren, Ph.D., NDRI, described the study methods and interview data, Robert Trotter, Ph.D., Northern Arizona University (NAU), provided a discussion of preliminary findings from the network analysis, Fen Rhodes, Ph.D., California State University Long Beach, reviewed the themes, issues, and implications stemming from the multi-site focus groups, and Robert Trotter, Ph.D., NAU, concluded with a presentation on findings from the focus group transcript analyses.

Elizabeth Lambert, M.Sc., DEPR, and Helen Cesari, M.S., DEPR, co-authored a presentation entitled "Understanding HIV-Related Risks among Men Who Use Drugs and Have Sex with Men: The Role of Multi-Site Research." This was the first of six presentations in a session on DU MSM, held at the 95th annual meeting of the American Anthropological Association, November 20-24, in San Francisco. Presentations were also given by Michelle Wood (of the Long Beach site), Michael Stark (Portland, Oregon), Russel Falck (Dayton/Columbus, Ohio), and Michelle Shedlin (New York, NY) .

Arnold Mills, M.S.W., CRB, DEPR, coordinated the National Technical Assistance Workshop and Annual Meeting for Faculty and Staff from Historically Black Colleges and Universities (HBCUs) participating in the Drug Abuse Research Technical Assistance Project (DARTAP), held September 9-12, 1996 in Bethesda, MD.

Arnold Mills, M.S.W., CRB, DEPR, gave an invited presentation on December 11, 1996 to faculty and staff of the Georgia Prevention Institute, Medical College of Georgia, Paine College, Augusta State University, and the Augusta Veterans Administration Hospital. The presentation, on NIDA's HIV/AIDS prevention research program, was in response to the medical college's interest in establishing a family-focused research program which would emphasize drug abuse and HIV/AIDS prevention research.

Moira O'Brien, ERB, DEPR, represented NIDA at an ONDCP interagency work group to develop a joint U.S./Mexico Drug Abuse Threat Assessment Paper for the U.S. Mexico bilateral High Level Contact Group on Drug Control.

Moira O'Brien, ERB, DEPR, participated in the Measurement Issues for Family Prevention Meeting in Salt Lake City, Utah, October 14, 1996 and gave a presentation on NIDA and World Health Organization collaboration in the development of comparable, cross culturally applicable epidemiologic instruments for drug abuse prevalence assessment.

Dr. Coryl Jones, ERB, DEPR was a discussant in several sessions exploring the role of drug abuse in child abuse and neglect and the seminar on Federal research initiatives at the National Conference of Child Abuse and Neglect, Washington, DC, September 16-19, 1996.

Dr. James Colliver, DEPR, presented information on adolescent drug use at a meeting on the President's Initiative on Youth, Drugs, and Driving, held November 14, 1996. Along with NIDA, representatives from DOT, NHTSA, FHWA, Dept of Ed., SAMHSA, DOJ, and ONDCP were present. Arthur Hughes, ERB/DEPR attended a subequent meeting held on December 4, 1996. These meetings were held to discuss issues in a variety of areas (e.g., epidemiology, pharmacology, drug testing, State laws, treatment, and prevention) and to propose recommendations on the initiative to reduce teenage driving under the influence of illicit drugs.

Dr. Rita Liu, OEPR, was an invited speaker at a meeting held in Hong Kong in December 1996. Dr. Liu gave a special topic presentation on the NIH Peer Review system to the attendants of the "Orientation Workshop on Opioid Research Across the Strait." The meeting was also attended by NIDA grantees Drs. Horace Loh, Lei Yu, I.K. Ho, and Ji-Sheng Han.

Dr. Jerry Frankenheim presented an invited seminar, "Methamphetamine: America's Newest Drug Problem" at the University of Mississippi Medical Center, Jackson MS on October 14, 1996. He also led a discussion of pharmacology/neuroscience/drug abuse research career opportunities with students at the Medical Center.

Dr. Jaylan S. Turkkan, Chief of the Behavioral Sciences Research Branch, was a discussant in a symposium organized by NIDA's Intramural Research Program entitled "Neurocognitive Approaches to Craving for Abused Drugs" at the 30th Annual Association for Advancement of Behavior Therapy (AABT) convention in NYC, November 1996.

Dr. Jaylan S. Turkkan gave a lecture entitled "Psychological Sciences at the Turn of the Century" at the annual meeting of the Pavlovian Society in Baltimore, December 1996.

Dr. Jaylan S. Turkkan represented NIDA at two nicotine-related meetings: the first was the executive meeting of the Society for Research on Nicotine and Tobacco (November 1996) in Washington, DC. The second was a trans-NIH planning group around tobacco and smoking-related research and initiatives (Dr. Peter Greenwald, NCI, Chairman. December 1996).

Dr. Bennett Fletcher, DCSR, attended the American Psychological Association meeting in Toronto during August and presented two papers: "Brief History of Treatment Outcome Research in the United States" and "Drug Abuse Treatment and Services: Reducing Violence in the Community" (coauthored with Dr. Peter Delany, DCSR). Dr. Fletcher also served as a discussant in a symposium presenting recent NIDA-funded research on treating special populations in therapeutic communities.

Dr. Sander Genser, CMB, DCSR, attended the Annual Meeting of the American Academy of Addiction Psychiatry in San Francisco and co-hosted with Dr. Jack Blaine, TRB, DCSR, a luncheon session on the NIDA Research Program.

Dr. Peter Delany, SRB, DCSR, attended the Annual Meeting of the National Association of Social Workers (NASW) and met with officials of NASW and the Institute for the Advancement of Social Work Research (IASWR) to discuss research trends and opportunities at NIDA.

Dr. Peter Delany, SRB, DCSR, helped plan and presented a paper entitled "Evaluating Your Practice: Answering So What?.." at the Uniformed Services Social Work Conference, in Cleveland, Ohio. This was the largest inter-service conference for social work professionals.
Dr. Mac Horton, ECNB, DCSR, gave a presentation entitled "Funding Opportunities at the National Institute on Drug Abuse"; chaired the session devoted to Disorders of Childhood and Adolescence; and presented a talk during the session on "Neuropsychological Assessment of Adult Attention Deficit Disorder," at the Fourth Annual Conference on Psychopathology, Psychopharmacology, Substance Abuse, and Culture, in Los Angeles, California, October 10-12, 1996

Dr. Horton presented a talk on "Research Opportunities at NIDA" at the 16th Annual National Academy of Neuropsychology Conference in New Orleans, Louisiana on November 1, 1996.

Dr. Frank Vocci, Acting Director, MDD, presented Grand Rounds at the Department of Psychiatry, New York University Medical Center, October 24, 1996. Dr. Vocci's topic was "Approaches to the Development of Medications for the Treatment of Cocaine Dependence."

Dr. Frank Vocci, MDD, was a discussant at a December 11, 1996 scientific session of the American College of Neuropsychopharmacology, San Juan, Puerto Rico. The session was entitled "Evolving Molecular Targets for Cocaine Pharmacotherapy" and showcased NIDA-sponsored research funded through various mechanisms. Dr. Barbara Fox, Dr. Eric Nestler, Dr. George Uhl, and Dr. Thomas Kosten presented on the development of a cocaine vaccine; potential medications aimed at the dopamine transporter; altering or reversing long-term intracellular changes; and clinical approaches to medications development, respectively.

Dr. Peter Cohen, MDD, participated with the Substance Abuse and Mental Health Services Administration as a member of two resource panels developing Treatment Improvement Protocols (TIPs) entitled Substance Abuse Among Older Americans, and Case Management for Substance Abuse Treatment.

Dr. Lula Beatty, Chief, Special Populations Office (SPO), chaired a panel on the need for research on drug abuse and other health issues of Black women on Black college campuses at a meeting of HBCU administrators and foundation representatives sponsored by CSAP on September 16, 1996 in Washington, DC.

Dr. Lula Beatty, SPO, moderated a panel on drug abuse in women at the American Psychological Association's women's conference on September 19, 1996 in Washington, DC.

Dr. Lula Beatty, SPO, was a panelist on a federal panel to discuss NIDA research needs and funding opportunities with scholars funded under CSAP's high risk program on September 20, 1996 in Washington, DC.

Dr. Lula Beatty, SPO, moderated two panels at the 4th Annual Psychopharmacology, Psychopathology, Substance Abuse and Culture Conference held on October 10-12, 1996 in Los Angeles, CA.

Dr. Lula Beatty, SPO, presented an overview of research with minority populations for the Humphrey Fellows on December 5, 1996 as part of a visit coordinated by NIDA's International Office.

Dr. Lula Beatty, SPO, was the keynote speaker for the MARC program at Temple University on December 21, 1996.

Dr. Mario De La Rosa, SPO, chaired a joint NIDA/NIH Office of Minority Research meeting in Washington, D.C. on September 26-27. The meeting was entitled "Drug Abuse Research with Minority Populations: Methodological and Theoretical Issues and Concerns." Twenty scientists presented information and data regarding the development and application of more effective methods to recruit and retain minority persons in drug abuse research studies.

Dr. Monique Ernst, IRP, presented papers entitled, "Functional Brain Imaging in ADHD," and "MAOIs in ADHD," at the 43rd Annual Meeting of the American Academy of Child and
Adolescent Psychiatry, Philadelphia, October 1996.

Dr. Steven Grant, IRP, gave a presentation entitled, "Activation of Memory Circuits During Cue-Elicited Cocaine Craving," at the Nuclear Magnetic Resonance Center, Massachusetts
General Hospital, Boston, MA, October 1996.

Dr. Edythe London, IRP, presented a lecture entitled, "Interactions of Nicotine with Specific Receptors and Circuits in Brain," at the 9th National Conference on Nicotine Dependence sponsored by the American Society of Addiction Medicine, Washington, D.C., November 1996.

Dr. Edythe D. London, IRP, presented a lecture entitled, "Activation of Memory Circuits During Cocaine Craving: PET Studies" at the NIDA Satellite Symposium, "What Can Cognitive Neuroscience Tell Us About Drug Abuse Disorders?" at the Annual Meeting of the Society for Neuroscience, Washington, D.C., November 1996.

Dr. Steven Grant, IRP, co-chaired the NIDA Satellite Symposium, "What Can Cognitive Neuroscience Tell Us About Drug Abuse Disorders," at the Annual Meeting of the Society for Neuroscience, Washington, D.C., November 1996.

Dr. Katherine Bonson, IRP, presented a paper entitled, "Regulation of 5-HT2 Receptors by Chronic DOM, DOI, Ritanserin or DOM plus Ritanserin: Behavioral Evidence," at the Annual Meeting of the Society for Neuroscience, Washington, D.C., November 1996.

Dr. Monique Ernst, IRP, presented a paper entitled, "PET with [fluorine-18]fluorodopa in Autism," at the Annual Meeting of the Society for Neuroscience, Washington, D.C., November 1996.

Dr. Steven Grant, IRP, presented a paper entitled, "Activation of Memory Circuits During Cue-Elicited Cocaine Craving," at the Annual Meeting of the American Association for Behavioral Therapy, New York City, NY, November 1996,

Dr. Steven Grant, IRP, presented a paper entitled, "PET Studies in Cocaine Craving," at the symposium entitled, "NIDA: The Next Generation," at the Annual Meeting of the Society for Neuroscience, Washington, D.C., November 1996.

Dr. Xiang Liu, IRP, presented a paper entitled, "Reduced Volume of Prefrontal Lobe in Polysubstance Abusers: A Magnetic Resonance Imaging Study" at the Annual Meeting of the Society for Neuroscience, Washington, D.C., November 1996.

Dr. John Matochik, IRP, presented a paper entitled, "Cerebral Metabolic Effects of Triiodothyronine in Adults with Resistance to Thyroid Hormone," at the Annual Meeting of the Society for Neuroscience, Washington, D.C., November 1996.

Dr. Evan Morris, IRP, presented a paper entitled, "Can Positron Emission Tomography Detect Changes in Intrasynaptic Dopamine? Computer Simulations Can Optimize the Experimental Design," at the Annual Meeting of the Society for Neuroscience, Washington, D.C., November 1996.

Dr. Masamitsu Takagishi, IRP, presented a paper entitled, "Effects of Low Dose Mecamylamine on Regional Cerebral Glucose Metabolism in Rats Receiving Chronic Nicotine," at the Annual Meeting of the Society for Neuroscience, Washington, D.C., November 1996.

Dr. Alexis Thompson, IRP, presented a paper entitled, "Delta-Opioid Receptor Blockade Prevents Sensitization to the Conditioned Reinforcing Effects of Morphine," at the Annual Meeting of the Society for Neuroscience, Washington, D.C., November 1996.

Dr. Bruce Vaupel, IRP, presented a paper entitled, "Inhibition of Constitutive but not Inducible Nitric Oxide Synthase Attenuates Signs of Morphine Withdrawal," at the Annual Meeting of the Society for Neuroscience, Washington, D.C., November 1996.

Dr. Edythe London, IRP, co-chaired a symposium entitled, "Controversies in Nicotine and Tobacco Smoking Actions," at the 35th Annual meeting of the American College of
Neuropsychopharmacology, San Juan, PR, December 1996.

Dr. Robert Phillips, IRP, made an oral presentation entitled, "PET Imaging: New Frontiers in Diagnosing Drug Addiction and Functional Brain Disorders," at a symposium of the Idaho Neurological Institute, St. Adolphus Hospital, Boise, Idaho, December 1966.

Drs. Charles Schindler and Steven Goldberg, IRP, organized and participated in a symposium on the "Motivational Factors in Drug Abuse" at the 1996 meeting of CPDD.

Dr. Amy Newman, IRP, presented a lecture entitled "In Search of a Cocaine-Abuse Therapeutic: New Clues from an Old Drug" as part of the NIH Director's Seminar Series.

Dr. David A. Gorelick, IRP, attended the Eighth International Catecholamine Symposium (held Oct., 1996 in Asilomar, CA) as co-chair of a session on drug abuse, and gave an invited presentation on "The Rate Hypothesis and Agonist Substitution Approaches to Cocaine Abuse Treatment."

Mann H., Hirata H., Ladenheim B., Moran T.H., and Cadet J.L. "Multidrug Resistant (mdrla) Knockout Mice are Differentially Affected by Methamphetamine (METH) and Methylenedioxy-methamphetamine (MDMA)" was presented at the Society for Neuroscience annual meeting held November 16-21, 1996.

Cadet J.L., Ordonez S., and Ordonez J. "Methamphetamine Causes Superoxide Generation and Apoptosis in Neural Cells" was presented at the Society for Neuroscience annual meeting held November 16-21, 1996.

Hirata H., and Cadet J.L. "Kainate-Induced Neurotoxicity is Attenuated in SOD-TG Mice" was presented at the Society for Neuroscience annual meeting, November 16-21, 1996.

Herning R.I., Better W., and Cadet J.L. "Blood Flow in Cocaine Dependence" was presented at the Society for Neuroscience annual meeting held November 16-21, 1996.

Tsao L-I, Ladenheim B. Cadet, J.L., and Su T-P. "Delta Opioid Peptide [D-ALA2, D-LEU5]-Enkephalin (DADLE) Attenuates Methamphetamine (METH)-Induced Neurotoxic Damage to Dopaminergic Neurons in Mice" was presented at the Society for Neuroscience annual meeting held November 16-21, 1996.

Sheng P., Ladenehim B., Moran T.H., Wang C.-B., and Cadet J.L."Methamphetamine- Induced Neurotoxicity is Associated with Prolonged Increase in Striatal AP-1 DNA-Binding in Mice" was presented at the Society for Neuroscience annual meeting held November 16-21, 1996.

Ladenheim B., Hirata H., and Cadet J.L. "Differential Regulation of Mu Receptors by Methamphetamine in p53 Knock-Out Mice" was presented at the Society for Neuroscience annual meeting held November 16-21, 1996.

McCoy M.T., and Cadet J.L. "Induction of Bclxs and Bclxl by Methamphetamine in Immortalized Neural Cells" was presented at the Society for Neuroscience annual meeting held November 16-21, 1996.

Cadet, J.L. "Cell Cycle and Apoptosis" was presented at the 3rd Annual Meeting of the Oxygen Society held in Miami Beach, Florida on November 21-25, 1996.


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