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NIDA Home > Publications > Director's Reports > February, 2008 Index    

Director's Report to the National Advisory Council on Drug Abuse - February, 2008



Program Activities

New NIDA PAs and RFAs

On December 10, 2007, NIDA issued PAS-08-041 entitled Design, Synthesis, and Preclinical Testing of Potential Treatment Agents for Drug Addiction (R01). Through this FOA NIDA invites research applications aimed at design, synthesis, and preclinical testing of potential treatment agents for drug addiction and/or relapse prevention. Recent advances in molecular neurobiological mechanisms underlying drug addiction provide a basis for development of new therapeutic targets and chemical entities to treat and prevent relapses of drug addiction. This FOA will utilize the NIH Research Project Grant (R01) award mechanism.

On December 21, 2007, NIDA issued PAS-08-061 entitled Long Acting, Sustainable Therapies for Opiate Addiction (R01). This FOA encourages Research Project Grant (R01) applications from institutions/organizations that propose the development of sustained pharmacotherapies and behavioral treatments to reduce the risk of contraction and transmission of HIV. Specifically, this FOA supports applications directed at the development of (1) heroin/morphine-protein conjugates (heretofore referred to as heroin/morphine conjugate vaccines or HCVs) for the treatment of opiate addiction, (2) clinical systems for the application of currently available long-acting (30-day or longer sustained-release) dosage forms for opiate pharmacotherapies to optimize these sustained pharmacotherapies to effect the reduction of the risk for acquisition and transmission of HIV, and (3) effective clinical treatment modalities, including behavioral treatment in conjunction with pharmacotherapies, to improve the effectiveness of opiate treatment and reduce the risk behaviors associated with transmission of HIV. Clinical studies should include the assessment of HIV risk behaviors as an outcome measure.

On January 14, 2008, NIDA issued PAR-08-073 entitled NIDA Core "Center of Excellence" Grant Program (P30). This FOA uses the Core Center of Excellence Grant (P30) mechanism. It is expected that a Center will transform knowledge in the sciences it is studying. Incremental work should not be the focus of Center activities; rather, new and creative directions are required. The P30 Center may support pilot research in any area of NIDA's mission. Research may occur in any area of NIDA's mission. Each separate core should bear an essential relationship to the integrating theme. The P30 Center of Excellence is expected to support the education, training, and mentoring of new investigators, who should be given meaningful roles to play in the Center projects. NIDA Centers are expected to share their findings, their data and their resources.

On November 9, 2007 NIDA issued RFA-DA-08-003 entitled 2008 NIDA Avant-Garde Award Program for HIV/AIDS Research (DP1). The NIDA Director's Avant-Garde Award Program for AIDS research is meant to complement NIDA's traditional investigator-initiated grant programs by supporting individual scientists of exceptional creativity who propose approaches in the forefront of drug abuse and HIV/AIDS research. This program is intended to fund scientists engaged in basic, clinical, or translational research on drug abuse and HIV/AIDS. The term "avant-garde" is used to describe highly innovative approaches that have the potential to produce an unusually high impact. The proposed research should reflect ideas substantially different from those already being pursued by the investigator or others. The research proposed must be in an area described in the Trans - NIH Plan for HIV-Related Research and be drug abuse relevant but need not be in a conventional biomedical or behavioral discipline. This FOA will utilize the NIH DP1 grant mechanism.

On December 11, 2007, NIDA released RFA DA-08-024 (R01) and DA-08-025 (R03), entitled Extinction and Pharmacotherapies for Drug Addiction. The purpose of these Funding Opportunity Announcements (FOAs), is to stimulate animal or human research on mechanisms underlying extinction in order to guide the development of interventions for enhancing extinction of drug-seeking behavior. It is expected that research supported under this FOA will ultimately be used to guide and implement combined behavioral/cognitive and pharmacological and/or molecular interventions for the treatment of drug abuse relapse.

In January 2008, NIDA issued three RFAs entitled: RFA-DA-08-013, Substance Abuse and Glial Regulation of Nervous System Function (R03); RFA-DA-08-014, Substance Abuse and Glial Regulation of Nervous System Function (R01); and RFA-DA-08-015, Substance Abuse and Glial Regulation of Nervous System Function (R21). Through these FOAs, NIDA requests research grant proposals to study the effects of drugs of abuse on glial cells, and the consequences of these effects on glial-neural cell signaling and communication, neuronal activity, and behavior within the nervous system. It is expected that this initiative will enhance and increase current understanding of the structural and functional interactions between glial and neuronal cells within the central and peripheral nervous systems, and the effects of drugs of abuse on these interactions.

NIDA issued an RFA entitled The Interaction of HIV, Drug Use, and the Criminal Justice System (R01) (RFA-DA-08-007). This initiative solicits R01 applications linking drug abuse, HIV/AIDS prevention or treatment, and the criminal justice system. Applications should include research projects for developing interventions, descriptive research that clearly can lead to effective new interventions, or research on transporting effective interventions into practice.

On November 27, 2007, NIDA issued RFA-DA-08-011 entitled Drug Interactions in Substance Abusers with HIV Infection and Other Comorbid Conditions (R01). This funding opportunity announcement (FOA) solicits grant applications through the NIH Investigator initiated Research Grant (R01) award mechanism from applicant organizations to gain new knowledge on the subject of drug-drug interactions observed during the treatment of infections in drug addicts. This program fosters the use of investigator initiated research grants mechanism (R01s) to determine the characteristics, extent, and underlying mechanisms of pharmacokinetic/pharmacodynamic interactions between pharmacotherapeutic agents used in the treatment of drug addiction, viral infections including HIV and opportunistic infections (OIs) such as hepatitis C, or other bacterial or fungal infections in drug addicts. This FOA will utilize the R01 research grant program, which can be carried out in a short period of time with limited resources.

On December 17, 2007, NIDA issued RFA-DA-08-010 entitled The National Institute on Drug Abuse HIV/AIDS Pilot Proteomics Centers (P20). This FOA solicits applications to establish Pilot Proteomics Centers that will address the complex biological mechanisms of interactions among drugs of abuse and HIV pathogenesis, their treatments, and host responses. The centers will use proteomics technologies and other related technologies (i.e., gene expression profiling) to look for protein changes and molecular signatures of disease progression of HIV/AIDS in combination with substance abuse/addiction, HIV treatment, and/or treatments for substance abuse. These proteomics centers are expected to help identify mechanisms related to susceptibility to and progression of HIV infection, viral replication, and viral evolution, particularly related to neuroAIDS.

On December 27, 2007, NIDA issued RFA-DA-08-009 entitled HIV-1 and Host Genetics in Drug Using Populations and Model Organisms (R01). This FOA solicits Research Project Grant applications that propose to elucidate the molecular mechanisms by which genetic variations provide protection from or vulnerability to infection, and how drugs of abuse, medications for drug addiction, and HIV-1 treatment interact with both host and viral genes. This FOA will utilize the NIH Research Project Grant (R01) award mechanism.

On January 10, 2008, NIDA issued RFA-DA-08-020 entitled Facilitating Self-Control of Substance Abuse Related Brain Activity through Real-Time Monitoring of fMRI Signals (R21/R33). Through the issuance of this RFA, NIDA seeks to encourage exploratory (i.e., descriptive, hypothesis-generating, and developmental) research focusing on the use of real time functional magnetic resonance imaging (rt-fMRI) in humans so that subjects can learn to modulate their own brain activity and monitor and control (modulate) activity of brain regions relevant to substance abuse. Proposals may incorporate development, implementation, and dissemination of requisite technology and methods as well as feasibility testing in healthy human subjects or substance abusers. This Funding Opportunity Announcement (FOA) will utilize the NIH R21/R33 Phased Innovation Award ((R21 [Phase I]/R33 [Phase II]) grant mechanism.

On January 14, 2008, NIDA issued RFA-DA-08-012 entitled Resource Core Transdisciplinary Prevention Research Centers (P30). The overall purpose of the NIDA Transdisciplinary Prevention Research Center (TPRC) program is to support environments in which scientists from the basic and applied/clinical disciplines can come together to develop a coherent program of transdisciplinary research. The ultimate goals of these centers are to encourage: (a) translational research between the basic sciences into the development and testing of novel preventive intervention approaches, and (b) translation of preventive intervention findings back into basic science laboratory studies that can better explicate underlying intervention mechanisms and effects on basic systems such as neurobiology. This type of translation research is bidirectional in nature, with the basic sciences informing intervention development and modification and intervention findings informing basic research inquiry. It is expected that a transdisciplinary approach will explore and catalyze new ways of conceptualizing prevention intervention research. This RFA uses the NIH Resource Core Center Grant (P30) mechanism to support centralized resources and facilities shared by transdisciplinary teams of drug abuse prevention research investigators.

PAs and RFAs with Other NIH Components/Agencies

On October 18, 2007, NIDA, in collaboration with other NIH components issued PAR-08-010 entitled Continued Development and Maintenance of Software (R01). Biomedical research laboratories increasingly undertake a software development project to solve a problem of interest specifically related to that laboratory. These software packages sometimes become useful to a much broader community of users that can include translational and clinical researchers. The goal of this program announcement is to support the continued development, maintenance, testing and evaluation of existing software. The proposed work should apply best practices and proven methods for software design, construction, and implementation to extend the applicability of existing biomedical informatics/computational biology software to a broader biomedical research community. This FOA will utilize the NIH Research Project Grant (R01) award mechanism.

On October 22, 2007, NIDA in collaboration with numerous other NIH components issued PA-08-012 entitled ELSI Regular Research Program (R01). This Funding Opportunity Announcement (FOA) issued by the National Human Genome Research Institute, National Institutes of Health, encourages Research Program Grant (R01) applications from institutions/organizations that propose to study the ethical, legal and social implications (ELSI) of human genome research.

On October 22, 2007, NIDA in collaboration with numerous other NIH components issued PA-08-013 entitled ELSI Small Research Grant Program (R03). This Funding Opportunity Announcement (FOA) issued by the National Human Genome Research Institute, National Institutes of Health, encourages Small Research Grant (R03) applications from institutions/organizations that propose to study the ethical, legal and social implications (ELSI) of human genome research. This announcement is specifically designed to: 1) encourage the development of small, focused research projects by legal, historical, ethics, humanities, social sciences and behavioral scholars; 2) support exploratory studies that may provide preliminary findings or pilot data for larger research proposals; 3) support the secondary analysis of existing data; 4) support the development of new methodologies; and 5) stimulate and facilitate the entry of promising new investigators into ELSI Research. This FOA will utilize the NIH Small Research Grant (R03) award mechanism.

On November 5, 2007, NIDA, in conjunction with numerous other NIH components, issued PAR-08-023 entitled Predictive Multiscale Models of the Physiome in Health and Disease (R01). This FOA solicits Research Project Grant (R01) applications from institutions/organizations that propose to develop predictive multiscale models of the physiome in health and disease. The goal of this solicitation is to move the field of biomedical computational modeling forward through the development of more realistic and predictive models of health and disease. NIH recognizes the need for sophisticated, predictive, computational models of development and disease that encompass multiple biological scales. These models may be designed to uncover biological mechanisms or to make predictions about clinical outcome and may draw on a variety of data sources including relevant clinical data. Ultimately the models and the information derived from their use will enable researchers and clinicians to better understand, prevent, diagnose and treat the diseases or aberrations in normal development. Specifically this FOA solicits the development of predictive multiscale models of health and disease states that must include higher scales of the physiome. The specific objectives are to develop multiscale models that are physiologically mechanistic and biomedically relevant, to bring together modeling and biomedical expertise to collaborate on building models, to validate and test models with standard datasets, and to develop models that can be explicitly shared with other modelers. This FOA will utilize the NIH Research Project Grant (R01) award mechanism.

On December 13, 2007, NIDA and NCI jointly issued PAR-08-046 entitled NIDA Research "Center of Excellence" Grant Program (P50). This FOA is to provide support for research centers that conduct drug abuse and addiction research that have outstanding innovative science and that are multidisciplinary, thematically integrated, synergistic, and are/will be serving as national resource(s) for the NIDA research fields. This FOA uses the Research Center of Excellence Grant (P50) mechanism. There should be evidence that the presence of a center structure is essential for the accomplishment of the research activities. It is expected that a Center will transform knowledge in the sciences it is studying. Incremental work should not be the focus of Center activities; rather, new and creative directions are required.

On December 18, 2007, NIDA, in collaboration with numerous other NIH components issued PA-08-052 entitled Nanoscience and Nanotechnology in Biology and Medicine (R01). This funding opportunity (FOA) is aimed at enhancing nanoscience and nanotechnology research focused on problems in biology and medicine. Nanoscience and nanotechnology refer to research and development on the understanding and control of matter at a length scale of approximately 1 - 100 nanometers, where novel properties and functions occur because of the size. A major challenge facing medicine is to develop novel and more sophisticated approaches for the diagnosis, treatment and management of an array of diseases and traumatic injuries. Nanotechnology and nanoscience have the capacity to drive a new wave of medical innovation through the engineering of bioactive nanoscale structures, processes and systems based on the advancement of our understanding of biology at the nanoscale. This Funding Opportunity Announcement (FOA) will utilize the R01 grant mechanism.

On December 18, 2007, NIDA, in collaboration with numerous other NIH components issued PA-08-053 entitled Nanoscience and Nanotechnology in Biology and Medicine (R21). This funding opportunity (FOA) is aimed at enhancing nanoscience and nanotechnology research focused on problems in biology and medicine. Nanoscience and nanotechnology refer to research and development on the understanding and control of matter at a length scale of approximately 1 - 100 nanometers, where novel properties and functions occur because of the size. A major challenge facing medicine is to develop novel and more sophisticated approaches for the diagnosis, treatment and management of an array of diseases and traumatic injuries. Nanotechnology and nanoscience have the capacity to drive a new wave of medical innovation through the engineering of bioactive nanoscale structures, processes and systems based on the advancement of our understanding of biology at the nanoscale. This Funding Opportunity Announcement (FOA) will use the NIH Exploratory/Developmental Research Grant Award (R21) mechanism.

On January 11, 2008, NIDA, in collaboration with NICHD and NIAAA issued PA-08-068 entitled The Science and Ecology of Early Development (SEED) (R03). This Funding Opportunity Announcement (FOA) encourages submission of investigator-initiated research grant applications that seek to develop a comprehensive program of research focused on the mechanisms through which social, economic, cultural, and community-level factors, and their interactions, impact the early cognitive, neurobiological, socio-emotional, and physical development of children. This FOA will utilize the NIH Small Research Grant (R03) award mechanism.

On January 11, 2008, NIDA, in collaboration with NICHD and NIAAA issued PA-08-069 entitled The Science and Ecology of Early Development (SEED) (R01). This Funding Opportunity Announcement (FOA) encourages submission of investigator-initiated research grant applications that seek to develop a comprehensive program of research focused on the mechanisms through which social, economic, cultural, and community-level factors, and their interactions, impact the early cognitive, neurobiological, socio-emotional, and physical development of children. This FOA will utilize the NIH Research Project Grant (R01) award mechanism.

On January 11, 2008, NIDA, in collaboration with other NIH components involved in the NIH Blueprint for Neuroscience Research issued PA-08-071 entitled Lab to Marketplace: Tools for Brain and Behavioral Research (SBIR [R43/R44]). This FOA encourages the translation of technologies for brain or behavioral research from academic and other non-small business research sectors to the marketplace. Solicited from Small Business Concerns (SBCs) are Small Business Innovation Research (SBIR) grant applications that propose to further develop, make more robust, and make more user-friendly such technologies in preparation for commercial dissemination. It is expected that this activity will require partnerships and close collaboration between the original developers of these technologies and SBCs, which may be accomplished in any of a number of ways, including the use of multiple principle investigators. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications.

On January 8, 2008, NIDA, in collaboration with other NIH components issued PAR-08-065 entitled NIH Revision Awards for Studying Interactions Among Social, Behavioral, and Genetic Factors in Health (R01). This FOA invites applications from current NIH-funded investigators to study how interactions among of genetic and behavioral/social factors influence health and disease. This funding opportunity will use the NIH Revision (formerly named Competitive Supplement) award mechanism to supplement existing NIH funded R01 awards.

On January 8, 2008, NIDA, in collaboration with other NIH components issued PAR-08-066 entitled NIH Revision Awards for Studying Interactions Among Social, Behavioral, and Genetic Factors in Health (R21). This FOA invites applications from current NIH-funded investigators to study how interactions among of genetic and behavioral/social factors influence health and disease. This funding opportunity will use the NIH Revision (formerly named Competitive Supplement) award mechanism to supplement existing NIH funded R21 awards.

On January 8, 2008, NIDA, in collaboration with other NIH components issued PAR-08-067 entitled NIH Revision Awards for Studying Interactions Among Social, Behavioral, and Genetic Factors in Health (P01, P20, P50, P60, U01, U10, U54). This FOA invites applications from current NIH-funded investigators to study how interactions among of genetic and behavioral/social factors influence health and disease. This funding opportunity will use the NIH Revision (formerly named Competitive Supplement) award mechanism to supplement existing NIH funded P01, P20, P50, P60, U01, U10, U54 awards.

On January 16, 2008, NIDA, in collaboration with other NIH components and the CDC issued PA-08-074 entitled Community Participation in Research (R01). This FOA solicits R01 grant applications that propose intervention research on health promotion, disease prevention, and health disparities that communities and researchers jointly conduct. For the purposes of this FOA, intervention research is quasi-experimental research projects that seek to influence preventive behaviors, treatment adherences, complementary behaviors, and related attitudes and beliefs. Natural experiments also may fall under the interventions rubric. This FOA will utilize the NIH Research Project Grant (R01) award mechanism.

On January 16, 2008, NIDA, in collaboration with other NIH components issued PAR-08-075 entitled Community Participation Research Targeting the Medically Underserved (R01). The ultimate goal of this FOA is to solicit Research Project Grant (R01) applications that propose research on health promotion, disease prevention, and health disparities that is jointly conducted by communities and researchers and targets medically underserved areas (MUAs) and medically underserved populations (MUPs) as defined by the Department of Health and Human Services (DHHS) Health Resources and Services Administration (HRSA). This FOA will use the R01 grant mechanism to encourage studies that specifically target medically underserved areas as well as underserved and underrepresented populations.

On January 16, 2008, NIDA, in collaboration with other NIH components issued PAR-08-076 entitled Community Participation Research Targeting the Medically Underserved (R21). The ultimate goal of this FOA is to solicit applications that propose research on health promotion, disease prevention, and health disparities that is jointly conducted by communities and researchers and targets medically underserved areas (MUAs) and medically underserved populations (MUPs) as defined by the Department of Health and Human Services (DHHS) Health Resources and Services Administration (HRSA). This FOA will use the R21 grant mechanism to encourage studies that specifically target medically underserved areas as well as underserved and underrepresented populations.

On January 25, 2008, NIDA, in collaboration with other NIH Components, the CDC, and the FDA issued PA-08-050 entitled PHS 2008-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]). This FOA invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) grant applications. United States SBCs that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH, CDC and FDA awarding components identified in this FOA are encouraged to submit SBIR grant applications in response to identified topics. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, Fast-Track, and Phase II Competing Renewal applications.

On January 25, 2008, NIDA, in collaboration with other NIH Components, the CDC, and the FDA issued PA-08-051 entitled PHS 2008-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent STTR [R41/R42]). This FOA invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) grant applications. United States SBCs that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH, CDC and FDA awarding components identified in this FOA are encouraged to submit SBIR grant applications in response to identified topics. This FOA will utilize the STTR (R41/R42) grant mechanisms for Phase I, Phase II, Fast-Track, and Phase II Competing Renewal applications.

On January 28, NIDA, in collaboration with NIA issued PAR-08-081 entitled Research Education Grants for Statistical Training in the Genetics of Addiction (R25). This FOA invites applications focused on research education for the development and testing of new statistical models to address genetics-based research problems in addiction. Applicants are expected to propose a well-integrated research education and training program in statistical models or computational methods in genetics for undergraduate, graduate, and/or postdoctoral level students. This FOA will use the NIH Research Education (R25) grant mechanism.

NIDA, along with NIA, NINDS and NIMH, issued an RFA entitled Collaborative Research to Explore New Uses for Existing Radioligands (R21/R33) (RFA-DA-08-001). This RFA seeks to encourage broader uses of established PET/SPECT radioligands by reducing barriers to their wider distribution, and expanding their utility to the study of diseases or organs for which the radioligand has not previously been studied. Applications for this RFA should demonstrate a high degree of innovation and novelty with regard to the new uses for existing radioligands. Although there is no requirement for preliminary data, a clear scientific rationale is essential. Applications for this RFA are expected to propose multi-institutional collaborations between investigators who have the capacity for routine production of a given radioligand for human use, and investigators who lack access to the radioligand but wish to demonstrate the feasibility of an innovative use for the radioligand in a novel patient population.

On October 19, 2007, NIDA, in collaboration with NIMH, issued RFA-MH-08-080 entitled Programs of Excellence in Scientifically Validated Behavioral Treatment (R25). The purpose of this FOA is to support curriculum development to train clinician-scientists who can develop, test, and rapidly translate into practice innovative learning-based treatments in the addictive and mental disorders. The goals in establishing the Programs of Excellence Award are to recognize and enhance current clinical training programs that teach and develop research-based clinical practices and to provide a model for clinician education nationwide. This FOA will use the NIH Research Education (R25) grant mechanism.

On November 16, 2007, NIDA in collaboration with NIMH, issued RFA-DA-08-008 entitled Research on HIV/AIDS and Drug Use in the Multicenter AIDS Cohort Study (MACS) (R03). This FOA solicits grant applications thorough the NIH Small Research Grant (R03) award mechanism from applicant organizations to give added value and gain new knowledge from the Multicenter AIDS Cohort Study or MACS. This program fosters the use of small research grants (R03s) to build on an existing resource, the Multicenter AIDS Cohort Study or MACS. NIDA will support drug use and HIV/AIDS-related clinical epidemiology, socio-behavioral, neuro-AIDS, and medical consequences research utilizing pilot and feasibility studies; secondary analysis of existing data; self-contained research projects; collaborative studies linked to larger research projects; studies of statistical methodologies and modeling; and studies of new assessments and research techniques. NIMH will support similar types of studies that focus on HIV, the central nervous system, pharmacotherapeutics, and biomarker development strategies among non-drug using MSM. This Funding Opportunity Announcement (FOA) will utilize the R03 small research grant program, which can be carried out in a short period of time with limited resources.

On December 13, 2007, NIDA, in collaboration with numerous other NIH components, issued RFA-NS-08-005 entitled Centers for Evaluation of Neurodevelopmental Antibodies (CENA, U24). The goal of this initiative is to create a center (or centers) to 1) evaluate new monoclonal antibodies (mABs) to neurodevelopmental antigens using multiple model systems and 2) provide detailed information for use of these reagents to the research community. This FOA uses the Resource-Related Research Projects-Cooperative Agreement (U24) award mechanism .

On December 21, 2007, NIDA, in collaboration with the Canadian Institutes of Health Research (CIHR), issued RFA-DA-08-016 entitled Non-coding RNAs and Other Post-transcriptional Regulatory Mechanisms in Neuroplasticity and Addiction (R01). The purpose of this FOA is to stimulate research on non-coding RNAs and other post-transcriptional regulatory mechanisms as they pertain to addictive processes. This Funding Opportunity Announcement (FOA) will utilize the R01 grant mechanism.

On December 21, 2007, NIDA, in collaboration with the Canadian Institutes of Health Research (CIHR), issued RFA-DA-08-017 entitled Non-coding RNAs and Other Post-transcriptional Regulatory Mechanisms in Neuroplasticity and Addiction (R03). The purpose of this FOA is to stimulate research on non-coding RNAs and other post-transcriptional regulatory mechanisms as they pertain to addictive processes. This Funding Opportunity Announcement (FOA) will utilize the R03 grant mechanism.

On January 3, 2008, NIDA, in collaboration with SAMHSA, issued RFA-DA-08-021 entitled Screening, Brief Intervention and Referral to Treatment (SBIRT) for Drug Abuse in General Medical Settings (R01). This FOA invites research applications to develop and test the effectiveness of models that integrate screening, brief intervention, and referral to specialized treatment for individuals with drug abuse entering into primary care and other general medical settings. This is a joint effort between the National Institute on Drug Abuse (NIDA) and the Substance Abuse and Mental Health Services Administration (SAMHSA). This funding opportunity will use the NIH Research Project Grant (R01) award mechanism.

Other Program Activities

Clinical Trials Network (CTN) Update

The CCTN received proposals in response to a NIH SBIR Contract Solicitation for Topic 089, Development of Practical Training Materials for Evidence-Based Treatment. Two proposals have been awarded.

A total of 31 protocols have been initiated since 2001. Over 8,500 participants have enrolled in studies. Of these studies, 20 have completed data lock; two are in the follow-up phase; and three are currently enrolling. Six new protocols are in the development phase.

Primary outcome papers are published and dissemination materials have been developed with CSAT's ATTC on the following:

Protocol CTN 0001, Buprenorphine/Naloxone versus Clonidine for Inpatient Opiate Detoxification

Protocol CTN 0002, Buprenorphine/Naloxone versus Clonidine for Outpatient Opiate Detoxification

Protocol CTN 0005, MI (Motivational Interviewing) To Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse

Protocol CTN 0006, Motivational Incentives for Enhanced Drug Abuse Recovery: Drug Free Clinics

Protocol CTN 0007, Motivational Incentives for Enhanced Drug Abuse Recovery: Methadone Clinics

Primary outcome papers are published or in press for:

Protocol CTN 0004, MET (Motivational Enhancement Treatment) To Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse

Protocol CTN 0008, A Baseline for Investigating Diffusion of Innovation

Protocol CTN 0009, Smoking Cessation Treatment with Transdermal Nicotine Replacement Therapy in Substance Abuse Rehabilitation Programs

Protocol CTN 0011, A Feasibility Study of a Telephone Enhancement Procedure (TELE) to Improve Participation in Continuing Care Activities

Protocol CTN 0012, Characteristics of Screening, Evaluation, and Treatment of HIV/AIDS, Hepatitis C Viral Infection, and Sexually Transmitted Infections in Substance Abuse Treatment Programs

Protocol CTN 0013, Motivational Enhancement Therapy to Improve Treatment Utilization and Outcome In Pregnant Substance Abusers

Protocol CTN 0016, Patient Feedback: A Performance Improvement Study in Outpatient Addiction Treatment

Protocol CTN 0021, Motivational Enhancement Treatment to Improve Treatment Engagement and Outcome for Spanish-Speaking Individuals Seeking Treatment for Substance Abuse. This is the first Spanish-only protocol in the CTN.

In addition, the following protocols have locked the data:

Protocol CTN 0003, Bup/Nx: Comparison of Two Taper Schedules

Protocol CTN 0010, (Buprenorphine/Naloxone Facilitated Rehabilitation for Opioid Dependent Adolescents/Young Adults)

Protocol CTN 0015, Women's Treatment for Trauma and Substance Use Disorder: A Randomized Clinical Trial

Protocol CTN 0020, Job Seekers Training for Substance Abusers. This study was also conducted in a Navajo American Indian site, the Na'nizhoozhi Center, Inc. in Gallup, New Mexico, the first CTN study to be conducted there.

The following protocols have also locked the data. Final reports have been presented and national presentations took place at the APA, CPDD and AATOD:

Protocol CTN 0017, HIV and HCV Intervention in Drug Treatment Settings

Protocol CTN 0018, Reducing HIV/STD Risk Behaviors: A Research Study for Men in Drug Abuse Treatment

Protocol CTN 0019, Reducing HIV/STD Risk Behaviors: A Research Study for Women in Drug Abuse Treatment

The following protocols have ended new enrollment and are in follow-up phase:

Protocol CTN 0014, Brief Strategic Family Therapy for Adolescent Drug Abusers (BSFT), has been implemented at eight sites. The study reached its enrollment target of 480 randomized participants in January 2007.

Protocol CTN 0029, A Pilot Study of Osmotic-Release Methylphenidate (OROS MPH) in Initiating and Maintaining Abstinence in Smokers with Attention Deficit Hyperactivity Disorder (ADHD). This study is being carried out at six community treatment sites across five Nodes. The study reached its enrollment target in September 2007. A total of 255 participants were enrolled and randomized.

Three protocols are currently enrolling:

Protocol CTN 0027, Starting Treatment with Agonist Replacement Therapies (START) is a randomized, open-label, multi-center study that was developed in collaboration with the Division of Pharmacotherapies & Medical Consequences of Drug Abuse (DPMCDA). Enrollment began in April 2006. As of November 30, 2007, there were 547 randomized participants.
CCTN 0027A, START Pharmacogenetics: Exploratory Genetic Studies In Starting Treatment With Agonist Replacement Therapies. This proposal outlines a supplementary pharmacogenetics component to the NIDA START trial. Patients participating in START will be offered the opportunity to volunteer for a genetics study that has the primary objective of genotyping patients for exploratory analyses. Genomic DNA from blood samples sent to an NIH repository will be extracted and saved for study. Investigators at the University of Pennsylvania will study the frequency of gene variants that have primarily been associated with addiction, while the Medical University of South Carolina researchers will examine the relationship between treatment drug plasma concentrations and gene variants associated with drug disposition and transport. It is expected that the results of this study will contribute to the rational design of future clinical trials for hypothesis-driven pharmacogenetic studies that can be incorporated into the NIDA Clinical Trials Network (CTN).

Protocol CTN 0028, Randomized Controlled Trial of Osmotic-Release Methylphenidate (OROS MPH) for Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents with Substance Use Disorders (SUD). Enrollment is now open at 11 sites. As of November 30, 2007, 209 participants have been randomized.
CTN 0028A, Does Methylphenidate treatment for ADHD increase the rate of smoking in adolescents with comorbid ADHD, SUD, and nicotine dependence? The purpose of this ancillary study is to measure any change in the rate of cigarette smoking among participants in the CTN study 0028 (at the LRADAC site only). The study will use the same urine sample to obtain semi-quantitative cotinine levels using a dipstick urine cotinine measure (NicAlert, Nymox Pharmaceuticals). The hypothesis is that Oros methylphenidate treatment for ADHD among adolescents with comorbid ADHD, SUD, and nicotine dependence will not increase the rate of cigarette smoking. The study will compare self-reported smoking rate and urine cotinine semi-quantitative levels in adolescents receiving Oros methylphenidate vs. those receiving placebo to test the hypothesis above.

Protocol CTN 0030, Prescription Opioid Addiction Treatment Study (POATS) is a randomized 2-phase, open-label, multi-center study in outpatient treatment settings. Pre-screening began in May 2006. The study is being carried out in 10 sites. As of November 30, 2007, there were 345 randomized participants.
CTN 0030A, Collection of Economic Data for the Prescription Opioid Addiction Treatment Study. This ancillary study is conducted in collaboration and support with NIDA DESPR. The aims of the proposed data collection supplement are: (1) to supplement POATS data by collecting and validating additional facility data necessary to conduct economic analyses associated with comparisons of bup/nx treatment with SMM and EMM; and (2) to supplement POATS data by collecting additional patient level data necessary to conduct economic analyses associated with comparisons of bup/nx treatment with SMM and EMM. The data collection in the two aims will provide information necessary to conduct cost effectiveness, cost-benefit and cost-utility analyses of treatment models being evaluated in the POATS clinical trial.

Six protocols are in the development phase:

Protocol CTN 0031, Stimulant Abuser Groups to Engage in 12-Step (STAGE-12): Evaluation of a Combined Individual-Group Intervention to Reduce Stimulant and Other Drug Use by Increasing 12-Step Involvement. The initial Investigators' meeting to train staff from the three Wave 1 sites (Maryhaven - Ohio Valley Node, ChangePoint - Oregon/Hawaii Node, and Recovery Centers of King County - Washington Node) was convened in Bethesda, MD on December 3-5, 2007. Participant recruitment will commence in January 2008. Three ancillary studies are being conducted in collaboration with the main study:
CTN 0031A, An evaluation of neurocognitive function, oxidative damage, and their association with treatment outcomes in methamphetamine and cocaine abusers, is being led by Dr. Theresa Winhusen and co-led by Dr. Eugene Somoza, (Ohio Valley Node). It will evaluate the relationships among neurocognitive functioning (as assessed by various measures of executive function), oxidative damage (including DNA, lipid, and protein damage) and substance abuse treatment outcomes (including treatment completion and stimulant use reduction). This study will be funded by the NIDA CTN.
CTN 0031B, The Role of Alcohol Consumption in Classifications of Alcohol Use Disorders: A Clinical Study, is being led by Dr. Deborah Hasin (Long Island Node) and co-led by Dr. Dennis Donovan. It will investigate the utility of adding a frequency measure of alcohol consumption (i.e., the first three items of the Alcohol Use Disorders Identification Test [AUDIT-C]), to the DSM-IV diagnostic criteria for alcohol use disorders. This study is funded by an MOU between NIDA and NIAAA.
CTN 0031C, Organizational Characteristics That Influence the Adoption of Evidence-Based Practices, is being co-led by Dennis McCarty (Oregon/Hawaii Node) and Joseph Guydish (California/Arizona Node). This project will assess core implementation components (staff selection, staff training, coaching and supervision, feedback to participating staff, and administrative supports and interventions) and document their impact on the eventual implementation and adoption of the STAGE-12 intervention. This project is supported by supplemental funds from DESPR. The baseline data obtained in this research will form the foundation for an R01 grant application to be submitted in 2008.

Protocol CTN 0032, HIV Rapid Testing and Counseling in Drug Abuse Treatment Programs in the U.S. This study seeks to evaluate the most effective strategy to ensure that persons in drug treatment programs are tested for HIV and receive their HIV test results. The Centers for Disease Control and Prevention (CDCP) have made a priority to bring HIV rapid testing and counseling into outpatient health care settings for high-risk populations, and the investigators have consulted closely with them. A final version of the protocol has been approved. Site selection will likely begin in spring of 2008.

Protocol CTN 0033, Methamphetamine Use Among American Indians. The first area of research emphasis in the National Institute on Drug Abuse's Strategic Plan on Reducing Health Disparities (2004 Revision) is the epidemiology of drug abuse, health consequences and infectious diseases among minority populations. Because there are limited data available on methamphetamine use in American Indian communities, exploratory and pilot studies will be conducted to develop collaborations with tribes and Native American treatment programs and to explore the epidemiology of methamphetamine use and co-occurring problems and disorders in diverse Native American communities. This preliminary research will be coordinated among the Nodes to provide a more comprehensive exploration of methamphetamine problems in Indian country. These studies will provide a solid foundation for more rigorous epidemiologic studies and/or clinical research on methamphetamine dependence in Indian Country. Due to the local considerations, the study will be broken into 3 separate ones. This study and its subcomponents are in development stage.
CTN 0033A, Oregon/Hawaii Node: Methamphetamine Use Among American Indians (in collaboration with the NIH National Center for Minority Health and Health Disparities). Exploratory and pilot studies will be conducted to develop collaborations with tribes and Native American treatment programs in the Northwest and to explore the epidemiology of methamphetamine use and co-occurring problems and disorders in their diverse Native American communities (reservation-based and urban treatment centers).
CTN 0033B, Southwest Node: Methamphetamine Use and Treatment in Native American Communities in the Southwest. Exploratory and pilot studies will be conducted to develop collaborations with tribes and Native American treatment programs in the Southwest and to explore the epidemiology of methamphetamine use and co-occurring problems and disorders in diverse Native American communities in the Southwest.
CTN 0033C, Pacific Northwest Node: Methamphetamine: Where Does It Fit In the Bigger Picture of Drug Use of American Indian and Alaska Native Communities and Treatment-Seekers? Exploratory and pilot studies will be conducted to develop collaborative working relationships with tribes and tribal treatment programs in the Western Washington and Southeast Alaska to assess the epidemiology of co-occurring health disorders among AIANs seeking treatment for methamphetamine and other substance use in reservation-based and urban treatment centers.

Protocol CTN 0034, Developing Research Capacity and Culturally Appropriate Research Methods: Community-based Participatory Research Manual for Collaborative Research in Drug Abuse for American Indians and Alaska Natives. This study is in collaboration with the NIH National Center for Minority Health and Health Disparities and will be conducted in the Pacific Northwest Node. The specific aim of this proposed supplement is to develop a "user friendly" manual or "field guide" on the use of community-based participatory research (CBPR) and Tribal participatory research (TPR) methods for academic researchers and Tribal communities to develop and implement culturally relevant, truly collaborative research in the areas of substance abuse, HIV/AIDS, mental health, and other areas of health disparities in American Indian/Alaska Native populations. The manual or field guide will be developed by collecting and incorporating information from several sources: (1) review of available literature; (2) focus groups or interviews with participants from Tribal communities; (3) focus groups or interviews with academic representatives; and (4) asking both community and academic partners to provide information about their experiences with research in AIAN communities (via listserv).

Protocol CTN 0035, Access to HIV and Hepatitis Screening and Care Among Ethnic Minority Drug Users In and Out of Drug Treatment. This study is in collaboration with the NIH National Center for Minority Health and Health Disparities and will be conducted in the CA-AZ Node. The primary goal of this study is to identify barriers and facilitators to HIV and hepatitis C screening and treatment among ethnic minority drug users. Using a combination of structured survey and qualitative focus group methods, researchers will interview drug users in and out-of-drug abuse treatment about their previous experiences in accessing HIV and HCV screening and treatment services. They will interview 348 HIV and/or HCV infected drug users recruited from three settings: methadone maintenance, HIV primary care, and syringe exchange programs. Recruiting from these three sites will allow an examination of barriers or facilitating factors that may be relevant to DUs who are not engaged in drug abuse treatment, HIV care or HCV care (the SEP cohort); DUs who are engaged in drug abuse treatment, but may not be engaged in HIV and or HCV care (methadone maintenance treatment cohort), or are already engaged in HIV care and may or may not be engaged in HCV care (HIV clinic cohort). Thus, recruitment from these three sites will allow us to assess factors related to screening and treatment services across the continuum of engagement in prevention and treatment services. Survey and focus group topics will be in five areas: 1) past and current experiences in accessing HIV and HCV screening and treatment, or other medical care; 2) perceptions of treatment settings and providers; 3) history of psychiatric illness and treatment; 4) HIV and HCV risk behaviors; 5) lifetime substance use and past 30-day use; 6) knowledge of HIV and HCV risk factors; 6) knowledge of HIV and HCV screening and treatment; 7) past and current motivation for screening and treatment; and 8) resource and structural barriers.

Protocol CTN 0036, Epidemiology and Ethnographic Survey of "Cheese" Heroin Use among Hispanics in Dallas County. This study is in collaboration with the NIH National Center for Minority Health and Health Disparities and will be conducted in the Texas Node. The study will focus on the development and implementation of a survey to further characterize the use of cheese-heroin among Hispanic youth in Dallas County. The survey will be administered to active cheese-heroin users in three CTPs within the Texas Node (Nexus Recovery Center, Phoenix House, and Dallas County Juvenile Justice Dept.). The survey will characterize factors related to route(s) of administration, progression to physical dependence (opioid withdrawal syndrome), progression to IV drug use (HIV risk behavior), parental drug use, healthcare utilization, school performance, level of assimilation (both primary user and familial). Additionally, the Addiction Severity Index will be applied to characterize the level of legal, social, psychiatric, occupational, medical, family.

In addition to the primary CTN trials, there are currently 33 funded studies supported by independent grants that use CTN studies as a platform and 21 completed, ongoing, and planned studies funded as supplements to the clinical trials.

NIDA has awarded Brandeis University's NIDA Research Center on Managed Care and Drug Abuse Treatment with an ancillary study to conduct an economic analysis of the interventions examined in the Prescription Opioid Addiction Treatment Study (POATS - CTN 0030). In September 2007, Brandeis University started collecting data to assess the costs and benefits of the two treatment approaches EMM (Enhanced Medical Management) and SMM (Standard Medical Management).

The NIDA Networking Project (NNP)

The National Institute on Drug Abuse (NIDA) launched a new website in October 2007 to reach drug abuse researchers, practitioners, and policy makers. The NIDA Networking Project (NNP) website provides opportunities for information sharing among those interested in addiction research and the potential for research collaboration among scientists across the country. The NNP Website gives users access to the locations, people, expertise, and resources of NIDA's research networks to help create synergies, improve efficiency, and accelerate scientific discovery.

This one-stop portal to drug abuse resources includes the following information:

  • Map locations and contacts for about 200 NIDA-supported network sites across the U.S.
  • Network missions and descriptions
  • Links to more than 15 network-related Websites
  • Links to scientific protocols and papers, as well as procedural policies and manuals
  • NIDA news and events of interest to scientists, clinicians, and addiction specialists
  • The NNP Colleagues Directory--a searchable data base of network members' expertise and research interests.

For more information, please contact: Susan David at 301-435-0640 or davids2@nida.nih.gov.

Health Disparities Supplement Program

Through the Health Disparities Supplement Program for Native Americans/Alaska Natives and Asian American/Pacific Islanders, NIDA awarded seven supplements (two from the support of NCMHD) to current grants to: (1) better understand patterns of drug abuse and addiction in NA/AN and AA/PI populations, (2) identify health, behavioral or social consequences associated with drug abuse, addiction and related disease, and (3) determine if there is a need for more appropriate and better targeted services, treatment and prevention interventions.

The Minority Recruitment & Training Program

The Minority Recruitment & Training Program is now accepting applications for its summer 2008 Program. The NIDA, IRP Minority Recruitment & Training Program (MRTP) is an intramural program that provides training opportunities for students from under-represented groups who are interested in the scientific basis of drug abuse. In this program, students gain basic science and/or clinical laboratory experience, attend student seminars and participate in a summer poster presentation. The goal of this program is to expose students to the realities of research, from experimental design to data analysis, interpretation and presentation. To request an application or to receive additional information, contact Christie Brannock at cbrann@intra.nida.nih.gov.




NIDA's New and Competing Continuation Grants Awarded Since September 2007

Abi-Dargham, Anissa -- Columbia University Health Sciences
Imaging Dopamine Transmission in Cannabis Dependence

Abood, Mary E. -- California Pacific Medical Center Research Institute
Molecular Characterization of GPR35 and GPR55, Putative Cannabinoid Receptors

Adinoff, Bryon H. -- University of Texas South West Medical Center/Dallas
Impulsivity, Neural Deficits, and Cocaine Relapse

Adler, Martin W. -- Temple University
Opioids, Cannabinoids, Chemokines: Functional Implications of Cross-Talk

Agrawal, Arpana -- Washington University
Cannabis and Tobacco Involvement: A Twin Study

Aharonovich, Efrat -- New York State Psychiatric Institute
Modified Behavioral Treatment for Cocaine Patients with Cognitive Deficits

Aidala, Angela A. -- Columbia University Health Sciences
Drug Abuse, Mental Illness, Homelessness, and HIV: Evaluating Models of Care

Ait-Daoud, Nassima -- University of Virginia Charlottesville
New Medication Treatments for Stimulant Dependence

Akil, Huda -- University of Michigan at Ann Arbor
Antecedents and Consequences of Drug Abuse: Heritability, Stress and Neurplasticity

Akins, Chana K. -- University of Kentucky
Prenatal Cocaine Effects on Sexual Motivation

Aldrich, Jane V. -- University of Kansas Lawrence
Peptidic Kappa Opioid Receptor Ligands as Potential Treatments for Drug Addiction

Alexandre, Pierre K. -- Johns Hopkins University
Economic Aspects of Ecstasy Use

Aloimonos, John Yiannis -- University of Maryland College Park Campus
HAL: A Tool for Assessing Human Action in the Workplace

Anagnostaras, Stephan G. -- University of California San Diego
Molecular Cognition of Addiction

Axinn, William G. -- University of Michigan at Ann Arbor
Electronic Journal Data Collection Technologies for Interdisciplinary Research

Babalonis, Shanna -- University of Kentucky
Separate and Combined Effects of Progesterone and Triazolam in Healthy Women

Baillargeon, Jacques G. -- University of Texas Medical Branch Galveston
Psychiatric Barriers to Outpatient Care in Released HIV-Infected Offenders

Baldwin, Gayle C. -- University of California Los Angeles
Cocaine Synergizes with T-Cell Activation as a Co-factor for HIV Infection

Baldwin, Marjorie L. -- Arizona State University-Tempe Campus
Labor Market Discrimination and Substance Use Disorders

Baum, Marianna K. -- Florida International University
HIV and HIV/HCV-Infection, Disease Progression, Oxidative Stress and Antioxidants

Beane, Lindsay R. -- Morgan State University
Barriers to HIV Testing Among Residents of A High Risk African American Community

Bedford, Mark T. -- University of Texas MD Anderson Cancer Center
Identifying and Characterizing Readers of the Neural Histone Code

Bentler, Peter M. -- University of California Los Angeles
Collaborative Research on Drug Abuse

Bickel, Warren K. -- University of Arkansas Medical Sciences Little Rock
The Behavioral Economics of Relapse

Blumberg, Hilary P. -- Yale University
Stress, Neurodevelopment and the Emergence of Addictive Behaviors in Adolescence

Boker, Steven M. -- University of Virginia Charlottesville
Open Mx: Multipurpose Software for Statistical Modeling

Booth, Raymond G. -- University of Florida
Novel 5HT2C Agonist Drugs with 5HT2A Antagonist Activity for Cocaine Addiction

Booth, Robert E. -- University of Colorado Denver/Health Ssciences Center Aurora
Intervention to Reduce Injection Drug Use

Boudreaux, Edwin D. -- University of Medicine/Dentisty of New Jersey - Robert Wood Johnson Medical School
Multicenter Pilot Studies for ED Tobacco Interventions

Bowen, Anne M. -- University of Wyoming
Wyoming Meth Use and AIDS Risk: Exploring Rural Culture and Context (WyMar)

Bradizza, Clara M. -- State University of New York at Buffalo
Affect Regulation Training for Pregnant Smokers

Braine, Naomi -- Beth Israel Medical Center (New York)
MSM Communities in NYC Respond to HIV and Methamphetamine

Brimijoin, William S. -- Mayo Clinic College of Medicine, Rochester
Development of a Human Hydrolase to Treat Cocaine Abuse and Overdose: Rat Models

Brown, Richard A. -- Butler Hospital, Providence, RI
Sequential Use of Fluoxetine for Smokers with Elevated Depressive Symptoms

Brownstein, Henry H. -- National Opinion Research Center
The Dynamics of Methamphetamine Markets: A Systematic Approach to the Process

Brunzell, Darlene H. -- Yale University
nACHR Subunit Contributions to Nicotine Dependent Behaviors

Budney, Alan J. -- University of Arkansas Medical Sciences Little Rock
Behavioral Treatment of Adolescent Marijuana Use

Budney, Alan J. -- University of Arkansas Medical Sciences Little Rock
Development and Efficacy Test of Computerized Treatment for Marijuana Dependence

Cacciola, John S. -- Treatment Research Institute, Inc. (TRI)
Monitoring and Feedback in Substance Abuse Treatment

Calsyn, Donald A. -- University of Washington
Computerized Assistance for Treatment Professionals in Assessment of Sexual Risk

Capitanio, John P. -- University of California Davis
Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes

Carelli, Regina M. -- University of North Carolina Chapel Hill
Neurophysiological Study: Cocaine and Natural Reinforcers

Carpenter, Matthew J. -- Medical University of South Carolina
A Novel Treatment to Boost Quit Attempts and Cessation Among Unmotivated Smokers

Carroll, Marilyn E. -- University of Minnesota Twin Cities
Adolescence, Impulsivity, and Drug Abuse: Sex/Hormones

Cass, Wayne A. -- University of Kentucky
Calcitriol and Methamphetamine Neurotoxicity

Celentano, David D. -- Johns Hopkins University
Preventing Rural Thai Methamphetamine Abuse and HIV by Community Mobilization

Clark, David J. -- Palo Alto Institute for Research and Education, Inc.
Genetic Determinants of Opioid-Induced Hyperalgesia

Colfax, Grant N. -- Public Health Foundation Enterprises
Aripiprazole to Reduce Methamphetamine Use Among MSM with High-Risk HIV Behaviors

Collins, Linda M. -- Pennsylvania State University-University Park
Dynamical Systems and Related Engineering Approaches to Improving Behavioral Intervetions

Commons, Kathryn G. -- Children's Hospital Boston
Nicotinic Control of Forebrain Serotonin

Conant, Katherine E. -- Johns Hopkins University
MMPs and Synaptic Injury with HIV/Meth

Cooper, Hannah L. -- Emory University
Spatial Variations in IDU HIV Risk: Relationship to Structural Interventions

Copersino, Marc -- McLean Hospital, Belmont, MA
Rapid Cognitive Screening of Patients with Substance Use Disorders

Cosford, Nicholas David -- Burnham Institute for Medical Research
Modulators of Metabotropic Glutamate Receptor Subtype 2 for Cocaine Dependence

Costello, Elizabeth J. -- Duke University
A Developmental Model of Gene-Environment Interplay in SUDs

Cowan, Ronald L. -- Vanderbilt University
Genetic Factors in Human MDMA Toxicity: A PET Study

Cropsey, Karen L. -- Virginia Commonwealth University
Relapse Prevention to Reduce HIV Among Women Prisoners

Czoty, Paul W. -- Wake Forest University Health Sciences
Cocaine Discrimination, Self-Administration and Microdialysis in Monkeys

Dalva, Matthew B. -- University of Pennsylvania
Cell-Contact Mediated Mechanisms Assembling Synapses

D'Amico, Elizabeth J. -- Rand Corporation
Brief Substance Use Intervention for Youth in Teen Court

Daughters, Stacey B. -- University of Maryland College Park Campus
Distress Tolerance and Adolescent Substance Use

Davidson, Leslie L. -- Columbia University Health Sciences
Health and Psychosocial Need: Children with Developmental Disorder in a Time of HIV

De Wit, Harriet -- University of Chicago
Craving During Smoking Abstinence: Does It Abate or Incubate?

Deadwyler, Samuel A. -- Wake Forest University Health Sciences
Neuronal Analysis of Cocaine Effects on Cognition

Delisi, Lynn E. -- Nathan S. Kline Institute for Psychiatric Research
Biological Prediction of Psychosis Susceptibility Among Adolescent Cannabis Users

Dematteo, David S. -- Treatment Research Institute, Inc. (TRI)
The Development of a Prevention Intervention for Low-Risk Drug Court Clients

Devi, Lakshmi A. -- Mount Sinai School of Medicine of New York University
Post-Translational Regulation of Opioid Receptors

Diez Roux, Ana V. -- University of Michigan at Ann Arbor
Tools for Measuring and Analyzing Cortisol Levels in Population Studies of Health

Donny, Eric C. -- University of Pittsburgh at Pittsburgh
Are Some Regular Smokers Resistant to Nicotine Dependence?

D'Souza, Deepak C. -- Yale University
Cannabinoids, Neural Synchrony and Information Processing

Dubocovich, Margarita L. -- Northwestern University
Modulation of Methamphetamine Actions in the CNS

Dymecki, Susan M. -- Harvard University Medical School
Developmental Genetics of Serotonin Neuron Subtypes in Brain Reward Circuits

Eaton, William W. -- Johns Hopkins University
Risks for Transitions in Drug Use Among Urban Adults

Eiden, Rina D. -- State University of New York at Buffalo
Maternal Substance Use and Toddler Self-Regulation

Ekker, Stephen C. -- Mayo Clinic College of Medicine, Rochester
Intron-Based Mutagenic Transposons for Zebrafish

Eldridge, Gloria D. -- University of Alaska Anchorage
HIV, Drugs, and Prisoners: Barriers to Epidemiologic and Intervention Research

Epstein, Leonard H. -- State University of New York at Buffalo
Food Reinforcement-Genotype Interactions and Eating

Ercal, Nuran -- University of Missouri-Rolla
A New Antioxidant Prevents Toxicity of HIV Proteins with Methamphetamine

Ernst, Thomas M. -- University of Hawaii at Manoa
RGR-Based Motion Tracking For Real-Time Adaptive MR Imaging and Spectroscopy

Evans, Suzette M. -- Columbia University Health Sciences
Sex Differences in Stress and Impulsivity in Cocaine Abusers

Evans, Suzette M. -- New York State Psychiatric Institute
Progesterone Treatment for Cocaine-Dependent Women

Evins, A. Eden -- Massachusetts General Hospital
Smoking Cessation and Smoking Relapse Prevention in Patients with Schizophrenia

Fawcett, Stephen B. -- University of Kansas Lawrence
Testing the Community Change Model with Substance Abuse Coalitions

Febo, Marcelo -- Northeastern University
Brain Imaging of Cocaine and Maternal Reward

Festinger, David S. -- Treatment Research Institute, Inc. (TRI)
Contingency Management for Cocaine Dependence: Cash vs. Vouchers

Fiellin, David -- Yale University
Buprenorphine Maintenance vs. Detoxification in Prescription Opioid Dependence

Fishbein, Diana H. -- Research Triangle Institute
Longitudinal Study of Adolescent Marijuana Use and Neurodevelopment

Foltin, Richard W. -- New York State Psychiatric Institute
Translational Approach to Models in Relapse

Ford, Sabrina -- University of Pennsylvania
Language as a Correlate of Risk Behaviors in African American Adolescents

Fox, Howard S. -- Scripps Research Institute
Methamphetamine/SIV Interaction in the CNS

Frangakis, Constantine -- Johns Hopkins University
Statistical Designs and Methods for Partially Controlled HIV/AIDS Studies

Frederick, Blaise D. -- McLean Hospital, Belmont, MA
Concurrent FMRI and NIRS of Frontal Lobe Activation During Marijuana Smoking

Friedman, Theodore C. -- Charles R. Drew University of Medicine and Science
The Mechanisms of the Nicotine-Induction of Insulin Resistance

Friedmann, Peter D. -- Rhode Island Hospital, Providence, RI
Stabilize Addiction/Affect, Begin Inmates' Interferon for HCV of Liver (STAABIHL)

Fuller, Crystal M. -- New York Academy of Medicine
Pharmacy Referral Intervention: IDU Access to Services

Gale, Michael J. -- University of Washington
Innate Immune Defense Against HCV and HIV: The Chimeric Mouse Model

Galea, Sandro -- University of Michigan at Ann Arbor
Ecologic Stressors, PTSD, and Drug Use in Detroit

Garcia, Victor Q. -- Indiana University of Pennsylvania
The Origin and Development of Drug Use Among Transnational Mexican Farmworkers

Gillette, Rhanor -- University of Illinois Urbana-Champaign
Toggling a Switch for Appetence and Avoidance

Ginsburg, Brett C. -- University of Texas Health Science Center San Antonio
Age, Ethanol, and Strain Effects on the Behavioral Pharmacology of Cannabinoids

Gintzler, Alan R. -- Suny Downstate Medical Center
Adenylyl Cyclase GBetaGamma Stimulation and Opioid Tolerance

Glass, Jonathan David -- Emory University
Discovering Calpain Inhibitors for Neurological Diseases

Gleason, Christine A. -- University of Washington
Long-term Behavioral Effects of Neonatal Pain and Morphine Treatment in Mice

Go, Vivian F. -- Johns Hopkins University
Prevention for Positives: A Randomized Controlled Trial Among Vietnamese HIV-Positive

Gold, Paul E. -- University of Illinois Urbana-Champaign
Protein Synthesis Inhibitor Effects On Neurotransmitters and Memory

Gonzales, Nancy -- Arizona State University-Tempe Campus
Effects of a Preventive Intervention for Mexican Origin Adolescents

Gorbach, Pamina M. -- University of California Los Angeles
Transmission Behavior in Partnerships of Newly HIV Infected Southern Californians

Griffin, Kenneth W. -- Weill Medical College of Cornell University
Competence-Enhancement Prevention Program Effects on Later Risky Sexual Behavior

Griffiths, Roland R. -- Johns Hopkins University
Human Clinical Pharmacology of Emerging Drugs of Abuse (Club Drugs)

Grimm, Jeffrey W. -- Western Washington University
Incubation of Craving: Neural Substrates (Competitive Renewal)

Gruber, Staci A. -- McLean Hospital, Belmont, MA
Marijuana and Mood: Frontal Predictors of Behavior

Gruenewald, Paul J. -- Pacific Institute for Research and Evaluation
Assessing the Development of Drug Markets Using Bayesian Space-Time Models

Guo, Xiaohui -- University of Miami School of Medicine
Measurement Invariance Analysis on ASI-Lite

Hagan, Holly C. -- National Development and Research Institutes
Reducing HIV Transmission by Promoting Sexual Health Among Drug Users

Haight, Wendy L. -- University of Illinois Urbana-Champaign
Rural Methamphetamine-Abusing Parents and Their Children

Heimer, Robert -- Yale University
Environmental Factors in HIV Transmission Among Suburban IDUs

Helal, Abdelsalam Ali -- University of Florida
Smart Home-Based Health Platform for Behavioral Monitoring Diabetes and Obesity

Henderson, Leslie P. -- Dartmouth College
Steroid Regulation of Ion Channels

Henderson, Leslie P. -- Dartmouth College
Interactions of Anabolic Steroids and Stress Hormones in the Forebrain

Henggeler, Scott W. -- Medical University of South Carolina
Enhancing Juvenile Drug Court Outcomes with EBPs

Heslin, Kevin C. -- Charles R. Drew University of Medicine and Science
Racial/Ethnic Disparities in Mental Healthcare Use by Substance Abuse Clients

Hildebrandt, Thomas B. -- Mount Sinai School of Medicine of New York University
Assessment of Appearance and Performance Enhancing Drug Use

Hillard, Cecilia J. -- Medical College of Wisconsin
Gender Differences in the Interactions between Endocannabinoids and Stress

Hiroi, Noboru -- Yeshiva University
Molecular Mechanisms of Nicotine Addiction and Extinction

Ho, Wenzhe -- Children's Hospital of Philadelphia
Opioids, HIV/HCV and Host Cell Innate Immunity

Horvitz, Jon C. -- Boston College
Accumbens Coding of Reward Expectation: Electrophysiology and Neuropharmacology

Houghten, Richard A. -- Torrey Pines Institute for Molecular Studies
In Vivo Screening of Mixture-Based Combinatorial Libraries

Hoven, Christina W. -- New York State Psychiatric Institute
Maternal Incarceration and Course of Child Psychopathology in the South Bronx

Howard, Matthew O. -- University of North Carolina Chapel Hill
Natural History, Comorbid Mental Disorders, and Consequences of Inhalant Abuse

Hunt, Geoffrey P. -- Scientific Analysis Corporation
Gangs, Gender and Drug Sales: A Qualitative Study

Hurt, Hallam -- Children's Hospital of Philadelphia
In Utero Cocaine Use: Adolescent and Young Adult Neurocognitive Outcome

Iacono, William G. -- University of Minnesota Twin Cities
Substance Abuse and Behavioral Disinhibition: Integrating Genes and Environment

Inciardi, James A. -- University of Delaware
Understanding the Scope and Magnitude of Prescription Drug Diversion

Jacobsen, Leslie K. -- Yale University
Prenatal Cocaine Exposure: Studies of Brain Function

Jaffrey, Samie R. -- Weill Medical College of Cornell University
Drug Abuse Signaling Pathways That Regulate CREB MRNA Translation in Dendrites

Janak, Patricia H. -- Ernest Gallo Clinic and Research Center
The Role of Noradrenergic Activation in the Stability of Extinction Learning

Jansen, Heiko T. -- Washington State University
Circadian Modulation of Drug-Seeking Behavior

Jarbe, Torbjorn U. -- Northeastern University
Endogenous/Exogenous Cannabinoids: A Comparison

Jason, Leonard A. -- De Paul University
Evaluating Alternative Aftercare Models for Ex-Offenders

Javitt, Daniel C. -- Nathan S. Kline Institute for Psychiatric Research
Phencyclidine Abuse and Psychosis: Biomedical Mechanisms

Jenkins, Bruce G. -- Massachusetts General Hospital
Imaging Dopamine Mediated Neurovascular Coupling

Johnson, Rodney W. -- University of Illinois Urbana-Champaign
Methamphetamine, HIV, Neuroinflammation and Behavior

Johnston, Lloyd D. -- University of Michigan at Ann Arbor
Drug Use and Lifestyles of American Youth

Johnston, Lloyd D. -- University of Michigan at Ann Arbor
A Cohort-Sequential Panel Study of Drug Use, Ages 19-50

Jones, Sara R. -- Wake Forest University Health Sciences
Dopamine Transporter Changes Following Cocaine Self-Administration

Justus, Alicia N. -- Brown University
Responsivity to Reward and Punishment Cues and Adolescent Substance Use Problems

Kamarck, Thomas W. -- University of Pittsburgh at Pittsburgh
Psychosocial Stress Exposure: Real-Time and Structured Interview Technologies

Kandel, Eric R. -- Columbia University Health Sciences
A Molecular Analysis of the Gateway Hypothesis in Mice

Kang, Sung-Yeon -- National Development and Research Institutes
Gender Differences in Healthcare and Drug Treatment Utilization Among Drug Users

Kantak, Kathleen M. -- Boston University
Strategies for Enhancing Extinction of Drug-Seeking Behavior

Keefe, Kristen A. -- University of Utah
Neural Substrates of Stimulus-Induced Drug Seeking

Kellar, Kenneth J. -- Georgetown University
Pharmacology and Regulation of Nicotinic Receptor Subtypes

Kelly, Brian C. -- Purdue University West Lafayette
Emerging Trends of Tryptamine Use: Contexts and Risks

Kendall, Debra A. -- University of Connecticut Storrs
Determinants of the Cannabinoid Receptor Life Cycle

Kenny, Paul J. -- Scripps Research Institute
Development of Orexin-1 Receptor Antagonists to Prevent Drug Relapse

Keyser-Marcus, Lori A. -- Virginia Commonwealth University
Familial Influences on the Expression of ADHD in Children

Kinlock, Timothy W. -- Friends Research Institute, Inc.
Buprenorphine for Prisoners

Kirk, Gregory -- Johns Hopkins University
Real Time Methods for Quantifying Exposure to Illicit Drugs and Psychosocial Stress

Kleinfeld, David -- University of California San Diego
Sentinel Cells That Report Neural and Neurovascular Signaling

Kliewer, Wendy L. -- Virginia Commonwealth University
Mediators of Violence Exposure and Drug Use in Youth

Knapp, Pamela E. -- Virginia Commonwealth University
Glial Progenitors as Targets of HIV/Opiate Interactions

Koek, Wouter -- University of Texas Health Science Center San Antonio
Neuropharmacology of GHB Discrimination

Kollins, Scott H. -- Duke University
Mechanisms of Nicotine Dependence in ADHD Adults

Koziel, Margaret J. -- Beth Israel Deaconess Medical Center
Impact of Opiates on Cellular Immune Responses in HIV/HCV Infection

Kozikowski, Alan P. -- University of Illinois at Chicago
Chemistry and Biology of 5-Ht2C Receptor Ligands for Drug Abuse

Kral, Alexander H. -- Research Triangle Institute
Qualitative Exploration of Low-Frequency Heroin Injectors Not In Drug Treatment

Kuhar, Michael J. -- Emory University
Promoter Characterization of the Cart Gene

Kumar, Santosh -- University of Memphis
AutoSense: Quantifying Exposures to Addictive Substances and Psychosocial Stress

Lachance, Heather R. -- National Jewish Medical and Research Center
Development of Behavioral Couples Treatment for Smoking Cessation

Lagasse, Linda L. -- Women and Infants Hospital-Rhode Island
Prenatal Methamphetamine Exposure and Child Development in New Zealand and USA

Langleben, Daniel D. -- University of Pennsylvania
Functional MRI of Anti-Tobacco Public Service Announcements

Lankenau, Stephen E. -- Children's Hospital Los Angeles
Non-Medical Prescription Drug Use Among High-Risk Youth

Lanza, Stephanie T. -- Pennsylvania State University-University Park
Identifying Risk Profiles for Substance Use and Comorbid Behavior

Lariviere, William R. -- University of Pittsburgh at Pittsburgh
Genetics of Neuropathic and Inflammatory Hypersensitivity

Latkin, Carl A. -- Johns Hopkins University
The Impact of Neighborhoods, Networks and Depression on Drug Users' HIV Risks

Lavin, Antonieta -- Medical University of South Carolina
Effects of Repeated Cocaine Administration in Activity of Cortical Interneurons

Ledgerwood, David M. -- Wayne State University
Prize Reinforcement for Smoking Cessation

Lee, Daeyeol -- Yale University
Stress, Prefrontal Cortex, and Decision Making

Lee, Debora -- University of California Los Angeles
Long-Term Follow Up of Community Intervention in Yunnan, China

Leissring, Malcolm A. -- Scripps Research Institute
HTS for Modulators of Beta-Amyloid Catabolism by Insulin-Degrading Enzyme

Lester, Barry M. -- Women and Infants Hospital-Rhode Island
Prenatal Methamphetamine Exposure and School Aged Outcome

Leung, Hoi-Chung -- State University New York Stony Brook
The Role of Frontostriatal Circuits in Multimodal Response Inhibition

Leve, Leslie D. -- Oregon Social Learning Center, Inc.
The Early Growth and Development Study: Family Process, Genes and School Entry

Levin, Frances R. -- New York State Psychiatric Institute
Extended Release Mixed Amphetamine Salts for Adult ADHD and Cocaine Dependence

Levine, Allen S. -- University of Minnesota Twin Cities
Effect of Sweet Tastants on Opioid-Melanocortin Interactions

Levine, Michele D. -- University of Pittsburgh at Pittsburgh
Addressing Postpartum Mood and Weight Concerns to Sustain Smoking Cessation

Levitt, Pat R. -- Vanderbilt University
Development of Reciprocal Neural Circuitry

Li, Runze -- Pennsylvania State University-University Park
New Statistical Models for Intensive Longitudinal Data

Lin, Zhicheng -- McLean Hospital, Belmont, MA
Human Dopamine Transporter Gene: Variations and Transcriptional Regulation

Lindsey, Kimberly P. -- McLean Hospital, Belmont, MA
FMRI of Cigarette Smoking: Effects of Dependence, Withdrawal, and Conditioned REI

Liu, Christina H. -- Massachusetts General Hospital
MR Assessment of Altered Cerebral Gene Expression after Amphetamine Exposure

Loh, Horace H. -- University of Minnesota Twin Cities
Structural and Functional Studies of MU Opiate Receptors

London, Edythe D. -- University of California Los Angeles
Response Inhibition and Dopamine Neurotransmission (RI)

Lowe, John R. -- Florida Atlantic University
Community Partnership to Affect Cherokee Adolescent Substance Abuse

Luedtke, Robert R. -- University of North Texas Health Science Center
D3 Receptor Compounds for the Treatment of Psychostimulant Abuse

Luthar, Suniya S. -- Columbia University Teachers College
Maternal Drug Abuse, Psychopathology, and Child Adaptation

MacDonald, Angus W. -- University of Minnesota Twin Cities
The Neuroanatomical Basis of Anti-Drug Media Messages: The Impact of Effectiveness

Mackler, Scott A. -- University of Pennsylvania
NACL, A Cocaine Regulated MRNA in the Rat Brain

Madden, Pamela A. -- Washington University
The Genetics of Vulnerability to Nicotine Addictions

Makriyannis, Alexandros -- Northeastern University
Endocannabinoid Active Sites as Therapeutic Targets

Markowitz, John S. -- Medical University of South Carolina
Drug Transporters and the Disposition of ADHD Therapeutic Agents

Martemyanov, Kirill A. -- University of Minnesota Twin Cities
Molecular Basis of RGS Protein Function in the Striatum

Martins, Silvia Saboia -- Johns Hopkins University
Trends in Problems Related to Extramedical Use of Analgesics

Mason, Michael J. -- Villanova University
Social Ecology of Urban Adolescent Substance Abuse: A Multiple Domain Approach

Mason, Peggy -- University of Chicago
Physiology of Raphe Magnus Cells During Wake and Sleep

Matell, Matthew S. -- Villanova University
Neuroanatomical Localization of the Dopaminergic Modulation of Clock Speed

Mathes, Lawrence E. -- Ohio State University
Do Psychostimulatory Drugs Enhance Lentivirus Infection?

Matsumoto, Rae R. -- University of Mississippi
Synthesis and Evaluation of Sigma-Active Cocaine Antagonists

Mayer, Andrew Robert -- The Mind Institute
Multimodal Imaging of the Sensory Gating Deficit in Chronic Cocaine Abusers

Mayer, Andrew Robert -- The Mind Institute
Neurochemistry of Pain: Measuring Glutamatergic Brain Activity in Response to Pain

Maziak, Wasim -- University of Memphis
Responding to the Changing Tobacco Epidemic in the Eastern Mediterranean Region

McCabe, Sean Esteban -- University of Michigan at Ann Arbor
Sexual Orientation, Substance Use and Mental Health

McCarty, Gregory S. -- North Carolina State University Raleigh
Implementing Nanogap Sensors in Neuroscience Research

McConnell, Kenneth John -- Oregon Health and Science University
Oregon's Parity Law: Comprehensive Parity in Today's Healthcare Environment

McKee, Sherry -- Yale University
Modeling Stress-Precipitated Smoking Lapse for Medication Development

McNeil, Michael R. -- Colorado State University-Fort Collins
HTS Screen of TB RmLC and RmLD dTDP-Rhamnose Formation Enzymes

McRae, Aimee L. -- Medical University of South Carolina
Stress and Marijuana Cue-Elicited Craving and Reactivity

Meisel, Robert L. -- Purdue University West Lafayette
Dopamine Sensitization by Motivated Behaviors

Melikian, Haley E. -- University of Massachusetts Medical School Worcester
The Role of Dopamine Transporter Trafficking in Psychostimulant Addiction

Meng, Ian D. -- University of New England
Chronic Morphine-Induced Sensitization of Trigeminal Dura Sensitive Neurons

Mertens, Jennifer -- Kaiser Foundation Research Institute
Brief Intervention to Reduce Substance Use in South African Primary Care

Metrik, Jane -- Brown University
Marijuana's Acute Effects on Risk Taking, Sexual/HIV Risk, and Impulsivity

Meucci, Olimpia -- Drexel University
Role of Chemokine Receptors in Neuronal Survival

Miech, Richard A. -- University of Colorado Denver/HSC Denver
The Growing Disparity in Illegal Drug Use across Socioeconomic Strata

Miller, Gregory M. -- Harvard University Medical School
Methamphetamine Effects via Trace Amine Associated Receptor 1

Miller, Ivan W. -- Butler Hospital, Providence, RI
Development of a Treatment Adherence Program for Bipolar Substance Abusers

Miller, Matthew J. -- Harvard University School of Public Health
Prescription Opioid Use and the Risk of Injury Among Elderly Americans

Molitor, Thomas W. -- University of Minnesota Twin Cities
Opiate Modulates Lymphocyte Trafficking into the CNS in TB Meningitis

Montague, P. Read -- Baylor College of Medicine
Dopaminergic Activity and Release During DBS Implantation in Humans

Monterosso, John R. -- University of California Los Angeles
Neural Recruitment During Self-Control of Smoking: An FMRI Paradigm

Morgan, Drake -- University of Florida
Chronic Opioids and Aging

Morgenstern, Jonathan -- National Center on Addiction and Substance Abuse
Restructuring Services for Drug Abusing TANF Women

Morgenstern, Jonathan -- National Center on Addiction/Substance Abuse
Disease Management for Chronic Drug Abuse

Moron-Concepcion, Jose A. -- University of Texas Medical Branch Galveston
PSD Protein Expression in Extinction of Morphine-Dependent Conditioned Behavior

Moyers, Theresa B. -- University of New Mexico Albuquerque
Testing Theory-Based Training in Motivational Interviewing

Nanovskaya, Tatiana N. -- University of Texas Medical Branch Galveston
Development of Bupropion for Smoking Cessation During Pregnancy

Narayan, Opendra -- University of Kansas Medical Center
Morphine and the Neuropathogenesis of SIV in Macaques

Nation, Jack R. -- Texas A&M University System
Heavy Metal and Drug Self-Administration: Mechanisms

Neiderhiser, Jenae M. -- Pennsylvania State University-University Park
Genes, Prenatal Drug Exposure, and the Postnatal Environment: An Adoption Study

Neisewander, Janet L. -- Arizona State University-Tempe Campus
Drugs as Conditioned Reinforcers and/or Enhancers of Social Reward in Adolescents

Neubig, Richard R. -- University of Michigan at Ann Arbor
Design of Small Molecules Acting At Regulators of G Protein Signaling

Newton, Thomas F. -- University of California Los Angeles
Cycloserine Enhancement of Extinction Learning

Nierenberg, Jay -- Nathan S. Kline Institute for Psychiatric Research
Longitudinal Study of Brain Recovery Following Abstinence from Cocaine

O'Dell, Laura Elena -- University of Texas El Paso
Nico-teen: Mechanisms of Nicotine Reward and Withdrawal During Adolescence

Olive, M. Foster -- Medical University of South Carolina
Metabotropic Glutamate Receptor Signaling and Extinction Learning

Ondersma, Steven J. -- Wayne State University
The WIDUS: Indirect Screening for Perinatal Drug Use

Ondersma, Steven J. -- Wayne State University
A Computer-Assisted Brief Motivational Intervention for Smoking During Pregnancy

O'Neill, Joseph -- University of California Los Angeles
Magnetic Resonance Spectroscopic Imaging of the Brain in Methamphetamine Abuse

O'Phelan, Kristine Hazel -- Queen's Medical Center
Effects of Methamphetamine in Traumatic Brain Injury

Orwin, Robert G. -- Westat, Inc.
Gender - Sensitive Treatment In Mixed - Gender Programs

Osgood, D. Wayne -- Pennsylvania State University-University Park
Friendship Networks and Emergence of Substance Use

Overman, William H. -- University of North Carolina Wilmington
A Novel Method to Improve Decision-Making in Young Adults and Adolescents

Owens, Douglas K. -- Stanford University
Making Better Decisions: Policy Modeling For AIDS and Drug Abuse

Owens, Samuel Michael -- University of Arkansas Medical Sciences Little Rock
Active Immunization for Treating Methamphetamine Abuse

Ozechowski, Timothy J. -- Oregon Research Institute
Item Response Theory for Sequential Data in Drug Therapy

Ozechowski, Timothy J. -- Oregon Research Institute
A Pilot Test of the Functional Family Therapy Coding and Rating Scale

Palmiter, Richard D. -- University of Washington
Effect of Killing or Removing GABA from NPY/AgRP Neurons

Parsons, Jeffrey T. -- Hunter College
Intervention Targeting Medication Adherence and Methamphetamine Use for HIV+ Men

Paulus, Martin P. -- University of California San Diego
Time Processing In Stimulant Users: Impulsivity and Temporal Discounting

Pellecchia, Maurizio -- Burnham Institute for Medical Research
Novel Chemotypes Against Influenza A Virus

Petry, Nancy M. -- University of Connecticut School of Medicine and Dentistry
Brief Therapies for Problem Gambling Substance Abusers

Phan, K. Luan -- University of Chicago
Functional Neuroimaging of Opioid Effects on Affective Experience

Podus, Deborah -- University of California Los Angeles
Emergency Management for Disruptions in Methadone Treatment

Polcin, Douglas L. -- Public Health Institute
Measuring Confrontation During Recovery

Poling, James C. -- Yale University
Pharmacotherapy and CM for Opioid and Cocaine Dependence

Porreca, Frank F. -- University of Arizona
Mechanisms of Opioid Induced Hyperalgesia

Porrino, Linda J. -- Wake Forest University Health Sciences
Neurobiological Correlates of Cocaine Abuse

Portoghese, Philip S. -- University of Minnesota Twin Cities
Selective Opioid Ligands

Rawls, Scott M. -- Temple University
Cannabinoid Regulation of Basal Ganglia Glutamate and GABA

Ray, Stuart C. -- Johns Hopkins University
Mechanisms of Hepatitis C Virus Evolution

Razdan, Raj K. -- Organix, Inc.
Synthesis of Delta9-Tetrahydrocannabinol Related Compounds

Rea, Mark S. -- Rensselaer Polytechnic Institute
Light Measuring Device for Correcting Circadian Disruption

Reed, John C. -- Burnham Institute for Medical Research
Chemical Inhibitors of ER Stress

Reiss, Allan L. -- Stanford University
Enhancing Interoperability and Usability of BrainImageJava for Morphometric Imaging

Rende, Richard -- Butler Hospital, Providence, RI
Sibling Contagion for Smoking: Social and Genetic Influences in Early Adulthood

Richter, Kimber P. -- University of Kansas Medical Center
Describing and Measuring Tobacco Treatment in Drug Treatment

Ries, Richard K. -- University of Washington
Contingency Management of Psychostimulant Abuse in the Severely Mentally Ill

Riley, Elise D. -- University of California San Francisco
Effects of Housing and HIV on Risk Behavior and Victimization of Indigent Women

Rohde, Paul D. -- Oregon Research Institute
Sequenced vs. Integrated Delivery of Treatment for Adolescent Depression and SUD

Roman, Paul M. -- University of Georgia
CTN Membership and Adoption of Innovative Tx Practices

Rosen, Gerald M. -- University of Maryland Baltimore
EPR Imaging of Brain O2 in Drug Abuse

Salo, Ruth E. -- University of California Davis
Neural Correlates of Methamphetamine Use in Schizophrenia: An MRS Study

Salzman, C. Daniel -- New York State Psychiatric Institute
Neural Mechanisms Underlying Reinforcement Learning

Scarinci, Isabel C. -- University of Alabama at Birmingham
Network for Tobacco Control Among Women in Parana, Brazil

Schensul, Jean J. -- Institute for Community Research
MDMA and STD/HIV Risk Among Hidden Networks of Ecstasy-Using Young Adults

Schmitz, Joy M. -- University of Texas Health Science Center Houston
Contingency Management plus Levodopa/Carbidopa for Treatment of Cocaine Dependence

Schottenfeld, Richard S. -- Yale University
Drug Counseling and Abstinent-Contingent Take Home Buprenorphine in Malaysia

Schwartz, Robert P. -- Friends Research Institute, Inc.
Entry into Comprehensive Methadone Treatment via Interim Maintenance

Scott, Christy K. -- Chestnut Health Systems, Inc.
Recovery Management Checkups for Women Offenders (RMC-WO) Experiment

See, Ronald E. -- Medical University of South Carolina
Interdisciplinary Medication Development for Multiple Risk Factors in Relapse

Sereno, Margaret -- University of Oregon
New Methods to Improve Measurement and Understanding of Successful Navigation

Sesack, Susan R. -- University of Pittsburgh at Pittsburgh
Persistent Impact of Developmental Nicotine on Cholinergic Input to DA Cells

Shaw, Daniel S. -- University of Pittsburgh at Pittsburgh
Parental Involvement, Extra-Familial Contexts and Prevention of Drug Use Risk

Shetty, Vivek -- University of California Los Angeles
Refinement and Validation of a Portable, Salivary Biosensor of Psychosocial Stress

Shoichet, Brian K. -- University of California San Francisco
Promiscuous and Specific Inhibitors of Cruzain

Shrier, Lydia A. -- Children's Hospital Boston
Affect and Marijuana Use in Adolescents and Young Adults

Sigmon, Stacey C. -- University of Vermont and State Agricultural College
Incentive-Based Smoking Cessation for Methadone Patients

Silk, Jennifer S. -- University of Pittsburgh at Pittsburgh
Emotion Regulation in Adolescence: A Social Affective Neuroscience Approach

Silverman, Kenneth -- Johns Hopkins University
A Bridge to Treatment for Out-of-Treatment Injection Heroin Users

Simmons, Janie E. -- National Development and Res Institutes
Barriers to Treatment-Based HIV Prevention for IDU Couples

Sipe, Jack C. -- Scripps Research Institute
Endocannabinoid Biomarkers of Obesity Using Integrated Genomics and Metabolomics

Skosnik, Patrick D. -- Indiana University Bloomington
The Effect of Cannabis Use on Human Cerebellar Function

Sneider, Jennifer Tropp -- McLean Hospital, Belmont, MA
FMRI of Hippocampal Function in Cannabis Users

Soderstrom, Kenneth M. -- East Carolina University
Cannabinoid-Altered Vocal Development

Sofuoglu, Mehmet -- Yale University
Cocaine Withdrawal and Pharmacotherapy Response

Sood, Amit -- Mayo Clinic College of Medicine, Rochester
SAMe for Smoking Abstinence

Spealman, Roger D. -- Harvard University Medical School
Nonhuman Primate Models of Reinstated Cocaine Seeking

Spoth, Richard L. -- Iowa State University
Partnership Model for Diffusion of Proven Prevention

Sprague, Jon E. -- Ohio Northern University
Hyperthermia: Uncoupling the Agony from Ecstasy

Stall, Ronald -- University of Pittsburgh at Pittsburgh
Long Term Health Effects of Methamphetamine Use in the MACS

Stark, Michael J. -- Multnomah County Health Department
Reducing HIV Risk Among Methamphetamine IDUs through Peer Education

Stein, Lynda A. -- University of Rhode Island
Motivation and Skills for Detained Teen Smokers

Stella, Nephi -- University of Washington
Novel CB Receptors

Stenger, Victor Andrew -- University of Hawaii at Manoa
Parallel MRI for High Field Neuroimaging

Stewart, Katharine E. -- University of Arkansas Medical Sciences Little Rock
Reducing Sexual Risk Behaviors Among Rural African-American Cocaine Users

Stitzel, Jerry A. -- University of Colorado at Boulder
Circadian Variations in Nicotine Sensitivity in Mice

Stolerman, Ian P. -- King's College London
Comprehensive Database of Drug Discrimination and Self-Administration Research

Straiker, Alex -- Indiana University Bloomington
Identification and Characterization of Two Novel Cannabinoid Receptors

Strathdee, Steffanie A. -- University of California San Diego
Drug Market Characteristics: Antecedents and Sequelae on the U.S. Mexico Border

Strecher, Victor J. -- University of Michigan at Ann Arbor
Neural Bases of Effectiveness of Individually-Tailored Smoking Cessation Messages

Sulzer, David L. -- Columbia University Health Sciences
Presynaptic Mechanisms in Dopamine Neurotransmission

Sun, Wenlin -- University of Tennessee Health Science Center
Neural Mechanisms of Cocaine Addiction

Surratt, Christopher K. -- Duquesne University
Monoamine Transporter Structure-Function Studies

Sussman, Steven Y. -- University of Southern California
Drug Abuse Prevention for High Risk Emerging Adults

Tarantino, Lisa M. -- Novartis Institute for Functional Genomics
Fine Mapping Genes for Cocaine Locomotor Response in ENU Mutagenized Mice

Teplin, Linda A. -- Northwestern University
Trajectories of Drugs Abuse in High Risk Youth

Thayer, Stanley A. -- University of Minnesota Twin Cities
Cannabinoid Modulation of Recovery from HIV-Associated Synaptic Toxicity

Thomas, David L. -- Johns Hopkins University
The Progression of Hepatitis C Among IDUs

Tiffany, Stephen T. -- State University of New York at Buffalo
Evaluations of Reactions to Drug Cues in Natural Settings

Tolan, Patrick H. -- University of Illinois at Chicago
Developmental Evaluation of Prevention Effects of the SAFE Children Interven

Toll, Lawrence R. -- SRI International
Mixed NOP/mu Compounds and the Involvement of their Receptors in Analgesia

Torres, Gonzalo E. -- University of Pittsburgh at Pittsburgh
Physical and Functional Link of the Dopamine Transporter with Synaptic Proteins

Torres, Gonzalo E. -- University of Pittsburgh at Pittsburgh
Disrupting DAT Protein-Protein Interactions in Vivo: Implications for Drug Abuse

Traynor, John R. -- University of Michigan at Ann Arbor
Role of Lipid Rafts in Adenylyl Cyclase Sensitization

Trudell, Mark L. -- Louisiana State University-University of New Orleans
Development of Cannabinoid Receptor Based Medications for Drug Addiction

Tyler, Kimberly A. -- University of Nebraska Lincoln
Social Networks, HIV Risk Behaviors, and Homeless Youth

Ursu, Stefan -- University of California Davis
The Human PFC Response to Drug Cues: Outcome Representation vs. Cognitive Control

Venner, Kamilla -- University of New Mexico Albuquerque
Zuni MI/CRA Project

Vernon-Feagans, Lynne -- University of North Carolina Chapel Hill
Children Living In Rural Poverty: The Continuation of the Family Life Project

Vespignani, Alessandro -- Indiana University Bloomington
EpiC: A Cyberinfrastructure That Supports the Plug-and-Play of Datasets and Algori

Vlahov, David -- New York Academy of Medicine
Heroin Cessation and HIV Risk: A Case-Control Study

Waldron, Holly B. -- Oregon Research Institute
Development of a Family-Based Treatment for Adolescent Methamphetamine Abuse

Waldron, Holly B. -- Oregon Research Institute
Adolescent Substance Abuse: Progressive Treatment

Wallace, Scyatta A. -- Suny Downstate Medical Center
Neighborhood Characteristics, Drug Use, and HIV Risk Among African American Youth

Wang, Jinghua -- University of Minnesota Twin Cities
Opioid Abuse and Host Defense against Streptococcus Pneumoniae Lung Infection

Wang, Qiming Jane -- University of Pittsburgh at Pittsburgh
IMAP-Based Fluorescent Polarization Assay For HTS Protein Kinase D Inhibitors

Wang, Ze -- University of Pennsylvania
SVM Based Group Data Analysis for Drug Abuse Disorder ASL Perfusion Study

Waterhouse, Barry D. -- Drexel University
Neurochemistry and Neurophysiology of MDMA (Ecstasy)

Wei, Li-Na L. -- University of Minnesota Twin Cities
Studies of Mouse Kappa Opioid Receptor Gene Regulation

Weinstein, Harel -- Weill Medical College of Cornell University
Hallucinogens and 5-HT Receptors: Mechanisms and Effects

Wentland, Mark P. -- Rensselaer Polytechnic Institute
Aminobenzomorphan: Potential Cocaine Abuse Medications

White, Tara L. -- Brown University
Imaging Individual Differences in Amphetamine Effects

White, Wesley O. -- Morehead State University
Mechanisms of Amphetamine Withdrawal and Recovery

Whiteaker, Paul -- University of Colorado at Boulder
Alpha-Conotoxin MII: A Selective Nicotinic Receptor Probe

Wightman, Robert M. -- University of North Carolina Chapel Hill
Dynamics of In Vivo Dopamine Release

Williams, Geoffrey C. -- University of Rochester
Creating a Virtual Clinician Research Tool

Wills, Thomas A. -- Yeshiva University
The Project Success Model: Evaluation of a Tiered Intervention

Wines, James D. -- McLean Hospital, Belmont, MA
Risk Factors for Severe Opioid-Related Overdose (ORO)

Winger, Gail D. -- University of Michigan at Ann Arbor
Behavioral Economic Analysis of Polydrug Abuse

Winickoff, Jonathan P. -- Massachusetts General Hospital
Addressing Parental Smoking by Changing Pediatric Office Systems

Winters, Ken C. -- University of Minnesota Twin Cities
Youth Drug Abuse, ADHD and Related Disruptive Behaviors

Wood, Evan -- University of British Columbia
Impacts of Universal Access to HIV/AIDS Care Among HIV+ Injection Drug Users

Wu, Li-Tzy T. -- Duke University
Epdemiology of Non-Medical Prescription Analgesic Use

Yaksh, Tony L. -- University of California San Diego
Characterization of Toxicity with Spinal Opiates

Yi, Richard -- University of Arkansas Medical Sciences Little Rock
The Discounting of Losses by Smokers in Nicotine Withdrawal

Yu, Aiming -- State University of New York at Buffalo
Pharmacogenetics in Indolealkylamine Metabolism and Drug Interactions

Yurgelun-Todd, Deborah A. -- McLean Hospital, Belmont, MA
MRS/FMRI Investigations of Adolescent Cannabis Use

Yurgelun-Todd, Deborah A. -- McLean Hospital, Belmont, MA
Brain Changes with Cannabis and Methamphetamine

Zacny, James P. -- University of Chicago
Abuse-Related Effects of Opioids and Adjuvant Drug Used By Chronic Pain Patients

Zangen, Abraham -- Weizmann Institute of Science
A Conflict Model of Cue-Induced Relapse to Cocaine

Zarkin, Gary A. -- Research Triangle Institute
Modeling Benefits and Costs of Prison-Based Substance Abuse Treatment

Zaveri, Nurulain T. -- SRI International
Discovery of Small-Molecular Orphanin FQ Receptor Ligands

Zhou, Fu-Ming -- University of Tennessee Health Science Center
Non-Transporter Cocaine Mechanisms in Dopamine System

Zimmerman, Marc A. -- University of Michigan at Ann Arbor
A Longitudinal Study of School Dropout and Substance Use


Index

Research Findings

Program Activities

Extramural Policy and Review Activities

Congressional Affairs

International Activities

Meetings and Conferences

Media and Education Activities

Planned Meetings

Publications

Staff Highlights

Grantee Honors



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