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National Institute on Drug Abuse

Director's Report to the National Advisory Council on Drug Abuse

February, 2000


Program Activities


New PAs/RFAs

A newly revised Program Announcement entitled "Research on the Origins and Pathways to Drug Abuse", (PAR-99-168, September 30, 1999) replaces PA-97-043, which was published in the NIH Guide, Vol. 26, No. 8, March 14, 1997. This PA encourages research exploring the origins of and pathways to drug abuse and addiction. Of particular interest are multidisciplinary, integrative, and developmental approaches. A complete copy of the PA including more information about the research that the PA seeks to encourage can be found at: http://grants.nih.gov/grants/guide/pa-files/PAR-99-168.html.

A Program Announcement entitled "Drug Abuse Prevention Intervention Research" (PA-00-002) was issued in the NIH Guide on October 5, 1999. This PA encourages research to examine the efficacy and effectiveness of new and innovative theory-based prevention approaches; to determine the components of research-based intervention strategies and programs that account for effectiveness of approaches; to clarify factors related to the effective and efficient provision of prevention services; and to develop and test methodologies appropriate for studying these complex aspects of prevention science.

On November 2, 1999, NIDA issued a Program Announcement entitled "Social Work Research Development Program" (PAR-00-008) announcing the availability of support for a Social Work Research Development Program (SWRD) focused on the development of social work research in all areas of drug abuse intervention and services research. The goals of this program are to build a stable infrastructure for drug abuse research in schools of social work and to increase interdisciplinary participation in drug abuse research in order to improve the quality of interventions aimed at reducing drug abuse and addiction in this country.

On January 19, 2000, NIDA issued a Program Announcement entitled "Neurobiological and Behavioral Research on Nicotine and Tobacco Components" (PA-00-045). The purpose of this PA is to encourage research on any aspect of the effects of nicotine and other tobacco components, using neurobiological, behavioral, or other methods in humans, animals, or in vitro systems, that seeks to explain nicotine use, addiction, or other effects in humans.

On October 8, 1999, NIDA, in conjunction with numerous other NIH Institutes, issued a PA entitled "Mentored Clinical Scientist Development Award (K08)" (PA-00-003). The purpose of this PA is to support the development of outstanding clinician research scientists. This mechanism provides specialized study for individuals with a health professional doctoral degree committed to a career in laboratory or field-based research.

On October 8, 1999, NIDA, in conjunction with numerous other NIH Institutes issued a PA entitled "Mentored Patient-Oriented Research Career Development Award (K23)" (PA-00-004). The purpose of this PA is to support the career development of investigators who have made a commitment to focus their research endeavors on patient-oriented research.

On October 8, 1999, NIDA, in conjunction with numerous other NIH Institutes issued a PA entitled "Midcareer Investigator Award in Patient-Oriented Research (K24)" (PA-00-005). The purpose of this PA is to provide support for clinicians to allow them protected time to devote to patient-oriented research and to act as mentors for beginning clinical investigators.

On November 30, 1999, NIDA, in conjunction with numerous other NIH components, issued a revision of the PA entitled "Bioengineering Research Partnerships" (PAS-00-006). This PA invites applications for R01 awards to support Bioengineering Research Partnerships (BRPs) for basic bioengineering research addressing important biological or medical research problems. A BRP is a multidisciplinary research team applying an integrative, systems approach to develop knowledge and/or methods to prevent, detect, diagnose and treat disease and understand health and behavior. The partnership must include bioengineering expertise in combination with basic and/or clinical investigators. A BRP may propose design-directed or hypotheses-driven research in universities, national laboratories, medical schools, private industry and other public and private entities.

On December 2, 1999, NIDA, in conjunction with numerous other NIH components issued a PA entitled "Bioengineering Nanotechnology Initiative" (PA-00-018). This PA, issued as an initiative of the trans-NIH Bioengineering Consortium (BECON), invites applications for Small Business Innovation Research (SBIR) projects on nanotechnologies useful to biomedicine. Nanotechnology, the creation of functional materials, devices and systems through control of matter at the scale of 1 to 100 nanometers, and the exploitation of novel properties and phenomena at the same scale is emerging as a field critical for enabling essential breakthroughs that may have tremendous potential for affecting biomedicine.

On December 2, 1999, NIDA, in conjunction with numerous other NIH Institutes issued a PA entitled "Mentored Research Scientist Development Award (K01)" (PA-00-019). This award provides for an intensive, supervised career development experience in one of the biomedical, behavioral or clinical sciences leading to research independence.

On December 2, 1999, NIDA, in conjunction with numerous other NIH Institutes issued a PA entitled "Independent Scientist Award (K02)" (PA-00-020). This award provides up to five years of salary support for newly independent scientists who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers. This award is intended to foster the development of outstanding scientists and enable them to expand their potential to make significant contributions to their field of research.

On December 2, 1999, NIDA, in conjunction with NIAAA, NIMH, NCI and the National Center for Complementary and Alternative Medicine issued a PA entitled "Senior Scientist Award K05)" (PA-00-021). This award provides stability of support to outstanding scientists who have demonstrated a sustained, high level of productivity and whose expertise, research accomplishments, and contributions to the field have been and will continue to be critical to the mission of the particular NIH Center or Institute.

NIDA, in conjunction with a number of other NIH components issued a PA entitled "The Role of Microglia in Normal and Abnormal Immune Responses of the Nervous System" (PA-00-029) on December 15, 1999. This PA invites applications to promote research into the role of microglia in the initiation and expansion of autoimmune processes of the central nervous system (CNS) and the resulting injury to CNS components.

An RFA entitled "Cognitive Approaches to Addictive Processes" (DA-01-001), developed by the Cognitive Science Working Group (Chairs: Herbert Weingartner, Ph.D. and Steven Grant, Ph.D.) was released on November 22, 1999. This RFA invites applications in the area of cognitive science and cognitive neuroscience that have the potential of addressing issues related to drug abuse and addiction. The objective is to stimulate cognitive science and cognitive neuroscience research that has the potential to advance our understanding of the causes, consequences, neuronal basis and treatment of drug abuse and addictive processes. Cognitive research is encouraged that is model-driven; and either (1) explores and delineates basic cognitive processes related to drug abuse and addiction and vulnerability to drug addiction, or (2) directly studies drug abuse and the effects of drugs on particular aspects of cognitive functions. The Letter of Intent Receipt date is May 15, 2000, and the Application Receipt date is July 14, 2000.

On December 16, 1999, NIDA issued an RFA entitled "Microarray-Based Research on Drug Abuse" (DA-00-003). This RFA encourages innovative studies that exploit emerging microarray technology, adapting and applying these techniques to the general problem of drug abuse. The creation of collaborative teams that will develop innovative approaches for analyzing microarray data is encouraged. Letter of Intent Receipt date for this RFA is February 28, 2000; Application Receipt date is March 28, 2000.

On December 16, 1999, NIDA issued an RFA entitled "Basic Behavioral, Cognitive, and Neurological Research: Applications to HIV/AIDS and Drug Abuse" (DA-00-005). This RFA encourages applications for research projects in the basic behavioral, cognitive and neurosciences that can address the complex relationship between drug abuse and addiction and HIV/AIDS transmission and progression. Letter of Intent Receipt date for this RFA is February 29, 2000; Application Receipt date is March 29, 2000.

On December 20, 1999, NIDA reissued the RFA entitled "National Drug Abuse Treatment Clinical Trials Network" (DA-00-002), inviting applications from established clinical investigators to participate in the National Drug Abuse Treatment Clinical Trials Network (CTN). CTN research is carried out in community-based treatment settings, in collaboration with other awardees and with NIDA. This RFA is a second issue with the intention to develop a geographically diverse and encompassing network. The Letter of Intent Receipt date for this RFA is February 17, 2000; Application Receipt date is March 16, 2000.

On December 20, 1999, NIDA issued an RFA entitled "HIV Therapy for Drug Users: Access, Adherence, Effectiveness" (DA-00-007). The purpose of this RFA is to encourage applications for research on access, adherence and effectiveness relevant to the treatment of drug users with HIV. This initiative will support research on a broad range of HIV care-related issues. Letter of Intent Receipt Date for this RFA is February 28, 2000; Application Receipt Date is March 29, 2000.

On December 20, 1999, NIDA issued an RFA entitled "The Next Generation of Drug Abuse Prevention Research" (DA-00-004) which encourages applications to examine components of empirically validated drug abuse prevention interventions that may account for program effectiveness. The purpose is to gain a better understanding of what accounts for program effectiveness through: empirical tests of theoretically derived processes that may account for program effectiveness; identification of patterns related to differential effectiveness; generating and testing alternate hypotheses accounting for effectiveness based on differential outcomes from previous research; and specification and testing of components singularly and in combination that contribute to effectiveness. Letter of Intent Receipt Date for this RFA is February 28, 2000; Application Receipt Date is March 28, 2000.

On January 11, 2000, NIDA, in collaboration with NIAAA issued an RFA entitled "Viral Hepatitis and HIV in Drug and Alcohol Users" (DA-00-006). This RFA is intended to address gaps in prevention, natural history, pathogenesis and treatment research related to viral hepatitis infection in drug and/or alcohol users, both with and without concomitant HIV infection, with an emphasis on research related to co-infections. Letter of Intent Receipt Date for this RFA is February 28, 2000; Application Receipt Date is March 28, 2000.

On January 21, 2000, NIDA issued an RFA entitled "Centers for Drug Abuse and AIDS Research Core Grants" (DA-00-008). The purpose of the CDAAR Core Grants is to create centers to enhance basic, clinical, epidemiological, prevention,and applied research on drug abuse and HIV infection and other co-occurring illnesses, through the support of shared resources. Letter of Intent Receipt Date for this RFA is March 13, 2000; Application Receipt Date is April, 12, 2000.

On September 7, 1999, NIDA, in conjunction with numerous other NIH components, issued an RFA entitled "Building Interdisciplinary Research Careers in Women's Health" (OD-99-008). This RFA invites career development award applications from junior faculty members, to be known as Interdisciplinary Women's Health Research (IWHR) Scholars, who have recently completed clinical training or postdoctoral fellowships, and who are commencing basic, translational, clinical and/or health services research relevant to women's health.

NIDA, in conjunction with several other NIH Institutes, issued an RFA on November 22, 1999 entitled "Gene Expression Profiling in the Nervous System" (MH-00-002). The purpose of this RFA is to solicit feasibility studies for profiling gene expression patterns in the mammalian nervous system. Exploratory research projects supported under this RFA will utilize neural tissue-specific cDNA reagents and state of the art microarray technologies in order to quantify in a highly parallel way, expression profiles of genes in mammalian neural tissue. The creation of collaborative teams is encouraged in which scientists with expertise in neuroscience research, genomics, and bioinformatics work to apply innovative approaches for analyzing microarray data.

NIDA, along with numerous other NIH components is co-sponsoring a new trans-institute NIH RFA entitled "Testing Interventions to Improve Adherence to Pharmacological Treatment Regimens" (OD-00-006). The NIH Office of Behavioral and Social Sciences Research (OBSSR) coordinated the effort for this RFA, issued in the NIH Guide on January 19, 2000. The purpose of this RFA is to encourage behavioral and social research on the effectiveness of interventions to improve adherence to therapeutic regimens in various settings. Letter of Intent Receipt Date is March 6, 2000; Application Receipt Date is April 6, 2000.


Notices

On December 8, 1999 NIDA issued a Notice in the NIH Guide entitled "Club Drug Research and Education Initiative" (DA-00-002). The purpose of this Notice is to inform the research community that NIDA is interested in expanding its research portfolio on all aspects related to the use, abuse, short- and long-term effects of "club drugs".

On December 13, 1999 NIDA issued a Notice in the NIH Guide announcing the availability of "Administrative Supplements for the Study of Drug Abuse and HIV/AIDS" (DA-00-003). The primary intent of this program is to encourage federal grantees who have not focused on drug use-related HIV/AIDS issues to do so, thus recognizing that drug abuse and HIV/AIDS are two diseases that often co-occur and interact and that must be prevented and treated together and in parallel. Projects that currently focus solely on either AIDS-related or drug abuse issues are encouraged to strengthen efforts in the complementary area.


Other Program Activities

National Drug Abuse Treatment Clinical Trials Network Grants Awarded

In an effort to dramatically improve treatment throughout the country, NIDA has awarded $55 million in grants over five years to establish a clinical trials network that will more rapidly move promising science-based drug addiction treatments into community settings. The five centers awarded grants are collectively the foundation for the National Drug Abuse Clinical Trials Network (CTN), which will provide a research infrastructure to test drug addiction treatments in real-life settings with diverse patient populations. The CTN will foster partnerships among NIDA, treatment researchers, and community-based treatment programs to bridge the gap between research and practice. The CTN, announced in January 1999 with an RFA, when complete, will consist of 20 to 30 regional research centers. At the local level, each center will be linked with 10 to 15 community treatment programs that represent a variety of treatment settings and patient populations available in that particular region of the country. The following universities have been selected as the cores for the first five regional centers. Each core will be linked with at least five community treatment programs throughout the region.

New England Node: Yale University, New Haven, CT
Delaware Valley Node: University of Pennsylvania, Philadelphia, PA
Mid-Atlantic Node: Johns Hopkins University, Baltimore, MD
Medical College of Virginia, Richmond, VA
Pacific Node: University of California at Los Angeles, Los Angeles, CA
Northwest Node: Oregon Health Sciences University, Portland, OR

Transdisciplinary Tobacco Use Research Centers

Seven academic institutions have been awarded grants totaling $14.5 million by the National Cancer Institute (NCI) and the National Institute on Drug Abuse (NIDA) to create the Transdisciplinary Tobacco Use Research Centers for studying new ways to combat tobacco use and its consequences. The Robert Wood Johnson Foundation (RWJF) has committed an additional $14 million over five years to complement NCI's and NIDA's efforts to improve the policy understanding and communications practices of the tobacco research teams. Each center, funded for five years, will foster unique collaborations among scientists across many disciplines, and will focus on areas where there are gaps in knowledge, such as adolescent smoking. Together, NCI and NIDA will spend about $70 million for the effort over five years. The centers' locations, principal investigators, and research themes follow.

The Brown University Center for Behavioral and Preventive Medicine at the Miriam Hospital, Providence, RI -- PI: David B. Abrams, Ph.D.
Theme: identify early childhood and lifetime psychiatric factors that determine smoking initiation, dependence, use patterns, cessation, and response to cessation treatment

The University of California at Irvine -- PI: Frances M. Leslie, Ph.D.
Theme: identify predictors of nicotine addiction in animals and tobacco susceptibility and use in humans using a shared conceptual model across multiple levels of analysis

The University of Southern California, Los Angeles -- PI: C. Anderson Johnson, Ph.D.
Theme: preventing tobacco use among youth of diverse cultures

Georgetown University, Washington, DC -- PI: Caryn Lerman, Ph.D.
Theme: identifying the bio-behavioral basis of smoking initiation, smoking treatment, and harm from tobacco exposure

University of Minnesota, Minneapolis -- PI: Dorothy K. Hatsukami, Ph.D.
Theme: treating smokers who have been resistant to conventional methods of intervention or who have not been previously targeted

University of Wisconsin Medical School, Madison -- PI: Michael Fiore, M.D., M.P.H.
Theme: relapse to tobacco use

Yale University, New Haven, CT -- PI: Stephanie S. O'Malley, Ph.D.
Theme: treatment of tobacco addiction

Buprenorphine/Naloxone New Drug Application

The New Drug Application for buprenorphine/naloxone, filed by Reckitt and Colman Pharmaceuticals, received an approvable status from the FDA on December 7, 1999. Both the buprenorphine and buprenorphine/naloxone New Drug Applications could be approved by mid-year 2000.

P-50 Center Grant Awards in Medications Development

DTR&D awarded a second group of P-50 center grants to the following persons and institutions: Dr. Herbert Kleber -- Columbia, University, NY; Dr. Marian Fishman -- Columbia University, NY; Dr. Tom Kosten -- Yale University, CT; Dr. Joseph Volpicelli -- University of Pennsylvania; and Dr. John Grabowski -- University of Texas, Houston.

Outpatient Study of Selegiline IR in Cocaine Dependence

A 4 site study of selegiline in the Department of Veterans Affairs Cooperative Studies Program (VACSP 1017) directed by Dr. Deborah Leiderman (DTR&D) has reached 60% enrollment. The trial should be completed by April 2000. A protocol for the Selegiline Transdermal System (STS) is currently undergoing review within the DVA and is projected to commence in the spring of 2000.

Drug Dependence and Neuroviral Infections

DTR&D has awarded a supplement to an NIMH grant to Dr. Ian Lipkin (as an Interagency agreement) to evaluate the concept that Antisocial Personality Disorder, which represents a major risk factor for development of refractory drug dependence, is associated with certain neuroviral infections. Based on preclinical data, it is hypothesized that such infections could alter brain biochemistry and make the infected individuals more vulnerable to drug dependence.

ONDCP National Youth Anti-Drug Media Campaign Evaluation

NIDA completed preparations for the evaluation of the ONDCP National Youth Anti-Drug Media Campaign and entered the field in November 1999. The complex science-based evaluation project is being conducted under contract with Westat, Inc., with two subcontractors, the Annenberg School for Communication, University of Pennsylvania, and the National Development Research Institute in North Carolina. The study, which is based on behavior change and social influence models, will be conducted in the household with parents and children in the same family. NIDA and the evaluation team spent approximately a year developing the research design, the six questionnaires for parents and youth, the sampling and analysis plans, programming of the questionnaires for laptop computers, and other extensive survey procedures. The study is being conducted at the national level with representative samples of parents and youth in a cross-sectional design and at the community level in four sites within major media markets in a longitudinal design. Reporting will take place every six months starting this summer with the report of the first wave.

Response to Child Neglect Research RFA

Seventy-three applications were submitted in response to RFA Child Neglect Research (OD-99-006) issued by the NIH Consortium on Child Abuse and Neglect for May 2000 Council. NIDA is the primary applicant institute on 8 of the applications and dual on 63. The NIDA contact is Dr. Coryl Jones (ERB/DESPR).


NIDA's New and Competing Awards Since September 1999

Abrams, David B. --- Miriam Hospital
Nicotine Dependence: Risk & Recovery Over Generations

Akil, Huda --- University of Michigan
The Orphanin System: Role In Stress and Addiction

Awbrey, James L. --- University of Georgia
Restructuring, Destructuring and Anonymous Organizations

Babich, John W. --- Zebra Pharmaceuticals, Inc.
Studies Of Novel Cocaine Medications Using PET

Barr, Gordon A. --- Hunter College of CUNY
MIDARP At Hunter College

Beinfeld, Margery C. --- Tufts University
Acute and Chronic Cocaine-Induced CCK Release

Bellack, Alan S. --- University of Maryland
Treatment For Substance Abuse In Schizophrenia

Bennett, Charles L. --- Northwestern University
Multicity Study of Quality of Care For HIV-Related TB

Benveniste, Helene D. --- Duke University
A 3D C57bl6/J Mouse Brain Atlas Magnetic Resonance Micro

Berkovitz, Robert A. --- Sensimetrics
Differential Spectrogram for Analysis of Nonlinearity

Berns, Gregory S. --- Emory University School of Medicine
Neuroimaging of Novelty Detection In Cocaine Dependence

Blendy, Julie A. --- University of Pennsylvania
Genetic Analysis of Drug Addiction

Blough, Bruce E. --- Research Triangle Institute
Potential Treatment Medications for Drug Abuse

Boot, Lee R. --- Infoculture
Neuroscience TV to Steer Teens from Substance Abuse

Broadhead, Robert S. --- University of Connecticut
Increasing Drug Users' Adherence To HIV Therapeutics

Brook, Judith S. --- Mount Sinai School of Medicine
Childhood Etiologic Determinants of Adolescent Drug Use

Brooner, Robert K. --- Johns Hopkins Bayview Campus
Clinical Trials Network Mid-Atlantic Collaborative Group

Brown, C. H. --- University of South Florida
Designs and Analyses for Mental Health Preventive Trials

Budney, Alan J. --- University of Vermont State Agricultural College
Clinical Significance of Marijuana Withdrawal

Burks, Thomas F. --- University of Texas Health Sciences Center
Opioid Gastrointestinal Tolerance and Dependence

Carey, Robert J. --- VA Medical Center
Interoceptive Drug Cue Conditioning of Cocaine Effects

Carise, Deni --- Treatment Research Institute
Linking Assessment Technology to Improved Patient Care

Carroll, Frank I. --- Research Triangle Institute
Selective Opioid Antagonist as Medication for Drug Abuse

Carroll, Kathleen M. --- Yale University
Clinical Trials Network: New England Node

Caton, Carol L. --- Columbia University
Drug Use and Course of Homelessness Among Single Adults

Chang, Linda --- Harbor-UCLA Research Education Institute
MR Spectroscopy to Monitor HAART In HIV Brain Injury

Chassin, Laurie A. --- Arizona State University
Substance Use Among Children of Alcoholics

Chavkin, Charles --- University of Washington
Endogenous Opioid Peptide Action In the Hippocampus

Chenausky, Karen V. --- Speech Technology & Applied Research Corp.
Automatic Analysis and Diagnosis of Dysarthria

Cheney, Paul D. --- University of Kansas Medical Center
Neuro-AIDS In Opiate Dependent Rhesus Macaques

Chiauzzi, Emil J. --- Innovative Training Systems
An Alternative for Incarcerated Substance Abusers

Childers, Steven R. --- Wake Forest University School of Medicine
Endogenous Cannabinoid Systems In Brain

Chiriboga, Claudia A. --- Neurological Institute
Quantified Fetal Cocaine Exposure and Neurodevelopment

Clark, Ann S. --- Dartmouth College
Neural and Behavioral Actions of Anabolic Steroids

Collins, Rebecca L. --- RAND
Substance Use and Sexual Risk Among HIV Positive Adults

Cottler, Linda B. --- Washington University
Prevention of HIV & STDs In Drug Using Women

Criado, Jose R. --- Scripps Research Institute
Cognitive and Reward Mechanisms In Opiate Addiction

Daunais, James B. --- Wake Forest University School of Medicine
Opioid - Dopamine Interactions In Primate Cocaine Abuse

De Wit, Harriet --- University of Chicago
Drug Abuse and Impulsivity: Human Laboratory Models

Delgado, Melvin --- Boston University
Boston University Social Work Minority Research Center

Des Jarlais, Don C. --- Beth Israel Medical Center
National Study of Syringe Exchange Programs

Devi, Lakshmi A. --- New York University School of Medicine
Post-Translational Regulation of Opioid Receptors

Dobs, Adrian S. --- Johns Hopkins University
Gonadal Hormones on Body Composition, HIV and Drug Use

Donohew, Lewis --- University of Kentucky
Persuasive Strategies for Effective Anti-Drug Messages

Dutta, Aloke K. --- Wayne State University
Dopamine Transporter Agents Against Cocaine Dependence

Edlin, Brian R. --- University of California
Hepatitis C Virus Transmission In Crack Cocaine Smokers

Edlin, Brian R. --- University of California
Clinical & Histologic Spectrum of HCV Liver Disease In IDUs

Ellinwood, Everett H. --- Duke University Medical Center
Cocaine Withdrawal: A Window of Treatment Opportunity

Filizola, Marta --- Moltech Corporation
Methods to Identify New Ligands for Opioid Receptors

Fischman, Marian W. --- Research Foundation for Mental Hygiene
Novel Pharmacotherapies for Cocaine Dependence

Flynn, Brian S. --- University of Vermont
Youth-Focused Media To Prevent Substance Use

Follette, William C. --- University of Nevada -- Reno
The Therapy Relationship and Anxiolytic Dependence

Frankfurt, Oskar S. --- Apostain, Inc.
A Novel Apoptosis Assay With Antibodies To SSDNA

Garvey, Arthur J. --- Harvard School of Dental Medicine
Individualizing Treatment For Addicted Smokers

Gelernter, Joel E. --- VA Connecticut Healthcare System
Genetics of Cocaine Dependence

George, Frank R. --- Amethyst Technologies, Inc.
Science Education: Neurobiology For Practitioners

George, John S. --- Los Alamos National Lab
Mapping Brain Function By Combined MRI, MEG and fMRI

Gevins, Alan A. --- Sam Technology, Inc.
Neurocognitive Measurement System for Marijuana Research

Ghasemzadeh, Mohammadhossein --- Medical University of South Carolina
Glutamate Receptor and Chronic Cocaine

Gomez, Felipe --- Pennsylvania State University Hershey Medical Center
Conditioned Corticosterone and Drugs of Abuse

Grabowski, John --- University of Texas Medical School
Substance Abuse Medications Development Research Center

Greenlick, Merwyn R. --- Oregon Health Sciences University
National Clinical Trials Network: Northwest Node

Griffiths, Roland R. --- Johns Hopkins University
Licit & Illicit Abused Stimulant Drugs

Grigson, Patricia S. --- Pennsylvania State University
Drugs of Abuse and Learned Aversions: Solving A Paradox

Grillon, Christian ---Yale University
Anxiety, Disinhibition, and Risk for Drug Abuse

Halkitis, Perry N. --- New Jersey City University
Protease Inhibitor Adherence Among Drug Users

Hanlon, Thomas E. --- Friends Research Institute, Inc.
Incarcerated Addict Mothers and Their Children

Hansen, William B. --- Tanglewood Research, Inc.
Drug Abuse Prevention Tool Kit for Community Groups

Harrison, Murelle G. --- Southern University and A&M College
Preventing Substance Use In Rural African-American Youth

Hatsukami, Dorothy K. --- University of Minnesota
Tobacco Exposure Reduction

Hayes, Steven C. --- University of Nevada
Treatment of Nicotine Dependent Smokers

Heimer, Robert --- Yale University School of Medicine
Simulating HIV-1 Transmission Risks Among IDUs

Heller, Craig H. --- Stanford University Dept. of Biological Sciences
A High-Throughput Assay for Genetic Studies of Sleep

Henggeler, Scott W. --- Medical University of South Carolina
Randomized Clinical Trial of Juvenile Drug Court and MST

Higgins, Stephen T. --- University of Vermont
Treating Cocaine Abuse: A Behavioral Approach

Ho, Wenzhe --- Children's Hospital of Philadelphia
Drug Abuse, Substance P And HIV

Hoffman, Jeffrey A. --- Danya International, Inc.
Smoking Cessation Intervention For Youth

Hoffman, Jeffrey A. --- Danya International, Inc.
Performance Measurement For Treatment Improvement (PMIT)

Hoffmann, John P. --- National Opinion Research Center
Drug Use and Economic Productivity

Hovorka, George B. --- Talking Lights Co.
Visible Light Patient Information/Tracking System

Howlett, Allyn C. --- Saint Louis University
Cannabinoid Receptor Structure Activity Relationships

Hser, Yih-Ing --- UCLA Drug Abuse Research Center
Drug Abuse: Epidemiology, Treatment Process, & Outcomes

Huffman, John W. --- Clemson University
Synthesis of Cannabinoids, Analogues and Metabolites

Hurd, Yasmin L. --- Karolinska Hospital
Molecular Effect of Drug Abuse On Human Neurodevelopment

Inciardi, James A. --- University of Delaware
Ongoing Studies of Treatment for High Risk Drug Users

Jackson, Michel T. --- Sensimetrics Corporation
Course Software In Articulation and Phonology

Jacob, Howard J. --- Medical College of Wisconsin
Rat Genome Database

Jewett, Don L. --- Abratech Corporation
G-Wave Equipment To Detect Specific Language Impairment

Johnson, Bankole A. --- University of Texas
Lab Trials To Develop Medications For Cocaine Dependence

Johnson, C. A. --- University of Southern California
Transdisciplinary Tobacco Use Research Center

Johnson, Rolley E. --- Johns Hopkins University
Methadone and Buprenorphine: Ante- And Post-Partum

Johnson, Wendell --- Emory University
Late Onset Crack Use

Kanouse, David E. --- RAND
HIV Prevention for Crystal Methamphetamine Users

Kaplan, Stanley A. --- Drugabuse Sciences, Inc.
Naltrexone IM Depot for Treatment of Heroin Addicts

Karlson, Kevin W. --- Lifetechniques-I,Lp.
Electronic Smoking Cessation Monitor and Communicator

Kaskutas, Lee A. --- Alcohol Research Group
Cost-Effectiveness of HMO Residential & Outpatient Care

King, Chi-Hsin R. --- Albany Molecular Research, Inc.
Synthesis of 18-Methoxycoronaridine Hydrochloride

Kinsley, Craig --- University of Richmond
Pregnancy & Neural & Behavioral Plasticity In the Female

Kleber, Herbert D. --- New York State Psychiatric Institute
A Study of Anesthesia-Assisted Heroin Detoxification

Kleber, Herbert D. --- Research Foundation for Mental Hygiene Inc.
Novel Medication Approaches For Substance Abuse

Klein, Robert S. --- Montefiore Medical Center
Natural History of HCV Infection In Drug Use

Kosten, Thomas R. --- VA Medical Center
Cocaine Pharmacotherapies for Comorbid Populations

Kouri, Elena M. --- McLean Hospital/Harvard Medical School
Nicotine's Effects on Other Drugs of Abuse

Kreek, Mary J. --- Rockefeller University
Addictions: Genotypes, Polymorphisms, and Function

Lai, Shenghan --- Johns Hopkins University School of Hygiene and Public Health
Subclinical Atherosclerosis In HIV+ Black Cocaine Users

Lamb, Richard J. --- University of Texas Health Sciences Center
Increasing Contingency Management Success Using Shaping

Langberg, Edwin --- Sensor Electronics, Inc
Efficient Tactor For Tactile Aids

Lattimore, Pamela K. --- Research Triangle Institute
Comparison of Alternative Coercive Drug Treatment Models

Lee, Nancy M. --- California Pacific Medical Center
Non-Opioid DNA: Molecular/Cellular/Physiological Studies

Lerman, Caryn E. --- Georgetown University
Transdisciplinary Tobacco Use Research Centers

Leslie, Frances M. --- University of California, Irvine
Center on Tobacco Use Susceptibility and Intervention

Leukefeld, Carl G. --- Center On Drug/Alcohol Research
Enhancing Drug Court Retention In A Rural State

Li, Ming D. --- University of Tennessee
Mapping of Susceptibility Loci For Nicotine Dependence

Liddle, Howard A. --- University of Miami
Transporting Family Therapy To Adolescent Day Treatment

Liguori, Anthony --- Wake Forest University School of Medicine
Sleep Deprivation and Alcohol Effects In Marijuana Users

Ling, Walter ---Friends Medical Sciences Research Center
Medication Development Unit For Stimulant Dependence

Ling, Walter --- UCLA Drug Abuse Research Center
National Drug Abuse Treatment Clinical Trials Network: Pacific Node

Lipkin, Ian --- University of California
Microbial & Immune Factors--Treatment Resistance Cocaine Addiction

Lochman, John E. --- University of Alabama
Indicated Prevention Of Substance Use In High Risk Boys

Loew, Gilda H. --- Molecular Research Institute
Pharmacochemical Studies of Opiate Narcotics

Magura, Stephen --- National Development & Research Institute, Inc.
Group Motivational Intervention In Drug Abuse Treatment

Maidment, Nigel T. --- University of California, Los Angeles
Role of Endogenous Opioids In Heroin Abuse

Marlowe, Douglas B. --- Treatment Research Institute
The Role of Judicial Status Hearings In Drug Court

Meaney, Michael --- McGill University
Individual Differences In Maternal Care In The Rat

Meisch, Richard A. --- University of Texas Medical School
The Economics of Polydrug Abuse

Mendelson, Jack H. --- McLean Hospital
Biobehavioral Studies of Narcotics Abuse

Miller, Maureen --- National Development & Research
Networks, Resources and Risk Among Women Drug Users

Miller, William R. --- University of New Mexico
Moving Motivational Interviewing Into Practice

Moss, Andrew R. --- University of California
HIV and Hepatitis In Young Injectors: A Community Study

Musto, David F. ---Yale University
Previous American Drug Experience & Future Perspectives

Muthuswamy, Jitendran --- Infinite Biomedical Technologies
Imicroelectromechanical Precision Drug Delivery

Napier, T. Celeste --- Loyola University
Opioids and the Physiology of the Ventral Pallidum

Nelson, Agatha P. --- University of Virgin Islands
Socialization, Risk Perception And Drug Use In VI Youth

Nelson, Kenrad --- Johns Hopkins University
The Epidemiology of Hepatitis C Infection in Thailand

Neumeyer, John L. --- National Pharmacia International, Inc.
Dopamine Agonists for the Therapy of Cocaine Addiction

Nunes, Edward V. --- Research Foundation for Mental Hygiene, Inc.
Behavioral Therapy For Depression In Drug Dependence

Olney, John W. --- Washington University
Developmental Brain Damage By Drugs of Abuse

O'Malley, Stephanie S. --- Yale University
Tobacco Dependence and Risk Factors for Treatment Failure

Passik, Steven D. --- Indiana Community Care, Inc.
Aberrant Drug Taking & Untreated Pain In Cancer and AIDS

Patterson, Thomas L. --- University of California
Promoting Safer Sex In HIV+ MSM Methamphetamine Users

Picker, Mitchell J. --- University of North Carolina @ Chapel Hill
Biobehavioral Actions of Partial Mu Agonists

Pierce, Robert Christopher --- Boston University School of Medicine
Neurotrophins and Repeated Cocaine

Pomerleau, Ovide F. --- University of Michigan
Differentiation of Phenotypes for Smoking

Porreca, Frank F. --- University of Arizona
Spinal Dynorphin and Opioid Tolerance

Porrino, Linda J. --- Wake Forest University
Regional Brain Activation During Cocaine Abstinence

Prendergast, Michael L. --- University of California
Evaluating Voucher-Based Contingencies In A Drug Court

Rajah, Valli --- Columbia University
Partner Abuse & HIV-Risk Resistance of Women In MMPTS

Rao, Mahendra S. --- University of Utah
Genes Involved In Long Term Neural Plasticity

Raviv, Gabriel --- Bio-Logic Systems Corporation
Screening Device For Detecting Small Acoustic Tumors

Reith, Maarten E. --- University of Illinois College of Medicine
Cocaine and Regulation of the Dopamine Transporter

Resnick, Heidi S. --- Medical University of South Carolina
Prevention of Postrape Psychopathology and Drug Abuse

Riley, William T. --- Personal Improvement Computer Systems
Computerized Scheduling of Nicotine Nasal Spray

Roberts, Laura W. --- University of New Mexico, Health Sciences
Center Stigma & Rurality: Drug Abuse, HIV/STD & Mental Illness

Roby, Richard J. --- Combustion Science & Engineering, Inc.
A Smoke Detector Alert Device for the Deaf

Roerig, Sandra C. --- Louisiana State University Medical Center
Spinal Nitric Oxide In Chronic Inflammatory Pain

Roman, Paul M. --- University of Georgia
Adoption Of Innovations In Private A&D Treatment Centers

Romich, Barry A. --- Prentke Romich Co.
Augmentative Communication Language Activity Monitor

Rosen, Bruce R. --- Massachusetts General Hospital
Functional Brain Mapping of Cocaine Action

Rounsaville, Bruce J. --- Connecticut Mental Health Center
Psychotherapy Development Research Center

Rowell, Peter P. --- University of Louisville School of Medicine
Functional Activity of Mesolimbic Nicotinic Receptors

Rudnick, Gary W. --- Yale University School of Medicine
Ion and Biogenic Amine Transport Mechanisms

Russell, Michael J. --- Aaken Laboratories, Inc.
Targeted Drug Delivery to the Brain

Sanudo-Pena, Clara M. --- Brown University
Motor Actions of Cannabinoids In A Parkinson's Model

Schafer, William --- University of California
Genetic Analysis of Nicotine Adaptation In C. Elegans

Schottenfeld, Richard S. --- Connecticut Mental Health Center
Counseling Conditions For Thrice Weekly Buprenorphine In A PCC

Schottenfeld, Richard S. --- Connecticut Mental Health Center
Brief Introductory Treatment For Demoralized Patients

Schottenfeld, Richard S. --- Connecticut Mental Health Center
Combining Behavioral Treatments With Agonist Maintenance

Schuster, Charles R. --- Wayne State University
High Doses of Methamphetamine on Human Brain Function

Sharma, Shubh D. --- Palatin Technologies, Inc.
Novel Metalopeptides As Opioid Analgesics

Shillingburg, Craig P. --- Integra Innovations, Inc
Rx System For Aged With Visual Impairment

Shoham, Varda --- University of Arizona
Family Consulation For Change-Resistant Smokers

Silverman, Kenneth --- Johns Hopkins Bayview Medical Center
A Reinforcement-Based Therapeutic Workplace

Simpson, D. D. --- Texas Christian University
Transferring Drug Abuse Treatment and Assessment Resource

Singer, Lynn T. --- Case Western Reserve University
Cocaine-Exposed Children and Anemia

Smith, James E. --- Wake Forest University
Drug Abuse & Neurotransmitter Receptor Autoantibodies

Smith, Miles P. --- Zebra Pharmaceuticals
Novel GBR Analogs for the Treatment of Cocaine Abuse

Smith, Miles P. --- Zebra Pharmaceuticals
Novel Bicyclic Analogs for Treatment of Cocaine Abuse

Stahler, Gerald J. --- Temple University
Cocaine Tx For Homeless Women: Community Support (CRA)

Stein, Elliot A. --- Medical College of Wisconsin
Functional MRI of Human Drug Abuse

Sterns, Ronni S. --- Creative Action, Inc.
De-Use System: An Intervention Product For Schools

Stitzer, Maxine L. --- Johns Hopkins Bayview Medical Center
Parametric Studies of Drug Abuse Abstinence Incentives

Stone, T. Howard --- University of Texas
Human Prisoners As Human Subjects In Therapeutic Research

Strauss, Shiela M. --- National Development & Research Institute
Drug Users' Self-Reported HIV Status: Validity/Methods

Sulk, Roberta A. --- CCtechnology
Low Risk Illicit Drug Level Monitoring

Sun, Lena Sy --- Columbia University
Cardiotoxicity After Maternal Cocaine Exposure

Surmeier, Dalton J. --- Northwestern University Medical School
Dopaminergic Signaling In the Nucleus Accumbens

Tang, Alice M. --- Tufts University
Nutritional Status of HIV Infected Injection Drug Users

Thiele, Dwain L. --- University of Texas Southwest Medical Center at Dallas
Opioid Metabolism By Immune System Peptidases

Thomas, David L. --- Johns Hopkins University
Hepatitis C Pathogenesis & the Human Genome

Tien, Allen Y. --- Medical Decision Logic, Inc.
Web-Based Client-Server Alcohol & Drug Abuse Assessment

Tien, Allen Y. --- Medical Decision Logic, Inc.
A Tool For Network Research On HIV Among Drug Users

Toga, Arthur W. --- University of California, Los Angeles
A Multimodal Multidimenstional (4D) Map of the Mouse Brain

Toll, Lawarence R. --- SRI International
Identifying Opioid Tolerance & Dependence-Related Genes

Tortu, Stephanie --- National Development & Research Institute, Inc.
Women Drug Users, Their Male Partners And HIV Risk

Trudell, Mark L. --- University of New Orleans
Novel Nicotinic Receptor Mediated Therapeutic Agents

Tsuang, Ming T. --- Massachusetts Mental Health Research Corp.
Molecular Genetics of Heroin Dependence

Turner, R. Jay --- Florida International University
Physical Disability, Mental Health and Substance Use

Victor, Ronald G. --- University of Texas Southwest Medical Center at Dallas
Cocaine and Sympathetic Nerve Activity In Humans

Vilim, Ferdinand Sven --- Mount Sinai School of Medicine
Neural Basis of Behavioral Priming: Induction and Memory

Voie, Arne H. --- Spencer Technologies, Inc.
Doppler Ultrasound Cochlear Bloodflow Monitor

Volkow, Nora D. --- Brookhaven Sciences Associates
Studies In Cocaine Abusers

Volpicelli, Joseph R. --- University of Pennsylvania
Innovative Approaches For Cocaine Pharmacotherapy

Wachtel, Stephen R. --- University of Chicago
Blockade of Methamphetamine Subjective Effects In Humans

Wagner, Glenn --- RAND
Adherence to HAART In the Context of Drug Abuse

Watkins, David I. --- Wisconsin Regional Primate Research Center
Study of MHC & CTL In Opiate-Dependent Monkeys With AIDS

Wechsberg, Wendee M. --- Research Triangle Institute
Pretreatment for African American Crack Abusers

Wehner, Jeanne M. --- Keystone Symposia
Genetics of Alcohol and Substance Abuse

Weisner, Constance --- Kaiser Foundation Research Institute
Long-Term Impact of Drug Treatment on Outcome & Cost

Wenzel, Suzanne L. --- RAND
Collaborative Linkages: Drug Courts & Service Providers

Wenzel, Suzanne L. --- RAND
Drug Abuse, Violence, and HIV/AIDS In Impoverished Women

White, Francis J. --- Chicago Medical School
Cocaine Addiction and Neuronal Excitability

Winger, Gail D. --- University of Michigan
Stimulants, Depressants & Hallucinogens As Reinforcers

Wolf, Marina E. --- Chicago Medical School
Dopamine/Glutamate Interactions In Nucleus Accumbens

Woody, George E. --- University of Pennsylvania
Clinical Research Cooperative

Woody, George E. --- University of Pennsylvania
Persistent Effects of LT/LI Drug Risk Counseling

Xu, Xiping --- Harvard School of Public Health
Genetics of Nicotine Addiction Vulnerability

Yeomans, David C. --- University of Illinois
Development of a Primate Behavioral Nociceptive Assay

Yu, Lei --- University of Cincinnati
Mu Opioid Receptor Gene In Heroin Addicts

Yu, Xiao-Fang --- Johns Hopkins University
Behavioral and Virologic Features of HIV+ IDUs In China

Zimmerman, Marc A. --- University of Michigan
A Longitudinal Study of School Dropout and Substance Use

Zink, M. Christine --- Johns Hopkins University
Effects of Cocaine On SIV AIDS & CNS Disease


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